-
1
-
-
0003799353
-
Aminoglycoside, macrolide, glycopeptide, and miscellaneous antibacterial antibiotics
-
Wolff ME, editor 5th edition John Wiley & Sons
-
Kirst HA. Aminoglycoside, macrolide, glycopeptide, and miscellaneous antibacterial antibiotics. In: Wolff ME, editor, Burger's medicinal chemistry and drug discovery. 5th edition. Volume 2. John Wiley & Sons; 1996. p. 463-525
-
(1996)
Burger's Medicinal Chemistry and Drug Discovery
, vol.2
, pp. 463-525
-
-
Kirst, H.A.1
-
2
-
-
84906433066
-
Macrolide antibiotics
-
Taylor JB, Triggle DJ, editors Elsevier
-
Kaneko T, Dougherty TJ, Magee TV. Macrolide antibiotics. In: Taylor JB, Triggle DJ, editors, Comprehensive medicinal chemistry II. Volume 7. Elsevier; 2007. p. 519-566
-
(2007)
Comprehensive Medicinal Chemistry II
, vol.7
, pp. 519-566
-
-
Kaneko, T.1
Dougherty, T.J.2
Magee, T.V.3
-
3
-
-
0000992991
-
Antibiotics (macrolides)
-
Seidel A, editor 5th edition John Wiley & Sons
-
Kirst HA. Antibiotics (macrolides). In: Seidel A, editor, Kirk-Othmer encyclopedia of chemical technology. 5th edition. Volume 15. John Wiley & Sons; 2005. p. 271-320
-
(2005)
Kirk-Othmer Encyclopedia of Chemical Technology
, vol.15
, pp. 271-320
-
-
Kirst, H.A.1
-
4
-
-
84944579401
-
Macrolides, clindamycin, and ketolides
-
Mandell GL, Bennett JE, Dolin R, editors (Chapter 30). 7th edition Churchill Livingstone
-
Sivapalasingam S, Steigbigel NH. Macrolides, clindamycin, and ketolides. In: Mandell GL, Bennett JE, Dolin R, editors, Mandell, Douglas, and Bennett's principles and practice of infectious diseases (Chapter 30). 7th edition. Volume 1. Churchill Livingstone; 2009
-
(2009)
Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases
, vol.1
-
-
Sivapalasingam, S.1
Steigbigel, N.H.2
-
5
-
-
64849096428
-
Macrolides
-
Yu VL, Edwards G, McKinnon PS, Peloquin C, Morse GD, editors 2nd edition ESun Technologies
-
Mulazimoglu L, Tulkens PM, Van Bambeke F. Macrolides. In: Yu VL, Edwards G, McKinnon PS, Peloquin C, Morse GD, editors, Antimicrobial therapy and vaccines. 2nd edition. Volume 2. ESun Technologies; 2005. p. 243-280
-
(2005)
Antimicrobial Therapy and Vaccines
, vol.2
, pp. 243-280
-
-
Mulazimoglu, L.1
Tulkens, P.M.2
Van Bambeke, F.3
-
6
-
-
0342297460
-
Ketolides, a new distinct semi-synthetic class of macrolides
-
Orlando, FL
-
Agouridas C, Benedetti Y, Denis A, et al. Ketolides, a new distinct semi-synthetic class of macrolides. 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. Orlando, FL; 1994. p. F-164
-
(1994)
34th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Agouridas, C.1
Benedetti, Y.2
Denis, A.3
-
7
-
-
0003259907
-
Ketolides, a new distinct class of macrolide antibacterials. Synthesis and structural characteristics of RU 004
-
San Francisco, CA
-
Agouridas C, Benedetti Y, Denis A, et al. Ketolides, a new distinct class of macrolide antibacterials. Synthesis and structural characteristics of RU 004. 35th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA; 1995. p. F-157
-
(1995)
35th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Agouridas, C.1
Benedetti, Y.2
Denis, A.3
-
8
-
-
0012473679
-
Ketolides: Novel antibacterial agents designed to overcome resistance to erythromycin A within gram-positive cocci
-
Schonfeld W Kirst HA editors Birkhauser Verlag
-
Bryskier A, Denis A. Ketolides: novel antibacterial agents designed to overcome resistance to erythromycin A within gram-positive cocci. In: Schonfeld W, Kirst HA, editors, Macrolide antibiotics.Birkhauser Verlag; 2002. p. 97-140
-
(2002)
Macrolide Antibiotics
, pp. 97-140
-
-
Bryskier, A.1
Denis, A.2
-
9
-
-
3042544481
-
Clinical efficacy of ketolides in the treatment of respiratory tract infections
-
Reinert RR. Clinical efficacy of ketolides in the treatment of respiratory tract infections. J Antimicrob Chemother 2004;53:918-927
-
(2004)
J Antimicrob Chemother
, vol.53
, pp. 918-927
-
-
Reinert, R.R.1
-
10
-
-
4344659147
-
Telithromycin
-
Wellington K, Noble S. Telithromycin. Drugs 2004;64:1683-1694
-
(2004)
Drugs
, vol.64
, pp. 1683-1694
-
-
Wellington, K.1
Noble, S.2
-
11
-
-
70349123742
-
Ketolides (telithromycin, cethromycin)
-
Yu VL, Edwards G, McKinnon PS, Peloquin C, Morse GD, editors 2nd edition ESun Technologies
-
Zhanel GG, Neuhauser MM. Ketolides (telithromycin, cethromycin). In: Yu VL, Edwards G, McKinnon PS, Peloquin C, Morse GD, editors, Antimicrobial therapy and vaccines. 2nd edition. Volume 2. ESun Technologies; 2005. p. 201-222
-
(2005)
Antimicrobial Therapy and Vaccines.
