Preparation of cyclic 2′,3′-carbamate derivatives of erythromycin macrolide antibiotics

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 9, 2007, Pages 3266-3277

  Heggelund, Audun ^a   Undheim, Kjell ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Clarithromycin ketolides; Cyclic carbamates; Isocyanate reactions; Phosgene carbonylation

Indexed keywords

10,11 ANHYDRO N NORCLARITHROMYCIN 2',3' CARBAMATE; 11 AMINO N (3 FLUORO 4 MORPHOLINOPHENYL) N' NOR 11 DEOXY 3 O DESCLADINOSYL 3 OXOCLARITHROMYCIN 11,12:2',3' DICARBAMATE; 3 O (ALLYLOXYCARBONYL) N NOR 3 O DESCLADINOSYLCLARITHROMYCIN 2',3' CARBAMATE 11,12 CARBONATE; 4'' O (ALLYLOXYCARBONYL) N NORCLARITHROMYCIN 2',3' CARBAMATE 11,12 CARBONATE; CARBAMIC ACID DERIVATIVE; CLARITHROMYCIN DERIVATIVE; ERYTHROMYCIN DERIVATIVE; MACROLIDE; N NOR 3 O DESCLADINOSYL 3 OXOCLARITHROMYCIN 2',3' CARBAMATE 11,12 CARBONATE; N NOR 3 O DESCLADINOSYLCLARITHROMYCIN 2',3' CARBAMATE 11,12 CARBONATE; N NORCLARITHROMYCIN 2',3' CARBAMATE 11,12 CARBONATE; PHOSGENE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BACTERIAL GROWTH; CARBONYLATION; CATALYSIS; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; CARBAMATES; CYCLIZATION; ERYTHROMYCIN; ESCHERICHIA COLI; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947577005     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.028     Document Type: Article

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