-
1
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
Lewis T. S., Shapiro P. S., Ahn N. G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74:1998;49-139.
-
(1998)
Adv. Cancer Res.
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
3
-
-
0028985079
-
MAP kinase pathways in yeast: For mating and more
-
Herskowitz I. MAP kinase pathways in yeast: For mating and more. Cell. 80:1995;187-197.
-
(1995)
Cell
, vol.80
, pp. 187-197
-
-
Herskowitz, I.1
-
4
-
-
0031026008
-
The protein kinases of budding yeast: Six score and more
-
Hunter T., Plowman G. D. The protein kinases of budding yeast: Six score and more. Trends Biochem. Sci. 22:1997;18-22.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 18-22
-
-
Hunter, T.1
Plowman, G.D.2
-
5
-
-
0005261734
-
Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro
-
Ray L. B., Sturgill T. W. Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro. Proc. Natl. Acad. Sci. USA. 84:1987;1502-1506.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 1502-1506
-
-
Ray, L.B.1
Sturgill, T.W.2
-
6
-
-
0024321507
-
Purification of a hepatic S6 kinase from cyclohexamide-treated rats
-
Price D., Nemenoff R., Avruch J. Purification of a hepatic S6 kinase from cyclohexamide-treated rats. J. Biol. Chem. 264:1989;13825-13833.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 13825-13833
-
-
Price, D.1
Nemenoff, R.2
Avruch, J.3
-
7
-
-
0023818515
-
2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts
-
2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts. J. Biol. Chem. 263:1988;5396-5401.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 5396-5401
-
-
Hoshi, M.1
Nishida, E.2
Sakai, H.3
-
8
-
-
0025290163
-
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
-
Boulton T. G., Yancopoulos G. D., Gregory J. S., Slaughter C., Moomaw C., Hsu J., Cobb M. H. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science. 249:1990;64-67.
-
(1990)
Science
, vol.249
, pp. 64-67
-
-
Boulton, T.G.1
Yancopoulos, G.D.2
Gregory, J.S.3
Slaughter, C.4
Moomaw, C.5
Hsu, J.6
Cobb, M.H.7
-
9
-
-
0025823448
-
ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
-
Boulton T. G., Nye S. H., Robbins D. J., Ip N. Y., Radziejewska E., Morgenbesser S. D., DePinho R. A., Panayotatos N., Cobb M. H., Yancopoulos G. D. ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65:1991;663-675.
-
(1991)
Cell
, vol.65
, pp. 663-675
-
-
Boulton, T.G.1
Nye, S.H.2
Robbins, D.J.3
Ip, N.Y.4
Radziejewska, E.5
Morgenbesser, S.D.6
Depinho, R.A.7
Panayotatos, N.8
Cobb, M.H.9
Yancopoulos, G.D.10
-
10
-
-
0024997935
-
Pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine
-
Kyriakis J. M., Avruch J. pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine. J. Biol. Chem. 265:1990;17355-17363.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 17355-17363
-
-
Kyriakis, J.M.1
Avruch, J.2
-
11
-
-
0027423418
-
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
-
Hibi M., Lin A., Smeal T., Minden A., Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:1993;2135-2148.
-
(1993)
Genes Dev.
, vol.7
, pp. 2135-2148
-
-
Hibi, M.1
Lin, A.2
Smeal, T.3
Minden, A.4
Karin, M.5
-
12
-
-
0028229012
-
The stress-activated protein kinase subfamily of c-Jun kinases
-
Kyriakis J. M., Banerjee P., Nikolakaki E., Dai T., Rubie E. A., Ahmad M. F., Avruch J., Woodgett J. R. The stress-activated protein kinase subfamily of c-Jun kinases. Nature. 369:1994;156-160.
-
(1994)
Nature
, vol.369
, pp. 156-160
-
-
Kyriakis, J.M.1
Banerjee, P.2
Nikolakaki, E.3
Dai, T.4
Rubie, E.A.5
Ahmad, M.F.6
Avruch, J.7
Woodgett, J.R.8
-
13
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
-
Dérijard B., Hibi M., Wu I.-H., Barrett T., Su B., Deng T., Karin M., Davis R. J. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76:1994;1025-1037.
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Dérijard, B.1
Hibi, M.2
Wu, I.-H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
14
-
-
0029744885
-
Sounding the alarm: Protein kinase cascades activated by stress and inflammation
-
Kyriakis J. M., Avruch J. Sounding the alarm: Protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271:1996;24313-24316.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 24313-24316
-
-
Kyriakis, J.M.1
Avruch, J.2
-
15
-
-
0032509479
-
Defective T cell differentiation in the absence of Jnk1
-
Dong C., Yang D. D., Wysk M., Whitmarsh A. J., Davis R. J., Flavell R. A. Defective T cell differentiation in the absence of Jnk1. Science. 282:1998;2092-2095.
-
(1998)
Science
, vol.282
, pp. 2092-2095
-
-
Dong, C.1
Yang, D.D.2
Wysk, M.3
Whitmarsh, A.J.4
Davis, R.J.5
Flavell, R.A.6
-
16
-
-
0033118607
-
The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
-
Kuan C. Y., Yang D. D., Samanta R. D., Davis R. J., Rakic P., Flavell R. A. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron. 22:1999;667-676.
-
(1999)
Neuron
, vol.22
, pp. 667-676
-
-
Kuan, C.Y.1
Yang, D.D.2
Samanta, R.D.3
Davis, R.J.4
Rakic, P.5
Flavell, R.A.6
-
17
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han J., Lee J.-D., Bibbs L., Ulevitch R. J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 265:1994;808-811.
-
(1994)
Science
, vol.265
, pp. 808-811
-
-
Han, J.1
Lee, J.-D.2
Bibbs, L.3
Ulevitch, R.J.4
-
18
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee J. C., Laydon J. T., Mcdonnell P. C., Gallagher T. F., Kumar S., Green D., McNulty D., Blumenthal M. J., Heys J. R., Landvatter S. W. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 372:1994;739-746.
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
Mcdonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
-
19
-
-
0028022750
-
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
-
Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T., Nebreda A. R. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell. 78:1994;1027-1037.
-
(1994)
Cell
, vol.78
, pp. 1027-1037
-
-
Rouse, J.1
Cohen, P.2
Trigon, S.3
Morange, M.4
Alonso-Llamazares, A.5
Zamanillo, D.6
Hunt, T.7
Nebreda, A.R.8
-
20
-
-
0032953307
-
Regulation of the MEF2 family of transcription factors by p38
-
Zhao M., New L., Kravchenko V. V., Kato Y., Gram H., Di Padova F., Olson E. N., Ulevitch R. J., Han J. Regulation of the MEF2 family of transcription factors by p38. Mol. Cell. Biol. 19:1999;21-30.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 21-30
-
-
Zhao, M.1
New, L.2
Kravchenko, V.V.3
Kato, Y.4
Gram, H.5
Di Padova, F.6
Olson, E.N.7
Ulevitch, R.J.8
Han, J.9
-
21
-
-
0032193226
-
P38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes
-
Craxton A., Shu G., Graves J. D., Saklatvala J., Krebs E. G., Clark E. A. p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J. Immunol. 161:1998;3225-3236.
-
(1998)
J. Immunol.
, vol.161
, pp. 3225-3236
-
-
Craxton, A.1
Shu, G.2
Graves, J.D.3
Saklatvala, J.4
Krebs, E.G.5
Clark, E.A.6
-
22
-
-
0029055761
-
Components of a new human protein kinase signal transduction pathway
-
Zhou G., Bao Z. Q., Dixon J. E. Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270:1995;12665-12669.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12665-12669
-
-
Zhou, G.1
Bao, Z.Q.2
Dixon, J.E.3
-
24
-
-
0032531881
-
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
-
Kato Y., Tapping R. I., Huang S., Watson M. H., Ulevitch R. J., Lee J. D. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor. Nature. 395:1998;713-716.
-
(1998)
Nature
, vol.395
, pp. 713-716
-
-
Kato, Y.1
Tapping, R.I.2
Huang, S.3
Watson, M.H.4
Ulevitch, R.J.5
Lee, J.D.6
-
25
-
-
0033615653
-
Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control
-
English J. M., Pearson G., Hockenberry T., Shivakumar L., White M. A., Cobb M. H. Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. J. Biol. Chem. 274:1999.
-
(1999)
J. Biol. Chem.
, vol.274
-
-
English, J.M.1
Pearson, G.2
Hockenberry, T.3
Shivakumar, L.4
White, M.A.5
Cobb, M.H.6
-
26
-
-
0030694387
-
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
-
Kato Y., Kravchenko V. V., Tapping R. I., Han J., Ulevitch R. J., Lee J. D. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. EMBO J. 16:1997;7054-7066.
-
(1997)
EMBO J.
, vol.16
, pp. 7054-7066
-
-
Kato, Y.1
Kravchenko, V.V.2
Tapping, R.I.3
Han, J.4
Ulevitch, R.J.5
Lee, J.D.6
-
27
-
-
0032512770
-
Identification of substrates and regulators of mitogen-activated protein kinases ERK5 using chimeric protein kinases
-
English J. M., Pearson G., Baer R., Cobb M. H. Identification of substrates and regulators of mitogen-activated protein kinases ERK5 using chimeric protein kinases. J. Biol. Chem. 273:1998;3854-3860.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 3854-3860
-
-
English, J.M.1
Pearson, G.2
Baer, R.3
Cobb, M.H.4
-
28
-
-
0032958382
-
Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth
-
Abe M. K., Kuo W. L., Hershenson M. B., Rosner M. R. Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth. Mol. Cell. Biol. 19:1999;1301-1312.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1301-1312
-
-
Abe, M.K.1
Kuo, W.L.2
Hershenson, M.B.3
Rosner, M.R.4
-
29
-
-
0026639223
-
Heterogeneous expression of four MAP kinase isoforms in human tissues
-
Gonzalez F. A., Raden D. L., Rigby M. R., Davis R. J. Heterogeneous expression of four MAP kinase isoforms in human tissues. FEBS Lett. 304:1992;170-178.
