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This report shows that macrolides can increase epithelial antimicrobial activity in the absence of inflammation, suggesting that macrolide treatment may contribute to improvement of the epithelial barrier function and defense against microorganisms by this mechanism.
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Ishizawa K., Suzuki T., Yamaya M., Jia Y.X., Kobayashi S., Ida S., Kubo H., Sekizawa K., and Sasaki H. Erythromycin increases bactericidal activity of surface liquid in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 289 (2005) L565-L573. This report shows that macrolides can increase epithelial antimicrobial activity in the absence of inflammation, suggesting that macrolide treatment may contribute to improvement of the epithelial barrier function and defense against microorganisms by this mechanism.
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