Current in vitro high throughput screening approaches to assess nuclear receptor activation

Current Drug Metabolism

Volumn 11, Issue 9, 2010, Pages 806-814

  Raucy, Judy L ^a   Lasker, Jerome M ^a  

^a Puracyp Inc   (United States)

Author keywords

Constitutive androstane receptor; Fluorescence polarization assays; P450 enzymes; Pregnane X receptor; Scintillation proximity assays; Stable cell lines; TR FRET; Transactivation assays; Yeast two hybrid

Indexed keywords

ANDROSTERONE; AROMATIC HYDROCARBON RECEPTOR; CELL NUCLEUS RECEPTOR; CLOTRIMAZOLE; COMPACTIN; CONSTITUTIVE ANDROSTANE RECEPTOR; DEXAMETHASONE; GLYCOPROTEIN P; MIFEPRISTONE; NUCLEAR RECEPTOR COACTIVATOR 2; OMEPRAZOLE; PHENOBARBITAL; PHENYTOIN; PREGNANE X RECEPTOR; RETINOID X RECEPTOR; RIFAMPICIN; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; TROGLITAZONE;

ARTICLE; FLUORESCENCE POLARIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; LIGAND BINDING; NONHUMAN; PROTEIN INTERACTION; REPORTER GENE; SCINTILLATION; TRANSACTIVATION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TOXICITY TESTS;

EID: 79851505734     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920010794328896     Document Type: Article

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