-
(1992)
FEBS Lett.
, vol.304
, pp. 170-178
-
-
Gonzalez, F.A.1
Raden, D.L.2
Rigby, M.R.3
Davis, R.J.4
-
30
-
-
0028171047
-
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3
-
Zhu A. X., Zhao Y. I., Moller D. E., Flier J. S. Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3. Mol. Cell. Biol. 14:1994;8202-8211.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 8202-8211
-
-
Zhu, A.X.1
Zhao, Y.I.2
Moller, D.E.3
Flier, J.S.4
-
31
-
-
0029988873
-
ERK3 is a constitutively expressed nuclear protein kinase
-
Cheng M., Boulton T. G., Cobb M. H. ERK3 is a constitutively expressed nuclear protein kinase. J. Biol. Chem. 271:1996;8951-8958.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8951-8958
-
-
Cheng, M.1
Boulton, T.G.2
Cobb, M.H.3
-
32
-
-
0027326410
-
Protein kinase Cα activates RAF-1 by direct phosphorylation
-
Kolch W., Heldecker G., Kochs G., Hummel R., Vahidi H., Mischak H., Finkenzeller G., Marmé D., Rapp U. R. Protein kinase Cα activates RAF-1 by direct phosphorylation. Nature. 364:1993;249-255.
-
(1993)
Nature
, vol.364
, pp. 249-255
-
-
Kolch, W.1
Heldecker, G.2
Kochs, G.3
Hummel, R.4
Vahidi, H.5
Mischak, H.6
Finkenzeller, G.7
Marmé, D.8
Rapp, U.R.9
-
34
-
-
0027168907
-
Identification of the major phosphorylation sites of the Raf-1 kinase
-
Morrison D. K., Heidecker G., Rapp U. R., Copeland T. D. Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem. 268:1993;17309-17316.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 17309-17316
-
-
Morrison, D.K.1
Heidecker, G.2
Rapp, U.R.3
Copeland, T.D.4
-
35
-
-
0030756069
-
Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling
-
Diaz B., Barnard D., Filson A., MacDonald S., King A., Marshall M. Phosphorylation of Raf-1 serine 338-serine 339 is an essential regulatory event for Ras-dependent activation and biological signaling. Mol. Cell. Biol. 17:1997;4509-4516.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4509-4516
-
-
Diaz, B.1
Barnard, D.2
Filson, A.3
MacDonald, S.4
King, A.5
Marshall, M.6
-
36
-
-
0033561041
-
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
-
Mason C. S., Springer C. J., Cooper R. G., Superti-Furga G., Marshall C. J., Marais R. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J. 18:1999;2137-2148.
-
(1999)
EMBO J.
, vol.18
, pp. 2137-2148
-
-
Mason, C.S.1
Springer, C.J.2
Cooper, R.G.3
Superti-Furga, G.4
Marshall, C.J.5
Marais, R.6
-
37
-
-
0029014973
-
Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases
-
Dent P., Jelinek T., Morrison D. K., Weber M. J., Sturgill T. W. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. Science. 268:1995;1902-1906.
-
(1995)
Science
, vol.268
, pp. 1902-1906
-
-
Dent, P.1
Jelinek, T.2
Morrison, D.K.3
Weber, M.J.4
Sturgill, T.W.5
-
38
-
-
0026647749
-
Raf-1 activates MAP kinase-kinase
-
Kyriakis J. M., App H., Zhang X.-F., Banerjee P., Brautigan D. L., Rapp U. R., Avruch J. Raf-1 activates MAP kinase-kinase. Nature. 358:1992;417-421.
-
(1992)
Nature
, vol.358
, pp. 417-421
-
-
Kyriakis, J.M.1
App, H.2
Zhang, X.-F.3
Banerjee, P.4
Brautigan, D.L.5
Rapp, U.R.6
Avruch, J.7
-
39
-
-
0026641090
-
Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro
-
Dent P., Haser W., Haystead T. A. J., Vincent L. A., Roberts T. M., Sturgill T. W. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science. 257:1992;1404-1407.
-
(1992)
Science
, vol.257
, pp. 1404-1407
-
-
Dent, P.1
Haser, W.2
Haystead, T.A.J.3
Vincent, L.A.4
Roberts, T.M.5
Sturgill, T.W.6
-
40
-
-
0025969093
-
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
-
Payne D. M., Rossomando A. J., Martino P., Erickson A. K., Her J.-H., Shananowitz J., Hunt D. F., Weber M. J., Sturgill T. W. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J. 10:1991;885-892.
-
(1991)
EMBO J.
, vol.10
, pp. 885-892
-
-
Payne, D.M.1
Rossomando, A.J.2
Martino, P.3
Erickson, A.K.4
Her, J.-H.5
Shananowitz, J.6
Hunt, D.F.7
Weber, M.J.8
Sturgill, T.W.9
-
41
-
-
0025832605
-
Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase
-
Ahn N. G., Seger R., Bratlien R. L., Diltz C. D., Tonks N. K., Krebs E. G. Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J. Biol. Chem. 266:1991;4220-4227.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 4220-4227
-
-
Ahn, N.G.1
Seger, R.2
Bratlien, R.L.3
Diltz, C.D.4
Tonks, N.K.5
Krebs, E.G.6
-
42
-
-
0026690922
-
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells
-
Seger R., Ahn N. G., Posada J., Munar E. S., Jensen A. M., Cooper J. A., Cobb M. H., Krebs E. G. Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J. Biol. Chem. 267:1992;14373-14381.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 14373-14381
-
-
Seger, R.1
Ahn, N.G.2
Posada, J.3
Munar, E.S.4
Jensen, A.M.5
Cooper, J.A.6
Cobb, M.H.7
Krebs, E.G.8
-
43
-
-
0026539931
-
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
-
Crews C., Alessandrini A., Erikson R. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science. 258:1992;478-480.
-
(1992)
Science
, vol.258
, pp. 478-480
-
-
Crews, C.1
Alessandrini, A.2
Erikson, R.3
-
44
-
-
0027323844
-
Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase
-
Zheng C.-F., Guan K. Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J. Biol. Chem. 268:1993;16116-16119.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 16116-16119
-
-
Zheng, C.-F.1
Guan, K.2
-
45
-
-
0026509971
-
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase
-
Nakielny S., Cohen P., Wu J., Sturgill T. MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. EMBO J. 11:1992;2123-2130.
-
(1992)
EMBO J.
, vol.11
, pp. 2123-2130
-
-
Nakielny, S.1
Cohen, P.2
Wu, J.3
Sturgill, T.4
-
46
-
-
0026766322
-
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation
-
Kosako H., Gotoh Y., Matsuda S., Ishikawa M., Nishida E. Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation. EMBO J. 11:1992;2903-2908.
-
(1992)
EMBO J.
, vol.11
, pp. 2903-2908
-
-
Kosako, H.1
Gotoh, Y.2
Matsuda, S.3
Ishikawa, M.4
Nishida, E.5
-
47
-
-
0027397368
-
Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase
-
Wu J., Harrison J. K., Vincent L. A., Haystead C., Haystead T. A. J., Michel H., Hunt D. F., Lynch K. R., Sturgill T. W. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase. Proc. Natl. Acad. Sci. USA. 90:1993;173-177.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 173-177
-
-
Wu, J.1
Harrison, J.K.2
Vincent, L.A.3
Haystead, C.4
Haystead, T.A.J.5
Michel, H.6
Hunt, D.F.7
Lynch, K.R.8
Sturgill, T.W.9
-
48
-
-
0030445778
-
Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs
-
Ferrell J. E. Jr. Tripping the switch fantastic: How a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem. Sci. 21:1996;460-466.
-
(1996)
Trends Biochem. Sci.
, vol.21
, pp. 460-466
-
-
Ferrell J.E., Jr.1
-
49
-
-
0029790351
-
Ultrasensitivity in the mitogen-activated protein kinase cascade
-
Huang C.-Y. F., Ferrell J. E. Jr. Ultrasensitivity in the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA. 93:1996;10078-10083.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10078-10083
-
-
Huang, C.-Y.F.1
Ferrell J.E., Jr.2
-
50
-
-
0032496358
-
The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
-
Ferrell J. E., Machleder E. M. The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. Science. 280:1998;895-898.
-
(1998)
Science
, vol.280
, pp. 895-898
-
-
Ferrell, J.E.1
Machleder, E.M.2
-
51
-
-
0030746219
-
Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase
-
Ferrell J. E., Bhatt R. R. Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. J. Biol. Chem. 272:1997;19008-19016.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19008-19016
-
-
Ferrell, J.E.1
Bhatt, R.R.2
-
52
-
-
0031203921
-
How responses get more switch like as you move down a protein kinase cascade
-
Ferrell J. E. How responses get more switch like as you move down a protein kinase cascade. Trends Biochem. Sci. 22:1997;288-289.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 288-289
-
-
Ferrell, J.E.1
-
53
-
-
0029584327
-
KSR, a novel protein kinase required for RAS signal transduction
-
Therrien M., Chang H. C., Solomon N. M., Karim F. D., Wassarman D. A., Rubin G. M. KSR, a novel protein kinase required for RAS signal transduction. Cell. 83:1995;879-888.
-
(1995)
Cell
, vol.83
, pp. 879-888
-
-
Therrien, M.1
Chang, H.C.2
Solomon, N.M.3
Karim, F.D.4
Wassarman, D.A.5
Rubin, G.M.6
-
54
-
-
0029559183
-
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction
-
Sundaram M., Han M. The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell. 83:1995;889-901.
-
(1995)
Cell
, vol.83
, pp. 889-901
-
-
Sundaram, M.1
Han, M.2
-
55
-
-
0029588204
-
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
-
Kornfeld K., Hom D. B., Horvitz H. R. The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell. 83:1995;903-913.
