Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on β-amyloid peptide fibrils

Journal of Biological Chemistry

Volumn 280, Issue 9, 2005, Pages 7677-7684

  Lockhart, Andrew ^a   Ye, Liang ^a   Judd, Duncan B ^b   Merrittu, Andy T ^b   Lowe, Peter N ^c   Morgenstern, Jennifer L ^a   Hong, Guizhu ^a   Gee, Antony D ^a   Brown, John ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b Cell Biology Unit   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; BINDING ENERGY; BIOASSAY; DISEASES; FLUORESCENCE; HALOGEN COMPOUNDS; MONOMERS; POSITRON EMISSION TOMOGRAPHY;

Β-AMYLOID PEPTIDE; ALZHEIMER'S DISEASE; AROMATIC RINGS; LIGANDS;

DRUG PRODUCTS;

AMYLOID BETA PROTEIN[1-40]; BENZOFURAN DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; HALOGEN; MONOMER; RADIOLIGAND; THIOFLAVINE;

ALZHEIMER DISEASE; ARTICLE; BINDING ASSAY; BINDING SITE; HUMAN; LIGAND BINDING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SUBSTITUTION REACTION; TOMOGRAPHY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; BINDING SITES; BINDING, COMPETITIVE; CENTRIFUGATION, DENSITY GRADIENT; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; KINETICS; LIGANDS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PEPTIDE FRAGMENTS; PEPTIDES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; THIAZOLES;

EID: 14844303913     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412056200     Document Type: Article

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