The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

Journal of Biological Chemistry

Volumn 272, Issue 51, 1997, Pages 32521-32527

  Kroll, Jens ^a   Waltenberger, Johannes ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE INHIBITOR; VASCULOTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SWINE; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SWINE;

EID: 0031466232     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.51.32521     Document Type: Article

References (58)

1. Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., and Ferrara, N. (1989) Science 246, 1306-1309
2. Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D. T. (1989) Science 246, 1309-1312
3. Plouët, J., Schilling, J., and Gospodarowicz, D. (1989) EMBO J. 8, 3801-3806
4. Connolly, D. T., Heuvelman, D. M., Nelson, R., Olander, J. V., Eppley, B. L., Delfino, J. J., Siegel, N. R., Leimgruber, R. M., and Feder, J. (1989) J. Clin. Invest. 84, 1470-1478
5. Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C.-H. (1994) J. Biol. Chem. 269, 26988-26995
6. Clauss, M., Gerlach, M., Gerlach, H., Brett, J., Wang, F., Familletti, P., Pan, Y.-C., Olander, J. V., Connolly, D. T., and Stern, D. (1990) J. Exp. Med. 172, 1535-1545
7. Shweiki, D., Itin, A., Soffer, D., and Keshet, E. (1992) Nature 359, 843-845
8. Plate, K. H., Breier, G., Weich, H. A., and Risau, W. (1992) Nature 359, 845-848
9. Banai, S., Shweiki, D., Pinson, A., Chandra, M., Lazarovici, G., and Keshet, E. (1994) Cardiovasc. Res. 28, 1176-1179
10. Tischer, E., Mitchell, R., Hartmann, R., Silva, M., Gospodarowicz, D., Fiddes, J. C., and Abraham, J. A. (1991) J. Biol. Chem. 266, 11947-11954
11. Olofsson, B., Pajusola, K., Kaipainen, A., Voneuler, G., Joukov, V., Saksela, O., Orpana, A., Petersson, R. F., Alitalo, K., and Eriksson, U. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 2576-2581
12. Joukov, V., Pajusola, K., Kaipainen, A., Chilov, D., Lahtinen, I., Kukk, E., Saksela, O., Kalkkinen, N., and Alitalo, K. (1996) EMBO J. 15, 290-298
13. Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H., and Sato, M. (1990) Oncogene 5, 519-524
14. de Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. (1992) Science 255, 989-991
15. Terman, B. I., Carrion, M. E., Kovacs, E., Rasmussen, B. A., Eddy, R. L., and Shows, T. B. (1991) Oncogene 6, 1677-1683
16. Terman, B. I., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D., Armellino, D. C., Gospodarowicz, D., and Böhlen, P. (1992) Biochem. Biophys. Res. Commun. 187, 1579-1586
17. Matthews, W., Jordan, C. T., Gavin, M., Jenkins, N. A., Copeland, N. G., and Lemischka, I. R. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 9026-9030
18. Aprelikova, O., Pajusola, K., Partanen, J., Armstrong, E., Alitalo, R., Bailey, S. K., McMahon, J., Wasmuth, J., Huebner, K., and Alitalo, K. (1992) Cancer Res. 52, 746-748
19. Heldin, C.-H. (1995) Cell 80, 213-223
20. Schlessinger, J., and Ullrich, A. (1992) Neuron 9, 383-391
21. Pawson, T. (1995) Nature 373, 573-580
22. Adachi, M., Fischer, E. H., Ihle, J., Imai, K., Jirik, F., Neel, B., Pawson, T., Shen, S. H., Thomas, M., Ullrich, A., and Zhao, Z. Z. (1996) Cell 85, 15
23. Hunter, T. (1996) Biochem. Soc. Trans. 24, 307-327
24. Waltenberger, J., Mayr, U., Pentz, S., and Hombach, V. (1996) Circulation 94, 1647-1654
25. Takahashi, T., and Shibuya, M. (1997) Oncogene 14, 2079-2089
26. Clauss, M., Weich, H., Breier, G., Knies, U., Rockl, W., Waltenberger, J., and Risau, W. (1996) J. Biol. Chem. 271, 17629-17634
27. Seetharam, L., Gotoh, N., Maru, Y., Neufeld, G., Yamaguchi, S., and Shibuya, M. (1995) Oncogene 10, 135-147
