Effect of anatomy on human nasal air flow and odorant transport patterns: Implications for olfaction

Chemical Senses

Volumn 29, Issue 5, 2004, Pages 365-379

  Zhao, Kai ^a   Scherer, Peter W ^a   Hajiloo, Shoreh A ^a   Dalton, Pamela ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

Finite element model; Human nasal cavity; Nasal deformation; Nasal fluid mechanics; Olfactory stimulus; Perireceptor

Indexed keywords

ARTICLE; COMPUTATIONAL FLUID DYNAMICS; COMPUTER ASSISTED TOMOGRAPHY; FINITE ELEMENT ANALYSIS; FUNCTIONAL ANATOMY; IMAGE ANALYSIS; MATHEMATICAL ANALYSIS; MODEL; NOSE AIRFLOW; NOSE MALFORMATION; ODOR; POLYP; PRIORITY JOURNAL; SMELLING; STIMULUS; TECHNIQUE; THREE DIMENSIONAL IMAGING; ABSORPTION; AIR; AUDIOVISUAL EQUIPMENT; FLOW KINETICS; HISTOLOGY; HUMAN; LUNG VENTILATION; NOSE CAVITY; NOSE DISEASE; NOSE MUCOSA; NUCLEAR MAGNETIC RESONANCE IMAGING; OLFACTORY RECEPTOR; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ABSORPTION; AIR MOVEMENTS; BIOLOGICAL TRANSPORT; HUMANS; MAGNETIC RESONANCE IMAGING; MODELS, ANATOMIC; NASAL CAVITY; NASAL MUCOSA; NOSE DISEASES; PULMONARY VENTILATION; RECEPTORS, ODORANT; RHEOLOGY; SMELL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 10644250420     PISSN: 0379864X     EISSN: None     Source Type: Journal    
DOI: 10.1093/chemse/bjh033     Document Type: Article

References (36)