-
(1995)
Cell
, vol.83
, pp. 903-913
-
-
Kornfeld, K.1
Hom, D.B.2
Horvitz, H.R.3
-
57
-
-
0030724987
-
KSR stimulates Raf-1 activity in a kinase-independent manner
-
Michaud N. R., Therrien M., Cacace A., Edsall L. C., Spiegel S., Rubin G. M., Morrison D. K. KSR stimulates Raf-1 activity in a kinase-independent manner. Proc. Natl. Acad. Sci. USA. 94:1997;12792-12796.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12792-12796
-
-
Michaud, N.R.1
Therrien, M.2
Cacace, A.3
Edsall, L.C.4
Spiegel, S.5
Rubin, G.M.6
Morrison, D.K.7
-
58
-
-
0031974812
-
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
-
Yu W., Fantl W. J., Harrowe G., Williams L. T. Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr. Biol. 8:1998;56-64.
-
(1998)
Curr. Biol.
, vol.8
, pp. 56-64
-
-
Yu, W.1
Fantl, W.J.2
Harrowe, G.3
Williams, L.T.4
-
59
-
-
0031974151
-
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
-
Denouel-Galy A., Douville E. M., Warne P. H., Papin C., Laugier D., Calothy G., Downward J., Eychene A. Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Curr. Biol. 8:1998;46-55.
-
(1998)
Curr. Biol.
, vol.8
, pp. 46-55
-
-
Denouel-Galy, A.1
Douville, E.M.2
Warne, P.H.3
Papin, C.4
Laugier, D.5
Calothy, G.6
Downward, J.7
Eychene, A.8
-
60
-
-
0032814144
-
Kinase suppressor of ras forms a multiprotein signaling complex and modulates MEK localization
-
Stewart S., Sundaram M., Zhang Y., Lee J., Han M., Guan K. L. Kinase suppressor of ras forms a multiprotein signaling complex and modulates MEK localization. Mol. Cell. Biol. 19:1999;5523-5534.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5523-5534
-
-
Stewart, S.1
Sundaram, M.2
Zhang, Y.3
Lee, J.4
Han, M.5
Guan, K.L.6
-
61
-
-
0033583040
-
KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation
-
Bell B., Xing H., Yan K., Gautam N., Muslin A. J. KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. J. Biol. Chem. 274:1999;7982-7986.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7982-7986
-
-
Bell, B.1
Xing, H.2
Yan, K.3
Gautam, N.4
Muslin, A.J.5
-
62
-
-
0031149850
-
The protein kinase KSR interacts with 14-3-3 protein and Raf
-
Xing H., Kornfeld K., Muslin A. J. The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr. Biol. 7:1997;294-300.
-
(1997)
Curr. Biol.
, vol.7
, pp. 294-300
-
-
Xing, H.1
Kornfeld, K.2
Muslin, A.J.3
-
63
-
-
0033607522
-
The N-terminal ERK binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo
-
Xu B., Wilsbacher J., Collisson T., Cobb M. H. The N-terminal ERK binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J. Biol. Chem. 1999.
-
(1999)
J. Biol. Chem.
-
-
Xu, B.1
Wilsbacher, J.2
Collisson, T.3
Cobb, M.H.4
-
64
-
-
0032536816
-
Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
-
Yang S. H., Whitmarsh A. J., Davis R. J., Sharrocks A. D. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J. 17:1998;1740-1749.
-
(1998)
EMBO J.
, vol.17
, pp. 1740-1749
-
-
Yang, S.H.1
Whitmarsh, A.J.2
Davis, R.J.3
Sharrocks, A.D.4
-
65
-
-
0033597309
-
Control of the cell morphology and the S phase entry by mitogen-activated protein kinase kinase. A regulatory role of its N-terminal region
-
Gotoh I., Fukuda M., Adachi M., Nishida E. Control of the cell morphology and the S phase entry by mitogen-activated protein kinase kinase. A regulatory role of its N-terminal region. J. Biol. Chem. 274:1999;11874-11880.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 11874-11880
-
-
Gotoh, I.1
Fukuda, M.2
Adachi, M.3
Nishida, E.4
-
66
-
-
0029164688
-
A proline-rich sequence unique to MEK1 and MEK2 is required for Raf binding and regulates MEK function
-
Catling A. D., Schaeffer H.-J., Reuter C. W. M., Reddy G. R., Weber M. J. A proline-rich sequence unique to MEK1 and MEK2 is required for Raf binding and regulates MEK function. Mol. Cell. Biol. 15:1995;5214-5225.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5214-5225
-
-
Catling, A.D.1
Schaeffer, H.-J.2
Reuter, C.W.M.3
Reddy, G.R.4
Weber, M.J.5
-
67
-
-
0032584728
-
The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells
-
Dang A., Frost J. A., Cobb M. H. The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells. J. Biol. Chem. 273:1998;19909-19913.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 19909-19913
-
-
Dang, A.1
Frost, J.A.2
Cobb, M.H.3
-
68
-
-
0027932676
-
Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: Determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis
-
Mansour S. J., Resing K. A., Candia J. M., Hermann A. S., Gloor J. W., Herskind K. R., Wartmann M., Davis R. J., Ahn N. G. Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: Determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis. J. Biochem. 116:1994;304-314.
-
(1994)
J. Biochem.
, vol.116
, pp. 304-314
-
-
Mansour, S.J.1
Resing, K.A.2
Candia, J.M.3
Hermann, A.S.4
Gloor, J.W.5
Herskind, K.R.6
Wartmann, M.7
Davis, R.J.8
Ahn, N.G.9
-
69
-
-
0028297817
-
MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase. Analysis of phosphopeptides and regulation of activity
-
Gardner A. M., Vaillancourt R. R., Lange-Carter C. A., Johnson G. L. MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase. Analysis of phosphopeptides and regulation of activity. Mol. Biol. Cell. 5:1994;193-201.
-
(1994)
Mol. Biol. Cell.
, vol.5
, pp. 193-201
-
-
Gardner, A.M.1
Vaillancourt, R.R.2
Lange-Carter, C.A.3
Johnson, G.L.4
-
70
-
-
0030358762
-
Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways
-
Cobb M. H., Xu S., Cheng M., Ebert D., Robbins D., Goldsmith E., Robinson M. Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways. Adv. Pharmacol. 36:1996;49-65.
-
(1996)
Adv. Pharmacol.
, vol.36
, pp. 49-65
-
-
Cobb, M.H.1
Xu, S.2
Cheng, M.3
Ebert, D.4
Robbins, D.5
Goldsmith, E.6
Robinson, M.7
-
71
-
-
0030830220
-
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
-
Frost J. A., Steen H., Shapiro P. S., Lewis R., Ahn J., Shaw P. E., Cobb M. H. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J. 16:1997;6426-6438.
-
(1997)
EMBO J.
, vol.16
, pp. 6426-6438
-
-
Frost, J.A.1
Steen, H.2
Shapiro, P.S.3
Lewis, R.4
Ahn, J.5
Shaw, P.E.6
Cobb, M.H.7
-
72
-
-
0032508538
-
MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
-
Schaeffer H. J., Catling A. D., Eblen S. T., Collier L. S., Krauss A., Weber M. J. MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science. 281:1998;1668-1671.
-
(1998)
Science
, vol.281
, pp. 1668-1671
-
-
Schaeffer, H.J.1
Catling, A.D.2
Eblen, S.T.3
Collier, L.S.4
Krauss, A.5
Weber, M.J.6
-
73
-
-
0031457622
-
Signaling through scaffold, anchoring, and adaptor proteins
-
Pawson T., Scott J. D. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278:1997;2075-2080.
-
(1997)
Science
, vol.278
, pp. 2075-2080
-
-
Pawson, T.1
Scott, J.D.2
-
74
-
-
0027312272
-
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
-
Li N., Batzer A., Daly R., Yajnik V., Skolnik E., Chardin P., Bar-Sagi D., Margolis B., Schlessinger J. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363:1993;85-88.
-
(1993)
Nature
, vol.363
, pp. 85-88
-
-
Li, N.1
Batzer, A.2
Daly, R.3
Yajnik, V.4
Skolnik, E.5
Chardin, P.6
Bar-Sagi, D.7
Margolis, B.8
Schlessinger, J.9
-
75
-
-
0030029343
-
Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation
-
Jelinek T., Dent P., Sturgill T. W., Weber M. J. Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation. Mol. Cell Biol. 16:1996;1027-1034.
-
(1996)
Mol. Cell Biol.
, vol.16
, pp. 1027-1034
-
-
Jelinek, T.1
Dent, P.2
Sturgill, T.W.3
Weber, M.J.4
-
76
-
-
0027250250
-
Mammalian Ras interacts directly with the serine/threonine kinase Raf
-
Vojtek A. B., Hollenberg S. M., Cooper J. A. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell. 74:1993;205-214.
-
(1993)
Cell
, vol.74
, pp. 205-214
-
-
Vojtek, A.B.1
Hollenberg, S.M.2
Cooper, J.A.3
-
77
-
-
0027337248
-
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
-
Zhang X., Settleman J., Kyriakis J. M., Takeuchi-Suzuki E., Elledge S. J., Marshall M. S., Bruder J. T., Rapp U. R., Avruch J. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature. 364:1993;308-313.
-
(1993)
Nature
, vol.364
, pp. 308-313
-
-
Zhang, X.1
Settleman, J.2
Kyriakis, J.M.3
Takeuchi-Suzuki, E.4
Elledge, S.J.5
Marshall, M.S.6
Bruder, J.T.7
Rapp, U.R.8
Avruch, J.9
-
78
-
-
0027200883
-
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
-
Warne P. H., Viciana P. R., Downward J. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature. 364:1993;353-355.
-
(1993)
Nature
, vol.364
, pp. 353-355
-
-
Warne, P.H.1
Viciana, P.R.2
Downward, J.3
-
79
-
-
0027337519
-
Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase
-
Moodie S. A., Willumsen B. M., Weber M. J., Wolfman A. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase. Science. 260:1993;1658-1660.