, vol.2
, pp. 201-222
-
-
Zhanel, G.G.1
Neuhauser, M.M.2
-
12
-
-
39049097113
-
Ketolides: Pharmacological profile and rational positioning in the treatment of respiratory tract infections
-
Van Bambeke F, Harms JM, Van Laethem Y, Tulkens PM. Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections. Expert Opin Pharmacother 2008;9:267-283
-
(2008)
Expert Opin Pharmacother
, vol.9
, pp. 267-283
-
-
Van Bambeke, F.1
Harms, J.M.2
Van Laethem, Y.3
Tulkens, P.M.4
-
13
-
-
77956701864
-
U. S. limits use of risky Sanofi antibiotic Ketek
-
Kaye D. U. S. limits use of risky Sanofi antibiotic Ketek. Clin Infect Dis 2007;44:iv
-
(2007)
Clin Infect Dis
, vol.44
-
-
Kaye, D.1
-
15
-
-
34247192001
-
The FDA and the case of Ketek
-
Ross DB. The FDA and the case of Ketek. N Engl J Med 2007;356:1601-1604
-
(2007)
N Engl J Med
, vol.356
, pp. 1601-1604
-
-
Ross, D.B.1
-
16
-
-
40949128223
-
Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections
-
Hammerschlag MR, Sharma R. Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections. Expert Opin Investig Drugs 2008;17:387-400
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 387-400
-
-
Hammerschlag, M.R.1
Sharma, R.2
-
17
-
-
33847400958
-
Cethromycin: A-195773, A-195773-0, A-1957730, Abbott-195773, ABT 773
-
Anonymous 95-102 Available from
-
Anonymous. Cethromycin: A-195773, A-195773-0, A-1957730, Abbott-195773, ABT 773. Drugs 2007;8:95-102 Available from: http://www.advancedlifesciences.com
-
(2007)
Drugs
, vol.8
-
-
-
18
-
-
10044284273
-
Synthesis of novel 6,11-O-bridged bicyclic ketolides via a palladium-catalyzed bis-allylation
-
Wang G, Niu D, Qiu Y-L, et al. Synthesis of novel 6,11-O-bridged bicyclic ketolides via a palladium-catalyzed bis-allylation. Org Lett 2004;6:4455-4458
-
(2004)
Org Lett
, vol.6
, pp. 4455-4458
-
-
Wang, G.1
Niu, D.2
Qiu, Y.-L.3
-
19
-
-
66149102781
-
Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers
-
Jiang L-J, Wang M, Or YS. Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Antimicrob Agents Chemother 2009;53:1786-1792
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 1786-1792
-
-
Jiang, L.-J.1
Wang, M.2
Or, Y.S.3
-
20
-
-
67749127609
-
Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study
-
Jiang L-J, Or YS. Pharmacokinetics of EDP-420 after multiple oral doses in healthy adult volunteers and in a bioequivalence study. Antimicrob Agents Chemother 2009;53:3218-3225
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 3218-3225
-
-
Jiang, L.-J.1
Or, Y.S.2
-
21
-
-
75749085747
-
Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects
-
Available from
-
Furuie H, Saisho Y, Yoshikawa T, Shimada J. Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. Antimicrob Agents Chemother 2010;54:866-870 Available from: http://www.enanta.com
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 866-870
-
-
Furuie, H.1
Saisho, Y.2
Yoshikawa, T.3
Shimada, J.4
-
22
-
-
13944259311
-
Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics
-
Liang C-H, Yao S, Chiu Y-H, et al. Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics. Bioorg Med Chem Lett 2005;15:1307-1310
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 1307-1310
-
-
Liang, C.-H.1
Yao, S.2
Chiu, Y.-H.3
-
23
-
-
13444257877
-
An efficient entry to new sugar modified ketolide antibiotics
-
Romero A, Liang C-H, Chiu Y-H, et al. An efficient entry to new sugar modified ketolide antibiotics. Tetrahedron Lett 2005;46:1483-1487
-
(2005)
Tetrahedron Lett
, vol.46
, pp. 1483-1487
-
-
