메뉴 건너뛰기




Volumn 17, Issue 25, 2010, Pages 2713-2728

Targeting death receptors to fight cancer: From biological rational to clinical implementation

Author keywords

Anticancer therapy; Cancer; Death receptors; Tumor biology

Indexed keywords

ANTINEOPLASTIC AGENT; APOMAB; BORTEZOMIB; CISPLATIN; DEATH RECEPTOR; FAS LIGAND; FLUOROURACIL; GEMCITABINE; LEXTUMUMAB; MAPATUMUMAB; SORAFENIB; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 77955593658     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986710791859342     Document Type: Article
Times cited : (15)

References (182)
  • 1
    • 0242669384 scopus 로고    scopus 로고
    • All in the family: Evolutionary and functional relationships among death receptors
    • Bridgham, J. T.; Wilder, J. A.; Hollocher, H.; Johnson, A. L. All in the family: evolutionary and functional relationships among death receptors. Cell Death Differ., 2003, 10, 19-25.
    • (2003) Cell Death Differ , vol.10 , pp. 19-25
    • Bridgham, J.T.1    Wilder, J.A.2    Hollocher, H.3    Johnson, A.L.4
  • 2
    • 33645760938 scopus 로고    scopus 로고
    • Chemotherapeutic approaches for targeting cell death pathways
    • Ricci, M. S.; Zong, W. X. Chemotherapeutic approaches for targeting cell death pathways. Oncologist, 2006, 11, 342-357.
    • (2006) Oncologist , vol.11 , pp. 342-357
    • Ricci, M.S.1    Zong, W.X.2
  • 3
    • 67649595826 scopus 로고    scopus 로고
    • Apoptosis and cancer: The genesis of a research field
    • Cotter, T. G. Apoptosis and cancer: the genesis of a research field. Nat. Rev. Cancer, 2009, 9, 501-507.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 501-507
    • Cotter, T.G.1
  • 4
    • 67349126692 scopus 로고    scopus 로고
    • Death ligands designed to kill: Development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands
    • Gerspach, J.; Wajant, H.; Pfizenmaier, K. Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands. Results Probl. Cell Differ., 2009, 49, 241-273.
    • (2009) Results Probl. Cell Differ , vol.49 , pp. 241-273
    • Gerspach, J.1    Wajant, H.2    Pfizenmaier, K.3
  • 5
    • 77649181792 scopus 로고    scopus 로고
    • Death receptors: Targets for cancer therapy
    • Mahmood, Z.; Shukla, Y. Death receptors: Targets for cancer therapy. Exp. Cell Res., 2010, 316, 887-899.
    • (2010) Exp. Cell Res , vol.316 , pp. 887-899
    • Mahmood, Z.1    Shukla, Y.2
  • 6
    • 44749085513 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis pathway in cancer
    • Ashkenazi, A. Targeting the extrinsic apoptosis pathway in cancer. Cytokine Growth Factor Rev., 2008, 19, 325-331.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 325-331
    • Ashkenazi, A.1
  • 7
    • 34249663310 scopus 로고    scopus 로고
    • Targeting death-inducing receptors in cancer therapy
    • Takeda, K.; Stagg, J.; Yagita, H.; Okumura, K.; Smyth, M. J. Targeting death-inducing receptors in cancer therapy. Oncogene, 2007, 26, 3745-3757.
    • (2007) Oncogene , vol.26 , pp. 3745-3757
    • Takeda, K.1    Stagg, J.2    Yagita, H.3    Okumura, K.4    Smyth, M.J.5
  • 8
    • 24644468274 scopus 로고    scopus 로고
    • Regulation of death receptors- relevance in cancer therapies
    • de Thonel, A.; Eriksson, J. E. Regulation of death receptors- relevance in cancer therapies. Toxicol. Appl. Pharmacol., 2005, 207, 123-132.
    • (2005) Toxicol. Appl. Pharmacol , vol.207 , pp. 123-132
    • de Thonel, A.1    Eriksson, J.E.2
  • 9
    • 20344385260 scopus 로고    scopus 로고
    • Targeting apoptosis pathways in cancer therapy
    • Ghobrial, I. M.; Witzig, T. E.; Adjei, A. A. Targeting apoptosis pathways in cancer therapy. CA Cancer J. Clin., 2005, 55, 178-194.
    • (2005) CA Cancer J. Clin , vol.55 , pp. 178-194
    • Ghobrial, I.M.1    Witzig, T.E.2    Adjei, A.A.3
  • 10
    • 17944371991 scopus 로고    scopus 로고
    • The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: Players, rules and the games
    • Hehlgans, T.; Pfeffer, K. The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games. Immunology, 2005, 115, 1-20.
    • (2005) Immunology , vol.115 , pp. 1-20
    • Hehlgans, T.1    Pfeffer, K.2
  • 11
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: A double-edged sword
    • Aggarwal, B. B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol., 2003, 3, 745-756.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 12
    • 0037204948 scopus 로고    scopus 로고
    • TNF-R1 signaling: A beautiful pathway
    • Chen, G.; Goeddel, D. V. TNF-R1 signaling: a beautiful pathway. Science, 2002, 296, 1634-1635.
    • (2002) Science , vol.296 , pp. 1634-1635
    • Chen, G.1    Goeddel, D.V.2
  • 13
    • 0037644804 scopus 로고    scopus 로고
    • Biological functions of tumor necrosis factor cytokines and their receptors
    • Pfeffer, K. Biological functions of tumor necrosis factor cytokines and their receptors. Cytokine Growth Factor Rev., 2003, 14, 185-191.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 185-191
    • Pfeffer, K.1
  • 14
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-kappaB puzzle
    • Ghosh, S.; Karin, M. Missing pieces in the NF-kappaB puzzle. Cell, 2002, 109 Suppl, S81-S96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 15
    • 0037149542 scopus 로고    scopus 로고
    • TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
    • Li, X.; Yang, Y.; Ashwell, J. D. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature, 2002, 416, 345-347.
    • (2002) Nature , vol.416 , pp. 345-347
    • Li, X.1    Yang, Y.2    Ashwell, J.D.3
  • 16
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanisms
    • Leist, M.; Jaattela, M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell. Biol., 2001, 2, 589-598.
    • (2001) Nat. Rev. Mol. Cell. Biol , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 17
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: Integrating mammalian biology
    • Locksley, R. M.; Killeen, N.; Lenardo, M. J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell, 2001, 104, 487-501.
    • (2001) Cell , vol.104 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 18
    • 0034648648 scopus 로고    scopus 로고
    • Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP
    • Kim, J. W.; Choi, E. J.; Joe, C. O. Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP. Oncogene, 2000, 19, 4491-4499.
    • (2000) Oncogene , vol.19 , pp. 4491-4499
    • Kim, J.W.1    Choi, E.J.2    Joe, C.O.3
  • 19
    • 1342285692 scopus 로고    scopus 로고
    • Tumor necrosis factor: An apoptosis JuNKie?
    • Varfolomeev, E. E.; Ashkenazi, A. Tumor necrosis factor: an apoptosis JuNKie? Cell, 2004, 116, 491-497.
    • (2004) Cell , vol.116 , pp. 491-497
    • Varfolomeev, E.E.1    Ashkenazi, A.2
  • 20
    • 0036020941 scopus 로고    scopus 로고
    • NF-kappaB as a therapeutic target in cancer
    • Orlowski, R. Z.; Baldwin, A. S., Jr. NF-kappaB as a therapeutic target in cancer. Trends Mol. Med., 2002, 8, 385-389.