-
(1993)
Science
, vol.260
, pp. 1658-1660
-
-
Moodie, S.A.1
Willumsen, B.M.2
Weber, M.J.3
Wolfman, A.4
-
80
-
-
0029810302
-
Negative regulation of Raf-1 by phosphorylation of serine 621
-
Mischak H., Seitz T., Janosch P., Eulitz M., Steen H., Schellerer M., Philipp A., Kolch W. Negative regulation of Raf-1 by phosphorylation of serine 621. Mol. Cell. Biol. 16:1996;5409-5418.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5409-5418
-
-
Mischak, H.1
Seitz, T.2
Janosch, P.3
Eulitz, M.4
Steen, H.5
Schellerer, M.6
Philipp, A.7
Kolch, W.8
-
81
-
-
0030068806
-
Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase
-
Kikuchi A., Williams L. T. Regulation of interaction of ras p21 with RalGDS and Raf-1 by cyclic AMP-dependent protein kinase. J. Biol. Chem. 271:1996;588-594.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 588-594
-
-
Kikuchi, A.1
Williams, L.T.2
-
82
-
-
0030664140
-
CAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation
-
D'Angelo G., Lee H., Weiner R. I. cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation. J. Cell. Biochem. 67:1997;353-366.
-
(1997)
J. Cell. Biochem.
, vol.67
, pp. 353-366
-
-
D'Angelo, G.1
Lee, H.2
Weiner, R.I.3
-
83
-
-
0032545328
-
A family of cAMP-binding proteins that directly activate Rap1
-
Kawasaki H., Springett G. M., Mochizuki N., Toki S., Nakaya M., Matsuda M., Housman D. E., Graybiel A. M. A family of cAMP-binding proteins that directly activate Rap1. Science. 282:1998;2275-2279.
-
(1998)
Science
, vol.282
, pp. 2275-2279
-
-
Kawasaki, H.1
Springett, G.M.2
Mochizuki, N.3
Toki, S.4
Nakaya, M.5
Matsuda, M.6
Housman, D.E.7
Graybiel, A.M.8
-
84
-
-
0032480888
-
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
-
de Rooij J., Zwartkruis F. J., Verheijen M. H., Cool R. H., Nijman S. M., Wittinghofer A., Bos J. L. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature. 396:1998;474-477.
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
De Rooij, J.1
Zwartkruis, F.J.2
Verheijen, M.H.3
Cool, R.H.4
Nijman, S.M.5
Wittinghofer, A.6
Bos, J.L.7
-
85
-
-
0030963439
-
CAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
-
Vossler M. R., Yao H., York R. D., Pan M. G., Rim C. S., Stork P. J. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell. 89:1997;73-82.
-
(1997)
Cell
, vol.89
, pp. 73-82
-
-
Vossler, M.R.1
Yao, H.2
York, R.D.3
Pan, M.G.4
Rim, C.S.5
Stork, P.J.6
-
86
-
-
0029083694
-
Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells
-
Erhardt P., Troppmair J., Rapp U. R., Cooper G. M. Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC12 cells. Mol. Cell. Biol. 15:1995;5524-5530.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 5524-5530
-
-
Erhardt, P.1
Troppmair, J.2
Rapp, U.R.3
Cooper, G.M.4
-
87
-
-
0033520427
-
Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway
-
Seidel M. G., Klinger M., Freissmuth M., Iler C. Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway. J. Biol. Chem. 274:1999;25833-25841.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 25833-25841
-
-
Seidel, M.G.1
Klinger, M.2
Freissmuth, M.3
Iler, C.4
-
88
-
-
0032531756
-
Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signaling
-
Zwartkruis F., Wolthuis R. M., Nabben N. M., Franke B., Bos J. L. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signaling. EMBO J. 17:1998;5905-5912.
-
(1998)
EMBO J.
, vol.17
, pp. 5905-5912
-
-
Zwartkruis, F.1
Wolthuis, R.M.2
Nabben, N.M.3
Franke, B.4
Bos, J.L.5
-
89
-
-
0030613761
-
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A
-
Daaka Y., Luttrell L. M., Lefkowitz R. J. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 390:1997;88-91.
-
(1997)
Nature
, vol.390
, pp. 88-91
-
-
Daaka, Y.1
Luttrell, L.M.2
Lefkowitz, R.J.3
-
90
-
-
0029778177
-
Role of c-Src tyrosine kinase in G protein-coupled receptor- and G-βγ subunit-mediated activation of mitogen-activated protein kinases
-
Luttrell L. M., Hawes B. E., Vanbiesen T., Luttrell D. K., Lansing T. J., Lefkowitz R. J. Role of c-Src tyrosine kinase in G protein-coupled receptor- and G-βγ subunit-mediated activation of mitogen-activated protein kinases. J. Biol. Chem. 271:1996;19443-19450.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19443-19450
-
-
Luttrell, L.M.1
Hawes, B.E.2
Vanbiesen, T.3
Luttrell, D.K.4
Lansing, T.J.5
Lefkowitz, R.J.6
-
91
-
-
0033538342
-
Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes
-
Hedin K. E., Bell M. P., Huntoon C. J., Karnitz L. M., McKean D. J. Gi proteins use a novel beta gamma- and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes. J. Biol. Chem. 274:1999;19992-20001.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 19992-20001
-
-
Hedin, K.E.1
Bell, M.P.2
Huntoon, C.J.3
Karnitz, L.M.4
McKean, D.J.5
-
92
-
-
0033606980
-
Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)
-
Mochizuki N., Ohba Y., Kiyokawa E., Kurata T., Murakami T., Ozaki T., Kitabatake A., Nagashima K., Matsuda M. Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i). Nature. 400:1999;891-894.
-
(1999)
Nature
, vol.400
, pp. 891-894
-
-
Mochizuki, N.1
Ohba, Y.2
Kiyokawa, E.3
Kurata, T.4
Murakami, T.5
Ozaki, T.6
Kitabatake, A.7
Nagashima, K.8
Matsuda, M.9
-
93
-
-
0029907265
-
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
-
Dikic I., Tokiwa G., Lev S., Courtneidge S. A., Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature. 383:1996;547-550.
-
(1996)
Nature
, vol.383
, pp. 547-550
-
-
Dikic, I.1
Tokiwa, G.2
Lev, S.3
Courtneidge, S.A.4
Schlessinger, J.5
-
94
-
-
0030044360
-
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
-
Daub H., Weiss F. U., Wallasch C., Ullrich A. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature. 379:1996;557-560.
-
(1996)
Nature
, vol.379
, pp. 557-560
-
-
Daub, H.1
Weiss, F.U.2
Wallasch, C.3
Ullrich, A.4
-
95
-
-
0029074408
-
Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells
-
Linseman D. A., Benjamin C. W., Jones D. A. Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells. J. Biol. Chem. 270:1995;12563-12568.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12563-12568
-
-
Linseman, D.A.1
Benjamin, C.W.2
Jones, D.A.3
-
96
-
-
0030683639
-
Signal characteristics of G protein-transactivated EGF receptor
-
Daub H., Wallasch C., Lankenau A., Herrlich A., Ullrich A. Signal characteristics of G protein-transactivated EGF receptor. EMBO J. 16:1997;7032-7044.
-
(1997)
EMBO J.
, vol.16
, pp. 7032-7044
-
-
Daub, H.1
Wallasch, C.2
Lankenau, A.3
Herrlich, A.4
Ullrich, A.5
-
97
-
-
0033553526
-
Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases
-
Dellarocca G. J., Maudsley S., Daaka Y., Lefkowitz R. J., Luttrell L. M. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. J. Biol. Chem. 274:1999;13978-13984.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13978-13984
-
-
Dellarocca, G.J.1
Maudsley, S.2
Daaka, Y.3
Lefkowitz, R.J.4
Luttrell, L.M.5
-
98
-
-
0029154733
-
2+-induced regulation of ion channel and MAP kinase functions
-
2+-induced regulation of ion channel and MAP kinase functions. Nature. 376:1995;737-745.
-
(1995)
Nature
, vol.376
, pp. 737-745
-
-
Lev, S.1
Moreno, H.2
Martinez, R.3
Canoll, P.4
Peles, E.5
Musacchio, J.M.6
Plowman, G.D.7
Rudy, B.8
Schlessinger, J.9
-
99
-
-
0032555202
-
Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells
-
Herrlich A., Daub H., Knebel A., Herrlich P., Ullrich A., Schultz G., Gudermann T. Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. Proc. Natl. Acad. Sci. USA. 95:1998;8985-8990.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8985-8990
-
-
Herrlich, A.1
Daub, H.2
Knebel, A.3
Herrlich, P.4
Ullrich, A.5
Schultz, G.6
Gudermann, T.7
-
100
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma
-
Lopez-Ilasaca M., Crespo P., Pellici P. G., Gutkind J. S., Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science. 275:1997;394-397.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
Gutkind, J.S.4
Wetzker, R.5
-
101
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
-
Stoyanov B., Volinia S., Hanck T., Rubio I., Loubtchenkov M., Malek D., Stoyanova S., Vanhaesebroeck B., Dhand R., Nurnberg B. Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase. Science. 269:1995;690-693.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volinia, S.2
Hanck, T.3
Rubio, I.4
Loubtchenkov, M.5
Malek, D.6
Stoyanova, S.7
Vanhaesebroeck, B.8
Dhand, R.9
Nurnberg, B.10
-
102
-
-
0029617910
-
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta
-
Berra E., Diazmeco M. T., Lozano J., Frutos S., Municio M. M., Sanchez P., Sanz L., Moscat J. Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J. 14:1995;6157-6163.
-
(1995)
EMBO J.
, vol.14
, pp. 6157-6163
-
-
Berra, E.1
Diazmeco, M.T.2
Lozano, J.3
Frutos, S.4
Municio, M.M.5
Sanchez, P.6
Sanz, L.7
Moscat, J.8
-
103
-
-
0032079960
-
Angiotensin II stimulates ERK via two pathways in epithelial cells - Protein kinase C suppresses a G-protein coupled receptor EGF receptor transactivation pathway
-
Li X., Lee J. W., Graves L. M., Earp H. S. Angiotensin II stimulates ERK via two pathways in epithelial cells - Protein kinase C suppresses a G-protein coupled receptor EGF receptor transactivation pathway. EMBO J. 17:1998;2574-2583.