Romero, A.1
Liang, C.-H.2
Chiu, Y.-H.3
-
24
-
-
77956665365
-
-
Optimer Pharmaceuticals Inc WO2004080391
-
Optimer Pharmaceuticals, Inc. Novel antibacterial agents. WO2004080391; 2004
-
(2004)
Novel Antibacterial Agents
-
-
-
26
-
-
73849107755
-
In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms
-
Available from
-
McGhee P, Clark C, Kosowska-Shick KM, et al. In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. Antimicrob Agents Chemother 2010;54:230-238 Available from: http://www.cempra.com
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 230-238
-
-
McGhee, P.1
Clark, C.2
Kosowska-Shick, K.M.3
-
29
-
-
77956687086
-
In vitro and in vivo antibacterial activity of PF-04287881: A new ketolide antimicrobial against recent bacterial clinical isolates
-
San Francisco, CA
-
Mullins LM, Huband MD, McCurdy SP, et al. In vitro and in vivo antibacterial activity of PF-04287881: a new ketolide antimicrobial against recent bacterial clinical isolates. 49th Interscience Conference on Antimicrobial Agents Chemotherapy. San Francisco, CA; 2009. p. F1-2042
-
(2009)
49th Interscience Conference on Antimicrobial Agents Chemotherapy
-
-
Mullins, L.M.1
Huband, M.D.2
McCurdy, S.P.3
-
30
-
-
77956656015
-
-
Pfizer Products Inc. WO2008110918
-
Pfizer Products, Inc. Erythromycin-based macrolides. WO2008110918; 2008
-
(2008)
Erythromycin-based Macrolides
-
-
-
31
-
-
72249086358
-
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections
-
Available from
-
Magee TV, Ripp SL, Li B, et al. Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. J Med Chem 2009;52:7446-7457 Available from: http://www.pfizer.com
-
(2009)
J Med Chem
, vol.52
, pp. 7446-7457
-
-
Magee, T.V.1
Ripp, S.L.2
Li, B.3
-
32
-
-
77956673378
-
New series of azetidinyl ketolide sulfonamides: Structure activity relationships and identification of PF-03438011 and PF-03438012
-
San Francisco CA
-
Flanagan ME, Chupak L, Dougherty TJ, et al. New series of azetidinyl ketolide sulfonamides: structure activity relationships and identification of PF-03438011 and PF-03438012. 49th Interscience Conference on Antimicrobial Agents Chemotherapy. San Francisco, CA; 2009. p. F1-2041
-
(2009)
49th Interscience Conference on Antimicrobial Agents Chemotherapy
-
-
Flanagan, M.E.1
Chupak, L.2
Dougherty, T.J.3
-
33
-
-
77956712938
-
-
Pfizer Products, Inc. WO2006067589
-
Pfizer Products, Inc. Macrolides. WO2006067589; 2006
-
(2006)
Macrolides
-
-
-
34
-
-
65649092130
-
Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity
-
Kouvela EC, Kalpaxis DL, Wilson DN, Dinos GP. Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity. Antimicrob Agents Chemother 2009;53:1411-1419
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 1411-1419
-
-
Kouvela, E.C.1
Kalpaxis, D.L.2
Wilson, D.N.3
Dinos, G.P.4
-
35
-
-
77956658608
-
-
Kosan Biosciences Inc. WO2003061671
-
Kosan Biosciences, Inc. Amido macrolides. WO2003061671; 2003
-
(2003)
Amido Macrolides
-
-
-
37
-
-
33845621530
-
Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase
-
Ward SL, Desai RP, Hu Z, et al. Precursor-directed biosynthesis of 6-deoxyerythronolide B analogues is improved by removal of the initial catalytic sites of the polyketide synthase. J Ind Microbiol Biotechnol 2007;34:9-15
-
(2007)
J Ind Microbiol Biotechnol
, vol.34
, pp. 9-15
-
-
Ward, S.L.1
Desai, R.P.2
Hu, Z.3
-
38
-
-
33644921212
-
A journey across the sequential development of macrolides and ketolides related to erythromycin
-