28. Fong, G.-H., Rossant, J., Gertsenstein, M., and Breitman, M. L. (1995) Nature 376, 66-70
29. Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., and Schuh, A. C. (1995) Nature 376, 62-66
30. Cooper, J. A., and Hunter, T. (1981) Mol. Cell. Biol. 1, 165-178
31. Strawn, L. M., McMahon, G., App, H., Schreck, R., Kuchler, W. R., Longhi, M. P., Hui, T. H., Tang, C., Levitzki, A., Gazit, A., Chen, I., Keri, G., Orfi, L., Risau, W., Flamme, I., Ullrich, A., Hirth, K. P., and Shawver, L. K. (1996) Cancer Res. 56, 3540-3545
32. Westermark, B., Siegbahn, A., Heldin, C.-H., and Claesson-Welsh, L. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 128-132
33. Dudley, D. T., Pang, L., Decker, S. J., Bridges, A. J., and Saltiel, A. R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7686-7689
34. Feng, G.-S., and Pawson, T. (1994) Trends Genet. 10, 54-58
35. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Grignani, F., Pawson, T., and Pelicci, P. G. (1992) Cell 70, 93-104
36. van der Geer, P., Wiley, S., Lai, V. K.-M., Oliver, J. P., Gish, G. D., Stephens, R., Kaplan, D., Shoelson, S., and Pawson, T. (1995) Curr. Biol. 5, 404-412
37. Salcini, A. E., McGlade, J., Pelicci, G., Nicoletti, I., Pawson, T., and Pelicci, P. G. (1994) Oncogene 9, 2827-2836
38. Fournier, E., Dubreuil, P., Birnbaum, D., and Borg, J.-P. (1995) Oncogene 11, 921-931
39. Fournier, E., Rosnet, O., Marchetto, S., Turck, C. W., Rottapel, R., Pelicci, P. G., Birnbaum, D., and Borg, J.-P. (1996) J. Biol. Chem. 271, 12956-12963
40. Yamane, A., Seetharam, L., Yamaguchi, S., Gotoh, N., Takahashi, T., Neufeld, G., and Shibuya, M. (1994) Oncogene 9, 2683-2690
41. Lehmann, J. M., Riethmuller, G., and Johnson, J. P. (1990) Nucleic Acids Res. 18, 1048
42. Clark, S. G., Stern, M. J., and Horvitz, H. R. (1992) Nature 356, 340-344
43. Matuoka, K., Shibata, M., Yamakawa, A., and Takenawa, T. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 9015-9019
44. Lowenstein, E. J., Daly, R. J., Batzer, A. G., Margolis, B., Lammers, R., Ullrich, A., Skolnik, E. Y., Barsagi, D., and Schlessinger, J. (1992) Cell 70, 431-442
45. Chou, M. M., Fajardo, J. E., and Hanafusa, H. (1992) Mol. Cell. Biol. 5834-5842
46. Li, W., Hu, P., Skolnik, E. Y., Ullrich, A., and Schlessinger, J. (1992) Mol. Cell. Biol. 5824-5833
47. Guo, D., Jia, Q., Song, H.-Y., Warren, R. S., and Donner, D. B. (1995) J. Biol. Chem. 270, 6729-6733
48. Yi, T., and Ihle, J. N. (1993) Mol. Cell. Biol. 13, 3350-3358
49. Chen, H. E., Chang, S., Trub, T., and Neel, B. G. (1996) Mol. Cell. Biol. 16, 3685-3697
50. Uchida, T., Matozaki, T., Noguchi, T., Yamao, T., Horita, K., Suzuki, T., Fujioka, Y., Sakamoto, C., and Kasuga, M. (1994) J. Biol. Chem. 269, 12220-12228
51. Vogel, W., Lammers, R., Huang, J., and Ullrich, A. (1993) Science 259, 1611-1614
52. Falet, H., Ramosmorales, F., Bachelot, C., Fischer, S., and Rendu, F. (1996) FEBS Lett. 383, 165-169
53. Su, L., Zhao, Z., Bouchard, P., Banville, D., Fischer, E. H., Krebs, E. G., and Shen, S.-H. (1996) J. Biol. Chem. 271, 10385-10390
54. Krautwald, S., Buscher, D., Kummer, V., Buder, S., and Baccarini, M. (1996) Mol. Cell. Biol. 16, 5955-5963
55. Klinghoffer, R. A., and Kazlauskas, A. (1995) J. Biol. Chem. 270, 22208-22217
56. Bennett, A. M., Tang, T. L., Sugimoto, S., Walsh, C. T., and Neel, B. G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7335-7339
57. Li, W., Nishimura, R., Kashishian, A., Batzer, A. G., Kim, W. J. H., Cooper, J. A., and Schlessinger, J. (1994) Mol. Cell. Biol. 14, 509-517
58. Tonks, N. K., and Neel, B. G. (1996) Cell 87, 365-368