Chemical input - Sensory output: Diverse modes of physiology-flavour interaction

Food Quality and Preference

Volumn 21, Issue 8, 2010, Pages 915-924

  Buettner, Andrea ^a,b   Beauchamp, Jonathan ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b FRAUNHOFER INSTITUTE FOR PROCESS ENGINEERING AND PACKAGING IVV   (Germany)

Author keywords

Acceptance; Breathing; Chewing; Food; Mastication; Metabolism; Preference; Salivation; Swallowing

Indexed keywords

EID: 78049423316     PISSN: 09503293     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodqual.2010.01.008     Document Type: Article

References (122)

1. Baraniuk J.N., Merck S.J. New concepts of neural regulation in human nasal mucosa. Acta Clinica Croatica 2009, 48(1):65-73.
2. Beauchamp, J., Scheibe, M., Hummel, T., & Buettner, A. (2009). Characterisation of odorant pathways in olfactory dysfunction. In Abstract in international conference on breath and breath odor research. Dortmund, Germany. http://breath2009.isas.de/.
3. Bender G., Hummel T., Negoias S., Small D.M. Separate signals for orthonasal vs. retronasal perception of food but not nonfood odors. Behavioral Neuroscience 2009, 123(3):481-489.
4. Bensafi M., Porter J., Pouliot S., Mainland J., Johnson B., Zelano C., et al. Olfactomotor activity during imagery mimics that during perception. Nature Neuroscience 2003, 6(11):1142-1144.
5. Blissett A., Hort J., Taylor A.J. Influence of chewing and swallowing behavior on volatile release in two confectionery systems. Journal of Texture Studies 2006, 37(5):476-496.
6. Blissett A., Prinz J.F., Wulfert F., Taylor A.J., Hort J. Effect of bolus size on chewing, swallowing, oral soft tissue and tongue movement. Journal of Oral Rehabilitation 2007, 34(8):572-582.
7. Bucking M., Steinhart H. Headspace GC and sensory analysis characterization of the influence of different milk additives on the flavor release of coffee beverages. Journal of Agricultural and Food Chemistry 2002, 50(6):1529-1534.
8. Buettner A. Influence of human salivary enzymes on odorant concentration changes occurring in vivo. 1. Esters and thiols. Journal of Agricultural and Food Chemistry 2002, 50(11):3283-3289.
9. Buettner A. Influence of human saliva on odorant concentrations. 2. Aldehydes, alcohols, 3-alkyl-2-methoxypyrazines, methoxyphenols, and 3-hydroxy-4,5-dimethyl-2(5H)-furanone. Journal of Agricultural and Food Chemistry 2002, 50(24):7105-7110.
10. Buettner A. Prolonged retronasal aroma perception - A phenomenon influenced by physiological factors and food matrix composition. Flavour research at the dawn of the twenty-first century 2003, Lavoisier, London. J. Le Quéré, P. Etiévant (Eds.).
11. Buettner A. Physiology and chemistry behind retronasal aroma perception during winetasting. Proceedings of the VIIth international symposium d'oenology 2003, Editions Tec & Doc, Paris. A. Lonvaud-Funel, G. de Revel, P. Darriet (Eds.).
12. Buettner A. Investigation of espresso-" Aftersmell" by use of the buccal odor screening system (BOSS). State-of-the-art in flavour chemistry and biology 2005, Eigenverlag Deutsche Forschungsanstalt für Lebensmittelchemie, Garching. T. Hofmann, T. Rothe, P. Schieberle (Eds.).
13. Buettner A. Aroma release and perception during consumption of food taking into account physiological aspects 2007, Verlag Dr. Hut, Munich, Germany.
14. Buettner, A., & Mestres, M. (2007). Targeting the qualitative, quantitative and temporal aspects of retronasal aroma perception: A challenge for time-intensity profiling? In A. Hansel (Ed.), 3rd international conference on proton transfer reaction mass spectrometry and its applications. Innsbruck.
15. Buettner A., Beauchamp J. Objectifying human perception: When physiology and psychology deceives analytics. Proceedings of the 4th PTR-MS conference 2009, Innsbruck University Press, Innsbruck. A. Hansel, J. Dunkl (Eds.).
16. Buettner A., Beer A. Anleitung zur Weinverkostung. Die physiologischen Geheimnisse der Geruchs- und Geschmackswahrnehmung. Journal Culinaire 2007, 4:58-67.
