A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 3, 2002, Pages 295-298

  Mathis, Chester A ^a   Bacskai, Brian J ^b   Kajdasz, Stephen T ^b   McLellan, Megan E ^b   Frosch, Matthew P ^c   Hyman, Bradley T ^b   Holt, Daniel P ^a   Wang, Yanming ^a   Huang, Guo Feng ^a   Debnath, Manik L ^a   Klunk, William E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4' (METHYLAMINO)PHENYL]BENZOTHIAZOLE; AMYLOID; BENZOTHIAZOLE DERIVATIVE; CARBON 11; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG METABOLISM; DRUG SYNTHESIS; DRUG UPTAKE; ISOTOPE LABELING; LIPOPHILICITY; MICROSCOPY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID; ANIMALS; BINDING, COMPETITIVE; BRAIN; CHEMISTRY, PHYSICAL; MICE; MICE, TRANSGENIC; MICROSCOPY; RADIOPHARMACEUTICALS; SENILE PLAQUES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TOMOGRAPHY, EMISSION-COMPUTED;

MUS MUSCULUS;

EID: 0037059914     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00734-X     Document Type: Article

References (32)