-
(1998)
EMBO J.
, vol.17
, pp. 2574-2583
-
-
Li, X.1
Lee, J.W.2
Graves, L.M.3
Earp, H.S.4
-
104
-
-
0029664963
-
G-α-12 and G-α-13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells
-
Voynoyasenetskaya T. A., Faure M. P., Ahn N. G., Bourne H. R. G-α-12 and G-α-13 regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. J. Biol. Chem. 271:1996;21081-21087.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 21081-21087
-
-
Voynoyasenetskaya, T.A.1
Faure, M.P.2
Ahn, N.G.3
Bourne, H.R.4
-
105
-
-
0029666415
-
Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac
-
Collins L. R., Minden A., Karin M., Brown J. H. Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. J. Biol. Chem. 271:1996;17349-17353.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17349-17353
-
-
Collins, L.R.1
Minden, A.2
Karin, M.3
Brown, J.H.4
-
106
-
-
0031975838
-
Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase
-
Daaka Y., Luttrell L. M., Ahn S., Dellarocca G. J., Ferguson S. G., Caron M. G., Lefkowitz R. J. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J. Biol. Chem. 273:1998;685-688.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 685-688
-
-
Daaka, Y.1
Luttrell, L.M.2
Ahn, S.3
Dellarocca, G.J.4
Ferguson, S.G.5
Caron, M.G.6
Lefkowitz, R.J.7
-
107
-
-
0033613938
-
Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
-
Luttrell L. M., Ferguson S. S., Daaka Y., Miller W. E., Maudsley S., Della R. G., Lin F., Kawakatsu H., Owada K., Luttrell D. K., Caron M. G., Lefkowitz R. J. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science. 283:1999;655-661.
-
(1999)
Science
, vol.283
, pp. 655-661
-
-
Luttrell, L.M.1
Ferguson, S.S.2
Daaka, Y.3
Miller, W.E.4
Maudsley, S.5
Della, R.G.6
Lin, F.7
Kawakatsu, H.8
Owada, K.9
Luttrell, D.K.10
Caron, M.G.11
Lefkowitz, R.J.12
-
108
-
-
0033609825
-
Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis
-
Schramm N. L., Limbird L. E. Stimulation of mitogen-activated protein kinase by G protein-coupled alpha(2)-adrenergic receptors does not require agonist-elicited endocytosis. J. Biol. Chem. 274:1999;24935-24940.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24935-24940
-
-
Schramm, N.L.1
Limbird, L.E.2
-
109
-
-
0033617443
-
Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor is internalization
-
Budd D. C., Rae A., Tobin A. B. Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor is internalization. J. Biol. Chem. 274:1999;12355-12360.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12355-12360
-
-
Budd, D.C.1
Rae, A.2
Tobin, A.B.3
-
110
-
-
0027489748
-
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways
-
Burgering B. M. T., de Vries-Smits A. M. M., Medema R. H., van Weeren P. C., Tertoolen L. G. J., Bos J. L. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Mol. Cell Biol. 13:1993;7248-7256.
-
(1993)
Mol. Cell Biol.
, vol.13
, pp. 7248-7256
-
-
Burgering, B.M.T.1
De Vries-Smits, A.M.M.2
Medema, R.H.3
Van Weeren, P.C.4
Tertoolen, L.G.J.5
Bos, J.L.6
-
111
-
-
0028920241
-
Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting β-cell line, INS-1
-
Frödin M., Sekine N., Roche E., Filloux C., Prentki M., Wollheim C. B., Van Obberghen E. Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting β-cell line, INS-1. J. Biol. Chem. 270:1995;7882-7889.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7882-7889
-
-
Frödin, M.1
Sekine, N.2
Roche, E.3
Filloux, C.4
Prentki, M.5
Wollheim, C.B.6
Van Obberghen, E.7
-
112
-
-
0030908291
-
Activation of MAP kinase by glucose is not required for insulin secretion
-
Khoo S., Cobb M. H. Activation of MAP kinase by glucose is not required for insulin secretion. Proc. Natl. Acad. Sci. USA. 94:1997;5599-5604.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 5599-5604
-
-
Khoo, S.1
Cobb, M.H.2
-
113
-
-
0028277844
-
Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras
-
Rosen L. B., Ginty D. D., Weber M. J., Greenberg M. E. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras. Neuron. 12:1994;1207-1221.
-
(1994)
Neuron
, vol.12
, pp. 1207-1221
-
-
Rosen, L.B.1
Ginty, D.D.2
Weber, M.J.3
Greenberg, M.E.4
-
114
-
-
0029098537
-
Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF
-
Farnsworth C. L., Freshney N. W., Rosen L. B., Ghosh A., Greenberg M. E., Feig L. A. Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF. Nature. 376:1995;524-527.
-
(1995)
Nature
, vol.376
, pp. 524-527
-
-
Farnsworth, C.L.1
Freshney, N.W.2
Rosen, L.B.3
Ghosh, A.4
Greenberg, M.E.5
Feig, L.A.6
-
115
-
-
0032078872
-
A synaptic Ras-GTPase activating protein (p135 SYNGAP) inhibited by CaM kinase II
-
Chen H. J., Rojassoto M., Oguni A., Kennedy M. B. A synaptic Ras-GTPase activating protein (p135 SYNGAP) inhibited by CaM kinase II. Neuron. 20:1998;895-904.
-
(1998)
Neuron
, vol.20
, pp. 895-904
-
-
Chen, H.J.1
Rojassoto, M.2
Oguni, A.3
Kennedy, M.B.4
-
116
-
-
0032957682
-
Calcium influx activates extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells
-
Egea J., Espinet C., Comella J. X. Calcium influx activates extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells. J. Biol. Chem. 274:1999;75-85.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 75-85
-
-
Egea, J.1
Espinet, C.2
Comella, J.X.3
-
118
-
-
0029662008
-
2+/calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoter
-
2+/calmodulin-dependent protein kinases propagate signals from endothelin-1 receptors to the c-fos promoter. Mol. Cell. Biol. 16:1996;5915-5923.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5915-5923
-
-
Wang, Y.1
Simonson, M.S.2
-
119
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
-
Ebinu J. O., Bottorff D. A., Chan E. Y., Stang S. L., Dunn R. J., Stone J. C. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science. 280:1998;1082-1086.
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
120
-
-
0032502765
-
Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells
-
Eguchi S., Numaguchi K., Iwasaki H., Matsumoto T., Yamakawa T., Utsunomiya H., Motley E. D., Kawakatsu H., Owada K. M., Hirata Y., Marumo F., Inagami T. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J. Biol. Chem. 273:1998;8890-8896.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 8890-8896
-
-
Eguchi, S.1
Numaguchi, K.2
Iwasaki, H.3
Matsumoto, T.4
Yamakawa, T.5
Utsunomiya, H.6
Motley, E.D.7
Kawakatsu, H.8
Owada, K.M.9
Hirata, Y.10
Marumo, F.11
Inagami, T.12
-
121
-
-
0030872062
-
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors - Convergence of G(i)- and G(q)-mediated pathways on calcium/calmodulin, PYK2, and Src kinase
-
Dellarocca G. J., Vanbiesen T., Daaka Y., Luttrell D. K., Luttrell L. M., Lefkowitz R. J. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors - Convergence of G(i)- and G(q)-mediated pathways on calcium/calmodulin, PYK2, and Src kinase. J. Biol. Chem. 272:1997;19125-19132.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19125-19132
-
-
Dellarocca, G.J.1
Vanbiesen, T.2
Daaka, Y.3
Luttrell, D.K.4
Luttrell, L.M.5
Lefkowitz, R.J.6
-
122
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall C. J. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:1995;179-185.
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
123
-
-
0032558692
-
Constitutively active ERK2 MAP kinase is sufficient for neurite outgrowth and cell transformation when targeted to the nucleus
-
Robinson M. J., Stippec S. A., Goldsmith E., White M. A., Cobb M. H. Constitutively active ERK2 MAP kinase is sufficient for neurite outgrowth and cell transformation when targeted to the nucleus. Curr. Biol. 8:1998;1141-1150.
-
(1998)
Curr. Biol.
, vol.8
, pp. 1141-1150
-
-
Robinson, M.J.1
Stippec, S.A.2
Goldsmith, E.3
White, M.A.4
Cobb, M.H.5
-
124
-
-
0027727564
-
Bacterial and viral protein tyrosine phosphatases
-
Guan K., Dixon J. E. Bacterial and viral protein tyrosine phosphatases. Semin. Cell Biol. 4:1993;389-396.
-
(1993)
Semin. Cell Biol.
, vol.4
, pp. 389-396
-
-
Guan, K.1
Dixon, J.E.2
-
125
-
-
0028125887
-
Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1
-
Ward Y., Gupta S., Jensen P., Wartmann M., Davis R. J., Kelly K. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature. 367:1994;651-657.
-
(1994)
Nature
, vol.367
, pp. 651-657
-
-
Ward, Y.1
Gupta, S.2
Jensen, P.3
Wartmann, M.4
Davis, R.J.5
Kelly, K.6
-
126
-
-
0027358722
-
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
-
Sun H., Charles C. H., Lau L. F., Tonks N. K. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 75:1993;487-493.
-
(1993)
Cell
, vol.75
, pp. 487-493
-
-
Sun, H.1
Charles, C.H.2
Lau, L.F.3
Tonks, N.K.4
-
127
-
-
0027306121
-
The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic Ras in Xenopus oocyte extracts
-
Alessi D. R., Smythe C., Keyse S. M. The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic Ras in Xenopus oocyte extracts. Oncogene. 8:1993;2015-2020.