    • (2002) Trends Mol. Med , vol.8 , pp. 385-389
    • Orlowski, R.Z.1    Baldwin Jr., A.S.2
  • 22
    • 0029033619 scopus 로고
    • Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells
    • Jaattela, M.; Benedict, M.; Tewari, M.; Shayman, J. A.; Dixit, V. M. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells. Oncogene, 1995, 10, 2297-2305.
    • (1995) Oncogene , vol.10 , pp. 2297-2305
    • Jaattela, M.1    Benedict, M.2    Tewari, M.3    Shayman, J.A.4    Dixit, V.M.5
  • 23
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • Fulda, S.; Kufer, M. U.; Meyer, E.; van Valen, F.; Dockhorn-Dworniczak, B.; Debatin, K. M. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene, 2001, 20, 5865-5877.
    • (2001) Oncogene , vol.20 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    van Valen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.M.6
  • 24
    • 0033764665 scopus 로고    scopus 로고
    • Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB
    • Aggarwal, B. B. Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappaB. Ann. Rheum. Dis., 2000, 59 Suppl 1, i6-16.
    • (2000) Ann. Rheum. Dis , vol.59 , Issue.SUPPL. 1
    • Aggarwal, B.B.1
  • 25
    • 0037203320 scopus 로고    scopus 로고
    • Ceramide and cell death receptor clustering
    • Gulbins, E.; Grassme, H. Ceramide and cell death receptor clustering. Biochim. Biophys. Acta, 2002, 1585, 139-145.
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 139-145
    • Gulbins, E.1    Grassme, H.2
  • 27
    • 0032079524 scopus 로고    scopus 로고
    • Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death
    • Liu, B.; Andrieu-Abadie, N.; Levade, T.; Zhang, P.; Obeid, L. M.; Hannun, Y. A. Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J. Biol. Chem., 1998, 273, 11313-11320.
    • (1998) J. Biol. Chem , vol.273 , pp. 11313-11320
    • Liu, B.1    Andrieu-Abadie, N.2    Levade, T.3    Zhang, P.4    Obeid, L.M.5    Hannun, Y.A.6
  • 29
    • 41149083660 scopus 로고    scopus 로고
    • Tumor necrosis factor-mediated interactions between inflammatory response and tumor vascular bed
    • ten Hagen, T. L.; Seynhaeve, A. L.; Eggermont, A. M. Tumor necrosis factor-mediated interactions between inflammatory response and tumor vascular bed. Immunol. Rev., 2008, 222, 299-315.
    • (2008) Immunol. Rev , vol.222 , pp. 299-315
    • Ten, H.T.L.1    Seynhaeve, A.L.2    Eggermont, A.M.3
  • 31
    • 0030728227 scopus 로고    scopus 로고
    • Lack of antitumour activity of human recombinant tumour necrosis factor-alpha, alone or in combination with melphalan in a nude mouse human melanoma xenograft system
    • Furrer, M.; Altermatt, H. J.; Ris, H. B.; Althaus, U.; Ruegg, C.; Lienard, D.; Lejeune, F. J. Lack of antitumour activity of human recombinant tumour necrosis factor-alpha, alone or in combination with melphalan in a nude mouse human melanoma xenograft system. Melanoma Res., 1997, 7 Suppl 2, S43-S49.
    • (1997) Melanoma Res , vol.7 , Issue.SUPPL. 2
    • Furrer, M.1    Altermatt, H.J.2    Ris, H.B.3    Althaus, U.4    Ruegg, C.5    Lienard, D.6    Lejeune, F.J.7
  • 32
    • 0024541450 scopus 로고
    • Macroscopic and microscopic early effects of tumour necrosis factor on murine Meth A sarcoma, and relation to curative activity
    • Van de Wiel, P. A.; Bloksma, N.; Kuper, C. F.; Hofhuis, F. M.; Willers, J. M. Macroscopic and microscopic early effects of tumour necrosis factor on murine Meth A sarcoma, and relation to curative activity. J. Pathol., 1989, 157, 65-73.
    • (1989) J. Pathol , vol.157 , pp. 65-73
    • Van de, W.P.A.1    Bloksma, N.2    Kuper, C.F.3    Hofhuis, F.M.4    Willers, J.M.5
  • 33
    • 0023931308 scopus 로고
    • Recombinant human tumor necrosis factor-alpha: Thrombus formation is a cause of anti-tumor activity
    • Shimomura, K.; Manda, T.; Mukumoto, S.; Kobayashi, K.; Nakano, K.; Mori, J. Recombinant human tumor necrosis factor-alpha: thrombus formation is a cause of anti-tumor activity. Int. J. Cancer, 1988, 41, 243-247.
    • (1988) Int. J. Cancer , vol.41 , pp. 243-247
    • Shimomura, K.1    Manda, T.2    Mukumoto, S.3    Kobayashi, K.4    Nakano, K.5    Mori, J.6
  • 34
    • 0022470478 scopus 로고
    • Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons
    • Balkwill, F. R.; Lee, A.; Aldam, G.; Moodie, E.; Thomas, J. A.; Tavernier, J.; Fiers, W. Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons. Cancer Res., 1986, 46, 3990-3993.
    • (1986) Cancer Res , vol.46 , pp. 3990-3993
    • Balkwill, F.R.1    Lee, A.2    Aldam, G.3    Moodie, E.4    Thomas, J.A.5    Tavernier, J.6    Fiers, W.7
  • 37
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Huang, X.; Molema, G.; King, S.; Watkins, L.; Edgington, T. S.; Thorpe, P. E. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science, 1997, 275, 547-550.
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1    Molema, G.2    King, S.3    Watkins, L.4    Edgington, T.S.5    Thorpe, P.E.6
  • 39
    • 0033847207 scopus 로고    scopus 로고
    • Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature
    • Stoelcker, B.; Ruhland, B.; Hehlgans, T.; Bluethmann, H.; Luther, T.; Mannel, D. N. Tumor necrosis factor induces tumor necrosis via tumor necrosis factor receptor type 1-expressing endothelial cells of the tumor vasculature. Am. J. Pathol., 2000, 156, 1171-1176.
    • (2000) Am. J. Pathol , vol.156 , pp. 1171-1176
    • Stoelcker, B.1    Ruhland, B.2    Hehlgans, T.3    Bluethmann, H.4    Luther, T.5    Mannel, D.N.6
  • 40
    • 0040887215 scopus 로고    scopus 로고
    • Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
    • Ruegg, C.; Yilmaz, A.; Bieler, G.; Bamat, J.; Chaubert, P.; Lejeune, F. J. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Nat. Med., 1998, 4, 408-414.
    • (1998) Nat. Med , vol.4 , pp. 408-414
    • Ruegg, C.1    Yilmaz, A.2    Bieler, G.3    Bamat, J.4    Chaubert, P.5    Lejeune, F.J.6
  • 41
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks, P. C.; Montgomery, A. M.; Rosenfeld, M.; Reisfeld, R. A.; Hu, T.; Klier, G.; Cheresh, D. A. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell, 1994, 79, 1157-1164.