Pal S. A journey across the sequential development of macrolides and ketolides related to erythromycin. Tetrahedron 2006;62:3171-3200
-
(2006)
Tetrahedron
, vol.62
, pp. 3171-3200
-
-
Pal, S.1
-
39
-
-
67649993432
-
Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity
-
Xu P, Liu L, Chen X-Z, et al. Synthesis of novel macrolide derivatives with imidazo[4,5-b]pyridinyl sulfur contained alkyl side chains and their antibacterial activity. Bioorg Med Chem Lett 2009;19:4079-4083
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 4079-4083
-
-
Xu, P.1
Liu, L.2
Chen, X.-Z.3
-
42
-
-
77956678188
-
-
Taisho Pharmaceutical Co Ltd. WO2005075495
-
Taisho Pharmaceutical Co., Ltd. 6-O-Substituted ketolide derivatives. WO2005075495; 2005
-
(2005)
6-O-Substituted Ketolide Derivatives
-
-
-
45
-
-
77956666707
-
-
Pfizer Inc US6809080
-
Pfizer, Inc. Macrolide antibiotics. US6809080; 2004
-
(2004)
Macrolide Antibiotics
-
-
-
46
-
-
34547875726
-
Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides
-
Kaneko T, McMillen W, Lynch MK. Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides. Bioorg Med Chem Lett 2007;17:5013-5018
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 5013-5018
-
-
Kaneko, T.1
McMillen, W.2
Lynch, M.K.3
-
47
-
-
0004140510
-
-
Glaxo Group Ltd. WO2002050092
-
Glaxo Group Ltd. Macrolide antibiotics. WO2002050092; 2002
-
(2002)
Macrolide Antibiotics
-
-
-
48
-
-
34547868479
-
A novel ketolide class: Synthesis and antibacterial activity of a lead compound
-
Andreotti D, Bientinesi I, Biondi S, et al. A novel ketolide class: synthesis and antibacterial activity of a lead compound. Bioorg Med Chem Lett 2007;17:5265-5269
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 5265-5269
-
-
Andreotti, D.1
Bientinesi, I.2
Biondi, S.3
-
49
-
-
2942512154
-
Novel ketolide antibiotics with a fused five-membered lactone ring-synthesis, physicochemical and antimicrobial properties
-
Hunziker D, Wyss P, Angehrn P, et al. Novel ketolide antibiotics with a fused five-membered lactone ring-synthesis, physicochemical and antimicrobial properties. Bioorg Med Chem 2004;12:3503-3519
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 3503-3519
-
-
Hunziker, D.1
Wyss, P.2
Angehrn, P.3
-
52
-
-
33750954010
-
Chemoselective synthesis of erythromycin A ketolides substituted in the C10-methyl group
-
Undheim K, Gunnes S. Chemoselective synthesis of erythromycin A ketolides substituted in the C10-methyl group. Bioorg Med Chem 2007;15:119-129
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 119-129
-
-
Undheim, K.1
Gunnes, S.2
-
53
-
-
33746206243
-
Synthesis and antibacterial activity of C12 des-methyl ketolides
-
Lin X, Rico AC, Chu DT, et al. Synthesis and antibacterial activity of C12 des-methyl ketolides. Bioorg Med Chem Lett 2006;16:4692-4696
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 4692-4696
-
-
Lin, X.1
Rico, A.C.2
Chu, D.T.3
-
54
-
-
33745610459
-
Synthesis and antibacterial activity of novel C12 ethyl ketolides
-
Burger MT, Hiebert C, Seid M, et al. Synthesis and antibacterial activity of novel C12 ethyl ketolides. Bioorg Med Chem 2006;14:5592-5604
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 5592-5604
-
-
Burger, M.T.1
Hiebert, C.2
Seid, M.3
-
55
-
-
33644871503
-
Synthesis and antibacterial activity of novel C12 vinyl ketolides
-
Burger MT, Lin X, Chu DT, et al. Synthesis and antibacterial activity of novel C12 vinyl ketolides. J Med Chem 2006;49:1730-1743
-
(2006)
J Med Chem
, vol.49
, pp. 1730-1743
-
-
Burger, M.T.1
Lin, X.2
Chu, D.T.3
-
56
-
-
