Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

Journal of Cell Biology

Volumn 149, Issue 4, 2000, Pages 775-781

  Zondag, Gerben C M ^a   Evers, Eva E ^a   Ten Klooster, Jean P ^a   Janssen, Lennert ^a   Van Der Kammen, Rob A ^a   Collard, John G ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Madin Darby canine kidney cells; RaF MAP kinase; Ras signaling; Rho like GTPases; Tiam1

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; RHO FACTOR;

ANIMAL CELL; ARTICLE; CELL MOTILITY; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; GENE ACTIVATION; GENE ACTIVITY; GENE CONTROL; MESENCHYME; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; DOGS; DOWN-REGULATION; EPITHELIAL CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; KIDNEY; MESODERM; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MORPHOGENESIS; PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RAC GTP-BINDING PROTEINS; RAS PROTEINS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034658674     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.149.4.775     Document Type: Article

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