-
(1993)
Oncogene
, vol.8
, pp. 2015-2020
-
-
Alessi, D.R.1
Smythe, C.2
Keyse, S.M.3
-
128
-
-
0029918680
-
The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificity and reduced activity in vivo toward the ERK2 Sevenmaker mutation
-
Chu Y. F., Solski P. A., Khosravifar R., Der C. J., Kelly K. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificity and reduced activity in vivo toward the ERK2 Sevenmaker mutation. J. Biol. Chem. 271:1996;6497-6501.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6497-6501
-
-
Chu, Y.F.1
Solski, P.A.2
Khosravifar, R.3
Der, C.J.4
Kelly, K.5
-
129
-
-
0029130053
-
HVH-5 - A protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase
-
Martell K. J., Seasholtz A. F., Kwak S. P., Clemens K. K., Dixon J. E. HVH-5 - A protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. J. Neurochem. 65:1995;1823-1833.
-
(1995)
J. Neurochem.
, vol.65
, pp. 1823-1833
-
-
Martell, K.J.1
Seasholtz, A.F.2
Kwak, S.P.3
Clemens, K.K.4
Dixon, J.E.5
-
130
-
-
0030049063
-
A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation
-
Mourey R. J., Vega Q. C., Campbell J. S., Wenderoth M. P., Hauschka S. D., Krebs E. G., Dixon J. E. A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation. J. Biol. Chem. 271:1996;3795-3802.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 3795-3802
-
-
Mourey, R.J.1
Vega, Q.C.2
Campbell, J.S.3
Wenderoth, M.P.4
Hauschka, S.D.5
Krebs, E.G.6
Dixon, J.E.7
-
131
-
-
0029905354
-
Differential regulation of the MAP, SAP and RK/p38 kinases by PYST1, a novel cytosolic dual-specificity phosphatase
-
Groom L. A., Sneddon A. A., Alessi D. R., Dowd S., Keyse S. M. Differential regulation of the MAP, SAP and RK/p38 kinases by PYST1, a novel cytosolic dual-specificity phosphatase. EMBO J. 15:1996;3621-3632.
-
(1996)
EMBO J.
, vol.15
, pp. 3621-3632
-
-
Groom, L.A.1
Sneddon, A.A.2
Alessi, D.R.3
Dowd, S.4
Keyse, S.M.5
-
132
-
-
0033532067
-
Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway
-
Todd J. L., Tanner K. G., Denu J. M. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J. Biol. Chem. 274:1999;13271-13280.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 13271-13280
-
-
Todd, J.L.1
Tanner, K.G.2
Denu, J.M.3
-
133
-
-
0029257329
-
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines
-
Alessi D. R., Gomez N., Moorhead G., Lewis T., Keyse S. M., Cohen P. Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines. Curr. Biol. 5:1995;283-295.
-
(1995)
Curr. Biol.
, vol.5
, pp. 283-295
-
-
Alessi, D.R.1
Gomez, N.2
Moorhead, G.3
Lewis, T.4
Keyse, S.M.5
Cohen, P.6
-
134
-
-
0027772552
-
The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation
-
Sontag E., Federov S., Robbins D., Cobb M., Mumby M. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the MAP kinase pathway and induces cell proliferation. Cell. 75:1993;887-897.
-
(1993)
Cell
, vol.75
, pp. 887-897
-
-
Sontag, E.1
Federov, S.2
Robbins, D.3
Cobb, M.4
Mumby, M.5
-
135
-
-
0038845769
-
Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm
-
Zuniga A., Torres J., Ubeda J., Pulido R. Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm. J. Biol. Chem. 274:1999;21900-21907.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21900-21907
-
-
Zuniga, A.1
Torres, J.2
Ubeda, J.3
Pulido, R.4
-
136
-
-
0032534791
-
PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
-
Pulido R., Zuniga A., Ullrich A. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif. EMBO J. 17:1998;7337-7350.
-
(1998)
EMBO J.
, vol.17
, pp. 7337-7350
-
-
Pulido, R.1
Zuniga, A.2
Ullrich, A.3
-
137
-
-
0027983908
-
Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
-
Choi K.-Y., Satterberg B., Lyons D. M., Elion E. A. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell. 78:1994;499-512.
-
(1994)
Cell
, vol.78
, pp. 499-512
-
-
Choi, K.-Y.1
Satterberg, B.2
Lyons, D.M.3
Elion, E.A.4
-
138
-
-
0027991228
-
Complexes between STE5 and components of the pheromone-responsive MAPK-module
-
Marcus S., Polverino A., Barr M., Wigler M. Complexes between STE5 and components of the pheromone-responsive MAPK-module. Proc. Natl. Acad. Sci. USA. 91:1994;7762-7766.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7762-7766
-
-
Marcus, S.1
Polverino, A.2
Barr, M.3
Wigler, M.4
-
139
-
-
0028046412
-
Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade
-
Printen J. A., Sprague G. F. J. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics. 138:1994;609-619.
-
(1994)
Genetics
, vol.138
, pp. 609-619
-
-
Printen, J.A.1
Sprague, G.F.J.2
-
140
-
-
0029146796
-
Association of the yeast pheromone response G protein Bτ subunits with the MAP kinase scaffold Ste5p
-
Whiteway M. S., Wu C., Leeuw T., Clark K., Fourest-Lieuvin A., Thomas D. Y., Leberer E. Association of the yeast pheromone response G protein Bτ subunits with the MAP kinase scaffold Ste5p. Science. 269:1995;1572-1575.
-
(1995)
Science
, vol.269
, pp. 1572-1575
-
-
Whiteway, M.S.1
Wu, C.2
Leeuw, T.3
Clark, K.4
Fourest-Lieuvin, A.5
Thomas, D.Y.6
Leberer, E.7
-
141
-
-
0032567815
-
Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11
-
Feng Y., Song L. Y., Kincaid E., Mahanty S. K., Elion E. A. Functional binding between Gbeta and the LIM domain of Ste5 is required to activate the MEKK Ste11. Curr. Biol. 8:1998;267-278.
-
(1998)
Curr. Biol.
, vol.8
, pp. 267-278
-
-
Feng, Y.1
Song, L.Y.2
Kincaid, E.3
Mahanty, S.K.4
Elion, E.A.5
-
142
-
-
0023664976
-
The yeast SCG1 gene: A G alpha-like protein implicated in the a- and alpha-factor response pathway
-
Dietzel C., Kurjan J. The yeast SCG1 gene: A G alpha-like protein implicated in the a- and alpha-factor response pathway. Cell. 50:1987;1001-1010.
-
(1987)
Cell
, vol.50
, pp. 1001-1010
-
-
Dietzel, C.1
Kurjan, J.2
-
143
-
-
0030815533
-
Ste5 RING-H2 domain: Role in Ste4-promoted oligomerization for yeast pheromone signaling
-
Inouye C., Dhillon N., Thorner J. Ste5 RING-H2 domain: Role in Ste4-promoted oligomerization for yeast pheromone signaling. Science. 278:1997;103-106.
-
(1997)
Science
, vol.278
, pp. 103-106
-
-
Inouye, C.1
Dhillon, N.2
Thorner, J.3
-
144
-
-
0033588242
-
Nuclear shuttling of the Ste5 scaffold protein is required for its localization to the plasma membrane and activation of the mating MAPK cascade
-
Mahanty S. K., Farley F. W., Elion E. Nuclear shuttling of the Ste5 scaffold protein is required for its localization to the plasma membrane and activation of the mating MAPK cascade. Cell. 98:1999;501-512.
-
(1999)
Cell
, vol.98
, pp. 501-512
-
-
Mahanty, S.K.1
Farley, F.W.2
Elion, E.3
-
145
-
-
0032508714
-
A mammalian scaffold complex that selectively mediates MAP kinase activation
-
Whitmarsh A. J., Cavanagh J., Tournier C., Yasuda J., Davis R. J. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science. 281:1998;1671-1674.
-
(1998)
Science
, vol.281
, pp. 1671-1674
-
-
Whitmarsh, A.J.1
Cavanagh, J.2
Tournier, C.3
Yasuda, J.4
Davis, R.J.5
-
146
-
-
0031450154
-
MEKK1 binds directly to the c-Jun N-terminal kinases stress-activated protein kinases
-
Xu S., Cobb M. H. MEKK1 binds directly to the c-Jun N-terminal kinases stress-activated protein kinases. J. Biol. Chem. 272:1997;32056-32060.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 32056-32060
-
-
Xu, S.1
Cobb, M.H.2
-
147
-
-
0032213146
-
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
-
Xia Y., Wu Z., Su B., Murray B., Karin M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 12:1998;3369-3381.
-
(1998)
Genes Dev.
, vol.12
, pp. 3369-3381
-
-
Xia, Y.1
Wu, Z.2
Su, B.3
Murray, B.4
Karin, M.5
-
148
-
-
0029928988
-
Mutation of position 52 in ERK2 creates a nonproductive binding mode for ATP
-
Robinson M. J., Harkins P. C., Zhang J., Baer R., Haycock J. W., Cobb M. H., Goldsmith E. J. Mutation of position 52 in ERK2 creates a nonproductive binding mode for ATP. Biochemistry. 35:1995;5641-5646.
-
(1995)
Biochemistry
, vol.35
, pp. 5641-5646
-
-
Robinson, M.J.1
Harkins, P.C.2
Zhang, J.3
Baer, R.4
Haycock, J.W.5
Cobb, M.H.6
Goldsmith, E.J.7
-
149
-
-
0030606319
-
C-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
-
Kallunki T., Deng T., Hibi M., Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 87:1996;929-939.
-
(1996)
Cell
, vol.87
, pp. 929-939
-
-
Kallunki, T.1
Deng, T.2
Hibi, M.3
Karin, M.4
-
150
-
-
0031882123
-
The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif
-
Yang S. H., Yates P. R., Whitmarsh A. J., Davis R. J., Sharrocks A. D. The Elk-1 ETS-domain transcription factor contains a mitogen-activated protein kinase targeting motif. Mol. Cell Biol. 18:1998;710-720.
