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Volumn 4, Issue 3, 2005, Pages 185-217

Recent progress in the field of antibacterial pristinamycins

Author keywords

Antibacterial; Pristinamycins; Ribosome; Semi synthesis; Streptogramins; Structure activity relationships; Synergy

Indexed keywords

AMOXICILLIN; ANTIINFECTIVE AGENT; CLARITHROMYCIN; DALFOPRISTIN; DALFOPRISTIN PLUS QUINUPRISTIN; ERYTHROMYCIN; GENTAMICIN; GLYCOPEPTIDE; LINCOSAMIDE; MACROLIDE; MIKAMYCIN B; NEW DRUG; OXACILLIN; PENICILLIN G; PRISTINAMYCIN; QUINUPRISTIN; RPR 131166; RPR 132493; RPR 132552; RPR 202868; STREPTOGRAMIN; TEICOPLANIN; UNCLASSIFIED DRUG; VANCOMYCIN; VIRGINIAMYCIN;

EID: 22144483423     PISSN: 15680126     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568012054368128     Document Type: Review
Times cited : (11)

References (43)
  • 6
    • 0036682463 scopus 로고    scopus 로고
    • c) Pearson, H. Nature, 2002, 418, 469.
    • (2002) Nature , vol.418 , pp. 469
    • Pearson, H.1
  • 10
    • 0003334991 scopus 로고
    • Corcoran J. N.; Hahn, F. E. (Eds), Springer Verlag: Berlin, Heidelberg, New York
    • Vasquez, D. In Antibiotics; Corcoran, J. N.; Hahn, F. E. (Eds), Springer Verlag: Berlin, Heidelberg, New York, 1975; Vol. III, pp 521-534.
    • (1975) Antibiotics , vol.3 , pp. 521-534
    • Vasquez, D.1
  • 14
    • 22144453503 scopus 로고    scopus 로고
    • Presented at the 41st ICAAC (Chicago), Posters F-359 to F-362
    • Presented at the 41st ICAAC (Chicago, 2001): Posters F-359 to F-362.
    • (2001)
  • 25
    • 22144435121 scopus 로고    scopus 로고
    • note
    • 50 values, corresponding to the concentration, expressed in μM, at which 50% of the cell-free poly(Phe) synthesis was blocked. See also ref. [22] for more details.
  • 26
    • 0002688443 scopus 로고
    • ed. Hill W. Dahlberg, A.; E.; Garrett, R.A.; Moore, P. B.; Schlessinger, D.; Warner, J.R. American Society for Microbiology: Washington, D.C
    • The ribosome, structure, function and evolution, ed. Hill W. Dahlberg, A.; E.; Garrett, R.A.; Moore, P. B.; Schlessinger, D.; Warner, J.R. American Society for Microbiology: Washington, D.C., 1990, pp. 56-70.
    • (1990) The Ribosome, Structure, Function and Evolution , pp. 56-70
  • 29
    • 22144489086 scopus 로고    scopus 로고
    • note
    • m of 2.5μM.
  • 35
    • 22144436210 scopus 로고    scopus 로고
    • note
    • 4 colony-forming units (cfu) of each strain tested to plates. Inoculated plates were incubated at 37 °C in conditions appropriate to the bacterial species studied. After incubation, the minimal inhibitory concentration (MIC) was defined as the lowest concentration in mg/l that completely inhibited the growth of bacteria.
  • 36
    • 22144465147 scopus 로고    scopus 로고
    • note
    • 0 controls ≥-3).
  • 38
    • 0022703897 scopus 로고
    • 50 was defined as the dose that protected 50% of treated mice from the formation of septic abscess, when all the controls had septic abscesses
    • 50 was defined as the dose that protected 50% of treated mice from the formation of septic abscess, when all the controls had septic abscesses.
    • (1986) J. Antimicrob. Chemother. , vol.17 , Issue.SUPPL. B , pp. 49
    • Rolin, O.1    Huet, Y.2    Bouanchaud, D.H.3
  • 39
    • 22144458993 scopus 로고    scopus 로고
    • note
    • 8 cfu/ml) and were treated orally by the new association or subcutaneously for Synercid® twice a day for 3 days beginning 18 h after infection. Results obtained ten days after infection were expressed as the average survival time (AST) in days and were statistically analysed by the Wilcoxon test, as already described (Rolin, O.; Huet, Y.; Bouanchaud, D.H. J. Antimicrob. Chemother, 1986, 17, suppl. B, 49). The minimal effective dose (MED) was defined as the dose (mg/kg per administration) yielding an average survival time (AST) significantly longer than that of the untreated infected controls.
  • 40
    • 22144479342 scopus 로고    scopus 로고
    • note
    • 9 cfu) were spread onto agar plates containing the drug to be tested at concentrations of 1, 2, 4 and 8 × MIC for the strain tested. The frequencies of mutation leading to resistance selected by each drug was calculated as the ratio of the number of colony forming units (cfu) growing at 1, 2, 4 or 8 × MIC after 72 h of incubation at 37°C to the number of cfu growing without antibiotic. The MICs of (5), (7), (3), erythromycin, pefloxacin, chloramphenicol and tetracycline were determined for the selected resistant mutants (first-step mutants).
  • 41
    • 22144474361 scopus 로고    scopus 로고
    • note
    • 2. (3) (30/70), (7) (3 strains) and (5) (strain Rob.) were tested at concentrations of 1, 2 and 4 × MIC. Clarithromycin (strain Rob.) and vancomycin (strains AS 5155 and AS TAT 2470) at concentrations of 1, 2 and 4 × MIC, were studied as reference compounds under the same experimental conditions. At intervals (1, 2, 3 and 4 h), three aliquots of cells were removed and disrupted by sonication. Bacteria released from ruptured cells were enumerated by dilution and plating.
  • 42
    • 22144432568 scopus 로고    scopus 로고
    • note
    • 0+60h.
  • 43
    • 0029059771 scopus 로고
    • 10 cfu/lung was considered to reflect in vivo bactericidal activity based on an internal convention
    • 10 cfu/lung was considered to reflect in vivo bactericidal activity based on an internal convention. See Berthaud, N.; Montay, G.; Conard, B.J.; Desnottes, J.F. J. Antimicrob. Chemother, 1995, 36, 365.
    • (1995) J. Antimicrob. Chemother. , vol.36 , pp. 365
    • Berthaud, N.1    Montay, G.2    Conard, B.J.3    Desnottes, J.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.