Cytoskeletal regulation of pulmonary vascular permeability

Journal of Applied Physiology

Volumn 91, Issue 4, 2001, Pages 1487-1500

  Dudek, Steven M ^a   Garcia, Joe G N ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

Actin binding proteins; Actomyosin contraction; Acute lung injury; Cytoskeleton; Endothelium

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; CALCIUM; CALMODULIN; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN KINASE; RHO FACTOR; RHO KINASE;

BLOOD VESSEL PERMEABILITY; CELL SHAPE; CYTOSKELETON; HUMAN; INFLAMMATION; INTERMEDIATE FILAMENT; LUNG BLOOD VESSEL; LUNG INJURY; LUNG INTERSTITIUM; MICROFILAMENT; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RESPIRATORY DISTRESS SYNDROME; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION; TIGHT JUNCTION; VASCULAR ENDOTHELIUM;

EID: 0034807581     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.91.4.1487     Document Type: Review

References (163)

1. Cadherin-catenin complex: Protein interactions and their implications for cadherin function
2. Formation of actin stress fibers and focal adhesions enhanced by Rho kinase
3. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome
4. A role for gelsolin in stress fiber dependent cell contraction
5. Subcellular distribution of shear stress at the surface of flow-aligned and nonaligned endothelial monolayers
6. The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin
7. Phosphorylation and supramolecular organization of murine small heat shock protein HSP25 abolish its actin polymerization-inhibiting activity
8. Efficacy and safety of recombinant human activated protein C for severe sepsis
9. Involvement of microtubules in the control of adhesion-dependent signal transduction
10. Soluble ligands of the αvβ3 integrin mediate enhanced tyrosine phosphorylation of multiple proteins in adherent bovine pulmonary artery endothelial cells
11. 2+ influx in pulmonary endothelial cells
12. Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60Src
13. Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines
14. Regulation of endothelial cell barrier function by calcium/calmodulin-dependent protein kinase II
15. Analysis of tight junctions during transendothelial migration
16. ROCK mediates thrombin's endothelial barrier dysfunction
17. 2 and genistein differentially modulate protein tyrosine phosphorylation, endothelial morphology, and monolayer barrier function
18. RhoA inactivation enhances endothelial barrier function
19. Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties
20. Mechanotransduction in response to shear stress
21. 2+ entry
22. Effects of mechanical forces on signal transduction and gene expression in endothelial cells
23. Intermediate filaments and cytoplasmic networking: New connections and more functions
24. Mice lacking vimentin develop and reproduce without an obvious phenotype
25. Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo
26. Integrating the actin and vimentin cytoskeletons: Adhesion-dependent formation of fimbrin-vimentin complexes in macrophages
27. Syndecan-4 and integrin: Combinatorial signaling in cell adhesion
28. Fibroblast contractility and actin organization are stimulated by microtubule inhibitors
29. Vascular endothelial (VE)-cadherin: Only an intercellular glue?
30. Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions
31. Shear stress inhibits apoptosis of human endothelial cells
32. Mechanisms of ventilator-induced lung injury: A perspective
33. Ventilator-induced lung injury
34. Expression profiling using cDNA microarrays
35. Syndecan-4 core protein is sufficient for the assembly of focal adhesions and actin stress fibers
36. Dynamics of alpha-actinin in focal adhesions and stress fibers visualized with alpha-actinin-green fluorescent protein
37. Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis
38. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells
39. Vimentin: The conundrum of the intermediate filament gene family
40. The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton
41. Tyrphostins disrupt stress fibers and cellular attachments in endothelial monolayers
42. Ligand binding regulates the directed movement of β1 integrins on fibroblasts
43. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
44. Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src
45. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
46. A structural scaffolding of intermediate filaments in health and disease
47. Shear stress induces spatial reorganization of the endothelial cytoskeleton
48. Angiopoietin-1 is an antipermeability and anti-inflammatory agent in vitro and targets cell junctions
49. Thrombin-induced increases in albumin clearance across cultured endothelial monolayers
50. Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation