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6    Cheresh, D.A.7
  • 42
    • 6044234745 scopus 로고    scopus 로고
    • Induction of endothelial nitric oxide synthase expression by melanoma sensitizes endothelial cells to tumor necrosis factor-driven cytotoxicity
    • Mocellin, S.; Provenzano, M.; Rossi, C. R.; Pilati, P.; Scalerta, R.; Lise, M.; Nitti, D. Induction of endothelial nitric oxide synthase expression by melanoma sensitizes endothelial cells to tumor necrosis factor-driven cytotoxicity. Clin. Cancer Res., 2004, 10, 6879-6886.
    • (2004) Clin. Cancer Res , vol.10 , pp. 6879-6886
    • Mocellin, S.1    Provenzano, M.2    Rossi, C.R.3    Pilati, P.4    Scalerta, R.5    Lise, M.6    Nitti, D.7
  • 43
    • 0030456873 scopus 로고    scopus 로고
    • Synergistic effects of TNF-alpha and melphalan in an isolated limb perfusion model of rat sarcoma: A histopathological, immunohistochemical and electron microscopical study
    • Nooijen, P. T.; Manusama, E. R.; Eggermont, A. M.; Schalkwijk, L.; Stavast, J.; Marquet, R. L.; de Waal, R. M.; Ruiter, D. J. Synergistic effects of TNF-alpha and melphalan in an isolated limb perfusion model of rat sarcoma: a histopathological, immunohistochemical and electron microscopical study. Br. J. Cancer, 1996, 74, 1908-1915.
    • (1996) Br. J. Cancer , vol.74 , pp. 1908-1915
    • Nooijen, P.T.1    Manusama, E.R.2    Eggermont, A.M.3    Schalkwijk, L.4    Stavast, J.5    Marquet, R.L.6    de Waal, R.M.7    Ruiter, D.J.8
  • 44
    • 0029985727 scopus 로고    scopus 로고
    • Synergistic antitumour effect of recombinant human tumour necrosis factor alpha with melphalan in isolated limb perfusion in the rat
    • Manusama, E. R.; Nooijen, P. T.; Stavast, J.; Durante, N. M.; Marquet, R. L.; Eggermont, A. M. Synergistic antitumour effect of recombinant human tumour necrosis factor alpha with melphalan in isolated limb perfusion in the rat. Br. J. Surg., 1996, 83, 551-555.
    • (1996) Br. J. Surg , vol.83 , pp. 551-555
    • Manusama, E.R.1    Nooijen, P.T.2    Stavast, J.3    Durante, N.M.4    Marquet, R.L.5    Eggermont, A.M.6
  • 45
    • 0345131696 scopus 로고    scopus 로고
    • Clinical applications of TNFalpha in cancer
    • Lejeune, F. J.; Ruegg, C.; Lienard, D. Clinical applications of TNFalpha in cancer. Curr. Opin. Immunol., 1998, 10, 573-580.
    • (1998) Curr. Opin. Immunol , vol.10 , pp. 573-580
    • Lejeune, F.J.1    Ruegg, C.2    Lienard, D.3
  • 46
    • 2342426475 scopus 로고    scopus 로고
    • Tumor vascular therapy with TNF: Critical review on animal models
    • Hagen, T. L.; Eggermont, A. M. Tumor vascular therapy with TNF: critical review on animal models. Methods Mol. Med., 2004, 98, 227-246.
    • (2004) Methods Mol. Med , vol.98 , pp. 227-246
    • Hagen, T.L.1    Eggermont, A.M.2
  • 47
    • 33645782015 scopus 로고    scopus 로고
    • TNF-alpha in cancer treatment: Molecular insights, antitumor effects, and clinical utility
    • van Horssen, R.; Ten Hagen, T. L.; Eggermont, A. M. TNF-alpha in cancer treatment: molecular insights, antitumor effects, and clinical utility. Oncologist, 2006, 11, 397-408.
    • (2006) Oncologist , vol.11 , pp. 397-408
    • Van Horssen, R.1    Ten, H.T.L.2    Eggermont, A.M.3
  • 48
    • 0036678175 scopus 로고    scopus 로고
    • Clinical use of TNF revisited: Improving penetration of anti-cancer agents by increasing vascular permeability
    • Lejeune, F. J. Clinical use of TNF revisited: improving penetration of anti-cancer agents by increasing vascular permeability. J. Clin. Invest., 2002, 110, 433-435.
    • (2002) J. Clin. Invest , vol.110 , pp. 433-435
    • Lejeune, F.J.1
  • 50
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • Balkwill, F. Tumour necrosis factor and cancer. Nat. Rev. Cancer, 2009, 9, 361-371.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 52
    • 0027274028 scopus 로고
    • Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: Monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression
    • Wu, S.; Boyer, C. M.; Whitaker, R. S.; Berchuck, A.; Wiener, J. R.; Weinberg, J. B.; Bast, R. C., Jr. Tumor necrosis factor alpha as an autocrine and paracrine growth factor for ovarian cancer: monokine induction of tumor cell proliferation and tumor necrosis factor alpha expression. Cancer Res., 1993, 53, 1939-1944.
    • (1993) Cancer Res , vol.53 , pp. 1939-1944
    • Wu, S.1    Boyer, C.M.2    Whitaker, R.S.3    Berchuck, A.4    Wiener, J.R.5    Weinberg, J.B.6    Bast Jr., R.C.7
  • 54
    • 0029950086 scopus 로고    scopus 로고
    • Prevention of murine radiogenic thymic lymphomas by tumor necrosis factor or by marrow grafting
    • Humblet, C.; Greimers, R.; Delvenne, P.; Deman, J.; Boniver, J.; Defresne, M. P. Prevention of murine radiogenic thymic lymphomas by tumor necrosis factor or by marrow grafting. J. Natl. Cancer Inst., 1996, 88, 824-831.
    • (1996) J. Natl. Cancer Inst , vol.88 , pp. 824-831
    • Humblet, C.1    Greimers, R.2    Delvenne, P.3    Deman, J.4    Boniver, J.5    Defresne, M.P.6
  • 56
    • 0033969322 scopus 로고    scopus 로고
    • Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism
    • Jaiswal, M.; LaRusso, N. F.; Burgart, L. J.; Gores, G. J. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res., 2000, 60, 184-190.
    • (2000) Cancer Res , vol.60 , pp. 184-190
    • Jaiswal, M.1    Larusso, N.F.2    Burgart, L.J.3    Gores, G.J.4
  • 57
  • 59
    • 1942437446 scopus 로고    scopus 로고
    • TNF. autovaccination induces self anti- TNF antibodies and inhibits metastasis in a murine melanoma model
    • Waterston, A. M.; Salway, F.; Andreakos, E.; Butler, D. M.; Feldmann, M.; Coombes, R. C. TNF autovaccination induces self anti- TNF antibodies and inhibits metastasis in a murine melanoma model. Br. J. Cancer, 2004, 90, 1279-1284.
    • (2004) Br. J. Cancer , vol.90 , pp. 1279-1284
    • Waterston, A.M.1    Salway, F.2    Andreakos, E.3    Butler, D.M.4    Feldmann, M.5    Coombes, R.C.6
  • 60
    • 0037112448 scopus 로고    scopus 로고
    • Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells
    • Kitakata, H.; Nemoto-Sasaki, Y.; Takahashi, Y.; Kondo, T.; Mai, M.; Mukaida, N. Essential roles of tumor necrosis factor receptor p55 in liver metastasis of intrasplenic administration of colon 26 cells. Cancer Res., 2002, 62, 6682-6687.
