Novel ureas and thioureas of 15-membered azalides with antibacterial activity against key respiratory pathogens

European Journal of Medicinal Chemistry

Volumn 44, Issue 9, 2009, Pages 3459-3470

  Bukvić Krajačić, Mirjana ^a   Novak, Predrag ^b   Dumić, Miljenko ^c   Cindrić, Mario ^c   Paljetak, Hana Čipčić ^a   Kujundžić, Nedjeljko ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c PLIVA CROATIA LTD   (Croatia)

Author keywords

Antibacterial activity; Azalides; Structure elucidation; Thioureas; Ureas

Indexed keywords

9 DEOXO 9 DIHYDRO 9A [N' (1 NAPHTHYL)CARBAMOYL GAMMA AMINOPROPYL] 9A AZA 9A HOMOERYTHROMYCIN A; 9 DEOXO 9 DIHYDRO 9A [N' (2 NAPHTHYL)CARBAMOYL GAMMA AMINOPROPYL] 9A AZA 9A HOMOERYTHROMYCIN A; 9 DEOXO 9 DIHYDRO 9A [N' (BETA CYANOETHYL) N' [1 (1 NAPHTHYL)ETHYL]CARBAMOYL GAMMA AMINOPROPYL] 9A AZA 9A HOMOERYTHROMYCIN A; 9 DEOXO 9 DIHYDRO 9A [N' [1 (1 NAPHTHYL)ETHYL]CARBAMOYL GAMMA AMINOPROPYL] 9A AZA 9A HOMOERYTHROMYCIN A; AZITHROMYCIN; ERYTHROMYCIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HAEMOPHILUS INFLUENZAE; INFRARED SPECTROSCOPY; MORAXELLA CATARRHALIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RESPIRATORY TRACT INFECTION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; BACTERIA; DRUG STABILITY; ERYTHROMYCIN; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; UREA;

EID: 67650424328     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.02.001     Document Type: Article

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