메뉴 건너뛰기




Volumn 42, Issue 15, 1999, Pages 2805-2815

Synthesis and amyloid binding properties of rhenium complexes: Preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; CONGO RED; LIGAND; RHENIUM COMPLEX; TECHNETIUM;

EID: 0033614955     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990103w     Document Type: Article
Times cited : (90)

References (56)
  • 1
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: A report of the NINCDS-ADRDA Work Group, department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann, G., et al. Clinical diagnosis of Alzheimer's disease: a report of the NINCDS-ADRDA Work Group, Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34, 939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1
  • 2
    • 0030978088 scopus 로고    scopus 로고
    • Alzheimer's disease: Diagnosis and treatment
    • Weiner, M. F. Alzheimer's disease: diagnosis and treatment. Harvard Rev. Psychiatry 1997, 4, 306-316.
    • (1997) Harvard Rev. Psychiatry , vol.4 , pp. 306-316
    • Weiner, M.F.1
  • 3
    • 0029784838 scopus 로고    scopus 로고
    • Amyloid β-protein and the genetics of Alzheimer's disease
    • Selkoe, D. J. Amyloid β-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 1996, 271, 18295-18298.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18295-18298
    • Selkoe, D.J.1
  • 4
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • Yankner, B. A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 1996, 16, 921-932.
    • (1996) Neuron , vol.16 , pp. 921-932
    • Yankner, B.A.1
  • 5
    • 0030464914 scopus 로고    scopus 로고
    • β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
    • Cummings, B. J.; Pike, C. J.; Shankle, R.; Cotman, C. W. β-Amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiol. Aging 1996, 17, 921-933.
    • (1996) Neurobiol. Aging , vol.17 , pp. 921-933
    • Cummings, B.J.1    Pike, C.J.2    Shankle, R.3    Cotman, C.W.4
  • 6
    • 0001193811 scopus 로고    scopus 로고
    • A reductionist view of Alzheimer's disease
    • Lansbury, P. T., Jr. A Reductionist view of Alzheimer's disease. Acc. Chem. Res. 1996, 29, 317-321.
    • (1996) Acc. Chem. Res. , vol.29 , pp. 317-321
    • Lansbury P.T., Jr.1
  • 7
    • 0031038918 scopus 로고    scopus 로고
    • Alzheimer's disease: Genotypes, phenotype, and treatments
    • Selkoe, D. Alzheimer's disease: genotypes, phenotype, and treatments. Science 1997, 275, 630-631.
    • (1997) Science , vol.275 , pp. 630-631
    • Selkoe, D.1
  • 8
    • 13344293701 scopus 로고    scopus 로고
    • Teller, J. K.; et al. Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome. Nature Med. 1996, 2, 93-95.
    • (1996) Nature Med. , vol.2 , pp. 93-95
    • Teller, J.K.1
  • 9
    • 0030007964 scopus 로고    scopus 로고
    • Sequence of deposition of heterogeneous amyloid β-peptides and Apo E in Down syndrome: Implications for initial events in amyloid plaque formation
    • Lemere, C. A.; et al. Sequence of deposition of heterogeneous amyloid β-peptides and Apo E in Down syndrome: Implications for initial events in amyloid plaque formation. Neurobiol. Disease 1996, 3, 16-32.
    • (1996) Neurobiol. Disease , vol.3 , pp. 16-32
    • Lemere, C.A.1
  • 10
    • 16044365171 scopus 로고    scopus 로고
    • The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
    • Lemere, C. A.; et al. The E280A presenilin 1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nature Med. 1996, 2, 1146-1148.
    • (1996) Nature Med. , vol.2 , pp. 1146-1148
    • Lemere, C.A.1
  • 11
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner, D.; et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 1996, 2, 864-870.
    • (1996) Nature Med. , vol.2 , pp. 864-870
    • Scheuner, D.1
  • 12
    • 0027258525 scopus 로고
    • The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett, J. T.; Berger, E. P.; Lansbury, P. T., Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 1993, 32, 4693-4697.
    • (1993) Biochemistry , vol.32 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury P.T., Jr.3
  • 13
  • 14
    • 0029664434 scopus 로고    scopus 로고
    • Aβ peptide length and apolipoprotein E genotype in Alzheimer's disease
    • Gearing, M.; Mori, H.; Mirra, S. S. Aβ peptide length and apolipoprotein E genotype in Alzheimer's disease. Ann. Neurol. 1996, 39, 395-399.
