Drugging the cancer stem cell compartment: Lessons learned from the hedgehog andwnt signal transduction pathways

Annual Review of Pharmacology and Toxicology

Volumn 51, Issue , 2011, Pages 289-310

  Dodge, Michael E ^a   Lum, Lawrence ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

cancer therapeutics; Porcupine; Smoothened; Tankyrase

Indexed keywords

2 CHLORO N [4 CHLORO 3 (2 PYRIDINYL)PHENYL] 4 METHANESULFONYLBENZAMIDE; ANTINEOPLASTIC AGENT; BETA CATENIN; BMS 833923; CUR 6141; INHIBITORS OF WNT PRODUCTION 1; INHIBITORS OF WNT PRODUCTION 2; INHIBITORS OF WNT PRODUCTION 3; INHIBITORS OF WNT PRODUCTION 4; LDE 225; PF 04449913; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TANKYRASE; UNCLASSIFIED DRUG; WNT PROTEIN; XAV 939;

ARTICLE; CANCER STEM CELL; CELL FATE; DRUG MECHANISM; DRUG TARGETING; HUMAN; NONHUMAN; PORCUPINE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TISSUE REGENERATION;

ADULT; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; DRUG DESIGN; HEDGEHOG PROTEINS; HUMANS; NEOPLASMS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; WNT PROTEINS;

ERINACEIDAE; METAZOA;

EID: 79951981206     PISSN: 03621642     EISSN: 15454304     Source Type: Book Series    
DOI: 10.1146/annurev-pharmtox-010510-100558     Document Type: Article

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