Synthesis and in vitro activity of heterocyclic inhibitors of CYP2A6 and CYP2A13, two cytochrome P450 enzymes present in the respiratory tract

ChemBioChem

Volumn 10, Issue 9, 2009, Pages 1562-1567

  Chaugnet, Antoinette ^a   Woggon, Wolf D ^a   Locher, Esther ^b   Schilling, Boris ^b  

^a UNIVERSITY OF BASEL   (Switzerland)

^b GIVAUDAN SCHWEIZ AG   (Switzerland)

Author keywords

CYP2A13; CYP2A6; Cytochromes; Inhibitors; Respiratory tract

Indexed keywords

1 (HEX 3 ENYL) 1H IMIDAZOLE; 1 (HEX 5 ENYL) 1H IMIDAZOLE; 2 (2,6 DIMETHYLHEPTA 1,5 DIENYL) 1H IMIDAZOLE; 2 (4 METHYLPENTYL)PYRAZINE; 2 (HEPT 6 ENYL)PYRAZINE; 2 (PENT 2 ENYL) 1H IMIDAZOLE; CYTOCHROME P450; CYTOCHROME P450 2A13; CYTOCHROME P450 2A6; FRAGRANCE; IMIDAZOLE DERIVATIVE; NICOTINE; NITROSAMINE; OXAZOLE DERIVATIVE; OXAZOLINE DERIVATIVE; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARCINOGEN DNA INTERACTION; CARCINOGENICITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SMOKING; VAPOR PRESSURE;

ARYL HYDROCARBON HYDROXYLASES; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; HUMANS; IMIDAZOLES; RESPIRATORY SYSTEM;

EID: 70349546336     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800712     Document Type: Article

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