-
1
-
-
0035893245
-
Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
-
Agdeppa E.D., Kepe V., Liu J., Flores-Torres S., Satyamurthy N., Petric A., Cole G.M., Small G.W., Huang S.C., Barrio J.R. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. J. Neurosci. 21:2001;189.
-
(2001)
J. Neurosci.
, vol.21
, pp. 189
-
-
Agdeppa, E.D.1
Kepe, V.2
Liu, J.3
Flores-Torres, S.4
Satyamurthy, N.5
Petric, A.6
Cole, G.M.7
Small, G.W.8
Huang, S.C.9
Barrio, J.R.10
-
3
-
-
0035163347
-
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
-
Dovey H.F., John V., Anderson J.P., Chen L.Z., de Saint Andrieu P., Fang L.Y. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J. Neurochem. 76:2001;173-181.
-
(2001)
J. Neurochem.
, vol.76
, pp. 173-181
-
-
Dovey, H.F.1
John, V.2
Anderson, J.P.3
Chen, L.Z.4
De Saint Andrieu, P.5
Fang, L.Y.6
-
4
-
-
0001320564
-
Molecular pathology of Alzheimer's disease and related disorders
-
A. Peters, & J.H. Morrison. New York: Kluwer Academic/Plenum
-
Ginsberg S.D., Schmidt M.L., Crino P.B., Eberwine J.H., Lee V.M.-Y., Trojanowski J.Q. Molecular pathology of Alzheimer's disease and related disorders. Peters A., Morrison J.H., Cerebral Cortex: Neurodegenerative and Age-related Changes in Structure and Function of Cerebral Cortex. 1999;603-654 Kluwer Academic/Plenum, New York.
-
(1999)
Cerebral Cortex: Neurodegenerative and Age-related Changes in Structure and Function of Cerebral Cortex
, pp. 603-654
-
-
Ginsberg, S.D.1
Schmidt, M.L.2
Crino, P.B.3
Eberwine, J.H.4
Lee, V.M.-Y.5
Trojanowski, J.Q.6
-
5
-
-
0011518741
-
An improved radioiodinated Chrysamine G derivative for amyloid plaque detection in Alzheimer's disease
-
Abstract No. 323.11
-
Hou C., Kung M.P., Zhuang Z.-P., Skovronsky D.M., Gur T.L., Trojanowski J.Q., Lee V.M.-Y., Kung H.F. An improved radioiodinated Chrysamine G derivative for amyloid plaque detection in Alzheimer's disease. Proceedings of the Society for Neuroscience Program 31th Annual Meeting, San Diego, CA. 2001;. Abstract No. 323.11.
-
(2001)
Proceedings of the Society for Neuroscience Program 31th Annual Meeting, San Diego, CA
-
-
Hou, C.1
Kung, M.P.2
Zhuang, Z.-P.3
Skovronsky, D.M.4
Gur, T.L.5
Trojanowski, J.Q.6
Lee, V.M.-Y.7
Kung, H.F.8
-
6
-
-
0032417251
-
Transgenic mice expressing Alzheimer amyloid precursor proteins
-
Hsiao K. Transgenic mice expressing Alzheimer amyloid precursor proteins. Exp. Gerontol. 33:1998;883-889.
-
(1998)
Exp. Gerontol.
, vol.33
, pp. 883-889
-
-
Hsiao, K.1
-
7
-
-
0001387952
-
Small-molecule beta-amyloid probes which distinguish homogenates of Alzheimer's and control brains
-
Klunk W.E., Debnath M.L., Pettegrew J.W. Small-molecule beta-amyloid probes which distinguish homogenates of Alzheimer's and control brains. Biol. Psychiatry. 35:1994;627.
-
(1994)
Biol. Psychiatry
, vol.35
, pp. 627
-
-
Klunk, W.E.1
Debnath, M.L.2
Pettegrew, J.W.3
-
8
-
-
0029083059
-
Chrysamine-G binding to Alzheimer's and control brain: Autopsy study of a new amyloid probe
-
Klunk W.E., Debnath M.L., Pettegrew J.W. Chrysamine-G binding to Alzheimer's and control brain: autopsy study of a new amyloid probe. Neurobiol. Aging. 16:1995;541-548.
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 541-548
-
-
Klunk, W.E.1
Debnath, M.L.2
Pettegrew, J.W.3
-
9
-
-
0035902875
-
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
-
Klunk W.E., Wang Y., Huang G.-F., Debnath M.L., Holt D.P., Mathis C.A. Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci. 69:2001;1471-1484.
-
(2001)
Life Sci.