    • (1996) Ann. Neurol. , vol.39 , pp. 395-399
    • Gearing, M.1    Mori, H.2    Mirra, S.S.3
  • 15
    • 0028899724 scopus 로고
    • Quantitative analysis of senile plaques in Alzheimer's disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome)
    • Hyman, B. T.; et al. Quantitative analysis of senile plaques in Alzheimer's disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome). Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 3586-3590.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 3586-3590
    • Hyman, B.T.1
  • 16
    • 0028986690 scopus 로고
    • Apolipoprotein E E4 allele is associated with deposition of amyloid β-protein following head injury
    • Nicoll, J. A. R.; Roberts, G. W.; Graham, D. I. Apolipoprotein E E4 allele is associated with deposition of amyloid β-protein following head injury. Nature Med. 1995, 1, 135-137.
    • (1995) Nature Med. , vol.1 , pp. 135-137
    • Nicoll, J.A.R.1    Roberts, G.W.2    Graham, D.I.3
  • 17
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games, D.; et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 1995, 373, 523-527.
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1
  • 18
    • 0029742199 scopus 로고    scopus 로고
    • Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
    • Hsiao, K.; et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 1996, 274, 99-102.
    • (1996) Science , vol.274 , pp. 99-102
    • Hsiao, K.1
  • 19
    • 0029801982 scopus 로고    scopus 로고
    • 123I-labeled serum amyloid P component and SPET
    • 123I-labeled serum amyloid P component and SPET. Nucl. Med. Commun. 1996, 17, 929-933.
    • (1996) Nucl. Med. Commun. , vol.17 , pp. 929-933
    • Bornebroek, M.1
  • 20
    • 0028076051 scopus 로고
    • Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease
    • Klunk, W. E.; Debnath, M. L.; Pettegrew, J. W. Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease. Neurobiol. Aging 1994, 15, 691-698.
    • (1994) Neurobiol. Aging , vol.15 , pp. 691-698
    • Klunk, W.E.1    Debnath, M.L.2    Pettegrew, J.W.3
  • 21
    • 0029083059 scopus 로고
    • Chrysamine-G binding to Alzheimer and control brain: Autopsy study of a new amyloid probe
    • Klunk, W. E.; Debnath, M. L.; Pettegrew, J. W. Chrysamine-G Binding to Alzheimer and Control Brain: Autopsy Study of a New Amyloid Probe. Neurobiol. Aging 1995, 541-548.
    • (1995) Neurobiol. Aging , pp. 541-548
    • Klunk, W.E.1    Debnath, M.L.2    Pettegrew, J.W.3
  • 22
    • 0030133644 scopus 로고    scopus 로고
    • Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides
    • Ashburn, T. T.; Han, H.; McGuinness, B. F.; Lansbury, P. T. Amyloid probes based on Congo Red distinguish between fibrils comprising different peptides. Chem. Biol. 1996, 3, 351-358.
    • (1996) Chem. Biol. , vol.3 , pp. 351-358
    • Ashburn, T.T.1    Han, H.2    McGuinness, B.F.3    Lansbury, P.T.4
  • 23
    • 15844405638 scopus 로고    scopus 로고
    • Technetium complexes for the quantitation of brain amyloid
    • Han, H.; Cho, C.-G.; Lansbury, P. T., Jr. Technetium complexes for the quantitation of brain amyloid. J. Am. Chem. Soc. 1996, 118, 4506-4507.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 4506-4507
    • Han, H.1    Cho, C.-G.2    Lansbury P.T., Jr.3
  • 25
    • 0028971069 scopus 로고
    • 125I-Labeled β-amyloid peptide Aβ1-40 through the blood-brain barrier and binding to Alzheimer's disease amyloid of the Aβ1-40/vector complex
    • 125I-Labeled β-amyloid peptide Aβ1-40 through the blood-brain barrier and binding to Alzheimer's disease amyloid of the Aβ1-40/vector complex. Proc. Natl. Acad. Sci. U.S.A. 1985, 92, 10227-10231.
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 10227-10231
    • Saito, Y.1    Buciak, J.2    Yang, J.3    Pardridge, W.M.4
  • 26
    • 0030808619 scopus 로고    scopus 로고
    • Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals: Recent developments and encouraging results
    • Horn, R. K.; Katzenellenbogen, J. A. Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals: recent developments and encouraging results. Nucl. Med. Biol. 1997, 24, 485-498.
    • (1997) Nucl. Med. Biol. , vol.24 , pp. 485-498
    • Horn, R.K.1    Katzenellenbogen, J.A.2
  • 27
    • 0010395011 scopus 로고
    • The preparation and use of radioiodinated Congo Red in detecting amyloidosis
    • Tubis, M.; Blahd, W. H.; Nordyke, R. A. The preparation and use of radioiodinated Congo Red in detecting amyloidosis. J. Am. Pharm. Assoc. 1960, 49, 422-425.
