Design, synthesis and antibacterial activity of a novel alkylide: 3-O-(3-aryl-propenyl)clarithromycin derivatives

Journal of Antibiotics

Volumn 62, Issue 11, 2009, Pages 605-611

  Liang, Jian Hua ^a   Wang, Yue Ying ^a   Zhu, Dan Yang ^a   Dong, Li Jing ^a   An, Mao Mao ^b   Wang, Rui ^b   Yao, Guo Wei ^a  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Allyl; Erythromycin; Heck; Isomerization; Regioselectivity

Indexed keywords

3 O (3 ARYLPROPENYL)CLARITHROMYCIN; 3 O [3 (1' PHENYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME 11,12 CARBONATE; 3 O [3 (3' PYRIDYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME; 3 O [3 (3' PYRIDYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME 11,12 CARBONATE; 3 O [3 (3' QUINOLYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A; 3 O [3 (3' QUINOLYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME; 3 O [3 (4' ISOQUINOLYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME; 3 O [3 (4' ISOQUINOLYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME 11,12 CARBONATE; 3 O [3 (5' INDOLYL) 2 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME 11,12 CARBONATE; 3 O [3 (5' PYRIMIDYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME; 3 O [3 (5' PYRIMIDYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME 11,12 CARBONATE; 3 O [3 (5' SOQUINOLYL) 1 PROPENYL] 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME 11,12 CARBONATE; 3 O ALLYL 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME; 3 O ALLYL 6 O METHYLERYTHROMYCIN A 9 O (2 CHLOROBENZYL)OXIME 11,12 CARBONATE; CETHROMYCIN; CLARITHROMYCIN; CLARITHROMYCIN DERIVATIVE; ERYTHROMYCIN; UNCLASSIFIED DRUG;

ALLYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; CLARITHROMYCIN; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE-ACTIVITY RELATIONSHIP;

STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 72449150157     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.89     Document Type: Article

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