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Volumn 7, Issue 6, 2010, Pages 477-486

Alzheimer's disease: SPECT and PET tracers for beta-amyloid imaging

Author keywords

Alzheimer's Disease; Beta Amyloid; PET; SPECT

Indexed keywords

AMYLOID BETA PROTEIN; CONGO RED; FLUORODEOXYGLUCOSE F 18; MATRIX METALLOPROTEINASE; RADIOLIGAND; THIOFLAVINE; TRACER;

EID: 78549279458     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720510792231757     Document Type: Article
Times cited : (15)

References (85)
  • 2
    • 0033518158 scopus 로고    scopus 로고
    • Alzheimer's disease. A firm base for drug development
    • De Strooper B, König G. Alzheimer's disease. A firm base for drug development. Nature 402: 471-472 (1999).
    • (1999) Nature , vol.402 , pp. 471-472
    • de Strooper, B.1    König, G.2
  • 3
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl.) 82: 239-259 (1991).
    • (1991) Acta Neuropathol (Berl.) , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 5
    • 33645942732 scopus 로고    scopus 로고
    • Amyloid Imaging: From Benchtop to Bedside
    • Wu C, Pike VW, Wang Y. Amyloid Imaging: From Benchtop to Bedside. Curr Top Dev Biol 70: 171-213 (2005).
    • (2005) Curr Top Dev Biol , vol.70 , pp. 171-213
    • Wu, C.1    Pike, V.W.2    Wang, Y.3
  • 6
    • 0030681218 scopus 로고    scopus 로고
    • Diagnostic criteria for Alzheimer's disease
    • Price JL. Diagnostic criteria for Alzheimer's disease. Neurobiol Aging 18: 67-70 (1997).
    • (1997) Neurobiol Aging , vol.18 , pp. 67-70
    • Price, J.L.1
  • 7
    • 0032521111 scopus 로고    scopus 로고
    • Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
    • Weldon DT, Rogers SD, Ghilardi JR, Finke MP, Cleary JP, O'Hare E, et al. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J Neurosci 18: 2161-2173 (1998).
    • (1998) J Neurosci , vol.18 , pp. 2161-2173
    • Weldon, D.T.1    Rogers, S.D.2    Ghilardi, J.R.3    Finke, M.P.4    Cleary, J.P.5    O'Hare, E.6
  • 8
    • 0035826782 scopus 로고    scopus 로고
    • Practice parameter: Diagnosis of dementia (an evidencebased review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Knopman DS, DeKosky ST, Cummings JL Chui H, Corey-Bloom J, Relkin N, et al. Practice parameter: diagnosis of dementia (an evidencebased review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56: 1143-1153 (2001).
    • (2001) Neurology , vol.56 , pp. 1143-1153
    • Knopman, D.S.1    DeKosky, S.T.2    Cummings, J.L.3    Chui, H.4    Corey-Bloom, J.5    Relkin, N.6
  • 9
    • 0037251059 scopus 로고    scopus 로고
    • Neuropharmacology and drug development
    • Gee AD. Neuropharmacology and drug development. Br Med Bull 65: 169-177 (2003).
    • (2003) Br Med Bull , vol.65 , pp. 169-177
    • Gee, A.D.1
  • 11
    • 0032446977 scopus 로고    scopus 로고
    • Functional and structural brain imagings in dementia
    • Ichimyia A. Functional and structural brain imagings in dementia. Psychiatry Clin Neurosci 52: 223-225 (1998).
    • (1998) Psychiatry Clin Neurosci , vol.52 , pp. 223-225
    • Ichimyia, A.1
  • 12
    • 15744380400 scopus 로고    scopus 로고
    • Emission tomography in dementia
    • Pakrasi S, O'Brien JT. Emission tomography in dementia. Nucl Med Commun 26: 189-196 (2005).
    • (2005) Nucl Med Commun , vol.26 , pp. 189-196
    • Pakrasi, S.1    O'Brien, J.T.2
  • 13
    • 0030660554 scopus 로고    scopus 로고
    • Neuropathological diagnosis of Alzheimer's disease: A perspective from longitudinal clinicopathological studies
    • Dickson DW. Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies. Neurobiol Aging 18: 21-26 (1997).