    • (2002) Cancer Res , vol.62 , pp. 6682-6687
    • Kitakata, H.1    Nemoto-Sasaki, Y.2    Takahashi, Y.3    Kondo, T.4    Mai, M.5    Mukaida, N.6
  • 61
    • 0027265279 scopus 로고
    • Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis
    • Qin, Z.; Kruger-Krasagakes, S.; Kunzendorf, U.; Hock, H.; Diamantstein, T.; Blankenstein, T. Expression of tumor necrosis factor by different tumor cell lines results either in tumor suppression or augmented metastasis. J. Exp. Med., 1993, 178, 355-360.
    • (1993) J. Exp. Med , vol.178 , pp. 355-360
    • Qin, Z.1    Kruger-Krasagakes, S.2    Kunzendorf, U.3    Hock, H.4    Diamantstein, T.5    Blankenstein, T.6
  • 62
    • 34848893989 scopus 로고    scopus 로고
    • Biologic treatment of rheumatoid arthritis and the risk of malignancy: Analyses from a large US observational study
    • Wolfe, F.; Michaud, K. Biologic treatment of rheumatoid arthritis and the risk of malignancy: analyses from a large US observational study. Arthritis Rheum., 2007, 56, 2886-2895.
    • (2007) Arthritis Rheum , vol.56 , pp. 2886-2895
    • Wolfe, F.1    Michaud, K.2
  • 63
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz, T.; Sutton, A. J.; Sweeting, M. J.; Buchan, I.; Matteson, E. L.; Montori, V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA, 2006, 295, 2275-2285.
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 64
    • 67549122368 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis and the risk of malignancies: A systematic review and individual patient data meta-analysis of randomised controlled trials
    • Bongartz, T.; Warren, F. C.; Mines, D.; Matteson, E. L.; Abrams, K. R.; Sutton, A. J. Etanercept therapy in rheumatoid arthritis and the risk of malignancies: a systematic review and individual patient data meta-analysis of randomised controlled trials. Ann. Rheum. Dis., 2009, 68, 1177-1183.
    • (2009) Ann. Rheum. Dis , vol.68 , pp. 1177-1183
    • Bongartz, T.1    Warren, F.C.2    Mines, D.3    Matteson, E.L.4    Abrams, K.R.5    Sutton, A.J.6
  • 65
    • 3342968806 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha in the pathogenesis and treatment of cancer
    • Anderson, G. M.; Nakada, M. T.; DeWitte, M. Tumor necrosis factor-alpha in the pathogenesis and treatment of cancer. Curr. Opin. Pharmacol., 2004, 4, 314-320.
    • (2004) Curr. Opin. Pharmacol , vol.4 , pp. 314-320
    • Anderson, G.M.1    Nakada, M.T.2    Dewitte, M.3
  • 67
    • 0037627840 scopus 로고    scopus 로고
    • Current uses of isolated limb perfusion in the clinic and a model system for new strategies
    • Eggermont, A. M.; de Wilt, J. H.; ten Hagen, T. L. Current uses of isolated limb perfusion in the clinic and a model system for new strategies. Lancet Oncol., 2003, 4, 429-437.
    • (2003) Lancet Oncol , vol.4 , pp. 429-437
    • Eggermont, A.M.1    de Wilt, J.H.2    Ten, H.T.L.3
  • 68
    • 63849231788 scopus 로고    scopus 로고
    • TNF-based isolated hepatic perfusion
    • Bellavance, E. C.; Alexander, H. R., Jr. TNF-based isolated hepatic perfusion. Front. Biosci., 2009, 14, 1771-1784.
    • (2009) Front. Biosci , vol.14 , pp. 1771-1784
    • Bellavance, E.C.1    Alexander Jr., H.R.2
  • 69
    • 0036337636 scopus 로고    scopus 로고
    • Isolated limb perfusion in locally advanced cutaneous melanoma
    • Rossi, C. R.; Foletto, M.; Pilati, P.; Mocellin, S.; Lise, M. Isolated limb perfusion in locally advanced cutaneous melanoma. Semin. Oncol., 2002, 29, 400-409.
    • (2002) Semin. Oncol , vol.29 , pp. 400-409
    • Rossi, C.R.1    Foletto, M.2    Pilati, P.3    Mocellin, S.4    Lise, M.5
  • 70
    • 0037829446 scopus 로고    scopus 로고
    • TNFalpha-based isolated perfusion for limb-threatening soft tissue sarcomas: State of the art and future trends
    • Rossi, C. R.; Mocellin, S.; Pilati, P.; Foletto, M.; Nitti, D.; Lise, M. TNFalpha-based isolated perfusion for limb-threatening soft tissue sarcomas: state of the art and future trends. J. Immunother., 2003, 26, 291-300.
    • (2003) J. Immunother , vol.26 , pp. 291-300
    • Rossi, C.R.1    Mocellin, S.2    Pilati, P.3    Foletto, M.4    Nitti, D.5    Lise, M.6
  • 71
    • 0036845222 scopus 로고    scopus 로고
    • Radiation-induced tumour necrosis factor-alpha expression: Clinical application of transcriptional and physical targeting of gene therapy
    • Weichselbaum, R. R.; Kufe, D. W.; Hellman, S.; Rasmussen, H. S.; King, C. R.; Fischer, P. H.; Mauceri, H. J. Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy. Lancet Oncol., 2002, 3, 665-671.
    • (2002) Lancet Oncol , vol.3 , pp. 665-671
    • Weichselbaum, R.R.1    Kufe, D.W.2    Hellman, S.3    Rasmussen, H.S.4    King, C.R.5    Fischer, P.H.6    Mauceri, H.J.7
  • 73
    • 25144471132 scopus 로고    scopus 로고
    • TNFerade, an adenovector carrying the transgene for human tumor necrosis factor alpha, for patients with advanced solid tumors: Surgical experience and longterm follow-up
    • McLoughlin, J. M.; McCarty, T. M.; Cunningham, C.; Clark, V.; Senzer, N.; Nemunaitis, J.; Kuhn, J. A. TNFerade, an adenovector carrying the transgene for human tumor necrosis factor alpha, for patients with advanced solid tumors: surgical experience and longterm follow-up. Ann. Surg. Oncol., 2005, 12, 825-830.
    • (2005) Ann. Surg. Oncol , vol.12 , pp. 825-830
    • McLoughlin, J.M.1    McCarty, T.M.2    Cunningham, C.3    Clark, V.4    Senzer, N.5    Nemunaitis, J.6    Kuhn, J.A.7
  • 75
    • 34948821201 scopus 로고    scopus 로고
    • Local gene delivery of tumor necrosis factor alpha can impact primary tumor growth and metastases through a host-mediated response
    • MacGill, R. S.; Davis, T. A.; Macko, J.; Mauceri, H. J.; Weichselbaum, R. R.; King, C. R. Local gene delivery of tumor necrosis factor alpha can impact primary tumor growth and metastases through a host-mediated response. Clin. Exp. Metastasis, 2007, 24, 521-531.
    • (2007) Clin. Exp. Metastasis , vol.24 , pp. 521-531
    • Macgill, R.S.1    Davis, T.A.2    Macko, J.3    Mauceri, H.J.4    Weichselbaum, R.R.5    King, C.R.6
  • 78
    • 0034022160 scopus 로고    scopus 로고
    • Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
    • Jo, M.; Kim, T. H.; Seol, D. W.; Esplen, J. E.; Dorko, K.; Billiar, T. R.; Strom, S. C. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat. Med., 2000, 6, 564-567.