17. Buettner A., Beer A., Hannig C., Settles M. Observation of the swallowing process by application of videofluoroscopy and real-time magnetic resonance imaging-consequences for retronasal aroma stimulation. Chemical Senses 2001, 26(9):1211-1219.
18. Buettner A., Beer A., Hannig C., Settles M., Schieberle P. Quantitation of the in-mouth release of heteroatomic odorants. Heteroatomic Aroma Compounds 2002, 826:304-319.
19. Buettner A., Beer A., Hannig C., Settles M., Schieberle P. Physiological and analytical studies on flavor perception dynamics as induced by the eating and swallowing process. Food Quality and Preference 2002, 13(7-8):497-504.
20. Buettner A., Griess M. Retronasal perception of espresso aroma. State-of-the-art in flavour chemistry and biology. Proceedings of the 7th Wartburg symposium on flavor chemistry & biology 2005, Eigenverlag Deutsche Forschungsanstalt für Lebensmittelchemie, Garching, Germany. T. Hofmann, T. Rothe, P. Schieberle (Eds.).
21. Buettner A., Mestres M. Investigation of the retronasal perception of strawberry aroma aftersmell depending on matrix composition. Journal of Agricultural and Food Chemistry 2005, 53(5):1661-1669.
22. Buettner A., Otto S., Beer A., Mestres M., Schieberle P., Hummel T. Dynamics of retronasal aroma perception during consumption: Cross-linking on-line breath analysis with medico-analytical tools to elucidate a complex process. Food Chemistry 2008, 108(4):1234-1246.
23. Buettner A., Schieberle P. Influence of mastication on the concentrations of aroma volatiles - Some aspects of flavour release and flavour perception. Food Chemistry 2000, 71:347-354.
24. Buettner A., Welle F. Intra-oral detection of potent odorants using a modified stir-bar sorptive extraction system in combination with HRGC-0 known as the buccal odor screening system (BOSS). Flavour and Fragrance Journal 2004, 19(6):505-514.
25. Buffo R., Rapp J., Krick T., Reineccius G. Persistence of aroma compounds in human breath after consuming an aqueous model aroma mixture. Food Chemistry 2005, 89:103-108.
26. Bult J.H., de Wijk R.A., Hummel T. Investigations on multimodal sensory integration: Texture, taste, and ortho- and retronasal olfactory stimuli in concert. Neuroscience Letters 2007, 411(1):6-10.
27. Burdach K., Doty R. The effects of mouth movements, swallowing, and spitting on retronasal odor perception. Physiology and Behavior 1987, 41:353-356.
28. Buttery R., Bomben J., Guadagni D., Ling L. Some considerations of the volatilities of organic flavour compounds in foods. Journal of Agricultural and Food Chemistry 1971, 19:1045-1048.
29. Buttery R., Guadagni D., Ling L. Flavor compounds: Volatilities in vegetable oil and oil-water mixtures. Estimation of odor thresholds. Journal of Agricultural and Food Chemistry 1973, 21:198-201.
30. Castellano J., Snow N.H. Modeling flavor release using inverse gas chromatography-mass spectrometry. Journal of Agricultural and Food Chemistry 2001, 49(9):4296-4299.
31. Chauncey H.H., Lionetti F., Winer R.A., Lisanti V.F. Enzymes of human saliva. I. The determination, distribution, and origin of whole saliva enzymes. Journal of Dental Research 1954, 33(3):321-334.
32. Chougnet A., Woggon W.D., Locher E., Schilling B. Synthesis and in vitro activity of heterocyclic inhibitors of CYP2A6 and CYP2A13, two cytochrome P450 enzymes present in the respiratory tract. Chembiochem 2009, 10(9):1562-1567.
33. Costanzo R.M., Mozell M.M. Electrophysiological evidence for a topographical projection of the nasal mucosa onto the olfactory bulb of the frog. Journal of General Physiology 1976, 68(3):297-312.
34. Cross, C. E., van der Vliet, A., O'Neill, C. A., Louie, S., & Halliwell, B. (1994). Oxidants, antioxidants, and respiratory tract lining fluids. Environmental Health Perspectives, 102(Suppl. 10), 185-191.
35. Dalton P., Doolittle N., Nagata H., Breslin P. The merging of the senses: Integration of subthreshold taste and smell. Nature Neuroscience 2000, 3(5):431-432.