    • (1997) Neurobiol Aging , vol.18 , pp. 21-26
    • Dickson, D.W.1
  • 14
    • 4644283049 scopus 로고    scopus 로고
    • PET imaging of amyloid in Alzheimer's disease
    • Nordberg A. PET imaging of amyloid in Alzheimer's disease. Lancet Neurol 3: 519-527 (2004).
    • (2004) Lancet Neurol , vol.3 , pp. 519-527
    • Nordberg, A.1
  • 18
    • 0037444535 scopus 로고    scopus 로고
    • The binding of 2-(4'-methylaminophenyl) benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    • Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Shao L, et al. The binding of 2-(4'-methylaminophenyl) benzothiazole to postmortem brain homogenates is dominated by the amyloid component. J Neurosci 23: 2086-2092 (2003).
    • (2003) J Neurosci , vol.23 , pp. 2086-2092
    • Klunk, W.E.1    Wang, Y.2    Huang, G.F.3    Debnath, M.L.4    Holt, D.P.5    Shao, L.6
  • 20
    • 84903202261 scopus 로고    scopus 로고
    • Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
    • Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, et al. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry 10: 24-35 (2002).
    • (2002) Am J Geriatr Psychiatry , vol.10 , pp. 24-35
    • Shoghi-Jadid, K.1    Small, G.W.2    Agdeppa, E.D.3    Kepe, V.4    Ercoli, L.M.5    Siddarth, P.6
  • 21
    • 0036330242 scopus 로고    scopus 로고
    • Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice
    • Shi J, Perry G, Berridge MS, Aliev G, Siedlak SL, Smith MA, et al. Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice. J Nucl Med 43: 1044-1051 (2002).
    • (2002) J Nucl Med , vol.43 , pp. 1044-1051
    • Shi, J.1    Perry, G.2    Berridge, M.S.3    Aliev, G.4    Siedlak, S.L.5    Smith, M.A.6
  • 24
    • 0035902875 scopus 로고    scopus 로고
    • Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
    • Klunk WE, Wang Y, Huang G, Debnath ML, Holt DP, Mathis CA. Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci 69: 1471-1484 (2001).
    • (2001) Life Sci , vol.69 , pp. 1471-1484
    • Klunk, W.E.1    Wang, Y.2    Huang, G.3    Debnath, M.L.4    Holt, D.P.5    Mathis, C.A.6
  • 25
    • 0030133644 scopus 로고    scopus 로고
    • Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides
    • Ashburn TT, Han H, McGuinness BF, Lansbury PT Jr. Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides. Chem Biol 3: 351-358 (1996).
    • (1996) Chem Biol , vol.3 , pp. 351-358
    • Ashburn, T.T.1    Han, H.2    McGuinness, B.F.3    Lansbury Jr., P.T.4
  • 26
    • 0024352110 scopus 로고
    • Quantitative evaluation of Congo red binding to amyloidlike proteins with a -pleated sheet conformation
    • Klunk WE, Pettegrew JW, Abraham DJ. Quantitative evaluation of Congo red binding to amyloidlike proteins with a -pleated sheet conformation. J Histochem Cytochem 37: 1273-1281 (1989).
    • (1989) J Histochem Cytochem , vol.37 , pp. 1273-1281
    • Klunk, W.E.1    Pettegrew, J.W.2    Abraham, D.J.3
  • 27
    • 0028076051 scopus 로고
    • Development of small molecule probes for the -amyloid protein of Alzheimer's disease
    • Klunk WE, Debnath ML, Pettegrew JW. Development of small molecule probes for the -amyloid protein of Alzheimer's disease. Neurobiol Aging 15: 691-698 (1994).
    • (1994) Neurobiol Aging , vol.15 , pp. 691-698
    • Klunk, W.E.1    Debnath, M.L.2    Pettegrew, J.W.3
  • 28
    • 0033614955 scopus 로고    scopus 로고
    • Synthesis and amyloid binding properties of rhenium complexes: Preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain
    • Zhen W, Han H, Anguiano M, Lemere CA, Cho CG, Lansbury PT Jr. Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain. J Med Chem 42: 2805-2815 (1999).
