Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras induced lung cancer

PLoS ONE

Volumn 3, Issue 5, 2008, Pages

  Yang, Yanan ^a   Iwanaga, Kentaro ^a   Raso, Maria Gabriela ^a   Wislez, Marie ^b   Hanna, Amy E ^a   Wieder, Eric D ^a   Molldrem, Jeffrey J ^a   Wistuba, Ignacio I ^a   Powis, Garth ^a   Demayo, Francesco J ^c   Kim, Carla F ^d   Kurie, Jonathan M ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PX 866; TENSIN; GONANE DERIVATIVE; PX-866;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CHROMOSOME 10; CHROMOSOME DELETION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; LUNG ADENOCARCINOMA; MOUSE; NONHUMAN; ONCOGENE K RAS; SIGNAL TRANSDUCTION; STEM CELL EXPANSION; TUMOR GROWTH; ADENOCARCINOMA; ANIMAL; BRONCHUS; CYTOLOGY; DISEASE MODEL; ENZYMOLOGY; GENETICS; LUNG ALVEOLUS; LUNG TUMOR; METABOLISM; ONCOGENE RAS; PATHOLOGY; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOCARCINOMA; ANIMALS; BRONCHI; DISEASE MODELS, ANIMAL; GENES, RAS; GONANES; LUNG NEOPLASMS; MICE; PULMONARY ALVEOLI; STEM CELLS;

EID: 48249099311     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002220     Document Type: Article

References (24)

1. Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS (2006) K-ras mutations in non-small-cell lung carcinoma: a review. Clin Lung Cancer 8: 30-38.
2. Mori M, Tezuka F, Chiba R, Funae Y, Watanabe M, et al. (1996) Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: their heterology in form and analogy in immunohistochemical characteristics. Cancer 77: 665-674.
3. Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, et al. (2001) Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes & Dev. 15: 3249-3262.
4. Guerra G, Mijimolle N, Dhawahir A, Dubus P, Barradas M, et al. (2003) Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell 4: 111-120.
5. Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, et al. (2001) Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes & Dev. 15: 3243-3248.
6. Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, et al. (2006) K-ras activation generates an inflammatory response in lung tumors. Oncogene 25: 2105-2112.
7. Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, et al. (2001) Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410: 1111-1116.
8. Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, et al. (2005) Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121: 823-835.
9. Rawlins EL, Hogan BL (2006) Epithelial stem cells of the lung: privileged few or opportunities for many? Development 133: 2455-2465.
10. Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, et al. (2006) A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10: 459-472.
11. Eng C (2003) PTEN: one gene, many syndromes. Human Mutat. 22: 183-198.
12. Marsit CJ, Zheng S, Aldape K, et al. (2005) PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Hum Pathol 36(7): 768-76.
13. Soria JC, Lee HY, Lee JI, et al. (2002) Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin Cancer Res 8(5): 1178-84.
14. Xia D, Srinivas H, Ahn YH, et al. (2007) Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway. J Biol Chem 282(6): 3507-19.
15. Forgacs E, Biesterveld EJ, Sekido Y, et al. (1998) Mutation analysis of the PTEN/MMAC1 gene in lung cancer. Oncogene 17(12): 1557-65.
16. Ihle NT, Williams R, Chow S, Chew W, Berggren MI, et al. (2004) Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol Cancer Ther. 3: 763-772.
17. Lesche R, Groszer M, Gao J, Wang Y, Messing A, et al. (2002) Cre/ loxP-mediated inactivation of the murine Pten tumor suppressor gene. Genesis 32: 148-149.
18. Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, et al. (2008) Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res. 68: 1119-1127.
19. Eramo A, Lotti F, Sette G, Pilozzi E, Biffoni M, et al. (2008) Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 15: 501-514.
20. Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, et al. (2007) Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Investig. 117: 2929-2940.
21. Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, et al. (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441: 475-482.
22. Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, et al. (2007) Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell 129: 957-968.
23. Angulo B, Suarez-Gauthier A, Lopez-Rios F, Medina PP, Conde E, et al. (2008) Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification. J Pathol 214: 347-356.
24. Wislez M, Spencer ML, Izzo JG, Juroske DM, Baihara K, et al. (2005) Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res. 65: 3226-3235.