-
1
-
-
0033835996
-
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Kholodenko D, Lee M, Lieberburg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Schenk D, Yednock T (2000) Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916-919.
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Kholodenko, D.11
Lee, M.12
Lieberburg, I.13
Motter, R.14
Nguyen, M.15
Soriano, F.16
Vasquez, N.17
Weiss, K.18
Welch, B.19
Schenk, D.20
Yednock, T.21
more..
-
2
-
-
0003089394
-
Neurotransmitter, hormone, or drug receptor binding methods
-
Yamamura HI, Enna SJ, Kuhar MJ, eds. New York: Raven
-
Bennett JP, Yamamura HI (1985) Neurotransmitter, hormone, or drug receptor binding methods. In: Neurotransmitter receptor binding (Yamamura HI, Enna SJ, Kuhar MJ, eds), pp 61-89. New York: Raven.
-
(1985)
Neurotransmitter Receptor Binding
, pp. 61-89
-
-
Bennett, J.P.1
Yamamura, H.I.2
-
3
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98:8850-8855.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.C.4
Paul, S.M.5
Holtzman, D.M.6
-
4
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, Mant R, Newton P, Rooke K, Roques P, Talbot C, Pericak-Vance M, Roses A, Williamson R, Rossor M, Owen M, Hardy J (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349:704-706.
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
Mant, R.11
Newton, P.12
Rooke, K.13
Roques, P.14
Talbot, C.15
Pericak-Vance, M.16
Roses, A.17
Williamson, R.18
Rossor, M.19
Owen, M.20
Hardy, J.21
more..
-
5
-
-
0034718203
-
Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease
-
Goedert M, Spillantini MG (2000) Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. Biochim Biophys Acta 1502:110-121.
-
(2000)
Biochim Biophys Acta
, vol.1502
, pp. 110-121
-
-
Goedert, M.1
Spillantini, M.G.2
-
6
-
-
0034718027
-
Biochemical detection of Abeta isoforms: Implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
-
Golde TE, Eckman CB, Younkin SG (2000) Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochim Biophys Acta 1502:172-187.
-
(2000)
Biochim Biophys Acta
, vol.1502
, pp. 172-187
-
-
Golde, T.E.1
Eckman, C.B.2
Younkin, S.G.3
-
7
-
-
0026546599
-
An "anatomical cascade hypothesis" for Alzheimer's disease
-
Hardy J (1992) An "anatomical cascade hypothesis" for Alzheimer's disease. Trends Neurosci 15:200-201.
-
(1992)
Trends Neurosci
, vol.15
, pp. 200-201
-
-
Hardy, J.1
-
8
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D (1991) Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 12:383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
9
-
-
0032150877
-
Genetic dissection of Alzheimer's disease and related dementias: Amyloid and its relationship to tau
-
Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (1998) Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat Neurosci 1:355-358.
-
(1998)
Nat Neurosci
, vol.1
, pp. 355-358
-
-
Hardy, J.1
Duff, K.2
Hardy, K.G.3
Perez-Tur, J.4
Hutton, M.5
-
11
-
-
0024447098
-
Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease
-
Joachim CL, Morris JH, Selkoe DJ (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol 135:309-319.
-
(1989)
Am J Pathol
, vol.135
, pp. 309-319
-
-
Joachim, C.L.1
Morris, J.H.2
Selkoe, D.J.3
-
12
-
-
0022547855
-
X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation
-
Kirschner DA, Abraham C, Selkoe DJ (1986) X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proc Natl Acad Sci USA 83:503-507.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 503-507
-
-
Kirschner, D.A.1
Abraham, C.2
Selkoe, D.J.3
-
13
-
-
0031971903
-
Biological markers of Alzheimer's disease
-
Klunk WE, (1998) Biological markers of Alzheimer's disease. Neurobiol Aging 19:145-147.
-
(1998)
Neurobiol Aging
, vol.19
, pp. 145-147
-
-
Klunk, W.E.1
-
14
-
-
0028076051
-
Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease
-
Klunk WE, Debnath ML, Pettegrew JW (1994) Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease. Neurobiol Aging 15:691-698.
-
(1994)
Neurobiol Aging
, vol.15
, pp. 691-698
-
-
Klunk, W.E.1
Debnath, M.L.2
Pettegrew, J.W.3
-
15
-
-
0035902875
-
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain
-
Klunk WE, Wang Y, Huang G-F, Debnath ML, Holt DP, Mathis CA (2001) Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain. Life Sci 69:1471-1484.
-
(2001)
Life Sci
, vol.69
, pp. 1471-1484
-
-
Klunk, W.E.1
Wang, Y.2
Huang, G.-F.3
Debnath, M.L.4
Holt, D.P.5
Mathis, C.A.6
-
16
-
-
0027502784
-
Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: Detection of amyloid aggregation in solution
-
LeVine H (1993) Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci 2:404-410.
-
(1993)
Protein Sci
, vol.2
, pp. 404-410
-
-
LeVine, H.1
-
17
-
-
0034719092
-
Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades. I
-
Lopez OL, Becker JT, Klunk WE, Saxton J, Hamilton RL, Kaufer DI, Sweet RA, Cidis-Meltzer C, Wisniewski S, Kamboh MI, DeKosky ST (2000) Research evaluation and diagnosis of probable Alzheimer's disease over the last two decades. I. Neurology 55:1854-1862.
-
(2000)
Neurology
, vol.55
, pp. 1854-1862
-
-
Lopez, O.L.1
Becker, J.T.2
Klunk, W.E.3
Saxton, J.4
Hamilton, R.L.5
Kaufer, D.I.6
Sweet, R.A.7
Cidis-Meltzer, C.8
Wisniewski, S.9
Kamboh, M.I.10
DeKosky, S.T.11
-
18
-
-
0031924815
-
Dementia of frontal type and dementias with subcortical gliosis
-
Mann DM (1998) Dementia of frontal type and dementias with subcortical gliosis. Brain Pathol 8:325-338.