    • (1999) J Med Chem , vol.42 , pp. 2805-2815
    • Zhen, W.1    Han, H.2    Anguiano, M.3    Lemere, C.A.4    Cho, C.G.5    Lansbury Jr., P.T.6
  • 29
    • 0010395011 scopus 로고
    • The preparation and use of radioiodinated Congo red in detecting amyloidosis
    • Tubis M, Blahd W, Nordyke R. The preparation and use of radioiodinated Congo red in detecting amyloidosis. J Am Pharm Assoc 49: 422-425 (1960).
    • (1960) J Am Pharm Assoc , vol.49 , pp. 422-425
    • Tubis, M.1    Blahd, W.2    Nordyke, R.3
  • 31
    • 0036707494 scopus 로고    scopus 로고
    • Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
    • Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, et al. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol 61: 797-805 (2002).
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 797-805
    • Klunk, W.E.1    Bacskai, B.J.2    Mathis, C.A.3    Kajdasz, S.T.4    McLellan, M.E.5    Frosch, M.P.6
  • 32
    • 0035821603 scopus 로고    scopus 로고
    • Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates
    • Zhuang ZP, Kung MP, Hou C, Skovronsky DM, Gur TL, Plössl K, et al. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J Med Chem 44: 1905-1914 (2001).
    • (2001) J Med Chem , vol.44 , pp. 1905-1914
    • Zhuang, Z.P.1    Kung, M.P.2    Hou, C.3    Skovronsky, D.M.4    Gur, T.L.5    Plössl, K.6
  • 33
    • 0035159024 scopus 로고    scopus 로고
    • IBOX(2-(4'-dimethylaminophenyl)-6-iodobenzoxazole): A ligand for imaging amyloid plaques in the brain
    • Zhuang ZP, Kung MP, Hou C, Plössl K, Skovronsky D, Gur TL, et al. IBOX(2-(4'-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain. Nucl Med Biol 28: 887-894 (2001).
    • (2001) Nucl Med Biol , vol.28 , pp. 887-894
    • Zhuang, Z.P.1    Kung, M.P.2    Hou, C.3    Plössl, K.4    Skovronsky, D.5    Gur, T.L.6
  • 34
    • 0036668810 scopus 로고    scopus 로고
    • Benzofuran derivatives as Abeta-aggregate-specific imaging agents for Alzheimer's disease
    • Ono M, Kung MP, Hou C, Kung HF. Benzofuran derivatives as Abeta-aggregate-specific imaging agents for Alzheimer's disease. Nucl Med Biol 29: 633-642 (2002).
    • (2002) Nucl Med Biol , vol.29 , pp. 633-642
    • Ono, M.1    Kung, M.P.2    Hou, C.3    Kung, H.F.4
  • 35
    • 0037195577 scopus 로고    scopus 로고
    • IMPY: An improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques
    • Kung MP, Hou C, Zhuang ZP, Zhang B, Skovronsky D, Trojanowski JQ, et al. IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques. Brain Res 956: 202-210 (2002).
    • (2002) Brain Res , vol.956 , pp. 202-210
    • Kung, M.P.1    Hou, C.2    Zhuang, Z.P.3    Zhang, B.4    Skovronsky, D.5    Trojanowski, J.Q.6
  • 37
    • 0036672696 scopus 로고    scopus 로고
    • Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease
    • Wang Y, Klunk WE, Huang GF, Debnath ML, Holt DP, Mathis CA. Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease. J Mol Neurosci 19: 11-16 (2002).
    • (2002) J Mol Neurosci , vol.19 , pp. 11-16
    • Wang, Y.1    Klunk, W.E.2    Huang, G.F.3    Debnath, M.L.4    Holt, D.P.5    Mathis, C.A.6
  • 38
    • 33847024952 scopus 로고    scopus 로고
    • Testing a test for Alzheimer disease
    • Bateman RJ, Eidelberg D. Testing a test for Alzheimer disease. Neurology 68: 482-483 (2007).
