Protein kinase Cβ selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons

Diabetes

Volumn 52, Issue 8, 2003, Pages 2102-2109

  Kim, Hyoh ^a   Sasaki, Teiji ^a   Maeda, Kengo ^a   Koya, Daisuke ^a   Kashiwagi, Atsunori ^a   Yasuda, Hitoshi ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; NITRIC OXIDE SYNTHASE; PROTEIN KINASE C BETA; PROTEIN KINASE C INHIBITOR; RUBOXISTAURIN; SODIUM CHANNEL; TETRODOTOXIN; ARGININE; ENZYME INHIBITOR; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NEUROPEPTIDE; NOS1 PROTEIN, RAT; PROTEIN KINASE C; SCN11A PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; ENZYME ACTIVITY; HYPERALGESIA; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; SPINAL GANGLION; STREPTOZOCIN DIABETES; ANIMAL; DIABETIC NEUROPATHY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; NOCICEPTIVE RECEPTOR; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ARGININE; CYCLIC GMP; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; ENZYME INHIBITORS; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; INDOLES; MALE; MALEIMIDES; NEUROPEPTIDES; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NOCICEPTORS; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TETRODOTOXIN;

EID: 0042415006     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.8.2102     Document Type: Article

References (49)

1. Thomas PK, Tomlinson DR: Diabetic and hypoglycemic neuropathy. In Peripheral neuropathy. Dyck PJ, Thomas PK, Griffin JW, Low PA, Poduslo JF, Eds. Philadelphia, WB Saunders, 1993, p. 1219-1250
2. Sima AA, Sugimoto K: Experimental diabetic neuropathy: an update. Diabetologia 42:773-788, 2001
3. Yagihashi S: Pathology and pathogenetic mechanisms of diabetic neuropathy. Diabete Metab Rev 11:193-225, 1995
4. Shiba T, Inoguchi T, Sportman JR, Heath W, Bursell S, King GL: Correlation of diacylglycerol and protein kinase C activity in rat retina to retinal circulation. Am J Physiol 265:E783-E793, 1993
5. Craven PA, DeRubertis FR: Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: possible mediation by glucose. J Clin Invest 83:1667-1675, 1989
6. Inoguchi T, Battan R, Handler E, Sportsman, Heath W, King GL: Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A 89:11059-11063, 1992
7. Nakamura, Kato K, Hamada Y, Nakayama M, Chaya S, Nakashima E, Naruse K, Kasuya Y, Mizubayashi R, Miwa K, Yasuda Y, Kamiya H, Ienaga K, Sakakibara F, Koh N, Hotta N: A protein kinase C-β-selective inhibitor ameliorates neural dysfunction in streptozocin-induced diabetic rats. Diabetes 48:2090-2095, 1999
8. Ruan X, Arendshorst WJ: Role of protein kinase C in angiotensin II-induced renal vasoconstriction in genetically hypertensive rats. Am J Physiol 270:F945-F952, 1996
9. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM Heath WF, Stramm LE, Feener EP, King GL: Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272:699-700, 1996
10. Koya D, Haneda M, Nakagawa H, Isshiki K, Sato H, Maeda S, Sugimoto T, Yasuda H, Kashiwagi A, Ways DK, King GL, Kikkawa R: Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC beta inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 14:439-447, 2000
11. Coderre TJ, Kangrga I, Ryu PD, Larew JS, Randic M: Multiple effects of phorbol esrers in the spinal dorsal horn. J Neurosci 9:3606-3617, 1989
12. Malmberg AB, Chen C, Tonegawa S, Basbaum AI: Preserved acute pain and reduced neuropathic pain in mice lacking PKCγ. Science 278:279-283, 1997
13. Khaser SG, Lin Y-H, Martin A, Dadgar J, McMahon T, Wang D, Hundle B, Aley KO, Isenberg W, McCarter G, Green PG, Hodge CW, Levine JD, Messing RO: A novel nociceptor signaling pathway revealed in protein kinase Cε mutant mice. Neuron 24:253-260, 1999
14. Igwe OJ, Chronwall BM: Hyperalgesia induced by peripheral inflammation is mediated by protein kinase CβII isozyme in the rat spinal cord. Neuroscience 104:875-890, 2001
15. Ahlgren SC, Levine JD: Protein kinase C inhibitor decrease hyperalgesia and C-fiber hyperexcitability in the streptozotocin-diabetic rat. J Neurophysiol 72:684-692, 1994
16. Barber LA, Vasko MR: Activation of protein kinase C augments peptide release from rat sensory neurons. J Neurochem 67:72-80, 1996
17. Sasaki T, Yasuda H, Maeda K, Kikkawa R: Hyperalgesia and decreased neuronal nitric oxide synthase in diabetic rats. Neuroreport 7:243-247, 1998
18. Hirade M, Yasuda H, Omatsu-Kanbe M, Kikkawa R, Kitasato H: Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats. Neuroscience 90:933-939, 1999
19. Waxman SG, Dib-Hajj S, Cummins TR, Black JA: Sodium channels and pain. Proc Natt Acad Sci U S A 96:7635-7639, 1999
20. Yiangou Y, Birch R, Sangameswaran L, Eglen R, Anand P: SNS/PN3 and SNS2/NaN dodium channel-like immunoreactivity in human adult and neonate injured sensory nerves. FEBS Lett 11:249-252, 2000
