Synthesis of 2-methyl 16-membered macrolide derived from tylosin

Journal of Antibiotics

Volumn 59, Issue 2, 2006, Pages 98-104

  Terui, Yuichi ^a   Kinoshita, Kenji ^b   Kaneda, Yoshie ^a   Akashi, Toshi ^a   Hamaguchi, Takuya ^a   Kawashima, Akira ^a  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

16 membered macrolide; Desmycosin; Metabolic stability; Tylosin

Indexed keywords

2 METHYL 3 KETO DESMYCOSIN; 2,2 DIMETHYL 3 DEHYDRO 2',4',4'' TRI O ACETYLDESMYCOSIN 20 DIETHYLACETAL; 2,2 DIMETHYL 3 KETO DESMYCOSIN; 2ALPHA METHYL 9,20 DI O TERT BUTYLDIMETHYLSILYL 2',4',4'' TRI O TRIETHYLSILYLDESMYCOSIN 3,20 ACETAL; 2ALPHA METHYLDESMYCOSIN; 2BETA METHYL 3 DEHYDRO 2',4',4'' TRI O ACETYLDESMYCOSIN 20 DIETHYLACETAL; 2BETA METHYL 3 EPI 9 HYDRO 2',4',4'' TRI O ACETYLDESMYCOSIN 20 DIETHYLACETAL; 2BETA METHYL 3 EPI DESMYCOSIN; 2BETA METHYL 9 HYDRO 9,20 DI O TERT BUTYLDIMETHYLSILYL 2',4',4'' TRI O TRIETHYLSILYLDESMYCOSIN 3,20 ACETAL; 2BETA METHYLDESMYCOSIN; 9 HYDRO 2',4',4'' TRI O ACETYLDESMYCOSIN 20 DIETHYLACETAL; 9 HYDRO 9,20 DI 0 TERT BUTYLDIMETHYLSILYL 2',4',4'' TRI O TRIETHYLSILYLDESMYCOSIN 3,20 ACETAL; 9 HYDRO 9,20 DI O TERT BUTYLDIMETHYLSILYL 2',4',4'' TRI O ACETYLDESMYCOSIN 3,20 ACETAL; DESMYCOSIN; MACROLIDE; TYLOSIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CARBOXYLESTERASE; HAEMOPHILUS INFLUENZAE; MICROBIAL SENSITIVITY TESTS; RATS; SERUM; STREPTOCOCCUS PNEUMONIAE; TYLOSIN;

EID: 33645762012     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2006.14     Document Type: Article

References (6)

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