    • (2000) Nat. Med , vol.6 , pp. 564-567
    • Jo, M.1    Kim, T.H.2    Seol, D.W.3    Esplen, J.E.4    Dorko, K.5    Billiar, T.R.6    Strom, S.C.7
  • 81
    • 71749102407 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL): A new path to anti-cancer therapies
    • Holoch, P. A.; Griffith, T. S. TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies. Eur. J. Pharmacol., 2009, 625, 63-72.
    • (2009) Eur. J. Pharmacol , vol.625 , pp. 63-72
    • Holoch, P.A.1    Griffith, T.S.2
  • 82
    • 0036467427 scopus 로고    scopus 로고
    • Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    • Cretney, E.; Takeda, K.; Yagita, H.; Glaccum, M.; Peschon, J. J.; Smyth, M. J. Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J. Immunol., 2002, 168, 1356-1361.
    • (2002) J. Immunol , vol.168 , pp. 1356-1361
    • Cretney, E.1    Takeda, K.2    Yagita, H.3    Glaccum, M.4    Peschon, J.J.5    Smyth, M.J.6
  • 83
    • 45849115453 scopus 로고    scopus 로고
    • TRAIL death receptors as tumor suppressors and drug targets
    • Finnberg, N.; El-Deiry, W. S. TRAIL death receptors as tumor suppressors and drug targets. Cell Cycle, 2008, 7, 1525-1528.
    • (2008) Cell Cycle , vol.7 , pp. 1525-1528
    • Finnberg, N.1    El-Deiry, W.S.2
  • 84
    • 43249088650 scopus 로고    scopus 로고
    • Trail receptors: Targets for cancer therapy
    • Humphreys, R. C.; Halpern, W. Trail receptors: targets for cancer therapy. Adv. Exp. Med. Biol., 2008, 615, 127-158.
    • (2008) Adv. Exp. Med. Biol , vol.615 , pp. 127-158
    • Humphreys, R.C.1    Halpern, W.2
  • 85
    • 37849033506 scopus 로고    scopus 로고
    • Biochemical analysis of the native TRAIL death-inducing signaling complex
    • Walczak, H.; Haas, T. L. Biochemical analysis of the native TRAIL death-inducing signaling complex. Methods Mol. Biol., 2008, 414, 221-239.
    • (2008) Methods Mol. Biol , vol.414 , pp. 221-239
    • Walczak, H.1    Haas, T.L.2
  • 87
    • 59449110529 scopus 로고    scopus 로고
    • Targeting the apoptosome for cancer therapy
    • Ledgerwood, E. C.; Morison, I. M. Targeting the apoptosome for cancer therapy. Clin Cancer Res., 2009, 15, 420-424.
    • (2009) Clin Cancer Res , vol.15 , pp. 420-424
    • Ledgerwood, E.C.1    Morison, I.M.2
  • 88
    • 43349088699 scopus 로고    scopus 로고
    • The apoptosome: Emerging insights and new potential targets for drug design
    • D'Amelio, M.; Tino, E.; Cecconi, F. The apoptosome: emerging insights and new potential targets for drug design. Pharm. Res., 2008, 25, 740-751.
    • (2008) Pharm. Res , vol.25 , pp. 740-751
    • D'Amelio, M.1    Tino, E.2    Cecconi, F.3
  • 89
    • 35348877298 scopus 로고    scopus 로고
    • Barriers to effective TRAIL-targeted therapy of malignancy
    • Dyer, M. J.; MacFarlane, M.; Cohen, G. M. Barriers to effective TRAIL-targeted therapy of malignancy. J. Clin. Oncol., 2007, 25, 4505-4506.
    • (2007) J. Clin. Oncol , vol.25 , pp. 4505-4506
    • Dyer, M.J.1    Macfarlane, M.2    Cohen, G.M.3
  • 91
    • 0033566163 scopus 로고    scopus 로고
    • The antiapoptotic decoy receptor TRID/TRAILR3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
    • Sheikh, M. S.; Huang, Y.; Fernandez-Salas, E. A.; El-Deiry, W. S.; Friess, H.; Amundson, S.; Yin, J.; Meltzer, S. J.; Holbrook, N. J.; Fornace, A. J., Jr. The antiapoptotic decoy receptor TRID/TRAILR3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract. Oncogene, 1999, 18, 4153-4159.
    • (1999) Oncogene , vol.18 , pp. 4153-4159
    • Sheikh, M.S.1    Huang, Y.2    Fernandez-Salas, E.A.3    El-Deiry, W.S.4    Friess, H.5    Amundson, S.6    Yin, J.7    Meltzer, S.J.8    Holbrook, N.J.9    Fornace Jr., A.J.10
  • 92
    • 36148948920 scopus 로고    scopus 로고
    • DcR2 (TRAIL-R4) siRNA and adenovirus delivery of TRAIL (Ad5hTRAIL) break down in vitro tumorigenic potential of prostate carcinoma cells
    • Sanlioglu, A. D.; Karacay, B.; Koksal, I. T.; Griffith, T. S.; Sanlioglu, S. DcR2 (TRAIL-R4) siRNA and adenovirus delivery of TRAIL (Ad5hTRAIL) break down in vitro tumorigenic potential of prostate carcinoma cells. Cancer Gene Ther., 2007, 14, 976-984.
    • (2007) Cancer Gene Ther , vol.14 , pp. 976-984
    • Sanlioglu, A.D.1    Karacay, B.2    Koksal, I.T.3    Griffith, T.S.4    Sanlioglu, S.5
  • 93
    • 67649304670 scopus 로고    scopus 로고
    • The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells
    • Buneker, C.; Mohr, A.; Zwacka, R. M. The TRAIL-receptor-1: TRAIL-receptor-3 and -4 ratio is a predictor for TRAIL sensitivity of cancer cells. Oncol. Rep., 2009, 21, 1289-1295.
    • (2009) Oncol. Rep , vol.21 , pp. 1289-1295
    • Buneker, C.1    Mohr, A.2    Zwacka, R.M.3
  • 95
    • 0033587111 scopus 로고    scopus 로고
    • Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma
    • Pineau, P.; Nagai, H.; Prigent, S.; Wei, Y.; Gyapay, G.; Weissenbach, J.; Tiollais, P.; Buendia, M. A.; Dejean, A. Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma. Oncogene, 1999, 18, 3127-3134.
    • (1999) Oncogene , vol.18 , pp. 3127-3134
    • Pineau, P.1    Nagai, H.2    Prigent, S.3    Wei, Y.4    Gyapay, G.5    Weissenbach, J.6    Tiollais, P.7    Buendia, M.A.8    Dejean, A.9
  • 96
    • 0032416597 scopus 로고    scopus 로고
    • Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas
    • Arai, T.; Akiyama, Y.; Okabe, S.; Saito, K.; Iwai, T.; Yuasa, Y. Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas. Cancer Lett., 1998, 133, 197-204.
    • (1998) Cancer Lett , vol.133 , pp. 197-204
    • Arai, T.1    Akiyama, Y.2    Okabe, S.3    Saito, K.4    Iwai, T.5    Yuasa, Y.6
  • 97
    • 0037178558 scopus 로고    scopus 로고
    • Mutation of the DR5/TRAIL receptor 2 gene is infrequent in hepatocellular carcinoma
    • Jeng, Y. M.; Hsu, H. C. Mutation of the DR5/TRAIL receptor 2 gene is infrequent in hepatocellular carcinoma. Cancer Lett., 2002, 181, 205-208.