    • (2007) Neurology , vol.68 , pp. 482-483
    • Bateman, R.J.1    Eidelberg, D.2
  • 39
    • 14844303913 scopus 로고    scopus 로고
    • Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils
    • Lockhart A, Judd L, Ye DB, Merritt AT, Lowe PN, Morgenstern JL, et al. Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils. J Biol Chem 280: 7677-7684 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 7677-7684
    • Lockhart, A.1    Judd, L.2    Ye, D.B.3    Merritt, A.T.4    Lowe, P.N.5    Morgenstern, J.L.6
  • 40
    • 21244492425 scopus 로고    scopus 로고
    • Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils
    • Ye L, Morgenstern JL, Gee AD, Hong G, Brown J, Lockhart A. Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils. J Biol Chem 280: 23599-23604 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 23599-23604
    • Ye, L.1    Morgenstern, J.L.2    Gee, A.D.3    Hong, G.4    Brown, J.5    Lockhart, A.6
  • 41
    • 41149109089 scopus 로고    scopus 로고
    • Amyloid plaque imaging in vivo: Current achievement and future prospects
    • Nordberg A. Amyloid plaque imaging in vivo: current achievement and future prospects. Eur J Nucl Med Mol Imaging 35 (Suppl 1): 46-50 (2008).
    • (2008) Eur J Nucl Med Mol Imaging , vol.35 , Issue.SUPPL. 1 , pp. 46-50
    • Nordberg, A.1
  • 42
    • 0037172826 scopus 로고    scopus 로고
    • Phases of A beta-deposition in the human brain and its relevance for the development of AD
    • Thal DR, Rub U, Orantes M, Braak H. Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 58: 1791-1800 (2002).
    • (2002) Neurology , vol.58 , pp. 1791-1800
    • Thal, D.R.1    Rub, U.2    Orantes, M.3    Braak, H.4
  • 43
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
    • Arnold SE, Hyman BT, Flory J, Damasio AR, Van Hoesen GW. The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb Cortex 1: 103-116 (1991).
    • (1991) Cereb Cortex , vol.1 , pp. 103-116
    • Arnold, S.E.1    Hyman, B.T.2    Flory, J.3    Damasio, A.R.4    van Hoesen, G.W.5
  • 44
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and preclinical Alzheimer's disease
    • Price JL, Morris JC. Tangles and plaques in nondemented aging and preclinical Alzheimer's disease. Ann Neurol 45: 358-368 (1999).
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 45
    • 0035168927 scopus 로고    scopus 로고
    • Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease
    • Morris JC, Price AL. Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease. J Mol Neurosci 17: 101-118 (2001).
    • (2001) J Mol Neurosci , vol.17 , pp. 101-118
    • Morris, J.C.1    Price, A.L.2
  • 46
    • 56749112290 scopus 로고    scopus 로고
    • The future of amyloid-beta imaging: A tale of radionuclides and tracer proliferation
    • Klunk WE, Mathis CA. The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation. Curr Opin Neurol 21: 683-687 (2008).
    • (2008) Curr Opin Neurol , vol.21 , pp. 683-687
    • Klunk, W.E.1    Mathis, C.A.2
  • 48
    • 0030017539 scopus 로고    scopus 로고
    • 1, 1-Dicyano-2-(6-dimethylaminonaphthalen-2-yl)propene (DDNP): A solvent polarity and viscosity sensitive fluorophore for fluorescence microscopy
    • Jacobson A, Petric A, Hogenkamp D, Sinur A, Barrio JR. 1, 1-Dicyano-2-(6-dimethylaminonaphthalen-2-yl)propene (DDNP): a solvent polarity and viscosity sensitive fluorophore for fluorescence microscopy. J Am Chem Soc 118: 5572-5579 (1996).
    • (1996) J Am Chem Soc , vol.118 , pp. 5572-5579
    • Jacobson, A.1    Petric, A.2    Hogenkamp, D.3    Sinur, A.4    Barrio, J.R.5
  • 49
    • 0037475148 scopus 로고    scopus 로고
    • In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F] fluoroethyl) (methyl) amino]-2-naphthyl] ethylidene) malononitrile
    • Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, et al. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F] fluoroethyl) (methyl) amino]-2-naphthyl] ethylidene) malononitrile. Neuroscience 117: 723-730 (2003).
    • (2003) Neuroscience , vol.117 , pp. 723-730
    • Agdeppa, E.D.1    Kepe, V.2    Petri, A.3    Satyamurthy, N.4    Liu, J.5    Huang, S.C.6
  • 50
    • 0345415139 scopus 로고    scopus 로고
    • 2-Dialkylamino-6 Acylmalononitrile Substituted Naphthalenes (DDNP Analogs): Novel Diagnostic and Therapeutic Tools in Alzheimer's Disease
    • Agdeppa ED, Kepe V, Liu J, Small GW, Huang S, Petric A, et al. 2-Dialkylamino-6 Acylmalononitrile Substituted Naphthalenes (DDNP Analogs): Novel Diagnostic and Therapeutic Tools in Alzheimer's Disease. Mol Imaging Biol 5: 404-417 (2003).