36. Davidson J.M., Linforth R.S., Hollowood T.A., Taylor A.J. Effect of sucrose on the perceived flavor intensity of chewing gum. Journal of Agricultural and Food Chemistry 1999, 47(10):4336-4340.
37. de Roos K. Physiochemical models of flavor release from foods. Flavor release 2000, American Chemical Society, New York. D. Roberts, A. Taylor (Eds.).
38. Debat H., Eloit C., Blon F., Sarazin B., Henry C., Huet J.C., et al. Identification of human olfactory cleft mucus proteins using proteomic analysis. Journal of Proteome Research 2007, 6(5):1985-1996.
39. Deibler K.D., Lavin E.H., Linforth R.S., Taylor A.J., Acree T.E. Verification of a mouth simulator by in vivo measurements. Journal of Agricultural and Food Chemistry 2001, 49(3):1388-1393.
40. Delconte J.D., Kelling S.T., Halpern B.P. Speed and consistency of human decisions to swallow or spit sweet and sour solutions. Experientia 1992, 48(11-12):1106-1109.
41. Frank R., Byran J. Taste-smell interactions are tastant and odorant dependent. Chemical Senses 1988, 13:445-455.
42. Frasnelli J., Ruth S.v., Kriukova I., Hummel T. Intranasal concentrations of orally administered flavors. Chemical Senses 2005, 30(7):575-582.
43. Giroux H.J., Perreault V., Britten M. Characterization of hydrophobic flavor release profile in oil-in-water emulsions. Journal of Food Science 2007, 72(2):S125-S129.
44. Guichard E. Flavour retention and release from protein solutions. Biotechnology Advances 2006, 24(2):226-229.
45. Guinard J.X., Zoumas-Morse C., Walchak C., Simpson H. Relation between saliva flow and flavor release from chewing gum. Physiology and Behavior 1997, 61(4):591-596.
46. Guth H., Fritzler R. Binding studies and computer-aided modelling of macromolecule/odorant interactions. Chemistry and Biodiversity 2004, 1(12):2001-2023.
47. Hahn I., Scherer P.W., Mozell M.M. Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. Journal of Applied Physiology 1993, 75(5):2273-2287.
48. Halpern B.P. Environmental factors affecting chemoreceptors: An overview. Environmental Health Perspectives 1982, 44:101-105.
49. Halpern B.P. Retronasal and orthonasal smelling. Chemosense 2004, 6:1-7.
50. Hansson A., Giannouli P., van Ruth S. The influence of gel strength on aroma release from pectin gels in a model mouth and in vivo, monitored with proton-transfer-reaction mass spectrometry. Journal of Agricultural and Food Chemistry 2003, 51(16):4732-4740.
51. Heath, M., & Prinz, J. (1999). Oral processing of foods and the sensory evaluation of texture. In A. Rosenthal (Ed.), Food texture. Aspen, Gaithersburg.
52. Heilmann S., Hummel T. A new method for comparing orthonasal and retronasal olfaction. Behavioral Neuroscience 2004, 118(2):412-419.
53. Hodgson M., Langridge J., Linforth R., Taylor A. Aroma release and delivery following the consumption of beverages. Journal of Agricultural and Food Chemistry 2005, 53:1700-1706.
54. Hodgson M., Linforth R., Taylor A. Simultaneous real time measurements of mastication, swallowing, nasal airflow and aroma release. Journal of Agricultural and Food Chemistry 2003, 51:5052-5057.
55. Hornung D.E., Leopold D.A., Youngentob S.L., Sheehe P.R., Gagne G.M., Thomas F.D., et al. Airflow patterns in a human nasal model. Archives of Otolaryngology - Head and Neck Surgery 1987, 113(2):169-172.
56. Hornung D.E., Youngentob S.L., Mozell M.M. Olfactory mucosa/air partitioning of odorants. Brain Research 1987, 413(1):147-154.
57. Hussein M., Kachikian R., Pidel A. Analysis for flavor residuals in the mouth by gaschromatography. Journal of Food Science 1983, 48:1884-1885.
58. Ihalin R., Loimaranta V., Tenovuo J. Origin, structure, and biological activities of peroxidases in human saliva. Archives of Biochemistry and Biophysics 2006, 445(2):261-268.