    • (2002) Cancer Lett , vol.181 , pp. 205-208
    • Jeng, Y.M.1    Hsu, H.C.2
  • 99
  • 100
    • 0036052719 scopus 로고    scopus 로고
    • Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL
    • Jin, Z.; Dicker, D. T.; El-Deiry, W. S. Enhanced sensitivity of G1 arrested human cancer cells suggests a novel therapeutic strategy using a combination of simvastatin and TRAIL. Cell Cycle, 2002, 1, 82-89.
    • (2002) Cell Cycle , vol.1 , pp. 82-89
    • Jin, Z.1    Dicker, D.T.2    El-Deiry, W.S.3
  • 101
    • 0033136321 scopus 로고    scopus 로고
    • Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis
    • Algeciras-Schimnich, A.; Griffith, T. S.; Lynch, D. H.; Paya, C. V. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. J. Immunol., 1999, 162, 5205-5211.
    • (1999) J. Immunol , vol.162 , pp. 5205-5211
    • Algeciras-Schimnich, A.1    Griffith, T.S.2    Lynch, D.H.3    Paya, C.V.4
  • 102
    • 0037018277 scopus 로고    scopus 로고
    • Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression
    • Fulda, S.; Meyer, E.; Debatin, K. M. Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression. Oncogene, 2002, 21, 2283-2294.
    • (2002) Oncogene , vol.21 , pp. 2283-2294
    • Fulda, S.1    Meyer, E.2    Debatin, K.M.3
  • 103
    • 0036341291 scopus 로고    scopus 로고
    • Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo
    • Fulda, S.; Wick, W.; Weller, M.; Debatin, K. M. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Nat. Med., 2002, 8, 808-815.
    • (2002) Nat. Med , vol.8 , pp. 808-815
    • Fulda, S.1    Wick, W.2    Weller, M.3    Debatin, K.M.4
  • 104
    • 0036606414 scopus 로고    scopus 로고
    • Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma
    • Griffith, T. S.; Fialkov, J. M.; Scott, D. L.; Azuhata, T.; Williams, R. D.; Wall, N. R.; Altieri, D. C.; Sandler, A. D. Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma. Cancer Res., 2002, 62, 3093-3099.
    • (2002) Cancer Res , vol.62 , pp. 3093-3099
    • Griffith, T.S.1    Fialkov, J.M.2    Scott, D.L.3    Azuhata, T.4    Williams, R.D.5    Wall, N.R.6    Altieri, D.C.7    Sandler, A.D.8
  • 106
    • 42049116091 scopus 로고    scopus 로고
    • Mcl-1: A gateway to TRAIL sensitization
    • Kim, S. H.; Ricci, M. S.; El-Deiry, W. S. Mcl-1: a gateway to TRAIL sensitization. Cancer Res., 2008, 68, 2062-2064.
    • (2008) Cancer Res , vol.68 , pp. 2062-2064
    • Kim, S.H.1    Ricci, M.S.2    El-Deiry, W.S.3
  • 107
    • 0035815649 scopus 로고    scopus 로고
    • Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis
    • Nesterov, A.; Lu, X.; Johnson, M.; Miller, G. J.; Ivashchenko, Y.; Kraft, A. S. Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosis. J. Biol. Chem., 2001, 276, 10767-10774.
    • (2001) J. Biol. Chem , vol.276 , pp. 10767-10774
    • Nesterov, A.1    Lu, X.2    Johnson, M.3    Miller, G.J.4    Ivashchenko, Y.5    Kraft, A.S.6
  • 108
    • 34547823047 scopus 로고    scopus 로고
    • Different modulation of TRAIL-induced apoptosis by inhibition of prosurvival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells
    • Vaculova, A.; Hofmanova, J.; Soucek, K.; Kozubik, A. Different modulation of TRAIL-induced apoptosis by inhibition of prosurvival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells. FEBS Lett., 2006, 580, 6565-6569.
    • (2006) FEBS Lett , vol.580 , pp. 6565-6569
    • Vaculova, A.1    Hofmanova, J.2    Soucek, K.3    Kozubik, A.4
  • 110
    • 0344321886 scopus 로고    scopus 로고
    • Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis
    • Siegmund, D.; Hadwiger, P.; Pfizenmaier, K.; Vornlocher, H. P.; Wajant, H. Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis. Mol. Med., 2002, 8, 725-732.
    • (2002) Mol. Med , vol.8 , pp. 725-732
    • Siegmund, D.1    Hadwiger, P.2    Pfizenmaier, K.3    Vornlocher, H.P.4    Wajant, H.5
  • 112
    • 11144230279 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells
    • Sinicrope, F. A.; Penington, R. C.; Tang, X. M. Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis is inhibited by Bcl-2 but restored by the small molecule Bcl-2 inhibitor, HA 14-1, in human colon cancer cells. Clin. Cancer Res., 2004, 10, 8284-8292.
    • (2004) Clin. Cancer Res , vol.10 , pp. 8284-8292
    • Sinicrope, F.A.1    Penington, R.C.2    Tang, X.M.3
  • 113
    • 33646846666 scopus 로고    scopus 로고
    • Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis
    • Clohessy, J. G.; Zhuang, J.; de Boer, J.; Gil-Gomez, G.; Brady, H. J. Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis. J. Biol. Chem., 2006, 281, 5750-5759.
    • (2006) J. Biol. Chem , vol.281 , pp. 5750-5759
    • Clohessy, J.G.1    Zhuang, J.2    de Boer, J.3    Gil-Gomez, G.4    Brady, H.J.5
  • 114
    • 53649109665 scopus 로고    scopus 로고
    • A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma
    • Ndozangue-Touriguine, O.; Sebbagh, M.; Merino, D.; Micheau, O.; Bertoglio, J.; Breard, J. A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma. Oncogene, 2008, 27, 6012-6022.
    • (2008) Oncogene , vol.27 , pp. 6012-6022
    • Ndozangue-Touriguine, O.1    Sebbagh, M.2    Merino, D.3    Micheau, O.4    Bertoglio, J.5    Breard, J.6
  • 117
    • 70149122276 scopus 로고    scopus 로고
    • TRAIL as a target in anti-cancer therapy
    • Wu, G. S. TRAIL as a target in anti-cancer therapy. Cancer Lett., 2009, 285, 1-5.
    • (2009) Cancer Lett , vol.285 , pp. 1-5
    • Wu, G.S.1
  • 118
    • 0034812659 scopus 로고    scopus 로고
    • Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: Characterization of in vivo efficacy, pharmacokinetics, and safety
    • Kelley, S. K.; Harris, L. A.; Xie, D.; Deforge, L.; Totpal, K.; Bussiere, J.; Fox, J. A. Preclinical studies to predict the disposition of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand in humans: characterization of in vivo efficacy, pharmacokinetics, and safety. J. Pharmacol. Exp. Ther., 2001, 299, 31-38.
    • (2001) J. Pharmacol. Exp. Ther , vol.299 , pp. 31-38
    • Kelley, S.K.1    Harris, L.A.2    Xie, D.3    Deforge, L.4    Totpal, K.5    Bussiere, J.6    Fox, J.A.7
  • 121
    • 68549136613 scopus 로고    scopus 로고
    • Cytotoxic effects of camptothecin and cisplatin combined with tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in a model of primary culture of non-small cell lung cancer
    • Frese, S.; Schuller, A.; Frese-Schaper, M.; Gugger, M.; Schmid, R. A. Cytotoxic effects of camptothecin and cisplatin combined with tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in a model of primary culture of non-small cell lung cancer. Anticancer Res., 2009, 29, 2905-2911.