    • (1960) J. Am. Pharm. Assoc. , vol.49 , pp. 422-425
    • Tubis, M.1    Blahd, W.H.2    Nordyke, R.A.3
  • 28
    • 0030947181 scopus 로고    scopus 로고
    • A Technetium-99m SPECT imaging agent which targets the dopamine transporter in primate brain
    • Meltzer, P. C.; et al. A Technetium-99m SPECT Imaging Agent Which Targets the Dopamine Transporter in Primate Brain. J. Med. Chem. 1997, 40, 1835-1844.
    • (1997) J. Med. Chem. , vol.40 , pp. 1835-1844
    • Meltzer, P.C.1
  • 29
    • 0021368992 scopus 로고
    • Synthesis and biodistribution of neutral lipid-soluble Tc-99m complexes that cross the blood-brain barrier
    • Kung, H. F.; Molnar, M.; Billings, J.; Wicks, R.; Blau, M. Synthesis and Biodistribution of Neutral Lipid-Soluble Tc-99m Complexes that cross the Blood-Brain Barrier. J. Nucl. Med. 1984, 25, 326-332.
    • (1984) J. Nucl. Med. , vol.25 , pp. 326-332
    • Kung, H.F.1    Molnar, M.2    Billings, J.3    Wicks, R.4    Blau, M.5
  • 30
    • 0021020662 scopus 로고
    • Relationship between lipophilicity and brain extraction of C-11-Labeled radiopharmaceuticals
    • Dischino, D. D.; Welch, M. J.; Kilbourn, M. R.; Raichle, M. E. Relationship Between Lipophilicity and Brain Extraction of C-11-Labeled Radiopharmaceuticals. J. Nucl. Med. 1983, 24, 1030-1038.
    • (1983) J. Nucl. Med. , vol.24 , pp. 1030-1038
    • Dischino, D.D.1    Welch, M.J.2    Kilbourn, M.R.3    Raichle, M.E.4
  • 31
    • 0023102649 scopus 로고
    • Technetium-99m d,l-HM-PAO: A new radiopharmaceutical for SPECT imaging of regional cerebral blood perfusion
    • Neirinckx, R. D.; et al. Technetium-99m d,l-HM-PAO: A New Radiopharmaceutical for SPECT Imaging of regional Cerebral Blood Perfusion. J. Nucl. Med. 1987, 28, 191-202.
    • (1987) J. Nucl. Med. , vol.28 , pp. 191-202
    • Neirinckx, R.D.1
  • 32
    • 0027218815 scopus 로고
    • Metal compounds in therapy and diagnosis
    • Abrams, M. J.; Murrer, B. A. Metal compounds in therapy and diagnosis. Science 1993, 261, 725-730.
    • (1993) Science , vol.261 , pp. 725-730
    • Abrams, M.J.1    Murrer, B.A.2
  • 33
    • 0000078975 scopus 로고
    • Vo (M = Tc, Re) amine-thiol complexes containing a pendant phenylpiperidine group
    • VO (M = Tc, Re) amine-thiol complexes containing a pendant phenylpiperidine group. Inorg. Chem. 1993, 32, 3114-3124.
    • (1993) Inorg. Chem. , vol.32 , pp. 3114-3124
    • Francesconi, L.C.1
  • 34
    • 0344768146 scopus 로고
    • A tetradentate ligand designed specifically to coordinate technetium
    • Davison, A.; Sohn, M.; Orvig, C.; Jones, A. G.; LaTegola, M. R. A tetradentate ligand designed specifically to coordinate technetium. J. Nucl. Med. 1979, 20, 641.
    • (1979) J. Nucl. Med. , vol.20 , pp. 641
    • Davison, A.1    Sohn, M.2    Orvig, C.3    Jones, A.G.4    LaTegola, M.R.5
  • 36
    • 0026215304 scopus 로고
    • Progestins-rhenium complexes: Metal-labeled steroids with receptor binding activity, potential receptor-directed agents for diagnostic imaging therapy
    • DiZio, J. P.; Fiaschi, R.; Davison, A.; Jones, A.; Katzenellenbogen, J. A. Progestins-rhenium complexes: metal-labeled steroids with receptor binding activity, potential receptor-directed agents for diagnostic imaging therapy. Bioconjugate Chem. 1991, 2, 353-366.