59. Ingham K., Taylor A., Chevance F., Farmer L. Effect of fat content on volatile release from foods. Flavour science: Recent developments 1996, Royal Society of Chemistry, London. A. Taylor, D. Mottram (Eds.).
60. Ishikawa S., Nakayama T., Watanabe M., Matsuzawa T. Visualization of flow resistance in physiological nasal respiration: Analysis of velocity and vorticities using numerical simulation. Archives of Otolaryngology - Head and Neck Surgery 2006, 132(11):1203-1209.
61. Ishikawa S., Nakayama T., Watanabe M., Matsuzawa T. Flow mechanisms in the human olfactory groove: Numerical simulation of nasal physiological respiration during inspiration, expiration, and sniffing. Archives of Otolaryngology - Head and Neck Surgery 2009, 135(2):156-162.
62. Jones N. The nose and paranasal sinuses physiology and anatomy. Advance Drug Delivery Reviews 2001, 51(1-3):5-19.
63. Keyhani K., Scherer P.W., Mozell M.M. Numerical simulation of airflow in the human nasal cavity. Journal of Biomechanical Engineering 1995, 117(4):429-441.
64. Keyhani K., Scherer P.W., Mozell M.M. A numerical model of nasal odorant transport for the analysis of human olfaction. Journal of Theoretical Biology 1997, 186(3):279-301.
65. King B.M., Arents P., Bouter N., Duineveld C.A., Meyners M., Schroff S.I., et al. Sweetener/sweetness-induced changes in flavor perception and flavor release of fruity and green character in beverages. Journal of Agricultural and Food Chemistry 2006, 54(7):2671-2677.
66. Kleemann A., Kopietz R., Albrecht J., Schöpf V., Pollatos O., Schreder T., et al. Investigation of breathing parameters during odor perception and olfactory imagery. Chemical Senses 2009, 34(1):1-9.
67. Kurtz D.B., Zhao K., Hornung D.E., Scherer P. Experimental and numerical determination of odorant solubility in nasal and olfactory mucosa. Chemical Senses 2004, 29(9):763-773.
68. Lafarge C., Bard M.H., Breuvart A., Doublier J.L., Cayot N. Influence of the structure of cornstarch dispersions on kinetics of aroma release. Journal of Food Science 2008, 73(2):S104-S109.
69. Laing D.G. Perceptual odour interactions and objective mixture analysis. Food Quality and Preference 1994, 5:75-80.
70. Land D. Perspectives on the effects of interactions on flavor perception: An overview. Flavor-food interactions 1994, American Chemical Society, Washington. R. McGorrin, J. Leland (Eds.).
71. Lawless H.T. Sensory interactions in mixtures. Journal of Sensory Studies 1986, 1:259-274.
72. Linforth R.S., Blissett A., Taylor A.J. Differences in the effect of bolus weight on flavor release into the breath between low-fat and high-fat products. Journal of Agricultural and Food Chemistry 2005, 53(18):7217-7221.
73. Linforth R.S., Pearson K.S., Taylor A.J. In vivo flavor release from gelatin-sucrose gels containing droplets of flavor compounds. Journal of Agricultural and Food Chemistry 2007, 55(19):7859-7863.
74. Mandel, I. D. (1987). The functions of saliva. Journal of Dental Research, 66(Spec No.), 623-627.
75. Mennella J., Griffin C., Beauchamp G. Flavor programming during infancy. Pediatre 2004, 113:840-845.
76. Mese H., Matsuo R. Salivary secretion, taste and hyposalivation. Journal of Oral Rehabilitation 2007, 34(10):711-723.
77. Mestres M., Kieffer R., Buettner A. Release and perception of ethyl butanoate during and after consumption of whey protein gels: Relation between textural and physiological parameters. Journal of Agricultural and Food Chemistry 2006, 54(5):1814-1821.
78. Mestres M., Moran N., Jordan A., Buettner A. Aroma release and retronasal perception during and after consumption of flavored whey protein gels with different textures. 1. In vivo release analysis. Journal of Agricultural and Food Chemistry 2005, 53(2):403-409.
79. Mozell M.M., Jagodowicz M. Mechanisms underlying the analysis of odorant quality at the level of the olfactory mucosa. I. Spatiotemporal sorption patterns. Amygdala in Brain Function: Basic and Clinical Approaches 1974, 237:76-90.