    • (2009) Anticancer Res , vol.29 , pp. 2905-2911
    • Frese, S.1    Schuller, A.2    Frese-Schaper, M.3    Gugger, M.4    Schmid, R.A.5
  • 122
    • 70349481308 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid sensitizes human oral cancer cells to TRAIL-induced apoptosis through increase DR5 expression
    • Yeh, C. C.; Deng, Y. T.; Sha, D. Y.; Hsiao, M.; Kuo, M. Y. Suberoylanilide hydroxamic acid sensitizes human oral cancer cells to TRAIL-induced apoptosis through increase DR5 expression. Mol. Cancer Ther., 2009, 8, 2718-2725.
    • (2009) Mol. Cancer Ther , vol.8 , pp. 2718-2725
    • Yeh, C.C.1    Deng, Y.T.2    Sha, D.Y.3    Hsiao, M.4    Kuo, M.Y.5
  • 124
    • 3442884825 scopus 로고    scopus 로고
    • P53 upregulates death receptor 4 expression through an intronic p53 binding site
    • Liu, X.; Yue, P.; Khuri, F. R.; Sun, S. Y. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res., 2004, 64, 5078-5083.
    • (2004) Cancer Res , vol.64 , pp. 5078-5083
    • Liu, X.1    Yue, P.2    Khuri, F.R.3    Sun, S.Y.4
  • 125
    • 2942565827 scopus 로고    scopus 로고
    • Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: Mechanisms and clinical implications
    • Shankar, S.; Srivastava, R. K. Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implications. Drug Resist. Updat., 2004, 7, 139-156.
    • (2004) Drug Resist. Updat , vol.7 , pp. 139-156
    • Shankar, S.1    Srivastava, R.K.2
  • 126
    • 33947356281 scopus 로고    scopus 로고
    • Bortezomibmediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma
    • Bonvini, P.; Zorzi, E.; Basso, G.; Rosolen, A. Bortezomibmediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphoma. Leukemia, 2007, 21, 838-842.
    • (2007) Leukemia , vol.21 , pp. 838-842
    • Bonvini, P.1    Zorzi, E.2    Basso, G.3    Rosolen, A.4
  • 127
    • 0038240386 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL mediated apoptosis by reducing levels of c-FLIP
    • Sayers, T. J.; Brooks, A. D.; Koh, C. Y.; Ma, W.; Seki, N.; Raziuddin, A.; Blazar, B. R.; Zhang, X.; Elliott, P. J.; Murphy, W. J. The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL mediated apoptosis by reducing levels of c-FLIP. Blood, 2003, 102, 303-310.
    • (2003) Blood , vol.102 , pp. 303-310
    • Sayers, T.J.1    Brooks, A.D.2    Koh, C.Y.3    Ma, W.4    Seki, N.5    Raziuddin, A.6    Blazar, B.R.7    Zhang, X.8    Elliott, P.J.9    Murphy, W.J.10
  • 128
    • 32244442000 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAILmediated apoptosis
    • Brooks, A. D.; Ramirez, T.; Toh, U.; Onksen, J.; Elliott, P. J.; Murphy, W. J.; Sayers, T. J. The proteasome inhibitor bortezomib (Velcade) sensitizes some human tumor cells to Apo2L/TRAILmediated apoptosis. Ann. N. Y. Acad. Sci., 2005, 1059, 160-167.
    • (2005) Ann. N. Y. Acad. Sci , vol.1059 , pp. 160-167
    • Brooks, A.D.1    Ramirez, T.2    Toh, U.3    Onksen, J.4    Elliott, P.J.5    Murphy, W.J.6    Sayers, T.J.7
  • 129
    • 60849086467 scopus 로고    scopus 로고
    • Mapatumumab and lexatumumab induce apoptosis in TRAILR1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib
    • Luster, T. A.; Carrell, J. A.; McCormick, K.; Sun, D.; Humphreys, R. Mapatumumab and lexatumumab induce apoptosis in TRAILR1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib. Mol. Cancer Ther., 2009, 8, 292-302.
    • (2009) Mol. Cancer Ther , vol.8 , pp. 292-302
    • Luster, T.A.1    Carrell, J.A.2    McCormick, K.3    Sun, D.4    Humphreys, R.5
  • 130
    • 35148900795 scopus 로고    scopus 로고
    • The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation
    • Rosato, R. R.; Almenara, J. A.; Coe, S.; Grant, S. The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation. Cancer Res., 2007, 67, 9490-9500.
    • (2007) Cancer Res , vol.67 , pp. 9490-9500
    • Rosato, R.R.1    Almenara, J.A.2    Coe, S.3    Grant, S.4
  • 131
    • 73849114072 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome- dependent inhibition of TRAIL degradation
    • Borbone, E.; Berlingieri, M. T.; De Bellis, F.; Nebbioso, A.; Chiappetta, G.; Mai, A.; Altucci, L.; Fusco, A. Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome- dependent inhibition of TRAIL degradation. Oncogene, 2010, 29, 105-116.
    • (2010) Oncogene , vol.29 , pp. 105-116
    • Borbone, E.1    Berlingieri, M.T.2    de Bellis, F.3    Nebbioso, A.4    Chiappetta, G.5    Mai, A.6    Altucci, L.7    Fusco, A.8
  • 132
    • 49349098483 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Mechanisms of cell death and promise in combination cancer therapy
    • Carew, J. S.; Giles, F. J.; Nawrocki, S. T. Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy. Cancer Lett., 2008, 269, 7-17.
    • (2008) Cancer Lett , vol.269 , pp. 7-17
    • Carew, J.S.1    Giles, F.J.2    Nawrocki, S.T.3
  • 133
    • 40449140444 scopus 로고    scopus 로고
    • Modulation of TRAIL-induced apoptosis by HDAC inhibitors
    • Fulda, S. Modulation of TRAIL-induced apoptosis by HDAC inhibitors. Curr. Cancer Drug Targets, 2008, 8, 132-140.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 132-140
    • Fulda, S.1
  • 134
    • 30944438284 scopus 로고    scopus 로고
    • Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor
    • Ray, S.; Bucur, O.; Almasan, A. Sensitization of prostate carcinoma cells to Apo2L/TRAIL by a Bcl-2 family protein inhibitor. Apoptosis, 2005, 10, 1411-1418.
    • (2005) Apoptosis , vol.10 , pp. 1411-1418
    • Ray, S.1    Bucur, O.2    Almasan, A.3
  • 138
    • 0034283942 scopus 로고    scopus 로고
    • Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis
    • Griffith, T. S.; Anderson, R. D.; Davidson, B. L.; Williams, R. D.; Ratliff, T. L. Adenoviral-mediated transfer of the TNF-related apoptosis-inducing ligand/Apo-2 ligand gene induces tumor cell apoptosis. J. Immunol., 2000, 165, 2886-2894.
    • (2000) J. Immunol , vol.165 , pp. 2886-2894
    • Griffith, T.S.1    Anderson, R.D.2    Davidson, B.L.3    Williams, R.D.4    Ratliff, T.L.5
  • 139
    • 0034855468 scopus 로고    scopus 로고
    • Suppression of tumor growth following intralesional therapy with TRAIL recombinant adenovirus
    • Griffith, T. S.; Broghammer, E. L. Suppression of tumor growth following intralesional therapy with TRAIL recombinant adenovirus. Mol. Ther., 2001, 4, 257-266.