, vol.69
, pp. 1471-1484
-
-
Klunk, W.E.1
Wang, Y.2
Huang, G.-F.3
Debnath, M.L.4
Holt, D.P.5
Mathis, C.A.6
-
10
-
-
0035915387
-
Novel stilbenes as probes for amyloid plaques
-
Kung H., Lee C., Zhuang Z., Kung M., Hou C., Plossl K. Novel stilbenes as probes for amyloid plaques. J. Am. Chem. Soc. 123:2001;12740-12741.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 12740-12741
-
-
Kung, H.1
Lee, C.2
Zhuang, Z.3
Kung, M.4
Hou, C.5
Plossl, K.6
-
11
-
-
12444341957
-
Detection of amyloid plaques by radioligands for Aβ40 and Aβ42: Potential imaging agents in Alzheimer's patients
-
in press
-
M.-P. Kung, D. Skovronsky, C. Hou, Z.-P. Zhuang, T. Gur, B. Zhang, J. Trojanowski, V. Lee, H. Kung. Detection of amyloid plaques by radioligands for Aβ40 and Aβ42: Potential imaging agents in Alzheimer's patients, J. Mol. Neurosci. (2002) in press.
-
(2002)
J. Mol. Neurosci.
-
-
Kung, M.-P.1
Skovronsky, D.2
Hou, C.3
Zhuang, Z.-P.4
Gur, T.5
Zhang, B.6
Trojanowski, J.7
Lee, V.8
Kung, H.9
-
12
-
-
0011510722
-
Radioiodinated ligands for mapping amyloid plaques in Alzheimer's disease
-
Abstract No. 82.19
-
Kung M.P., Hou C., Zhuang Z.-P., Skovronsky D.M., Lee V.M.-Y., Trojanowski J.Q., Kung H.F. Radioiodinated ligands for mapping amyloid plaques in Alzheimer's disease. Proceedings of the Society for Neuroscience Program 30th Annual Meeting, New Orleans, LA. 2000;. Abstract No. 82.19.
-
(2000)
Proceedings of the Society for Neuroscience Program 30th Annual Meeting, New Orleans, LA
-
-
Kung, M.P.1
Hou, C.2
Zhuang, Z.-P.3
Skovronsky, D.M.4
Lee, V.M.-Y.5
Trojanowski, J.Q.6
Kung, H.F.7
-
13
-
-
0033625647
-
111In] chelation, conjugation to poly(ethylene glycol)-biotin linkers, and autoradiography with Alzheimer's disease brain sections
-
111In] chelation, conjugation to poly(ethylene glycol)-biotin linkers, and autoradiography with Alzheimer's disease brain sections. Bioconj. Chem. 11:2000;380-386.
-
(2000)
Bioconj. Chem.
, vol.11
, pp. 380-386
-
-
Kurihara, A.1
Pardridge, W.M.2
-
14
-
-
0036173189
-
Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Aβ peptide radiopharmaceutical
-
Lee H.J., Zhang Y., Zhu C., Duff K., Pardridge W.M. Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Aβ peptide radiopharmaceutical. J. Cereb. Blood Flow Metab. 22:2002;223-231.
-
(2002)
J. Cereb. Blood Flow Metab.
, vol.22
, pp. 223-231
-
-
Lee, H.J.1
Zhang, Y.2
Zhu, C.3
Duff, K.4
Pardridge, W.M.5
-
15
-
-
0029917884
-
Regulation of tau phosphorylation in Alzheimer's disease
-
Lee V.M. Regulation of tau phosphorylation in Alzheimer's disease. Ann. NY Acad. Sci. 777:1996;107-113.
-
(1996)
Ann. NY Acad. Sci.
, vol.777
, pp. 107-113
-
-
Lee, V.M.1
-
16
-
-
0037059914
-
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
-
Mathis C.A., Bacskai B.J., Kajdasz S.T., McLellan M.E., Frosch M.P., Hyman B.T., Holt D.P., Wang Y., Huang G.-F., Debnath M.L., Klunk W.E. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg. Med. Chem. Lett. 12:2002;295-298.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 295-298
-
-
Mathis, C.A.1
Bacskai, B.J.2
Kajdasz, S.T.3
McLellan, M.E.4
Frosch, M.P.5
Hyman, B.T.6
Holt, D.P.7
Wang, Y.8
Huang, G.-F.9
Debnath, M.L.10
Klunk, W.E.11
-
17
-
-
0001732855
-
In vivo evaluation and imaging of a lipophilic derivative of Congo Red for amyloid assessment [abstract]
-
Mathis C.A., Holt D.P., Wang Y., Debnath M.L., Bacskai B.J., Hyman B.T., Klunk W.E. In vivo evaluation and imaging of a lipophilic derivative of Congo Red for amyloid assessment [abstract]. J. Nucl. Med. 42:2001;252.