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 710-720
-
-
Yang, S.H.1
Yates, P.R.2
Whitmarsh, A.J.3
Davis, R.J.4
Sharrocks, A.D.5
-
151
-
-
0033617341
-
Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition
-
Hasegawa M., Cuenda A., Spillantini M. G., Thomas G. M., Buee-Scherrer V., Cohen P., Goedert M. Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. J. Biol. Chem. 274:1999;12626-12631.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 12626-12631
-
-
Hasegawa, M.1
Cuenda, A.2
Spillantini, M.G.3
Thomas, G.M.4
Buee-Scherrer, V.5
Cohen, P.6
Goedert, M.7
-
152
-
-
0032509335
-
Analysis of the interaction between c-Jun and c-Jun N-terminal kinase in vivo
-
May G. H., Allen K. E., Clark W., Funk M., Gillespie D. A. Analysis of the interaction between c-Jun and c-Jun N-terminal kinase in vivo. J. Biol. Chem. 273:1998;33429-33435.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 33429-33435
-
-
May, G.H.1
Allen, K.E.2
Clark, W.3
Funk, M.4
Gillespie, D.A.5
-
153
-
-
0033555229
-
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
-
Jacobs D., Glossip D., Xing H., Muslin A. J., Kornfeld K. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes Dev. 13:1999;163-175.
-
(1999)
Genes Dev.
, vol.13
, pp. 163-175
-
-
Jacobs, D.1
Glossip, D.2
Xing, H.3
Muslin, A.J.4
Kornfeld, K.5
-
154
-
-
0033011595
-
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors
-
Yang S. H., Galanis A., Sharrocks A. D. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol. Cell. Biol. 19:1999;4028-4038.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4028-4038
-
-
Yang, S.H.1
Galanis, A.2
Sharrocks, A.D.3
-
155
-
-
0030894683
-
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation
-
Han J., Jiang Y., Li Z., Kravchenko V. V., Ulevitch R. J. Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation. Nature. 386:1997;296-299.
-
(1997)
Nature
, vol.386
, pp. 296-299
-
-
Han, J.1
Jiang, Y.2
Li, Z.3
Kravchenko, V.V.4
Ulevitch, R.J.5
-
156
-
-
0030972494
-
Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase
-
Fukuda M., Gotoh Y., Nishida E. Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J. 16:1997;1901-1908.
-
(1997)
EMBO J.
, vol.16
, pp. 1901-1908
-
-
Fukuda, M.1
Gotoh, Y.2
Nishida, E.3
-
157
-
-
0033613857
-
Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
-
Smith J. A., Poteet-Smith C. E., Malarkey K., Sturgill T. W. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo. J. Biol. Chem. 274:1999;2893-2898.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2893-2898
-
-
Smith, J.A.1
Poteet-Smith, C.E.2
Malarkey, K.3
Sturgill, T.W.4
-
158
-
-
0033545604
-
A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1
-
Gavin A. C., Nebreda A. R. A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKAP kinase-1. Curr. Biol. 9:1999;281-284.
-
(1999)
Curr. Biol.
, vol.9
, pp. 281-284
-
-
Gavin, A.C.1
Nebreda, A.R.2
-
159
-
-
0028157664
-
Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution
-
Zhang F., Strand A., Robbins D., Cobb M. H., Goldsmith E. J. Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution. Nature. 367:1994;704-710.
-
(1994)
Nature
, vol.367
, pp. 704-710
-
-
Zhang, F.1
Strand, A.2
Robbins, D.3
Cobb, M.H.4
Goldsmith, E.J.5
-
160
-
-
0029644242
-
Activity of the MAP kinase ERK2 is controlled by a flexible surface loop
-
Zhang J., Zhang F., Ebert D., Cobb M. H., Goldsmith E. J. Activity of the MAP kinase ERK2 is controlled by a flexible surface loop. Structure. 3:1995;299-307.
-
(1995)
Structure
, vol.3
, pp. 299-307
-
-
Zhang, J.1
Zhang, F.2
Ebert, D.3
Cobb, M.H.4
Goldsmith, E.J.5
-
161
-
-
0029998541
-
Crystal structure of p38 mitogen-activated protein kinase
-
Wilson K. P., Fitzgibbon M. J., Caron P. R., Griffith J. P., Chen W., McCaffrey P. G., Chambers S. P., Su M. S. Crystal structure of p38 mitogen-activated protein kinase. J. Biol. Chem. 271:1996;27696-27700.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27696-27700
-
-
Wilson, K.P.1
Fitzgibbon, M.J.2
Caron, P.R.3
Griffith, J.P.4
Chen, W.5
McCaffrey, P.G.6
Chambers, S.P.7
Su, M.S.8
-
162
-
-
0030911867
-
The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution
-
Wang Z., Harkins P. C., Ulevitch R. J., Han J., Cobb M. H., Goldsmith E. J. The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution. Proc. Natl. Acad. Sci. USA. 94:1997;2327-2332.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2327-2332
-
-
Wang, Z.1
Harkins, P.C.2
Ulevitch, R.J.3
Han, J.4
Cobb, M.H.5
Goldsmith, E.J.6
-
163
-
-
0032528998
-
Crystal structure of JNK3: A kinase implicated in neuronal apoptosis
-
Xie X., Gu Y., Fox T., Coll J. T., Fleming M. A., Markland W., Caron P. R., Wilson K. P., Su M. S. Crystal structure of JNK3: A kinase implicated in neuronal apoptosis. Structure. 6:1998;983-991.
-
(1998)
Structure
, vol.6
, pp. 983-991
-
-
Xie, X.1
Gu, Y.2
Fox, T.3
Coll, J.T.4
Fleming, M.A.5
Markland, W.6
Caron, P.R.7
Wilson, K.P.8
Su, M.S.9
-
164
-
-
0030866897
-
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
-
Canagarajah B. J., Khokhlatchev A., Cobb M. H., Goldsmith E. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell. 90:1997;859-869.
-
(1997)
Cell
, vol.90
, pp. 859-869
-
-
Canagarajah, B.J.1
Khokhlatchev, A.2
Cobb, M.H.3
Goldsmith, E.4
-
165
-
-
0026342401
-
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
-
Knighton D. R., Zheng J., Ten Eyck L. F., Ashford V. A., Xuong N.-H., Taylor S. S., Sowadski J. M. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 253:1991;407-413.
-
(1991)
Science
, vol.253
, pp. 407-413
-
-
Knighton, D.R.1
Zheng, J.2
Ten Eyck, L.F.3
Ashford, V.A.4
Xuong, N.-H.5
Taylor, S.S.6
Sowadski, J.M.7
-
166
-
-
0026326821
-
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
-
Knighton D. R., Zheng J., Ten Eyck L. F., Xuong N.-H., Taylor S. S., Sowadski J. M. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science. 253:1991;414-429.
-
(1991)
Science
, vol.253
, pp. 414-429
-
-
Knighton, D.R.1
Zheng, J.2
Ten Eyck, L.F.3
Xuong, N.-H.4
Taylor, S.S.5
Sowadski, J.M.6
-
167
-
-
0027532627
-
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro
-
Robbins D. J., Zhen E., Owaki H., Vanderbilt C., Ebert D., Geppert T. D., Cobb M. H. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J. Biol. Chem. 268:1993;5097-5106.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 5097-5106
-
-
Robbins, D.J.1
Zhen, E.2
Owaki, H.3
Vanderbilt, C.4
Ebert, D.5
Geppert, T.D.6
Cobb, M.H.7
-
168
-
-
0028818886
-
How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase
-
Taylor S. S., Radzio-Andzelm E., Hunter T. How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase. FASEB J. 9:1995;1255-1266.
-
(1995)
FASEB J.
, vol.9
, pp. 1255-1266
-
-
Taylor, S.S.1
Radzio-Andzelm, E.2
Hunter, T.3
-
169
-
-
0032524356
-
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
-
Khokhlatchev A., Canagarajah B., Wilsbacher J., Robinson M., Atkinson M., Goldsmith E., Cobb M. H. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell. 93:1998;605-615.
-
(1998)
Cell
, vol.93
, pp. 605-615
-
-
Khokhlatchev, A.1
Canagarajah, B.2
Wilsbacher, J.3
Robinson, M.4
Atkinson, M.5
Goldsmith, E.6
Cobb, M.H.7
-
170
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki A., Gazit A. Tyrosine kinase inhibition: An approach to drug development. Science. 267:1995;1782-1788.
-
(1995)
Science
, vol.267
, pp. 1782-1788
-
-
Levitzki, A.1
Gazit, A.2
-
171
-
-
0031197185
-
Protein kinase inhibition: Natural and synthetic variations on a theme
-
Taylor S. S., Radzio-Andzelm E. Protein kinase inhibition: Natural and synthetic variations on a theme. Curr. Opin. Chem. Biol. 1:1997;219-226.
-
(1997)
Curr. Opin. Chem. Biol.
, vol.1
, pp. 219-226
-
-
Taylor, S.S.1
Radzio-Andzelm, E.2
-
172
-
-
0029043582
-
How MAP kinases are regulated
-
Cobb M. H., Goldsmith E. How MAP kinases are regulated. J. Biol. Chem. 270:1995;14843-14846.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14843-14846
-
-
Cobb, M.H.1
Goldsmith, E.2
-
173
-
-
0029993727
-
Active and inactive protein kinases: Structural basis for regulation
-
Johnson L. N., Noble M. E., Owen D. J. Active and inactive protein kinases: Structural basis for regulation. Cell. 85:1996;149-158.
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.2
Owen, D.J.3
-
174
-
-
0032925147
-
Structural analysis of receptor tyrosine kinases
-
Hubbard S. R. Structural analysis of receptor tyrosine kinases. Prog. Biophys. Mol. Biol. 71:1999;343-358.
-
(1999)
Prog. Biophys. Mol. Biol.
, vol.71
, pp. 343-358
-
-
Hubbard, S.R.1
-
175
-
-
0033030207
-
P38 mitogen-activated protein kinase inhibitors - Mechanisms and therapeutic potentials
-
Lee J. C., Kassis S., Kumar S., Badger A., Adams J. L. p38 mitogen-activated protein kinase inhibitors - Mechanisms and therapeutic potentials. Pharmacol. Ther. 82:1999;389-397.
-
(1999)
Pharmacol. Ther.