77956663562
-
-
Enanta Pharmaceuticals Inc. WO2003097659
-
Enanta Pharmaceuticals, Inc. 6,11 Bicyclic ketolide derivatives. WO2003097659; 2003
-
(2003)
6,11 Bicyclic Ketolide Derivatives
-
-
-
61
-
-
77956698333
-
-
Enanta Pharmaceuticals, Inc. 6, 11-Bridged tricyclic macrolides. WO2007044927; 2007
-
Enanta Pharmaceuticals, Inc. 6, 11-Bridged tricyclic macrolides. WO2007044927; 2007
-
-
-
-
62
-
-
4544293607
-
In vitro and in vivo antibacterial activities of the tricyclic ketolide TE-802 and its analogs
-
Ono T, Kashimura M, Suzuki K, et al. In vitro and in vivo antibacterial activities of the tricyclic ketolide TE-802 and its analogs. J Antibiot 2004;57:518-527
-
(2004)
J Antibiot
, vol.57
, pp. 518-527
-
-
Ono, T.1
Kashimura, M.2
Suzuki, K.3
-
63
-
-
77956697356
-
-
Enanta Pharmaceuticals Inc. WO2006063039
-
Enanta Pharmaceuticals, Inc. 3, 6-Bicyclolides. WO2006063039; 2006
-
(2006)
3, 6-Bicyclolides
-
-
-
64
-
-
56249127111
-
Synthesis of 3,6-bicyclolides: A novel class of macrolide antibiotics
-
Gai Y, Tang D, Xu G, et al. Synthesis of 3,6-bicyclolides: a novel class of macrolide antibiotics. Bioorg Med Chem Lett 2008;18:6315-6318
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 6315-6318
-
-
Gai, Y.1
Tang, D.2
Xu, G.3
-
65
-
-
51349151983
-
Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes
-
Tang D, Gai Y, Polemeropoulos A, et al. Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. Bioorg Med Chem Lett 2008;18:5078-5082
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 5078-5082
-
-
Tang, D.1
Gai, Y.2
Polemeropoulos, A.3
-
66
-
-
77956664810
-
-
Enanta Pharmaceuticals Inc. WO2006065721
-
Enanta Pharmaceuticals, Inc. 11, 12-Lactone bicyclolides. WO2006065721; 2006
-
(2006)
11, 12-Lactone Bicyclolides
-
-
-
67
-
-
77956695867
-
-
Enanta Pharmaceuticals Inc. WO2007115278
-
Enanta Pharmaceuticals, Inc. 3,6,11-Tricyclolide. WO2007115278; 2007
-
(2007)
3, 6,11-Tricyclolide
-
-
-
68
-
-
77956655875
-
-
Enanta Pharmaceuticals Inc. WO2006065743
-
Enanta Pharmaceuticals, Inc. Tetracyclic bicyclolides. WO2006065743; 2006
-
(2006)
Tetracyclic Bicyclolides
-
-
-
69
-
-
34249661567
-
Azalides from azithromycin to new azalide derivatives
-
Mutak S. Azalides from azithromycin to new azalide derivatives. J Antibiot 2007;60:85-122
-
(2007)
J Antibiot
, vol.60
, pp. 85-122
-
-
Mutak, S.1
-
70
-
-
43049128476
-
Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics
-
Basnet DB, Park JW, Yoon YJ. Combinatorial biosynthesis of 5-O-desosaminyl erythronolide A as a potent precursor of ketolide antibiotics. J Biotechnol 2008;135:92-96
-
(2008)
J Biotechnol
, vol.135
, pp. 92-96
-
-
Basnet, D.B.1
Park, J.W.2
Yoon, Y.J.3
-
71
-
-
34249312995
-
Synthesis and antibacterial activity of derivatives of 6-O-allylic acylides
-
Xu P, Liu L, Jin Z, Lei P. Synthesis and antibacterial activity of derivatives of 6-O-allylic acylides. Bioorg Med Chem Lett 2007;17:3330-3334
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 3330-3334
-
-
Xu, P.1
Liu, L.2
Jin, Z.3
Lei, P.4
-
73
-
-
72449150157
-
Design, synthesis and antibacterial activity of a novel alkylide: 3-O-(3-aryl-propenyl)clarithromycin derivatives
-
Liang J-H, Wang Y-Y, Zhu D-Y, et al. Design, synthesis and antibacterial activity of a novel alkylide: 3-O-(3-aryl-propenyl)clarithromycin derivatives. J Antibiot 2009;62:605-611
-
(2009)
J Antibiot
, vol.62
, pp. 605-611
-
-
Liang, J.-H.1
Wang, Y.-Y.2
Zhu, D.-Y.3
-
75
-
-
0038474136
-
Structural consideration of macrolide antibiotics in relation to the ribosomal interaction and drug design