    • (2003) Mol Imaging Biol , vol.5 , pp. 404-417
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Small, G.W.4    Huang, S.5    Petric, A.6
  • 51
    • 0035893245 scopus 로고    scopus 로고
    • Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
    • Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, et al. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J Neurosci 21: 189 (2001).
    • (2001) J Neurosci , vol.21 , pp. 189
    • Agdeppa, E.D.1    Kepe, V.2    Liu, J.3    Flores-Torres, S.4    Satyamurthy, N.5    Petric, A.6
  • 55
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner G, Wong C. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 3: 885-890 (1984).
    • (1984) Biochem Biophys Res Commun , vol.3 , pp. 885-890
    • Glenner, G.1    Wong, C.2
  • 56
    • 0023275358 scopus 로고
    • Amyloid angiopathy of Alzheimer's disease: Amino acid composition and partial sequence of a 4200 dalton peptide isolated from cortical microvessels
    • Pardridge WM, Vinters HV, Yang J, Eisenberg J, Choi T, Tourtellote WW, et al. Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4200 dalton peptide isolated from cortical microvessels. J Neurochem 49: 1394-1401 (1987).
    • (1987) J Neurochem , vol.49 , pp. 1394-1401
    • Pardridge, W.M.1    Vinters, H.V.2    Yang, J.3    Eisenberg, J.4    Choi, T.5    Tourtellote, W.W.6
  • 57
    • 0028301348 scopus 로고
    • Macromolecular permeability across the blood-nerve and blood-brain barriers
    • Poduslo JF, Curran GL, Berg CT. Macromolecular permeability across the blood-nerve and blood-brain barriers. Proc Natl Acad Sci USA 91: 5705-5709 (1994).
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5705-5709
    • Poduslo, J.F.1    Curran, G.L.2    Berg, C.T.3
  • 58
    • 0030958078 scopus 로고    scopus 로고
    • Immunocytochemical evaluation of blood-brain barrier to endogenous albumin in scrapie-infected mice
    • Vorbrodt AW, Dobrogowska DH, Tarnawski M, Meeker HC, Carp RI. Immunocytochemical evaluation of blood-brain barrier to endogenous albumin in scrapie-infected mice. Acta Neuropathol 93: 341-348 (1997).
    • (1997) Acta Neuropathol , vol.93 , pp. 341-348
    • Vorbrodt, A.W.1    Dobrogowska, D.H.2    Tarnawski, M.3    Meeker, H.C.4    Carp, R.I.5
  • 59
    • 0026753096 scopus 로고
    • Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study
    • Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol 141: 249-259 (1992).
    • (1992) Am J Pathol , vol.141 , pp. 249-259
    • Yamaguchi, H.1    Yamazaki, T.2    Lemere, C.A.3    Frosch, M.P.4    Selkoe, D.J.5
  • 60
    • 0030930364 scopus 로고    scopus 로고
    • Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
    • Wu D, Yang J, Pardridge WM. Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J Clin Invest 100: 1804-1812 (1997).
    • (1997) J Clin Invest , vol.100 , pp. 1804-1812
    • Wu, D.1    Yang, J.2    Pardridge, W.M.3
  • 61
    • 0028491602 scopus 로고
    • Development of an anti-A beta monoclonal antibody for in vivo imaging of amyloid angiopathy in Alzheimer's disease
    • Friedland RP, Majocha RE, Reno JM, Lyle LR, Marotta CA. Development of an anti-A beta monoclonal antibody for in vivo imaging of amyloid angiopathy in Alzheimer's disease. Mol Neurobiol 9: 107-113 (1994).
    • (1994) Mol Neurobiol , vol.9 , pp. 107-113
    • Friedland, R.P.1    Majocha, R.E.2    Reno, J.M.3    Lyle, L.R.4    Marotta, C.A.5
  • 62
    • 0026459302 scopus 로고
    • Development of a monoclonal antibody specific for beta/A4 amyloid in Alzheimer's disease brain for application to in vivo imaging of amyloid angiopathy
    • Majocha RE, Reno JM, Friedland RP, Van Haight C, Lyle LR, Marotta CA. Development of a monoclonal antibody specific for beta/A4 amyloid in Alzheimer's disease brain for application to in vivo imaging of amyloid angiopathy. J Nucl Med 33: 2184-2189 (1992).