, vol.82
, pp. 389-397
-
-
Lee, J.C.1
Kassis, S.2
Kumar, S.3
Badger, A.4
Adams, J.L.5
-
176
-
-
0345251973
-
Pharmacological modulation of cytokine action and production through signaling pathways
-
Young P. R. Pharmacological modulation of cytokine action and production through signaling pathways. Cytokine Growth Factor Rev. 9:1998;239-257.
-
(1998)
Cytokine Growth Factor Rev.
, vol.9
, pp. 239-257
-
-
Young, P.R.1
-
177
-
-
0030899779
-
Oncogene products as therapeutic targets for cancer
-
Huang P. S., Heimbrook D. C. Oncogene products as therapeutic targets for cancer. Curr. Opin. Oncol. 9:1997;94-100.
-
(1997)
Curr. Opin. Oncol.
, vol.9
, pp. 94-100
-
-
Huang, P.S.1
Heimbrook, D.C.2
-
178
-
-
0033178359
-
The development and therapeutic potential of protein kinase inhibitors
-
Cohen P. The development and therapeutic potential of protein kinase inhibitors. Curr. Opin. Chem. Biol. 3:1999;459-465.
-
(1999)
Curr. Opin. Chem. Biol.
, vol.3
, pp. 459-465
-
-
Cohen, P.1
-
179
-
-
0032530336
-
Structural basis of inhibitor selectivity in MAP kinases
-
Wang Z., Canagarajah B. J., Boehm J. C., Kassisa S., Cobb M. H., Young P. R., Abdel-Meguid S., Adams J. L., Goldsmith E. J. Structural basis of inhibitor selectivity in MAP kinases. Structure. 6:1998;1117-1128.
-
(1998)
Structure
, vol.6
, pp. 1117-1128
-
-
Wang, Z.1
Canagarajah, B.J.2
Boehm, J.C.3
Kassisa, S.4
Cobb, M.H.5
Young, P.R.6
Abdel-Meguid, S.7
Adams, J.L.8
Goldsmith, E.J.9
-
180
-
-
10744227768
-
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
-
Gum R. J., McLaughlin M. M., Kumar S., Wang Z., Bower M. J., Lee J. C., Adams J. L., Livi G. P., Goldsmith E. J., Young P. R. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J. Biol. Chem. 273:1998;15605-15610.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15605-15610
-
-
Gum, R.J.1
McLaughlin, M.M.2
Kumar, S.3
Wang, Z.4
Bower, M.J.5
Lee, J.C.6
Adams, J.L.7
Livi, G.P.8
Goldsmith, E.J.9
Young, P.R.10
-
181
-
-
0032102902
-
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
-
Eyers P. A., Craxton M., Morrice N., Cohen P., Goedert M. Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem. Biol. 5:1998;321-328.
-
(1998)
Chem. Biol.
, vol.5
, pp. 321-328
-
-
Eyers, P.A.1
Craxton, M.2
Morrice, N.3
Cohen, P.4
Goedert, M.5
-
182
-
-
0031793432
-
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase
-
Fox T., Coll J. T., Xie X., Ford P. J., Germann U. A., Porter M. D., Pazhanisamy S., Fleming M. A., Galullo V., Su M. S., Wilson K. P. A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase. Protein Sci. 7:1998;2249-2255.
-
(1998)
Protein Sci.
, vol.7
, pp. 2249-2255
-
-
Fox, T.1
Coll, J.T.2
Xie, X.3
Ford, P.J.4
Germann, U.A.5
Porter, M.D.6
Pazhanisamy, S.7
Fleming, M.A.8
Galullo, V.9
Su, M.S.10
Wilson, K.P.11
-
183
-
-
0032564311
-
Molecular basis for p38 protein kinase inhibitor specificity
-
Lisnock J., Tebben A., Frantz B., O'Neill E. A., Croft G., O'Keefe S. J., Li B., Hacker C., de Laszlo S., Smith A., Libby B., Liverton N., Hermes J., LoGrasso P. Molecular basis for p38 protein kinase inhibitor specificity. Biochemistry. 37:1998;16573-16581.
-
(1998)
Biochemistry
, vol.37
, pp. 16573-16581
-
-
Lisnock, J.1
Tebben, A.2
Frantz, B.3
O'Neill, E.A.4
Croft, G.5
O'Keefe, S.J.6
Li, B.7
Hacker, C.8
De Laszlo, S.9
Smith, A.10
Libby, B.11
Liverton, N.12
Hermes, J.13
Lograsso, P.14
-
184
-
-
0030954172
-
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
-
Tong L., Pav S., White D. M., Rogers S., Crane K. M., Cywin C. L., Brown M. L., Pargellis C. A. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat. Struct. Biol. 4:1997;311-316.
-
(1997)
Nat. Struct. Biol.
, vol.4
, pp. 311-316
-
-
Tong, L.1
Pav, S.2
White, D.M.3
Rogers, S.4
Crane, K.M.5
Cywin, C.L.6
Brown, M.L.7
Pargellis, C.A.8
-
185
-
-
12644277392
-
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
-
Wilson K. P., McCaffrey P. G., Hsiao K., Pazhanisamy S., Galullo V., Bemis G. W., Fitzgibbon M. J., Caron P. R., Murcko M. A., Su M. S. The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. Chem. Biol. 4:1997;423-431.
-
(1997)
Chem. Biol.
, vol.4
, pp. 423-431
-
-
Wilson, K.P.1
McCaffrey, P.G.2
Hsiao, K.3
Pazhanisamy, S.4
Galullo, V.5
Bemis, G.W.6
Fitzgibbon, M.J.7
Caron, P.R.8
Murcko, M.A.9
Su, M.S.10
-
186
-
-
0005318501
-
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo
-
Hall-Jackson C. A., Goedert M., Hedge P., Cohen P. Effect of SB 203580 on the activity of c-Raf in vitro and in vivo. Oncogene. 18:1999;2047-2054.
-
(1999)
Oncogene
, vol.18
, pp. 2047-2054
-
-
Hall-Jackson, C.A.1
Goedert, M.2
Hedge, P.3
Cohen, P.4
-
187
-
-
0033578080
-
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase
-
Liverton N. J., Butcher J. W., Claiborne C. F., Claremon D. A., Libby B. E., Nguyen K. T., Pitzenberger S. M., Selnick H. G., Smith G. R., Tebben A., Vacca J. P., Varga S. L., Agarwal L., Dancheck K., Forsyth A. J., Fletcher D. S., Frantz B., Hanlon W. A., Harper C. F., Hofsess S. J., Kostura M., Lin J., Luell S., O'Neill E. A., O'Keefe S. J. Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase. J. Med. Chem. 42:1999;2180-2190.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 2180-2190
-
-
Liverton, N.J.1
Butcher, J.W.2
Claiborne, C.F.3
Claremon, D.A.4
Libby, B.E.5
Nguyen, K.T.6
Pitzenberger, S.M.7
Selnick, H.G.8
Smith, G.R.9
Tebben, A.10
Vacca, J.P.11
Varga, S.L.12
Agarwal, L.13
Dancheck, K.14
Forsyth, A.J.15
Fletcher, D.S.16
Frantz, B.17
Hanlon, W.A.18
Harper, C.F.19
Hofsess, S.J.20
Kostura, M.21
Lin, J.22
Luell, S.23
O'Neill, E.A.24
O'Keefe, S.J.25
more..
-
188
-
-
0032578559
-
The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding
-
Frantz B., Klatt T., Pang M., Parsons J., Rolando A., Williams H., Tocci M. J., O'Keefe S. J., O'Neill E. A. The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding. Biochemistry. 37:1998;13846-13853.
-
(1998)
Biochemistry
, vol.37
, pp. 13846-13853
-
-
Frantz, B.1
Klatt, T.2
Pang, M.3
Parsons, J.4
Rolando, A.5
Williams, H.6
Tocci, M.J.7
O'Keefe, S.J.8
O'Neill, E.A.9
-
189
-
-
0029166667
-
A synthetic inhibitor of the mitogen-activated protein kinase cascade
-
Dudley D. T., Pang L., Decker S. J., Bridges A. J., Saltiel A. R. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. USA. 92:1995;7686-7689.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 7686-7689
-
-
Dudley, D.T.1
Pang, L.2
Decker, S.J.3
Bridges, A.J.4
Saltiel, A.R.5
-
190
-
-
0028884033
-
PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi D. R., Cuenda A., Cohen P., Dudley D. T., Saltiel A. R. PD098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, A.R.5
-
191
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata M. F., Horiuchi K. Y., Manos E. J., Daulerio A. J., Stradley D. A., Feeser W. S., Van Dyk D. E., Pitts W. J., Earl R. A., Hobbs F., Copeland R. A., Magolda R. L., Scherle P. A., Trzaskos J. M. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273:1998;18623-18632.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
Feeser, W.S.6
Van Dyk, D.E.7
Pitts, W.J.8
Earl, R.A.9
Hobbs, F.10
Copeland, R.A.11
Magolda, R.L.12
Scherle, P.A.13
Trzaskos, J.M.14
-
192
-
-
0032984348
-
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
-
Sebolt-Leopold J. S., Dudley D. T., Herrera R., Van Becelaere K., Wiland A., Gowan R. C., Tecle H., Barrett S. D., Bridges A., Przybranowski S., Leopold W. R., Saltiel A. R. Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat. Med. 5:1999;810-816.
-
(1999)
Nat. Med.
, vol.5
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
Van Becelaere, K.4
Wiland, A.5
Gowan, R.C.6
Tecle, H.7
Barrett, S.D.8
Bridges, A.9
Przybranowski, S.10
Leopold, W.R.11
Saltiel, A.R.12
-
193
-
-
0344838156
-
Parke-Davis cell biologists test colon tumor inhibitor in mice: Human trials foreseen in 2000
-
Leff D. N. Parke-Davis cell biologists test colon tumor inhibitor in mice: Human trials foreseen in 2000. Bioworld Today. 10:1999;1-4.
-
(1999)
Bioworld Today
, vol.10
, pp. 1-4
-
-
Leff, D.N.1
|