Activity of the novel macrolide BAL19403 against ribosomes from erythromvcin-resistant Propionibacterium acnes

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 12, 2007, Pages 4361-4365

  Dreier, Jürg ^a   Amantea, Eva ^a   Kellenberger, Laurenz ^a   Page, Malcolm G P ^a  

^a BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BAL 19403; ERYTHROMYCIN; LINCOSAMIDE; MACROLIDE; RNA 23S; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; GENE MUTATION; IC 50; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; PROTEIN EXPRESSION; RIBOSOME;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; ERYTHROMYCIN; MACROLIDES; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PROPIONIBACTERIUM ACNES; RIBOSOMES;

EID: 36749006633     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00672-07     Document Type: Article

References (37)

1. +/polyamine system for polyuridine-dependent polyphenylalanine synthesis with near in vivo characteristics. Methods Enzymol. 164:650-658.
2. Blaha, G., U. Stelzl, C. M. Spahn, R. K. Agrawal, J. Frank, and K. H. Nierhaus. 2000. Preparation of functional ribosomal complexes and effect of buffer conditions on tRNA positions observed by cryoelectron microscopy. Methods Enzymol. 317:292-309.
3. Bojar, R. A., and K. T. Holland. 2004. Acne and Propionibacterium acnes. Clin. Dermatol. 22:375-379.
4. Capobianco, J. O., Z. Cao, V. D. Shortridge, Z. Ma, R. K. Flamm, and P. Zhong. 2000. Studies of the novel ketolide ABT-773: transport, binding to ribosomes, and inhibition of protein synthesis in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44:1562-1567.
5. Cooper, A. J. 1998. Systematic review of Propionibacterium acnes resistance to systemic antibiotics. Med. J. Aust. 169:259-261.
6. Di Giambattista, M., Y. Engelborghs, E. Nyssen, and C. Cocito. 1987. Kinetics of binding of macrolides, lincosamides, and synergimycins to ribosomes. J. Biol. Chem. 262:8591-8597.
7. Dinos, G. P., S. R. Connell, K. H. Nierhaus, and D. L. Kalpaxis. 2003. Erythromycin, roxithromycin, and clarithromycin: use of slow-binding kinetics to compare their in vitro interaction with a bacterial ribosomal complex active in peptide bond formation. Mol. Pharmacol. 63:617-623.
8. Dinos, G. P., and D. L. Kalpaxis. 2000. Kinetic studies on the interaction between a ribosomal complex active in peptide bond formation and the macrolide antibiotics tylosin and erythromycin. Biochemistry 39:11621-11628.
9. Douthwaite, S., L. H. Hansen, and P. Mauvais. 2000. Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. Mol. Microbiol. 36:183-193.
10. Douthwaite, S., J. Jalava, and L. Jakobsen. 2005. Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm. Mol. Microbiol. 58:613-622.
11. Eady, E. A., M. Gloor, and J. J. Leyden. 2003. Propionibacterium acnes resistance: a worldwide problem. Dermatology 206:54-56.
12. Goldman, R. C., S. W. Fesik, and C. C. Doran. 1990. Role of protonated and neutral forms of macrolides in binding to ribosomes from gram-positive and gram-negative bacteria. Antimicrob. Agents Chemother. 34:426-431.
13. Goldman, R. C., and S. K. Kadam. 1989. Binding of novel macrolide structures to macrolides-lincosamides-streptogramin B-resistant ribosomes inhibits protein synthesis and bacterial growth. Antimicrob. Agents Chemother. 33:1058-1066.
14. Goldman, R. C., D. Zakula, R. Flamm, J. Beyer, and J. Capobianco. 1994. Tight binding of clarithromycin, its 14-(R)-hydroxy metabolite, and erythromycin to Helicobacter pylori ribosomes. Antimicrob. Agents Chemother. 38:1496-1500.
15. Graham, G. M., M. D. Farrar, J. E. Cruse-Sawyer, K. T. Holland, and E. Ingham. 2004. Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. Br. J. Dermatol. 150:421-428.
16. Heller, S., L. Kellenberger, and S. Shapiro. 2007. Antipropionibacterial activity of BAL19403, a novel macrolide antibiotic. Antimicrob. Agents Chemother. 51:1956-1961.