    • (1991) Bioconjugate Chem. , vol.2 , pp. 353-366
    • DiZio, J.P.1    Fiaschi, R.2    Davison, A.3    Jones, A.4    Katzenellenbogen, J.A.5
  • 37
    • 0026603216 scopus 로고
    • Technetium and rhenium labeled progestins: Synthesis, receptor binding and in vivo distribution of an 11β-substituted progestin labeled with technetium-99 and rhenium-186
    • DiZio, J. P.; et al. Technetium and rhenium labeled progestins: synthesis, receptor binding and in vivo distribution of an 11β-substituted progestin labeled with technetium-99 and rhenium-186. J. Nucl. Med. 1992, 33, 558-569.
    • (1992) J. Nucl. Med. , vol.33 , pp. 558-569
    • DiZio, J.P.1
  • 38
    • 0025940173 scopus 로고
    • Synthesis of a new class of Tc chelating agents: Monoamine-monoamide (MAMA) ligands
    • Gustavson, L. M.; Rao, T. N.; Jones, D. S.; Fritzberg, A. R. Synthesis of a new class of Tc chelating agents: monoamine-monoamide (MAMA) ligands. Tetrahedron Lett. 1991, 32, 5485-5488.
    • (1991) Tetrahedron Lett. , vol.32 , pp. 5485-5488
    • Gustavson, L.M.1    Rao, T.N.2    Jones, D.S.3    Fritzberg, A.R.4
  • 39
    • 0030068840 scopus 로고    scopus 로고
    • 99mtechnetium probe to label the dopamine transporter in brain by SPECT imaging
    • 99mtechnetium probe to label the dopamine transporter in brain by SPECT imaging. Synapse 1996, 22, 239-246.
    • (1996) Synapse , vol.22 , pp. 239-246
    • Madras, B.K.1
  • 40
    • 0001666244 scopus 로고
    • Preparation and structural characterization of monoamine-monoamide bis(thiol) oxo complexes of technetium (V) and rhenium (V)
    • O'Neil, J. P.; Wilson, S. R.; Katzenellenbogen, J. A. Preparation and structural characterization of monoamine-monoamide bis(thiol) oxo complexes of technetium (V) and rhenium (V). Inorg. Chem. 1994, 33, 319-323.
    • (1994) Inorg. Chem. , vol.33 , pp. 319-323
    • O'Neil, J.P.1    Wilson, S.R.2    Katzenellenbogen, J.A.3
  • 41
    • 0029957462 scopus 로고    scopus 로고
    • Imaging of dopamine transporters in humans with technetium-99m TRODAT-1
    • Kung, H. F.; et al. Imaging of dopamine transporters in humans with technetium-99m TRODAT-1. Eur. J. Nucl. Med. 1996, 23, 1527-1530.
    • (1996) Eur. J. Nucl. Med. , vol.23 , pp. 1527-1530
    • Kung, H.F.1
  • 42
    • 0031033546 scopus 로고    scopus 로고
    • Synthesis and characterization of Technetium-99m-Labeled tropanes as dopamine transporter-imaging agents
    • Meegalla, S. K.; et al. Synthesis and Characterization of Technetium-99m-Labeled Tropanes as Dopamine Transporter-Imaging Agents. J. Med. Chem. 1997, 40, 9-17.
    • (1997) J. Med. Chem. , vol.40 , pp. 9-17
    • Meegalla, S.K.1
  • 43
    • 0344166699 scopus 로고
    • Ph.D. Thesis, MIT, Cambridge, MA 02139
    • Wolfe, J. A. Ph.D. Thesis, MIT, Cambridge, MA 02139, 1991.
    • (1991)
    • Wolfe, J.A.1
  • 44
    • 0022432233 scopus 로고
    • Chemical synthesis of oligonucleotides containing a free sulphydryl group and subsequent attachment of thiol specific probes
    • Connolly, B. A. Chemical synthesis of oligonucleotides containing a free sulphydryl group and subsequent attachment of thiol specific probes. Nucleic Acids Res. 1985, 13, 4485-4502.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 4485-4502
    • Connolly, B.A.1
  • 45
    • 0025777951 scopus 로고
    • Synthesis and selective cleavage of an oligonucleotide containing a bridged internucleotide 5′-phosphorothioate linkage
    • Mag, M.; Luking, S.; Engels, J. W. Synthesis and selective cleavage of an oligonucleotide containing a bridged internucleotide 5′-phosphorothioate linkage. Nucleic Acids Res. 1991, 19, 1437-1441.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 1437-1441
    • Mag, M.1    Luking, S.2    Engels, J.W.3
  • 46
    • 0028062189 scopus 로고
    • Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro
    • Tomiyama, T.; et al. Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro. Biochem. Biophys. Res. Commun. 1994, 204, 76-83.