51. Myosin light chain kinase in endothelium: Molecular cloning and regulation
52. Regulation of endothelial cell gap formation and paracellular permeability
53. Diperoxovanadate alters endothelial cell focal contacts and barrier function: Role of tyrosine phosphorylation
54. Adherent neutrophils activate endothelial myosin light chain kinase: Role in transendothelial migration
55. src
56. Tumor necrosis factor enhances the neutrophil dependent increase in endothelial permeability
57. Regulation of endothelial cell myosin light chain phosphorylation and permeability by vanadate
58. Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium
59. Biomechanical activation: An emerging paradigm in endothelial adhesion biology
60. Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2
61. Thrombospondin-1 induces tyrosine phosphorylation of adherens junction proteins and regulates an endothelial paracellular pathway
62. The function of intermediate filaments in cell shape and cytoskeletal integrity
63. Functional cooperation between the microtubule and actin cytoskeletons
64. Fluid flow rapidly activates G proteins in human endothelial cells: Involvement of G proteins in mechanochemical signal transduction
65. Filamin and gelsolin influence Ca(2+)-sensitivity of smooth muscle thin filaments
66. Focal and regional variations in the composition of the glycocalyx of large vessel endothelium
67. Monitoring gene expression using DNA microarrays
68. Location of focal silver staining at endothelial gaps in inflamed venules examined by scanning electron microscopy
69. Stimulated neutrophils induce myosin light chain phosphorylation and isometric tension in endothelial cells
70. α-thrombin-induced pulmonary vasoconstriction
71. Vascular-endothelial-cadherin modulates endothelial monolayer permeability
72. Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells
73. Down-regulation of the filamentous actin cross-linking activity of cortactin by src-mediated tyrosine phosphorylation
74. Rearrangement of adherens junctions by transforming growth factor-β1: Role of contraction
75. Characterization of the actin binding properties of the vasodilator-stimulated phospho-protein VASP
76. MAP kinase activation by flow in endothelial cells: Role of integrins and tyrosine kinases
77. The molecular architecture of focal adhesions
78. Lateral zone of cell-cell adhesion as the major fluid shear stress-related signal transduction site
79. 2+ and permeability
80. Classical cadherins
81. 2-mediated permeability: Role of MAPK and occludin
82. Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins
83. Role of calmodulin and myosin light chain kinase in lung ischemia-reperfusion injury
84. Disruption of endothelial microfilaments selectively reduces the transendothelial migration of monocytes
85. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
86. Weaving a tangled web: The interconnected cytoskeleton
87. Contraction due to microtubule disruption is associated with increased phosphorylation of myosin regulatory light chain
88. Isometric contraction by fibroblasts and endothelial cells in tissue culture: A quantitative study
89. Activation of mitogen-activated protein kinase pathways by cyclic GMP and cyclic GMP-dependent protein kinase in contractile vascular smooth muscle cells
90. Sites of leakage in three models of acute lung injury
91. The role of integrins in the maintenance of endothelial monolayer integrity
92. The effects of caldesmon on smooth muscle heavy actomeromyosin ATPase activity and binding of heavy meromyosin to actin
93. A single human myosin light chain kinase gene (MLCK; MYLK) transcribes multiple nonmuscle isoforms
94. Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress
95. Stop-flow studies of the distribution of filtration in rat lungs
96. Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis: Involvement of Giα2-linked Rho kinase activity
97. Leukocyte repletion reverses protective effect of neutropenia in thrombin-induced increase in lung vascular permeability
98. Thrombin-induced alterations in lung fluid balance in awake sheep
99. The Arp2/3 complex: A multi-functional actin organizer
100. Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
101. Studies on inflammation. 1. Effect of histamine and serotonin on vascular permeability: An electron microscopic study
102. i-coupled Src kinase signaling pathway
103. Molecular architecture of tight junctions
104. Regulation of endothelial cell adhesion by profilin
105. The small GTPase RalA targets filamin to induce filopodia
106. Altered cell adhesion activity by pervanadate due to the dissociation of α-catenin from the E-cadherin-catenin complex
107. Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury
108. Mechanisms of ventilator-induced lung injury
109. Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lungs
110. Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lung
111. Phosphotyrosine phosphatase and tyrosine kinase inhibition modulate airway pressure-induced lung injury
112. Influence of extracellular matrix in tumor necrosis factor-induced increase in endothelial permeability
113. Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of α-actinin
114. Differential effect of MLC kinase in TNF-α-induced endothelial cell apoptosis and barrier dysfunction
115. Spatial variations in endothelial barrier function in disturbed flows in vitro
116. Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin
117. Segmental barrier properties of the pulmonary microvascular bed
118. The small GTP-binding protein rho regulates assembly of focal adhesions and actin stress fibers in response to growth factors
119. 4-induced neutrophil-mediated endothelial leakage in vitro and in vivo
120. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
121. Endothelial myosin light chain kinase regulates neutrophil migration across human umbilical vein endothelial cell monolayer
122. Inhibition of myosin light chain kinase by p21-activated kinase
123. Agonist-mediated disassembly of cytoskeletal-adherens junction linkages: Role in endothelial cell barrier regulation
124. Thrombin-induced focal adhesion plaque reorganization in endothelium: Role of protein phosphorylation
125. In vivo evaluation of hsp27 as an inhibitor of actin polymerization: hsp27 limits actin stress fiber and focal adhesion formation after heat shock
126. gp60 Is an albumin-binding glycoprotein expressed by continuous endothelium involved in albumin trans-cytosis
127. Bidirectional signaling between the cytoskeleton and integrins
128. Role of endothelial cell cytoskeleton in control of endothelial permeability
129. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells
130. Involvement of c-Src in diperoxovanadate-induced endothelial cell barrier dysfunction
131. Blood-flow sensing by anionic biopolymers
132. Anionic biopolymers as blood flow sensors
133. Protein kinase C phosphorylates caldesmon 77 and vimentin and enhances albumin permeability across cultured bovine pulmonary artery endothelial cell monolayers
134. Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function
135. Expression of podocalyxin inhibits cell-cell adhesion and modifies junctional properties in Madin-Darby canine kidney cells
136. Rho, Rac, and Cdc42 GTPases regulate the organization of the actin cytoskeleton
137. Spectrin: The ghost in the machine
138. Angiopoietin-1 protects the adult vasculature against plasma leakage
139. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
140. Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability
141. Activated neutrophils induce hyperpermeability and phosphorylation of adherens junction proteins in coronary venular endothelial cells
142. Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway
143. Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts
144. SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin
145. Laminar shear stress upregulates integrin expression. Role in endothelial cell adhesion and apoptosis
146. Activation of Arp2/3 complex-mediated actin polymerization by cortactin
147. Transient and prolonged increase in endothelial permeability induced by histamine and thrombin
148. Microtubule disassembly increases endothelial cell barrier dysfunction: Role of microfilament crosstalk and myosin light chain phosphorylation
149. Biochemical regulation of the nonmuscle myosin light chain kinase isoform in bovine endothelium
150. Expression of a novel high molecular-weight myosin light chain kinase in endothelium
151. Molecular mechanisms that control endothelial cell contacts
152. Microtubule structure and dynamics
153. Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature
154. Effects of novel and conventional anti-cancer agents on human endothelial permeability: Influence of tumour secreted factors
155. Vinculin is part of the cadherin-catenin junctional complex: Complex formation between α-catenin and vinculin
156. Pulmonary capillary stress failure
157. Effect of fibronectin on permeability of normal and TNF-treated lung endothelial cell monolayers
158. Endothelial monolayer integrity. Perturbation of F actin filaments and the dense peripheral band-vinculin network
159. The effect of ethchlorvynol on cultured endothelial cells. A model for the study of the mechanism of increased vascular permeability
160. Regulation of permeabilized endothelial cell retraction by myosin phosphorylation
161. Evidence for modulation of smooth muscle force by the p38 MAP kinase/HSP27 pathway
162. Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II
163. Endotoxin causes phosphorylation of MARCKS in pulmonary vascular endothelial cells