-
(2001)
J. Nucl. Med.
, vol.42
, pp. 252
-
-
Mathis, C.A.1
Holt, D.P.2
Wang, Y.3
Debnath, M.L.4
Bacskai, B.J.5
Hyman, B.T.6
Klunk, W.E.7
-
18
-
-
0019061918
-
LIGAND: A versatile computerized approach for characterization of ligand binding system
-
Munson P.J., Rodbard D. LIGAND: a versatile computerized approach for characterization of ligand binding system. Anal. Biochem. 107:1980;220-239.
-
(1980)
Anal. Biochem.
, vol.107
, pp. 220-239
-
-
Munson, P.J.1
Rodbard, D.2
-
19
-
-
0028971069
-
125I] labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer's disease amyloid of the A beta 1-40/vector complex
-
125I] labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer's disease amyloid of the A beta 1-40/vector complex. Proc. Natl. Acad. Sci. USA. 92:1995;10227-10231.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 10227-10231
-
-
Saito, Y.1
Buciak, J.2
Yang, J.3
Pardridge, W.M.4
-
20
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse [see comments]
-
Schenk D., Barbour R., Dunn W., Gordon G., Grajeda H., Guido T., Hu K., Huang J., Johnson-Wood K., Khan K., Kholodenko D., Lee M., Liao Z., Lieberburg I., Motter R., Mutter L., Soriano F., Shopp G., Vasquez N., Vandevert C., Walker S., Wogulis M., Yednock T., Games D., Seubert P. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse [see comments]. Nature. 400:1999;173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
21
-
-
0034858025
-
The fluorescent Congo Red derivative (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbony-4-hydroxy)styrylbenzene (BSB) labels diverse β-pleated sheet structures in postmortem human neurodegenerative disease brains
-
Schmidt M.L., Schuck T., Sheridan S., Kung M.-P., Kung H.F., Zhuang Z.-P., Bergeron C., Lamarche J.S., Skovronsky D., Giasson B.I., Lee V.M.-Y., Trojanowski J.Q. The fluorescent Congo Red derivative ( trans, trans )-1-bromo-2,5-bis-(3-hydroxycarbony-4-hydroxy)styrylbenzene (BSB) labels diverse β-pleated sheet structures in postmortem human neurodegenerative disease brains. Am. J. Pathol. 159:2001;937-943.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 937-943
-
-
Schmidt, M.L.1
Schuck, T.2
Sheridan, S.3
Kung, M.-P.4
Kung, H.F.5
Zhuang, Z.-P.6
Bergeron, C.7
Lamarche, J.S.8
Skovronsky, D.9
Giasson, B.I.10
Lee, V.M.-Y.11
Trojanowski, J.Q.12
-
22
-
-
0032211830
-
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
-
Selkoe D.J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8:1998;447-453.
-
(1998)
Trends Cell Biol.
, vol.8
, pp. 447-453
-
-
Selkoe, D.J.1
-
23
-
-
0002680504
-
Biology of β-amyloid precursor protein and the mechanism of Alzheimer's disease
-
R.D. Terry, R. Katzman, K.L. Bick, & S.S. Sisodia. Philadelphia: Lippincot/Williams & Wilkins
-
Selkoe D.J. Biology of β-amyloid precursor protein and the mechanism of Alzheimer's disease. Terry R.D., Katzman R., Bick K.L., Sisodia S.S., Alzheimer's Disease. 1999;293-310 Lippincot/Williams & Wilkins, Philadelphia.
-
(1999)
Alzheimer's Disease
, pp. 293-310
-
-
Selkoe, D.J.1
-
24
-
-
0033869349
-
Imaging Alzheimer's amyloid
-
Selkoe D.J. Imaging Alzheimer's amyloid. Nature Biotechnol. 18:2000;823-824.
-
(2000)
Nature Biotechnol.
, vol.18
, pp. 823-824
-
-
Selkoe, D.J.1
-
25
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81:2001;741-766.
-
(2001)
Physiol. Rev.
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
26
-
-
84903202261
-
Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease: Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease
-
Shoghi-Jadid K., Small G.W., Agdeppa E.D., Kepe V., Ercoli L.M., Siddarth P., Read S., Satyamurthy N., Petric A., Huang S.C., Barrio J.R., Liu J., Flores-Torres S., Cole G.M. Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease: Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for beta-amyloid plaques in Alzheimer's disease. Am. J. Geriatr. Psychiatry. 10:2002;24-35.