-
(1998)
Brain Pathol
, vol.8
, pp. 325-338
-
-
Mann, D.M.1
-
19
-
-
0029884821
-
A typical amyloid (A beta) deposition in the cerebellum in Alzheimer's disease: An immunohistochemical study using end-specific A beta monoclonal antibodies
-
Mann DM, Iwatsubo T, Snowden JS (1996) A typical amyloid (A beta) deposition in the cerebellum in Alzheimer's disease: an immunohistochemical study using end-specific A beta monoclonal antibodies. Acta Neuropathol 91:647-653.
-
(1996)
Acta Neuropathol
, vol.91
, pp. 647-653
-
-
Mann, D.M.1
Iwatsubo, T.2
Snowden, J.S.3
-
20
-
-
0037059914
-
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
-
Mathis CA, Bacskai BJ, Kajdasz ST, Mclellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang G-F, Debnath ML, Klunk WE (2002) A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett 12:295-298.
-
(2002)
Bioorg Med Chem Lett
, vol.12
, pp. 295-298
-
-
Mathis, C.A.1
Bacskai, B.J.2
Kajdasz, S.T.3
Mclellan, M.E.4
Frosch, M.P.5
Hyman, B.T.6
Holt, D.P.7
Wang, Y.8
Huang, G.-F.9
Debnath, M.L.10
Klunk, W.E.11
-
21
-
-
0006164301
-
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
-
McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen EN, Ballard C, de Vos RA, Wilcock GK, Jellinger KA, Perry RH (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47:1113-1124.
-
(1996)
Neurology
, vol.47
, pp. 1113-1124
-
-
McKeith, I.G.1
Galasko, D.2
Kosaka, K.3
Perry, E.K.4
Dickson, D.W.5
Hansen, L.A.6
Salmon, D.P.7
Lowe, J.8
Mirra, S.S.9
Byrne, E.J.10
Lennox, G.11
Quinn, N.P.12
Edwardson, J.A.13
Ince, P.G.14
Bergeron, C.15
Burns, A.16
Miller, B.L.17
Lovestone, S.18
Collerton, D.19
Jansen, E.N.20
Ballard, C.21
De Vos, R.A.22
Wilcock, G.K.23
Jellinger, K.A.24
Perry, R.H.25
more..
-
22
-
-
0025908356
-
The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
-
Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41:479-486.
-
(1991)
Neurology
, vol.41
, pp. 479-486
-
-
Mirra, S.S.1
Heyman, A.2
McKeel, D.3
Sumi, S.M.4
Crain, B.J.5
Brownlee, L.M.6
Vogel, F.S.7
Hughes, J.P.8
Van Belle, G.9
Berg, L.10
-
23
-
-
0026907151
-
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
-
Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L (1992) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1:345-347.
-
(1992)
Nat Genet
, vol.1
, pp. 345-347
-
-
Mullan, M.1
Crawford, F.2
Axelman, K.3
Houlden, H.4
Lilius, L.5
Winblad, B.6
Lannfelt, L.7
-
24
-
-
0034915965
-
Progress towards testing the amyloid hypothesis: Inhibitors of APP processing
-
Olson RE, Copeland RA, Seiffert D (2001) Progress towards testing the amyloid hypothesis: inhibitors of APP processing. Curr Opin Drug Discov Devel 4:390-401.
-
(2001)
Curr Opin Drug Discov Devel
, vol.4
, pp. 390-401
-
-
Olson, R.E.1
Copeland, R.A.2
Seiffert, D.3
-
25
-
-
0034888987
-
The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HHT1A receptor
-
Roth BL, Ernsberger P, Steinberg SA, Rao S, Rauser L, Savage J, Hufeisen S, Berridge MS, Muzic RF Jr (2001) The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HHT1A receptor. Psychopharmacology 157:111-114.
-
(2001)
Psychopharmacology
, vol.157
, pp. 111-114
-
-
Roth, B.L.1
Ernsberger, P.2
Steinberg, S.A.3
Rao, S.4
Rauser, L.5
Savage, J.6
Hufeisen, S.7
Berridge, M.S.8
Muzic R.F., Jr.9
-
26
-
-
0034610435
-
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
-
Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL (2000) Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 102:2836-2841.
-
(2000)
Circulation
, vol.102
, pp. 2836-2841
-
-
Rothman, R.B.1
Baumann, M.H.2
Savage, J.E.3
Rauser, L.4
McBride, A.5
Hufeisen, S.J.6
Roth, B.L.7
-
27
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
28
-
-
0033857342
-
X-34, a fluorescent derivative of Congo red: A novel histochemical stain for Alzheimer's disease pathology
-
Styren SD, Hamilton RL, Styren GC, Klunk WE (2000) X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J Histochem Cytochem 48:1223-1232.
-
(2000)
J Histochem Cytochem
, vol.48
, pp. 1223-1232
-
-
Styren, S.D.1
Hamilton, R.L.2
Styren, G.C.3
Klunk, W.E.4
-
29
-
-
0024561561
-
Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain
-
Yamaguchi H, Hirai S, Morimatsu M, Shoji M, Nakazato Y (1989) Diffuse type of senile plaques in the cerebellum of Alzheimer-type dementia demonstrated by beta protein immunostain. Acta Neuropathol 77:314-319.
-
(1989)
Acta Neuropathol
, vol.77
, pp. 314-319
-
-
Yamaguchi, H.1
Hirai, S.2
Morimatsu, M.3
Shoji, M.4
Nakazato, Y.5
|