Novel azalides derived from 16-membered macrolides. Part II: Isolation of the linear 9-formylcarboxylic acid and its sequential macrocyclization with an amino alcohol or an azidoamine

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 10129-10156

  Miura, Tomoaki ^a   Kanemoto, Kenichi ^a   Natsume, Satomi ^a   Atsumi, Kunio ^a   Fushimi, Hideki ^a   Yoshida, Takuji ^a   Ajito, Keiichi ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Azalactam; Azalide; Midecamycin A1; Miokamycin; Sixteen membered macrolide

Indexed keywords

9 ACETYLIMINO 3 DEHEXAPYRANOSYLOXY 9 DEOXO 3 OXO 6 O,11 O [2 [6 (1 PYRAZOLYL) 3 PYRIDINYLMETHOXYIMINO]PROPYLENE]ERYTHROMYCIN; 9 FORMYLCARBOXYLIC ACID; ALDEHYDE; AMINOALCOHOL; AZITHROMYCIN; CARBOXYLIC ACID DERIVATIVE; CLARITHROMYCIN; DESMYCOSIN; LACTAM DERIVATIVE; MACROLIDE; MIDECAMYCIN; MIOKAMYCIN; TELITHROMYCIN; UNCLASSIFIED DRUG;

AMINATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CYCLIZATION; DEPROTECTION REACTION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ERM GENE; GENE; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS INFLUENZAE TYPE A; MEF GENE; METHANOLYSIS; MORAXELLA CATARRHALIS; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

AMINO ALCOHOLS; ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; AZITHROMYCIN; CARBOXYLIC ACIDS; KITASAMYCIN; MACROLIDES; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55749097391     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.054     Document Type: Article

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