    • (1992) J Nucl Med , vol.33 , pp. 2184-2189
    • Majocha, R.E.1    Reno, J.M.2    Friedland, R.P.3    van Haight, C.4    Lyle, L.R.5    Marotta, C.A.6
  • 64
    • 0028390154 scopus 로고
    • Development and in vitro characterization of a cationized monoclonal antibody against beta A4 protein: A potential probe for Alzheimer's disease
    • Bickel U, Lee VM, Trojanowski JQ, Pardridge WM. Development and in vitro characterization of a cationized monoclonal antibody against beta A4 protein: A potential probe for Alzheimer's disease. Bioconjug Chem 5: 119-125 (1994).
    • (1994) Bioconjug Chem , vol.5 , pp. 119-125
    • Bickel, U.1    Lee, V.M.2    Trojanowski, J.Q.3    Pardridge, W.M.4
  • 65
    • 0034060294 scopus 로고    scopus 로고
    • Prospects for noninvasive imaging of brain amyloid beta in Alzheimer's disease
    • Friedland RP, Shi J, Lamanna JC, Smith MA, Perry G. Prospects for noninvasive imaging of brain amyloid beta in Alzheimer's disease. Ann N Y Acad Sci 903: 123-128 (2000).
    • (2000) Ann N Y Acad Sci , vol.903 , pp. 123-128
    • Friedland, R.P.1    Shi, J.2    Lamanna, J.C.3    Smith, M.A.4    Perry, G.5
  • 68
    • 0026729137 scopus 로고
    • Reversible in vitro growth of Alzheimer disease - amyloid plaques by deposition of labeled amyloid peptide
    • Maggio JE, Stimson ER, Ghilard JR, Allen CJ, Dahl CE, Whitcomb DC, et al. Reversible in vitro growth of Alzheimer disease - amyloid plaques by deposition of labeled amyloid peptide. Proc Natl Acad Sci 89: 5462-5466 (1992).
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 5462-5466
    • Maggio, J.E.1    Stimson, E.R.2    Ghilard, J.R.3    Allen, C.J.4    Dahl, C.E.5    Whitcomb, D.C.6
  • 71
    • 0033136645 scopus 로고    scopus 로고
    • 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors
    • 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors. Bioconjug Chem 10: 502-511 (1999).
    • (1999) Bioconjug Chem , vol.10 , pp. 502-511
    • Kurihara, A.1    Deguchi, Y.2    Pardridge, W.M.3
  • 73
    • 0033625647 scopus 로고    scopus 로고
    • 111In Chelation, Conjugation to Poly(ethylene glycol) Biotin Linkers, and Autoradiography with Alzheimer's Disease Brain Sections
    • 111In Chelation, Conjugation to Poly(ethylene glycol) Biotin Linkers, and Autoradiography with Alzheimer's Disease Brain Sections. Bioconjug Chem 11: 380-386 (2000).
    • (2000) Bioconjug Chem , vol.11 , pp. 380-386
    • Kurihara, A.1    Pardridge, W.M.2
  • 74
    • 0033572574 scopus 로고    scopus 로고
    • Imaging brain tumors by targeting peptide radiopharmaceuticals throught the blood brain barrier
    • Kurihara A, Pardridge WM. Imaging brain tumors by targeting peptide radiopharmaceuticals throught the blood brain barrier. Cancer Res 54: 6159-6163 (1999).
    • (1999) Cancer Res , vol.54 , pp. 6159-6163
    • Kurihara, A.1    Pardridge, W.M.2
  • 75
    • 34250784515 scopus 로고    scopus 로고
    • Targeting of matrix metalloproteinase activation for non-invasive detection of vulnerable atherosclerotic lesions
    • Hartung D, Schäfers M, Fujimoto S, Levkau B, Narula N, Kopka K, et al. Targeting of matrix metalloproteinase activation for non-invasive detection of vulnerable atherosclerotic lesions. Eur J Nucl Med Mol Imaging 34: 1-8 (2007).
