Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5078-5082

  Tang, Datong ^a   Gai, Yonghua ^a   Polemeropoulos, Alexander ^a   Chen, Zhigang ^a   Wang, Zhe ^a   Or, Yat Sun ^a  

^a Enanta Pharmaceuticals Inc   (United States)

Author keywords

Antibacterial; Bicyclolide; MIC; Oxime

Indexed keywords

3,6 BICYCLOLIDE OXIME DERVIVATIVE; 9 ACETYLIMINO 3 DEHEXAPYRANOSYLOXY 9 DEOXO 3 OXO 6 O,11 O [2 [6 (1 PYRAZOLYL) 3 PYRIDINYLMETHOXYIMINO]PROPYLENE]ERYTHROMYCIN; EP 1304; ERYTHROMYCIN; KETOLIDE; OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL INFECTION; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG DESIGN; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ERM GENE; ERMA GENE; GENE; HAEMOPHILUS INFLUENZAE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; ISOMER; MEFA GENE; NONHUMAN; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ERYTHROMYCIN; HAEMOPHILUS INFLUENZAE; MACROLIDES; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; OXIMES; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 51349151983     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.118     Document Type: Article

References (8)

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7. 3) δ 217.1, 177.3, 158.5, 157.7, 137.7, 128.6, 128.5, 128.1, 103.4, 84.4, 82.3, 81.0, 80.9, 76.6, 76.3, 73.1, 70.0, 68.2, 67.2, 58.6, 44.4, 44.1, 43.3, 41.4, 40.5, 39.5, 37.3, 32.0, 22.6, 21.7, 21.0, 20.1, 14.1, 13.4, 12.3, 11.3, 11.1 ppm.
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