21. Hannun YA, Loomis CR, Bell RM: Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem 260:10039-10043, 1985
22. Forman LJ, Lewis SEM, Vasilenko P: Streptozotocin diabetes alters endorphin levels and pain perception after 8 weeks in female immunoreactive rats. Diabetes 35:1309-1313, 1986
23. Couteix C, Eschalier A, Lavarenne J: Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain. Pain 53:81-88, 1993
24. Ziegler D, Mayer P, Wiefels K, Gries FA: Assessment of small and large fiber function in long-term type 1 (insulin-dependent) diabetic patients with and without painful neuropathy. Pain 34:1-10, 1988
25. Fox A, Eastwood C, Gentry C, Manning D, Urban L: Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. Pain 81:307-316, 1999
26. Morley GK, Mooradian AD, Levine AS, Morley JE: Mechanism of pain in diabetic peripheral neuropathy: effect of glucose on pain perception in humans. Am J Med 77:79-82, 1984
27. Chu PC, Lin MT, Shian LR, Leu SY: Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats. Diabetes 35:481-485, 1986
28. Courteix C, Bourget P, Caussade F, Bardin M, Coudore F, Fialip J, Eschalier A: Is the reduced efficacy of morphine in diabetic rats caused by alterations of opiate receptors or of morphine pharmacokinetics? J Pharmacol Exp Ther 285:63-70, 1998
29. Zurek JR, Nadeson R, Goodchild CS: Spinal and supraspinal components of opioid antinociception in streptozocin induced diabetic neuropathy in rats. Pain 90:57-63, 2001
30. Ahlgren SC, White DM, Levine JD: Increased responsiveness of sensory neurons in the saphenous nerve of the streptozotocin-diabetic rat. J Neurophysiol 68:2077-2085, 1992
31. Kostyuk E, Voitenko N, Kruglikov I, Shmigol A, Shishkin V, Efimov A, Kostyuk P: Diabetes-induced changes in calcium homeostasis and the effects of calcium channel blockers in rat and mice nociceptive neurons. Diabetologia 44:1302-1309, 2001
32. Hall KE, Sima AA, Willey JW: Opiate-mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat. J Clin Invest 97:1165-1172, 1996
33. Burgess GM, Mullaney I, McNeill M, Dunn PM, Rang HP: Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture. J Neurosci 9:3314-3325, 1989
34. Urban MO, Gebhart GF: Supraspinal contributions to hyperalgesia. Proc Natl Acad Sci U S A 96:7687-7692, 1999
35. Mao J, Price DD, Mayer DJ: Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. Pain 61:353-364, 1995
36. Mao JR, Price DD, Phillips LL, Lu J, Mayer DJ: Increases in protein kinase C gamma immunoreactivity in the spinal cord dorsal horn of rats with painful mononeuropathy. Neurosci Lett 198:75-78, 1995
37. Kim J, Rushovich EH, Thomas TP, Ueda T, Agranoff BW, Greene DA: Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by dietary myoinositol. Diabetes 40:1545-1554, 1991
38. Kowluru RA, Jirousek MR, Stramm L, Farid N, Engerman RL, Kern TS: Abnormalities of retinal metabolism in diabetes or experimental galactosemia. V. Relationship between protein kinase C and ATPases. Diabetes 47:464-469, 1998
39. Borghini I, Ania-Lahuerta A, Regazzi R, Ferrari G, Gjinovci A, Wollheim CB, Pralong WF: α,βI, βII, δ, and ε protein kinase C isoforms and compound activity in the sciatic nerve of normal and diabetic rats. J Neurochem 62:686-696, 1994
40. +-ATPase activity and glutathione content in diabetic rats. Diabetologia 42:1120-1130, 1999
41. Kamei J, Iwamoto Y, Misawa M, Nagase H, Kasuya Y: Antinociceptive effect of L-arginine in diabetic mice. Eur J Pharmacol 254:113-117, 1994
42. Qian Y, Chao DS, Santillano DR, Cornwell TL, Nairn AC, Greengard P, Lincoln TM, Bredt DS: cGMP-dependent protein kinase in dorsal root ganglion: relationship with nitric oxide synthase and nociceptive neurons. J Neurosci 16:3130-3138, 1996
43. Ward SM, Shttleworth CWR, Kenyon JL: Dorsal root ganglion neurons of embryonic chicks contain nitric oxide synthase and respond to nitric oxide. Brain Res 648:249-258, 1994
44. Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catteral WA: Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini. J Biol Chem 269:7390-7396, 1994
45. Niedbala B, Sanchez A, Feria M: Nitric oxide mediates neuropathic pain behavior in peripherally denervated rats. Neurosci Lett 188:57-60, 1995
46. Lewin MR, Walters ET: Cyclic GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons. Nat Neurosci 2:18-23, 1999
47. Craven PA, Studer RK, DeRubertis FR: Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats: evidence for protein kinase C-mediated suppression of the cholinergic response. J Clin Invest 93:311-320, 1994
48. Shindo H, Thomas TP, Karihaloo AK, Inada H, Onaya T, Stevens MJ, Greene DA: Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells. J Clin Invest 97:736-745, 1996
49. Okuse K, Chaplan SR, McMahon SB, Luo ZD, Calcutt NA, Scott BP, Akopien AN, Wood JN: Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain. Mol Cell Neurosci 10:196-207, 1997