    • (1994) Biochem. Biophys. Res. Commun. , vol.204 , pp. 76-83
    • Tomiyama, T.1
  • 47
    • 0028177534 scopus 로고
    • Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid β protein analogues
    • Tomiyama, T.; et al. Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid β protein analogues. J. Biol. Chem. 1994, 269, 10205-10208.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10205-10208
    • Tomiyama, T.1
  • 48
    • 0028971326 scopus 로고
    • Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure
    • Soto, C.; Castano, E. M.; Kumar, R. A.; Beavis, R. C.; Frangione, B. Fibrillogenesis of synthetic amyloid-beta peptides is dependent on their initial secondary structure. Neurosci. Lett. 1995, 200, 105-108.
    • (1995) Neurosci. Lett. , vol.200 , pp. 105-108
    • Soto, C.1    Castano, E.M.2    Kumar, R.A.3    Beavis, R.C.4    Frangione, B.5
  • 49
    • 0000541470 scopus 로고
    • Structural proof of syn/ anti isomerism in N-alkylated diamine dithiol complexes of technetium
    • Lever, S. Z.; Baidoo, K. E.; Mahmood, A. Structural proof of syn/ anti isomerism in N-alkylated diamine dithiol complexes of technetium. Inorg. Chim. Acta 1990, 176, 183-184.
    • (1990) Inorg. Chim. Acta , vol.176 , pp. 183-184
    • Lever, S.Z.1    Baidoo, K.E.2    Mahmood, A.3
  • 50
    • 0019124032 scopus 로고
    • Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
    • Levin, V. Relationship of Octanol/Water Partition Coefficient and Molecular Weight to Rat Brain Capillary Permeability. J. Med. Chem. 1980, 23, 682-684.
    • (1980) J. Med. Chem. , vol.23 , pp. 682-684
    • Levin, V.1
  • 51
    • 0031197194 scopus 로고    scopus 로고
    • Inhibition of amyloid formation: A strategy to delay the onset of Alzheimer's disease
    • Lansbury, P. T. Inhibition of amyloid formation: a strategy to delay the onset of Alzheimer's disease. Curr. Opin. Chem. Biol. 1997, 1, 260-267.
    • (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 260-267
    • Lansbury, P.T.1
  • 52
    • 0020646741 scopus 로고
    • Conversion of Congo red and 2-azoxyfluorene to mutagens following in vitro reduction by whole-cell rat cecal bacteria
    • Reid, T. M.; Morton, K. C.; Wang, C. Y.; King, C. M. Conversion of Congo red and 2-azoxyfluorene to mutagens following in vitro reduction by whole-cell rat cecal bacteria. Mutat. Res. 1983, 117, 105-112.
    • (1983) Mutat. Res. , vol.117 , pp. 105-112
    • Reid, T.M.1    Morton, K.C.2    Wang, C.Y.3    King, C.M.4
  • 53
    • 0027949973 scopus 로고
    • A chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid fibril formation
    • Kelly, J. W.; Lansbury, P. T., Jr. A chemical approach to elucidate the mechanism of transthyretin and β-protein amyloid fibril formation. Amyloid: Int. J. Exp. Clin. Invest. 1994, 1, 186-205.
    • (1994) Amyloid: Int. J. Exp. Clin. Invest. , vol.1 , pp. 186-205
    • Kelly, J.W.1    Lansbury P.T., Jr.2
  • 54
    • 0024352110 scopus 로고
    • Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation
    • Klunk, W. E.; Pettegrew, J. W.; Abraham, D. J. Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation. J. Histochem. Cytochem. 1989, 37, 1273-1281.
    • (1989) J. Histochem. Cytochem. , vol.37 , pp. 1273-1281
    • Klunk, W.E.1    Pettegrew, J.W.2    Abraham, D.J.3
  • 55
    • 0003089394 scopus 로고
    • Neurotransmitter hormone, or drug receptor binding methods
    • Yamamura, H. I., et al., Eds.; Raven Press: New York
    • Bennett, J. J.; Yamamura, H. I. Neurotransmitter Hormone, or Drug Receptor Binding Methods. In Neurotransmitter Receptor Binding; Yamamura, H. I., et al., Eds.; Raven Press: New York, 1985; pp 61-89.
    • (1985) Neurotransmitter Receptor Binding , pp. 61-89
    • Bennett, J.J.1    Yamamura, H.I.2
  • 56
    • 0028927279 scopus 로고
    • The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain: An immunocytochemical study
    • Lemere, C. A.; et al. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain: An immunocytochemical study. Am. J. Pathol. 1995, 146, 848-860.
    • (1995) Am. J. Pathol. , vol.146 , pp. 848-860
    • Lemere, C.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.