1. Abraham, M.H. and Weathersby, P.K. (1994) Hydrogen bonding. 30. Solubility of gases and vapors in biological liquids and tissues. J. Pharmacol. Sci., 83, 1450-1456.
2. Abraham, M.H., Kamlet, M.J., Taft, R.W., Doherty, R.M. and Weathersby, P.K. (1985) Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids. J. Med. Chem., 28, 865-870.
3. Damm, M., Vent, J., Schmidt, M., Theissen, P., Eckel, H., Lötsch, J. and Hummel, T. (2002) Intranasal volume and olfactory function. Chem. Senses, 27, 831-839.
4. Feron, F., Perry, C., McGrath, J.J. and Mackay-Sim, A. (1998) New techniques for biopsy and culture of human olfactory epithelial neurons. Arch. Otolaryngol. Head Neck Surg., 124, 861-866.
5. Fluent Inc. (1998) Fluent User Guide. Fluent, Lebanon, NH.
6. Getchell, T.V., Margolis, T.V. and Getchell, M.L. (1984) Perireceptor and receptor events in vertebrate olfaction. Prog. Neurobiol., 23, 317-345.
7. Girardin, M., Bilgen, E. and Arbour, P. (1983) Experimental study of velocity fields in a human nasal fossa by laser anemometry. Ann. Otol. Rhinol. Laryngol., 92, 231-236.
8. Hahn, I., Scherer, P.W. and Mozell, M.M. (1993) Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. Modeling Physiol., 75, 2273-2287.
9. Hahn, I., Scherer, P.W. and Mozell, M.M. (1994) A mass transport model of olfaction. J. Theor. Biol., 167, 115-128.
10. Haight, J.J. and Cole, P. (1984) Reciprocating nasal airflow resistances. Acta Otolaryngol., 97, 93-98.
11. Hornung, D.E. and Mozell, M.M. (1981) Accessibility of odorant molecules to the receptors. In Cagan, R.H. and Kare, M.R. (eds), Biochemistry of Taste and Olfaction. Academic Press, New York, pp. 33-45.
12. Hornung, D.E., Mozell, M.M. and Serio, J.A. (1980) Olfactory mucus/air partitioning of odorant. In van der Starre, H. (ed.), Olfaction and Taste VII. IRL Press, London, pp. 167-170.
13. Hornung, D.E., Leopold, D.A., Youngentob, S.L., Sheehe, P.R., Gagne, G.M., Thomas, F.D. and Mozell, M.M. (1987) Airflow patterns in a human nasal model. Arch. Otolaryngol. Head Neck Surg., 113, 169-172.
14. Hornung, D.E., Smith, D.J., Kurtz, D.B., White, T. and Leopold, D.A. (2001) Effect of nasal dilaors on nasal structures, sniffing strategies, and olfactory ability. Rhinology, 39, 84-87.
15. Kelly, J.T., Prasad, A.K. and Wexler, A.S. (2000) Detailed flow patterns in the nasal cavity. J. Appl. Physiol., 89, 323-337.
16. Keyhani, K., Scherer, P.W. and Mozell, M.M. (1995) Numerical simulation of airflow in the human nasal cavity. J. Biomech. Eng., 117, 429-441.
17. Keyhani, K., Scherer, P.W. and Mozell, M.M. (1997) Numerical model of nasal odorant transport for the analysis of human olfaction. J. Theor. Biol., 186, 279-301.
18. Leopold, D.A. (1988) The relationship between nasal anatomy and human olfaction. Laryngoscope, 98, 1232-1238.
19. Martonen, T.B., Quan, L., Zhang, Z. and Musante, C.J. (2002) Flow simulation in the human upper respiratory tract. Cell Biochem. Biophys., 37, 27-36.
20. Masing, H. (1967) Experimental studies on the flow in nose model. Arch. Klin. Exp. Ohren Nasen Kehlkopfheilkd., 189, 59-70.
21. Moulton, D.G. (1976) Spatial patterning of response to odors in the peripheral olfactory system. Physiol. Rev., 56, 578-593.
22. Mozell, M.M. (1966) The spatiotemporal analysis of odorants at the level of the olfactory receptor sheet. J. Gen. Physiol., 50, 25-41.
23. Mozell, M.M. (1970) Evidence for a chromatographic model of olfaction. J. Gen. Physiol., 56, 46-63.
24. Mozell, M.M. and Jagodowicz, M. (1974) Mechanisms underlying the analysis of odorant quality at the level of the olfactory mucosa. I. Spatiotemporal sorption patterns. Ann. N. Y. Acad. Sci., 237, 76-90.
25. Newton, J.W., Zhao, K., Hornung, D.E. and Kurtz, D.B. (2000) Determination of odorant solubility in the olfactory mucosa. Chem. Senses, 25, 609-609.
26. Pallanch, J.F., McCaffrey, T.V. and Kern, E.B. (1985) Normal nasal resistance. Arch. Otolaryngol. Head NeckSurg., 93, 778-785.
27. Perry, R.H., Chilton, C.H. and Kirkpatrick, S.D. (1963) Chemical Engineers' Handbook. McGraw-Hill, New York.
28. Pribitkin, E.D., Cowart, B.J., Rosen, D., and Klock, C.T. (2003) Prognosis for olfactory dysfunction: the good, the bad, and the ugly [abstract]. Chem. Senses, 28, 000.
29. Proctor, D.F. (1982) The upper airway. In Proctor, D.E. and Andersen, I.B. (eds), The Nose. Elsevier Biomedical, New York, pp. 23-43.
30. Proetz, A.W. (1951) Air currents in the upper respiratory tract and their clinical importance. Ann. Otol. Rhinol. Laryngol., 60, 439-467.
31. Schreck, S., Sullivan, K.J., Ho, C.M. and Chang, H.K. (1993) Correlations between flow resistance and geometry in a model of the human nose. J. Appl. Physiol., 75, 1767-1775.
32. Stuiver, M. (1958) Biophysics of the Sense of Smell. Dissertation, Rijks University, Groningen, The Netherlands.
33. Subramaniam, R.P., Richardson, R.B., Morgan, K.T. and Kimbell, J.S. (1999) Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal. Toxicol., 10, 91-120.
34. Swift, D. L. and Proctor, D.F. (1977) Access of air to the respiratory tract. In Brain, J.D., Proctor, D.F. and Reid, L.M. (eds), Respiratory Defense Mechanism. Marcel Dekker, New York, pp. 63-91.
35. Welty, J.R., Wicks, G.E. and Wilson, R.E. (1976) Fundamentals of Momentum, Heat and Mass Transfer, 2nd edn. Wiley, New York.
36. Wolfensberger, M. and Hummel, T. (2002) Anti-inflammatory and surgical therapy of olfactory disorders related to sino-nasal disease. Chem. Senses, 27, 617-622.