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , pp. 1-8
    • Hartung, D.1    Schäfers, M.2    Fujimoto, S.3    Levkau, B.4    Narula, N.5    Kopka, K.6
  • 76
    • 0034507907 scopus 로고    scopus 로고
    • Role of ECM remodeling in thyroid hormone-dependent apoptosis during anuran metamorphosis
    • Damjanovski S, Amano T, Li Q, Ueda S, Shi YB, Ishizuya-Oka A. Role of ECM remodeling in thyroid hormone-dependent apoptosis during anuran metamorphosis. Ann NY Acad Sci 926: 180-191 (2000).
    • (2000) Ann NY Acad Sci , vol.926 , pp. 180-191
    • Damjanovski, S.1    Amano, T.2    Li, Q.3    Ueda, S.4    Shi, Y.B.5    Ishizuya-Oka, A.6
  • 78
    • 0034703594 scopus 로고    scopus 로고
    • Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease
    • Leake A, Morris CM, Whateley J. Brain matrix metalloproteinase 1 levels are elevated in Alzheimer's disease. Neurosci Lett 291: 201-203 (2000).
    • (2000) Neurosci Lett , vol.291 , pp. 201-203
    • Leake, A.1    Morris, C.M.2    Whateley, J.3
  • 79
    • 0035572133 scopus 로고    scopus 로고
    • Chalcones: Structural requirements for antioxidant, estrogenic and antiproliferative activities
    • Calliste CA, Le Bail JC, Trouillas P, Pouget C, Habrioux G, Chulia AJ, et al. Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities. Anticancer Res 21: 3949-3956 (2001).
    • (2001) Anticancer Res , vol.21 , pp. 3949-3956
    • Calliste, C.A.1    Le Bail, J.C.2    Trouillas, P.3    Pouget, C.4    Habrioux, G.5    Chulia, A.J.6
  • 80
    • 54349113605 scopus 로고    scopus 로고
    • Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
    • Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J, et al. Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation 5: 41 (2008).
    • (2008) J Neuroinflammation , vol.5 , pp. 41
    • Rezai-Zadeh, K.1    Ehrhart, J.2    Bai, Y.3    Sanberg, P.R.4    Bickford, P.5    Tan, J.6
  • 81
    • 28544450496 scopus 로고    scopus 로고
    • Radioiodinated Flavones for in Vivo Imaging of -Amyloid Plaques in the Brain
    • Ono M, Yoshida N, Ishibashi K, Haratake M, Arano Y, Mori H, et al. Radioiodinated Flavones for in Vivo Imaging of -Amyloid Plaques in the Brain. J Med Chem 48: 7253-7260 (2005).
    • (2005) J Med Chem , vol.48 , pp. 7253-7260
    • Ono, M.1    Yoshida, N.2    Ishibashi, K.3    Haratake, M.4    Arano, Y.5    Mori, H.6
  • 82
    • 0141642253 scopus 로고    scopus 로고
    • Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease
    • Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem 87: 172-181 (2003).
    • (2003) J Neurochem , vol.87 , pp. 172-181
    • Ono, K.1    Yoshiike, Y.2    Takashima, A.3    Hasegawa, K.4    Naiki, H.5    Yamada, M.6
  • 83
    • 33749265462 scopus 로고    scopus 로고
    • Circumin and dehydrozingerone derivatives: Synthesis, radiolabeling and evaluation for bete-amyloid plaque imaging
    • Ryu E, Choe Y, Lee K, Choi Y, Kim B. Circumin and dehydrozingerone derivatives: synthesis, radiolabeling and evaluation for bete-amyloid plaque imaging. J Med Chem 49: 6111-6119 (2006).
    • (2006) J Med Chem , vol.49 , pp. 6111-6119
    • Ryu, E.1    Choe, Y.2    Lee, K.3    Choi, Y.4    Kim, B.5
  • 84
    • 34548535442 scopus 로고    scopus 로고
    • Novel chalcones as probes for in vivo imaging of b-amyloid plaques in Alzheimer's brains
    • Ono M, Haratake M, Mori H, Nakayama M. Novel chalcones as probes for in vivo imaging of b-amyloid plaques in Alzheimer's brains. Bioorg Med Chem 15: 6802-6809 (2007).
    • (2007) Bioorg Med Chem , vol.15 , pp. 6802-6809
    • Ono, M.1    Haratake, M.2    Mori, H.3    Nakayama, M.4


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