Identificationof pregnane x receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening

Assay and Drug Development Technologies

Volumn 7, Issue 2, 2009, Pages 143-169

  Shukla, Sunita J ^a   Nguyen, Dac Trung ^a   MaCarthur, Ryan ^a   Simeonov, Anton ^a   Frazee, William J ^b   Hallis, Tina M ^b   Marks, Bryan D ^b   Singh, Upinder ^b   Eliason, Hildegard C ^b   Printen, John ^b   Austin, Christopher P ^a   Inglese, James ^a   Auld, Douglas S ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Invitrogen Discovery Assays and Services   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,5 DIBROMO 4 HYDROXYBENZYLIDENE) 1,3 DIHYDRO 5 IODO 2 INDOLONE; 4 AMINO 1,8 NAPHTHALIMIDE; 5 (N,N DIMETHYL)AMILORIDE; 5 (N,N HEXAMETHYLENE)AMILORIDE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMSACRINE DERIVATIVE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BU 99006; CIBACRON BLUE F3GA; DEPHOSTATIN; DOPA; EMODIN; IDARUBICIN; METHYSERGIDE MALEATE; MITOXANTRONE; MYRICETIN; NAPHTHALIMIDE DERIVATIVE; NSC 95397; PREGNANE X RECEPTOR; QUERCETIN; RIFAMPICIN; SU 4312; TYRPHOSTIN; TYRPHOSTIN 25; TYRPHOSTIN 47; TYRPHOSTIN 51; TYRPHOSTIN AG 112; TYRPHOSTIN AG 34; TYRPHOSTIN AG 538; UNCLASSIFIED DRUG; UNINDEXED DRUG; LIGAND; STEROID RECEPTOR;

ARTICLE; CONCENTRATION RESPONSE; DRUG SCREENING; DRUG SELECTIVITY; DRUG SENSITIVITY; ENZYME ASSAY; FIELD EMISSION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; LIGAND BINDING; MOLECULAR LIBRARY; PROTEIN DETERMINATION; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; DOSE RESPONSE; HUMAN; METABOLISM; METHODOLOGY; STRUCTURE ACTIVITY RELATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; LIGANDS; RECEPTORS, STEROID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67651207389     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2009.193     Document Type: Article

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