-
Takashima H. Structural consideration of macrolide antibiotics in relation to the ribosomal interaction and drug design. Curr Topics Med Chem 2003;3:991-999
-
(2003)
Curr Topics Med Chem
, vol.3
, pp. 991-999
-
-
Takashima, H.1
-
76
-
-
76449114848
-
Synthesis and antibacterial activity of novel 11,12-cyclic carbonate azithromycin 4¢¢-O-carbamate derivatives
-
Ma C, Liu Z, Song H, et al. Synthesis and antibacterial activity of novel 11,12-cyclic carbonate azithromycin 4¢¢-O-carbamate derivatives. J Antibiot 2010;63:3-8
-
(2010)
J Antibiot
, vol.63
, pp. 3-8
-
-
Ma, C.1
Liu, Z.2
Song, H.3
-
77
-
-
67651171212
-
Synthesis and antibacterial activity of novel 15-membered macrolide derivatives: 4¢¢-carbamate, 11,12-cyclic carbonate-4¢¢- carbamate and 11,4¢¢-di-O-arylcarbamoyl analogs of azithromycin
-
Ma S, Ma R, Liu Z, et al. Synthesis and antibacterial activity of novel 15-membered macrolide derivatives: 4¢¢-carbamate, 11,12-cyclic carbonate-4¢¢-carbamate and 11,4¢¢-di-O-arylcarbamoyl analogs of azithromycin. Eur J Med Chem 2009;44:4010-4020
-
(2009)
Eur J Med Chem
, vol.44
, pp. 4010-4020
-
-
Ma, S.1
Ma, R.2
Liu, Z.3
-
78
-
-
63849173970
-
Synthesis and biological properties of 4¢¢-O-acyl derivatives of 8a-aza-8a-homoerythromycin
-
Stimac V, Alihodzic S, Lazarevski G, et al. Synthesis and biological properties of 4¢¢-O-acyl derivatives of 8a-aza-8a-homoerythromycin. J Antibiot 2009;62:133-144
-
(2009)
J Antibiot
, vol.62
, pp. 133-144
-
-
Stimac, V.1
Alihodzic, S.2
Lazarevski, G.3
-
79
-
-
53349103140
-
Synthesis and antibacterial activity of 4¢¢-O- heteroarylcarbamoyl derivatives of macrolide
-
Xu P, Liu L, Jin Z-P, et al. Synthesis and antibacterial activity of 4¢¢-O-heteroarylcarbamoyl derivatives of macrolide. Bioorg Med Chem Lett 2008;18:5507-5511
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 5507-5511
-
-
Xu, P.1
Liu, L.2
Jin, Z.-P.3
-
80
-
-
68649102987
-
The use of ribosomal crystal structures in antibiotic drug design
-
Wimberly BT. The use of ribosomal crystal structures in antibiotic drug design. Curr Opin Investig Drugs 2009;10:750-765
-
(2009)
Curr Opin Investig Drugs
, vol.10
, pp. 750-765
-
-
Wimberly, B.T.1
-
85
-
-
77149149048
-
Synthesis of an antibacterial compound containing a 14-substituted 1H-123-triazole: A scaleable alternative to the "click" reaction
-
Hanselmann R, Job GE, Johnson G, et al. Synthesis of an antibacterial compound containing a 1,4-substituted 1H-1,2,3-triazole: a scaleable alternative to the "click" reaction. Org Proc. Res Dev 2010;14:152-158
-
(2010)
Org Proc. Res Dev
, vol.14
, pp. 152-158
-
-
Hanselmann, R.1
Job, G.E.2
Johnson, G.3
-
86
-
-
33947577005
-
Preparation of cyclic 2',3'-carbamate derivatives of erythromycin macrolide antibiotics
-
Heggelund A, Undheim K. Preparation of cyclic 2',3'-carbamate derivatives of erythromycin macrolide antibiotics. Bioorg Med Chem 2007;15:3266-3277
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 3266-3277
-
-
Heggelund, A.1
Undheim, K.2
-
88
-
-
36749006633
-
Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes
-
Dreier J, Amantea E, Kellenberger L, Page MGP. Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes. Antimicrob Agents Chemother 2007;51:4361-4365
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 4361-4365
-
-
Dreier, J.1
Amantea, E.2
Kellenberger, L.3
Page, M.G.P.4
-
89
-
-
16244366774
-
In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis
-