80. Nahon D.F., Harrison M., Roozen J.P. Modeling flavor release from aqueous sucrose solutions, using mass transfer and partition coefficients. Journal of Agricultural and Food Chemistry 2000, 48(4):1278-1284.
81. Odake S., Roozen J.P., Burger J.J. Flavor release of diacetyl and 2-heptanone from cream style dressings in three mouth model systems. Bioscience Biotechnology and Biochemistry 2000, 64(12):2523-2529.
82. Pedersen A.M., Bardow A., Jensen S.B., Nauntofte B. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion. Oral Diseases 2002, 8(3):117-129.
83. Pelosi P., Zhou J.J., Ban L.P., Calvello M. Soluble proteins in insect chemical communication. Cellular and Molecular Life Sciences 2006, 63(14):1658-1676.
84. Peynaud E. The taste of wine, the art and science of wine appreciation 1987, The Wine Appreciation Guild, San Francisco.
85. Piggot J., Schaschke C. Release cells, breath analysis and in-mouth analysis in flavour research. Biomolecular Engineering 2001, 17:129-136.
86. Potineni R.V., Peterson D.G. Influence of flavor solvent on flavor release and perception in sugar-free chewing gum. Journal of Agricultural and Food Chemistry 2008, 56(9):3254-3259.
87. Rabe S., Krings U., Banavara D.S., Berger R.G. Computerized apparatus for measuring dynamic flavor release from liquid food matrices. Journal of Agricultural and Food Chemistry 2002, 50(22):6440-6447.
88. Rabe S., Krings U., Berger R.G. In vitro study of the influence of physiological parameters on dynamic in-mouth flavour release from liquids. Chemical Senses 2004, 29(2):153-162.
89. Rabe S., Linforth R.S., Krings U., Taylor A.J., Berger R.G. Volatile release from liquids: A comparison of in vivo APCI-MS, in-mouth headspace trapping and in vitro mouth model data. Chemical Senses 2004, 29(2):163-173.
90. Relkin P., Fabre M., Guichard E. Effect of fat nature and aroma compound hydrophobicity on flavor release from complex food emulsions. Journal of Agricultural and Food Chemistry 2004, 52(20):6257-6263.
91. Roberts D., Acree T. Simulation of retronasal aroma using a modified headspace technique: Investigating the effects of saliva, temperature, shearing, and oil on flavor release. Journal of Agricultural and Food Chemistry 1995, 43:2179-2186.
92. Ruijschop R.M., Boelrijk A.E., de Ru J.A., de Graaf C., Westerterp-Plantenga M.S. Effects of retro-nasal aroma release on satiation. British Journal of Nutrition 2008, 99(5):1140-1148.
93. Ruijschop R.M., Burgering M.J., Jacobs M.A., Boelrijk A.E. Retro-nasal aroma release depends on both subject and product differences: A link to food intake regulation?. Chemical Senses 2009, 34(5):395-403.
94. Savary G., Semon E., Meunier J.M., Doublier J.L., Cayot N. Impact of destroying the structure of model gels on volatile release. Journal of Agricultural and Food Chemistry 2007, 55(17):7099-7106.
95. Scherer P.W., Hahn I.I., Mozell M.M. The biophysics of nasal airflow. Otolaryngologic Clinics of North America 1989, 22(2):265-278.
96. Schifferstein H., Verlegh P. The role of congruency and pleasantness in odor-induced taste enhancement. Acta Psychologica 1996, 94:87-105.
97. Schilling, B., Granier, T., Frater, G., & Hanhart, A. (2008). Organic compounds and compositions having the ability to modulate fragrance compositions. Patent: PCT/CH2008/000128.
98. Small D.M., Gerber J.C., Mak Y.E., Hummel T. Differential neural responses evoked by orthonasal versus retronasal odorant perception in humans. Neuron 2005, 47(4):593-605.
99. Spitzer, J., & Buettner, A. (2009a). The influence of storage conditions on flavour changes in human milk. In 8th pangborn sensory science symposium. Florence, Italy.
100. Spitzer, J., & Buettner, A. (2009b). Characterization of off-odor development in human milk during storage at -18°C. In AChemS 31st annual meeting. Sarasota, FL.
101. Spitzer J., Buettner A. Characterization of off-odor development in human milk during storage at -19°C. Food Chemistry 2009, 120(1):240-246.
