Targeting Alzheimer amyloid plaques in vivo

Nature Biotechnology

Volumn 18, Issue 8, 2000, Pages 868-872

  Wengenack, T M ^a   Curran, G L ^a   Poduslo, J F ^a  

^a MAYO CLINIC   (United States)

Author keywords

Alzheimer disease; Amyloid; Diagnosis; Imaging; Labeling; Transgenic

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MALE; MICE; MICE, TRANSGENIC; NEUROFIBRILLARY TANGLES; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SENILE PLAQUES;

EID: 0033883760     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/78482     Document Type: Article

References (23)

1. Brain amyloid - A physicochemical perspective
2. Beta-amyloid-induced toxicity in rat hippocampal cells: In vitro evidence for the involvement of free radicals
3. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
4. Alzheimer's disease: Genotypes, phenotype, and treatments
5. Correlative memory deficits, A-beta elevation, and amyloid plaques in transgenic mice
6. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
7. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity
8. Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide
9. Intra-arterial infusion of [I-125]A-beta 1-40 labels amyloid deposits in the aged primate brain in vivo
10. Increased permeability across the blood-nerve barrier of albumin glycated in vitro and in vivo from patients with diabetic polyneuropathy
11. Glycation increases in permeability of proteins across the blood-nerve and blood-brain barriers
12. Macromolecular permeability across the blood-nerve and blood-brain barriers
13. Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers
14. Increased permeability of superoxide dismutase at the blood-nerve and blood-brain barriers with retained enzymatic activity after covalent modification with the naturally occurring polyamine, putrescine
15. Putrescine-modified catalase with preserved enzymatic activity exhibits increased permeability at the blood-nerve and blood-brain barriers
16. Putrescine-modified NGF: Bioactivity, pharmacokinetics, blood-brain/nerve barrier permeability, and nervous system biodistribution
17. Permeability and residual plasma volume of human, Dutch variant, and rat amyloid β-protein 1-40 at the blood-brain barrier
18. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier
19. Amyloid in the brains of aged squirrel monkeys
20. The blood-brain barrier in Alzheimer's disease
21. Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation
22. Beta-sheet breaker peptide inhibitor of Alzheimer's amyloidogenesis with increased blood-brain barrier permeability and resistance to proteolytic degradation in plasma
23. Delivery of imaging agents into brain