Falzari K, Zhu Z, Pan D, et al. In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis. Antimicrob Agents Chemother 2005;49:1447-1454
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 1447-1454
-
-
Falzari, K.1
Zhu, Z.2
Pan, D.3
-
90
-
-
67650424328
-
Novel ureas and thioureas of 15-membered azalides with antibacterial activity against key respiratory pathogens
-
Krajacic MB, Novak P, Dumic M, et al. Novel ureas and thioureas of 15-membered azalides with antibacterial activity against key respiratory pathogens. Eur J Med Chem 2009;44:3459-3470
-
(2009)
Eur J Med Chem
, vol.44
, pp. 3459-3470
-
-
Krajacic, M.B.1
Novak, P.2
Dumic, M.3
-
91
-
-
0036247950
-
Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin
-
Creemer LC, Toth JE, Kirst HA. Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin. J Antibiot 2002;55:427-436
-
(2002)
J Antibiot
, vol.55
, pp. 427-436
-
-
Creemer, L.C.1
Toth, J.E.2
Kirst, H.A.3
-
92
-
-
0346962946
-
Semisynthetic macrolide antibacterials derived from tylosin. Synthesis and structure-activity relationships of novel desmycosin analogues
-
Mutak S, Marsic N, Kramaric MD, Pavlovic D. Semisynthetic macrolide antibacterials derived from tylosin. Synthesis and structure-activity relationships of novel desmycosin analogues. J Med Chem 2004;47:411-431
-
(2004)
J Med Chem
, vol.47
, pp. 411-431
-
-
Mutak, S.1
Marsic, N.2
Kramaric, M.D.3
Pavlovic, D.4
-
93
-
-
33645762012
-
Synthesis of 2-methyl 16-membered macrolide derived from tylosin
-
Terui Y, Kinoshita K, Kaneda Y, et al. Synthesis of 2-methyl 16-membered macrolide derived from tylosin. J Antibiot 2006;59:98-104
-
(2006)
J Antibiot
, vol.59
, pp. 98-104
-
-
Terui, Y.1
Kinoshita, K.2
Kaneda, Y.3
-
94
-
-
75149152271
-
Preparation and biological evaluation of novel leucomycin analogs derived from nitroso Diels-Alder reactions
-
Yang B, Zollner T, Gebhardt P, et al. Preparation and biological evaluation of novel leucomycin analogs derived from nitroso Diels-Alder reactions. Org Biomol Chem 2010;8:691-697
-
(2010)
Org Biomol Chem
, vol.8
, pp. 691-697
-
-
Yang, B.1
Zollner, T.2
Gebhardt, P.3
-
96
-
-
41649088186
-
Novel 16-membered macrolides modified at C-12 and C-13 positions of midecamycin A1 and miokamycin. Part 1
-
Miura T, Kurihara K, Furuuchi T, et al. Novel 16-membered macrolides modified at C-12 and C-13 positions of midecamycin A1 and miokamycin. Part 1. Bioorg Med Chem 2008;16:3985-4002
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 3985-4002
-
-
Miura, T.1
Kurihara, K.2
Furuuchi, T.3
-
97
-
-
42149148168
-
Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II
-
Furuuchi T, Miura T, Kurihara K, et al. Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II. Bioorg Med Chem 2008;16:4401-4418
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 4401-4418
-
-
Furuuchi, T.1
Miura, T.2
Kurihara, K.3
-
99
-
-
55749097391
-
Novel azalides derived from 16-membered macrolides Part II
-
Miura T, Kanemoto K, Natsume S, et al. Novel azalides derived from 16-membered macrolides. Part II. Bioorg Med Chem 2008;16:10129-10156
-
(2008)
Bioorg Med Chem
, vol.16
, pp. 10129-10156
-
-
Miura, T.1
Kanemoto, K.2
Natsume, S.3
-
100
-
-
38449091444
-
Novel azalides derived from 16-membered macrolides
-
Miura T, Natsume S, Kanemoto K, et al. Novel azalides derived from 16-membered macrolides. J Antibiot 2007;60:407-435
-
(2007)
J Antibiot
, vol.60
, pp. 407-435
-
-
Miura, T.1
Natsume, S.2
Kanemoto, K.3
-
101
-
-
67649345201
-
-
Enanta Pharmaceuticals Inc. WO2008019240
-