102. Starkenmann C. Analysis of a model reaction system containing cysteine and (E)-2-methyl-2-butenal, (E)-2-hexenal, or mesityl oxide. Journal of Agricultural and Food Chemistry 2003, 51(24):7146-7155.
103. Starkenmann C., Le Calve B., Niclass Y., Cayeux I., Beccucci S., Troccaz M. Olfactory perception of cysteine-S-conjugates from fruits and vegetables. Journal of Agricultural and Food Chemistry 2008, 56(20):9575-9580.
104. Steiner J. Human facial expressions in response to taste and smell stimuli. Advances in Child Development and Behavior 1979, 13:257-295.
105. Sun B.C., Halpern B.P. Identification of air phase retronasal and orthonasal odorant pairs. Chemical Senses 2005, 30(8):693-706.
106. Taylor A.J. Volatile flavor release from foods during eating. Critical Reviews in Food Science and Nutrition 1996, 36(8):765-784.
107. Taylor A.J., Cook D.J., Scott D. Role of odor binding protein: Comparing hypothetical mechanisms with experimental data. Chemosensory Perception 2008, 2:153-162.
108. Taylor A., Linforth R. Flavour release from foods: Recent developments. Flavor perception, aroma, evaluation 1997, Deutsches Institut für Ernährungsforschung, Potsdam. H.-P. Kruse, M. Rothe (Eds.).
109. Tegoni M., Pelosi P., Vincent F., Spinelli S., Campanacci V., Grolli S., et al. Mammalian odorant binding proteins. Biochimica et Biophysica Acta 2000, 1482(1-2):229-240.
110. Thornton-Manning J.R., Dahl A.R. Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes. Mutation Research 1997, 380(1-2):43-59.
111. van Ruth S.M., Grossmann I., Geary M., Delahunty C.M. Interactions between artificial saliva and 20 aroma compounds in water and oil model systems. Journal of Agricultural and Food Chemistry 2001, 49(5):2409-2413.
112. Visschers R.W., Jacobs M.A., Frasnelli J., Hummel T., Burgering M., Boelrijk A.E. Cross-modality of texture and aroma perception is independent of orthonasal or retronasal stimulation. Journal of Agricultural and Food Chemistry 2006, 54(15):5509-5515.
113. Voirol E., Daget N. Comparative study of nasal and retronasal olfactory perception. Lebensmittel-Wissenschaft & Technologie 1986, 19:316-319.
114. Weel K.G., Boelrijk A.E., Alting A.C., Van Mil P.J., Burger J.J., Gruppen H., et al. Flavor release and perception of flavored whey protein gels: Perception is determined by texture rather than by release. Journal of Agricultural and Food Chemistry 2002, 50(18):5149-5155.
115. Weel K.G., Boelrijk A.E., Burger J.J., Verschueren M., Gruppen H., Voragen A.G., et al. New device to simulate swallowing and in vivo aroma release in the throat from liquid and semiliquid food systems. Journal of Agricultural and Food Chemistry 2004, 52(21):6564-6571.
116. Welge-Lussen A., Drago J., Wolfensberger M., Hummel T. Gustatory stimulation influences the processing of intranasal stimuli. Brain Research 2005, 1038(1):69-75.
117. Welge-Lussen A., Husner A., Wolfensberger M., Hummel T. Influence of simultaneous gustatory stimuli on orthonasal and retronasal olfaction. Neuroscience Letters 2009, 454(2):124-128.
118. Wilkes F.J., Laing D.G., Hutchinson I., Jinks A.L., Monteleone E. Temporal processing of olfactory stimuli during retronasal perception. Behavioural Brain Research 2009, 200(1):68-75.
119. Yang G.C., Scherer P.W., Zhao K., Mozell M.M. Numerical modeling of odorant uptake in the rat nasal cavity. Chemical Senses 2007, 32(3):273-284.
120. Youngentob S.L., Mozell M.M., Sheehe P.R., Hornung D.E. A quantitative analysis of sniffing strategies in rats performing odor detection tasks. Physiology and Behavior 1987, 41(1):59-69.
121. Zhang X., Zhang Q.Y., Liu D., Su T., Weng Y., Ling G., et al. Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa. Drug Metabolism and Disposition 2005, 33(10):1423-1428.
122. Zhao K., Scherer P.W., Hajiloo S.A., Dalton P. Effect of anatomy on human nasal air flow and odorant transport patterns: Implications for olfaction. Chemical Senses 2004, 29(5):365-379.