17. Kellenberger, L., V. Bitsch, P. Guerry, S. Heller, S. Shapiro, M. Wiederkehr, X.-P. Wu, and L. Xu. 2006. BAL19403: synthesis and in vitro antibacterial activity of a novel macrolide, abstr. F1-1977. Abstr. 46th Intersci. Conf. Antimicrob. Agents Chemother.
18. Kersey, P., M. Sussman, and M. Dahl. 1980. Delayed skin test reactivity to Propionibacterium acnes correlates with severity of inflammation in acne vulgaris. Br. J. Dermatol. 103:651-655.
19. Leyden, J. J. 2004. Antibiotic resistance in the topical treatment of acne vulgaris. Cutis 73:6-10.
20. Leyden, J. J., K. J. McGinley, O. H. Mills, and A. M. Kligman. 1975. Age-related changes in the resident bacterial flora of the human face. J. Investig. Dermatol. 65:379-381.
21. Liu, M., and S. Douthwaite. 2002. Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA. Antimicrob. Agents Chemother. 46:1629-1633.
22. Mathews, S., E. Spieser, F. Bachmann, and J. Heim. 2006. BAL19403: a novel macrolide with potent anti-inflammatory properties, abstr. F1-1978. Abstr. 46th Intersci. Conf. Antimicrob. Agents Chemother.
23. McGinley, K. J., G. F. Webster, and J. J. Leyden. 1978. Regional variations of cutaneous Propionibacteria. Appl. Environ. Microbiol. 35:62-66.
24. McGinley, K. J., G. F. Webster, M. R. Ruggieri, and J. J. Leyden. 1980. Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. J. Clin. Microbiol. 12:672-675.
25. Moureau, P., Y. Engelborghs, M. Di Giambattista, and C. Cocito. 1983. Fluorescence stopped flow analysis of the interaction of virginiamycin components and erythromycin with bacterial ribosomes. J. Biol. Chem. 258: 14233-14238.
26. Oprica, C., S. Lofmark, B. Lund, C. Edlund, L. Emtestam, and C. E. Nord. 2005. Genetic basis of resistance in Propionibacterium acnes strains isolated from diverse types of infection in different European countries. Anaerobe 11:137-143.
27. Oprica, C., and C. E. Nord. 2005. European surveillance study on the antibiotic susceptibility of Propionibacterium acnes. Clin. Microbiol. Infect. 11:204-213.
28. 14C]erythromycin to Escherichia coli ribosomes. Antimicrob. Agents Chemother. 6:474-478.
29. Ross, J. I., E. A. Eady, E. Carnegie, and J. H. Cove. 2002. Detection of transposon Tn5432-mediated macrolide-lincosamide-streptogramin B (MLSB) resistance in cutaneous Propionibacteria from six European cities. J. Antimicrob. Chemother. 49:165-168.
30. Ross, J. I., E. A. Eady, J. H. Cove, C. E. Jones, A. H. Ratyal, Y. W. Miller, S. Vyakrnam, and W. J. Cunliffe. 1997. Clinical resistance to erythromycin and clindamycin in cutaneous Propionibacteria isolated from acne patients is associated with mutations in 23S rRNA. Antimicrob. Agents Chemother. 41:1162-1165.
31. Ross, J. I., E. A. Eady, J. H. Cove, A. H. Ratyal, and W. J. Cunliffe. 1998. Resistance to erythromycin and clindamycin in cutaneous Propionibacteria is associated with mutations in 23S rRNA. Dermatology 196:69-70.
32. Ross, J. I., A. M. Snelling, E. Carnegie, P. Coates, W. J. Cunliffe, V. Bettoli, G. Tosti, A. Katsambas, J. I. Galvan Perez Del Pulgar, O. Rollman, L. Torok, E. A. Eady, and J. H. Cove. 2003. Antibiotic-resistant acne: lessons from Europe. Br. J. Dermatol. 148:467-478.
33. Ross, J. I., A. M. Snelling, E. A. Eady, J. H. Cove, W. J. Cunliffe, J. J. Leyden, P. Collignon, B. Dreno, A. Reynaud, J. Fluhr, and S. Oshima. 2001. Phenotypic and genotypic characterization of antibiotic-resistant Propionibacterium acnes isolated from acne patients attending dermatology clinics in Europe, the USA, Japan and Australia. Br. J. Dermatol. 144:339-346.
34. Tan, H. H. 2004. Topical antibacterial treatments for acne vulgaris: comparative review and guide to selection. Am. J. Clin. Dermatol. 5:79-84.
35. Webster, G. F. 1995. Inflammation in acne vulgaris. J. Am. Acad. Dermatol. 33:247-253.
36. Weisblum, B. 1995. Erythromycin resistance by ribosome modification. Antimicrob. Agents Chemother. 39:577-585.
37. Zalacain, M., and E. Cundliffe. 1989. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J. Bacteriol. 171:4254-4260.