Enanta Pharmaceuticals, Inc. 3,6-Bridged tylosin derivatives. WO2008019240; 2008
-
(2008)
3,6-Bridged Tylosin Derivatives
-
-
-
102
-
-
77956679123
-
-
WO2009013351
-
Intervet International B. V. Macrolide solid-state forms. WO2009013351; 2009
-
(2009)
Macrolide Solid-state Forms
-
-
-
103
-
-
77956682724
-
-
WO2008012343
-
Intervet International B. V. Macrolide synthesis process. WO2008012343; 2008
-
(2008)
Macrolide Synthesis Process
-
-
-
107
-
-
75749124216
-
Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci
-
Ulanova D, Novotna J, Smutna Y, et al. Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci. Antimicrob Agents Chemother 2010;54:927-930
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 927-930
-
-
Ulanova, D.1
Novotna, J.2
Smutna, Y.3
-
108
-
-
73849103134
-
In vitro activity of mirincamycin (U24729A) against Plasmodium falciparum isolates in Gabon
-
Held J, Westerman R, Kremsner PG, Mordmuller B. In vitro activity of mirincamycin (U24729A) against Plasmodium falciparum isolates in Gabon. Antimicrob Agents Chemother 2010;54:540-542
-
(2010)
Antimicrob Agents Chemother
, vol.54
, pp. 540-542
-
-
Held, J.1
Westerman, R.2
Kremsner, P.G.3
Mordmuller, B.4
-
109
-
-
84906438313
-
Anti-gram positive agents of natural product origins
-
Taylor JB, Triggle DJ, editors Elsevier
-
Lee VJ. Anti-gram positive agents of natural product origins. In: Taylor JB, Triggle DJ, editors, Comprehensive medicinal chemistry II. Volume 7. Elsevier; 2007. p. 660-664
-
(2007)
Comprehensive Medicinal Chemistry II
, vol.7
, pp. 660-664
-
-
Lee, V.J.1
-
112
-
-
77956711689
-
A phase II double-blind, double-dummy, multicenter study of two doses of linopristin/flopristin (NXL103) vs. amoxicillin in the treatment of mild to moderate community acquired pneumonia (CAP) in adults
-
San Francisco, CA
-
Rangaraju M, Rabie W, Ponte N, et al. A phase II double-blind, double-dummy, multicenter study of two doses of linopristin/flopristin (NXL103) vs. amoxicillin in the treatment of mild to moderate community acquired pneumonia (CAP) in adults. 49th Interscience Conference on Antimicrobial Agents Chemotherapy. San Francisco, CA; 2009. p. L1-336
-
(2009)
49th Interscience Conference on Antimicrobial Agents Chemotherapy
-
-
Rangaraju, M.1
Rabie, W.2
Ponte, N.3
-
113
-
-
77649133971
-
NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA
-
Politano AD, Sawyer RG. NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA. Curr Opin Investig Drugs 2010;11:225-236
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 225-236
-
-
Politano, A.D.1
Sawyer, R.G.2
-
114
-
-
13244291394
-
Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions?
-
Amsden GW. Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J Antimicrob Chemother 2005;55:10-21
-
(2005)
J Antimicrob Chemother
, vol.55
, pp. 10-21
-
-
Amsden, G.W.1
-
115
-
-
44649152300
-
Macrolides as immunomodulatory medications for the therapy of chronic lung diseases
-
Lopez-Boado YS, Rubin BK. Macrolides as immunomodulatory medications for the therapy of chronic lung diseases. Curr Opin Pharmacol 2008;8:286-291
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 286-291
-
-
Lopez-Boado, Y.S.1
Rubin, B.K.2
-
116
-
-
36849073243
-
Macrolides beyond the conventional antimicrobials: A class of potent immunomodulators
-
Giamarellos-Bourboulis EJ. Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. Int J Antimicrob Agents 2008;31:12-20
-
(2008)
Int J Antimicrob Agents
, vol.31
, pp. 12-20
-
-
Giamarellos-Bourboulis, E.J.1
|