Synthesis and antibacterial activity of C12 des-methyl ketolides

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 17, 2006, Pages 4692-4696

  Lin, Xiaodong ^a   Rico, Alice C ^a   Chu, Daniel T ^a   Carroll, Georgia L ^a   Barker, Lynn ^a   Shawar, Ribhi ^a   Desai, Manoj C ^a   Plattner, Jacob J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antibacterial; Ketolide; Macrolide

Indexed keywords

ANTIINFECTIVE AGENT; EPOXIDE; KETOLIDE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ELIMINATION REACTION; NONHUMAN; PATHOGENESIS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; CARBON; GRAM-POSITIVE COCCI; HAEMOPHILUS INFLUENZAE; KETOLIDES; METHYLATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

STREPTOCOCCUS PNEUMONIAE;

EID: 33746206243     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.104     Document Type: Article

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25. 3D pictures of the crystal structures are provided in Supporting Information. The deposition numbers are CCDC 609190-609192 at the Cambridge Crystallographic Data Centre.
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