-
(2002)
Am. J. Geriatr. Psychiatry
, vol.10
, pp. 24-35
-
-
Shoghi-Jadid, K.1
Small, G.W.2
Agdeppa, E.D.3
Kepe, V.4
Ercoli, L.M.5
Siddarth, P.6
Read, S.7
Satyamurthy, N.8
Petric, A.9
Huang, S.C.10
Barrio, J.R.11
Liu, J.12
Flores-Torres, S.13
Cole, G.M.14
-
27
-
-
0033613129
-
Cellular mechanisms of beta-amyloid production and secretion
-
Sinha S., Lieberburg I. Cellular mechanisms of beta-amyloid production and secretion. Proc. Natl. Acad. Sci. USA. 96:1999;11049-11053.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11049-11053
-
-
Sinha, S.1
Lieberburg, I.2
-
28
-
-
0034691124
-
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
-
Skovronsky D., Zhang B., Kung M.-P., Kung H.F., Trojanowski J.Q., Lee V.M.-Y. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA. 97:2000;7609-7614.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7609-7614
-
-
Skovronsky, D.1
Zhang, B.2
Kung, M.-P.3
Kung, H.F.4
Trojanowski, J.Q.5
Lee, V.M.-Y.6
-
29
-
-
0033857342
-
X-34, a fluorescent derivative of Congo Red: A novel histochemical stain for Alzheimer's disease pathology
-
Styren S.D., Hamilton R.L., Styren G.C., Klunk W.E. X-34, a fluorescent derivative of Congo Red: a novel histochemical stain for Alzheimer's disease pathology. J. Histochem. Cytochem. 48:2000;1223-1232.
-
(2000)
J. Histochem. Cytochem.
, vol.48
, pp. 1223-1232
-
-
Styren, S.D.1
Hamilton, R.L.2
Styren, G.C.3
Klunk, W.E.4
-
31
-
-
0033991035
-
The cause of neuronal degeneration in Alzheimer's disease
-
Vickers J.C., Dickson T.C., Adlard P.A., Saunders H.L., King C.E., McCormack G. The cause of neuronal degeneration in Alzheimer's disease. Prog. Neurobiol. 60:2000;139-165.
-
(2000)
Prog. Neurobiol.
, vol.60
, pp. 139-165
-
-
Vickers, J.C.1
Dickson, T.C.2
Adlard, P.A.3
Saunders, H.L.4
King, C.E.5
McCormack, G.6
-
33
-
-
0030930364
-
Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
-
Wu D., Yang J., Pardridge W.M. Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J. Clin. Invest. 100:1997;1804-1812.
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 1804-1812
-
-
Wu, D.1
Yang, J.2
Pardridge, W.M.3
-
34
-
-
0033614955
-
Synthesis and amyloid binding properties of rhenium complexes: Preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain
-
Zhen W., Han H., Anguiano M., Lemere C.A., Cho C.G., Lansbury P.T. Jr. Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain. J. Med. Chem. 42:1999;2805-2815.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 2805-2815
-
-
Zhen, W.1
Han, H.2
Anguiano, M.3
Lemere, C.A.4
Cho, C.G.5
Lansbury P.T., Jr.6
-
35
-
-
0035159024
-
IBOX(2-(4′-dimethylaminophenyl)-6-iodobenzoxazole): A ligand for imaging amyloid plaques in the brain
-
Zhuang Z.-P., Kung M.-P., Hou C., Plossel K., Skovronsky D., Gur T.L., Trojanowski J.Q., Lee V.M.-Y., Kung H.F. IBOX(2-(4′-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain. Nucl. Med. Biol. 28:2001;887-894.
-
(2001)
Nucl. Med. Biol.
, vol.28
, pp. 887-894
-
-
Zhuang, Z.-P.1
Kung, M.-P.2
Hou, C.3
Plossel, K.4
Skovronsky, D.5
Gur, T.L.6
Trojanowski, J.Q.7
Lee, V.M.-Y.8
Kung, H.F.9
-
36
-
-
0035821603
-
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates
-
Zhuang Z.-P., Kung M.-P., Hou C., Skovronsky D., Gur T.L., Trojanowski J.Q., Lee V.M.-Y., Kung H.F. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. J. Med. Chem. 44:2001;1905-1914.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1905-1914
-
-
Zhuang, Z.-P.1
Kung, M.-P.2
Hou, C.3
Skovronsky, D.4
Gur, T.L.5
Trojanowski, J.Q.6
Lee, V.M.-Y.7
Kung, H.F.8
|