    • (2001) Mol. Ther , vol.4 , pp. 257-266
    • Griffith, T.S.1    Broghammer, E.L.2
  • 140
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)
    • Ashkenazi, A.; Holland, P.; Eckhardt, S. G. Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). J. Clin. Oncol., 2008, 26, 3621-3630.
    • (2008) J. Clin. Oncol , vol.26 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 141
    • 0037507288 scopus 로고    scopus 로고
    • Adenoviral gene transfer of tumor necrosis factor-related apoptosis-inducing ligand overcomes an impaired response of hepatoma cells but causes severe apoptosis in primary human hepatocytes
    • Armeanu, S.; Lauer, U. M.; Smirnow, I.; Schenk, M.; Weiss, T. S.; Gregor, M.; Bitzer, M. Adenoviral gene transfer of tumor necrosis factor-related apoptosis-inducing ligand overcomes an impaired response of hepatoma cells but causes severe apoptosis in primary human hepatocytes. Cancer Res., 2003, 63, 2369-2372.
    • (2003) Cancer Res , vol.63 , pp. 2369-2372
    • Armeanu, S.1    Lauer, U.M.2    Smirnow, I.3    Schenk, M.4    Weiss, T.S.5    Gregor, M.6    Bitzer, M.7
  • 142
    • 33749011709 scopus 로고    scopus 로고
    • Eliminating established tumor in nu/nu nude mice by a tumor necrosis factor-alpha-related apoptosisinducing ligand-armed oncolytic adenovirus
    • Dong, F.; Wang, L.; Davis, J. J.; Hu, W.; Zhang, L.; Guo, W.; Teraishi, F.; Ji, L.; Fang, B. Eliminating established tumor in nu/nu nude mice by a tumor necrosis factor-alpha-related apoptosisinducing ligand-armed oncolytic adenovirus. Clin. Cancer Res., 2006, 12, 5224-5230.
    • (2006) Clin. Cancer Res , vol.12 , pp. 5224-5230
    • Dong, F.1    Wang, L.2    Davis, J.J.3    Hu, W.4    Zhang, L.5    Guo, W.6    Teraishi, F.7    Ji, L.8    Fang, B.9
  • 143
    • 34249034598 scopus 로고    scopus 로고
    • Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL
    • Kock, N.; Kasmieh, R.; Weissleder, R.; Shah, K. Tumor therapy mediated by lentiviral expression of shBcl-2 and S-TRAIL. Neoplasia, 2007, 9, 435-442.
    • (2007) Neoplasia , vol.9 , pp. 435-442
    • Kock, N.1    Kasmieh, R.2    Weissleder, R.3    Shah, K.4
  • 144
    • 34347226747 scopus 로고    scopus 로고
    • Combined treatment with AdhTRAIL and DTIC or SAHA is associated with increased mitochondrial- mediated apoptosis in human melanoma cell lines
    • Lillehammer, T.; Engesaeter, B. O.; Prasmickaite, L.; Maelandsmo, G. M.; Fodstad, O.; Engebraaten, O. Combined treatment with AdhTRAIL and DTIC or SAHA is associated with increased mitochondrial- mediated apoptosis in human melanoma cell lines. J. Gene Med., 2007, 9, 440-451.
    • (2007) J. Gene Med , vol.9 , pp. 440-451
    • Lillehammer, T.1    Engesaeter, B.O.2    Prasmickaite, L.3    Maelandsmo, G.M.4    Fodstad, O.5    Engebraaten, O.6
  • 147
    • 57049155399 scopus 로고    scopus 로고
    • Directing cancer cells to self-destruct with proapoptotic receptor agonists
    • Ashkenazi, A. Directing cancer cells to self-destruct with proapoptotic receptor agonists. Nat. Rev. Drug Discov., 2008, 7, 1001-1012.
    • (2008) Nat. Rev. Drug Discov , vol.7 , pp. 1001-1012
    • Ashkenazi, A.1
  • 148
    • 62449168519 scopus 로고    scopus 로고
    • TRAIL agonists on clinical trials for cancer therapy: The promises and the challenges
    • Bellail, A. C.; Qi, L.; Mulligan, P.; Chhabra, V.; Hao, C. TRAIL agonists on clinical trials for cancer therapy: the promises and the challenges. Rev. Recent Clin. Trials, 2009, 4, 34-41.
    • (2009) Rev. Recent Clin. Trials , vol.4 , pp. 34-41
    • Bellail, A.C.1    Qi, L.2    Mulligan, P.3    Chhabra, V.4    Hao, C.5
  • 149
    • 34248187996 scopus 로고    scopus 로고
    • Phase I. pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factorrelated apoptosis-inducing ligand receptor-1
    • Tolcher, A. W.; Mita, M.; Meropol, N. J.; von Mehren, M.; Patnaik, A.; Padavic, K.; Hill, M.; Mays, T.; McCoy, T.; Fox, N. L.; Halpern, W.; Corey, A.; Cohen, R. B. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factorrelated apoptosis-inducing ligand receptor-1. J. Clin. Oncol., 2007, 25, 1390-1395.
    • (2007) J. Clin. Oncol , vol.25 , pp. 1390-1395
    • Tolcher, A.W.1    Mita, M.2    Meropol, N.J.3    von Mehren, M.4    Patnaik, A.5    Padavic, K.6    Hill, M.7    Mays, T.8    McCoy, T.9    Fox, N.L.10    Halpern, W.11    Corey, A.12    Cohen, R.B.13
  • 150
    • 76349085626 scopus 로고    scopus 로고
    • Phase IItrial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis- inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
    • Trarbach, T.; Moehler, M.; Heinemann, V.; Kohne, C. H.; Przyborek, M.; Schulz, C.; Sneller, V.; Gallant, G.; Kanzler, S. Phase IItrial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis- inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br. J. Cancer, 2010, 102, 506-512.
    • (2010) Br. J. Cancer , vol.102 , pp. 506-512
    • Trarbach, T.1    Moehler, M.2    Heinemann, V.3    Kohne, C.H.4    Przyborek, M.5    Schulz, C.6    Sneller, V.7    Gallant, G.8    Kanzler, S.9
  • 151
    • 45649084324 scopus 로고    scopus 로고
    • Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
    • Greco, F. A.; Bonomi, P.; Crawford, J.; Kelly, K.; Oh, Y.; Halpern, W.; Lo, L.; Gallant, G.; Klein, J. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer, 2008, 61, 82-90.
    • (2008) Lung Cancer , vol.61 , pp. 82-90
    • Greco, F.A.1    Bonomi, P.2    Crawford, J.3    Kelly, K.4    Oh, Y.5    Halpern, W.6    Lo, L.7    Gallant, G.8    Klein, J.9
  • 152
  • 155
    • 47949092316 scopus 로고    scopus 로고
    • Apomab: An agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors
    • Camidge, D. R. Apomab: an agonist monoclonal antibody directed against Death Receptor 5/TRAIL-Receptor 2 for use in the treatment of solid tumors. Expert Opin. Biol. Ther., 2008, 8, 1167-1176.
    • (2008) Expert Opin. Biol. Ther , vol.8 , pp. 1167-1176
    • Camidge, D.R.1
  • 156
    • 60149085396 scopus 로고    scopus 로고
    • The many roles of FAS receptor signaling in the immune system
    • Strasser, A.; Jost, P. J.; Nagata, S. The many roles of FAS receptor signaling in the immune system. Immunity, 2009, 30, 180-192.
    • (2009) Immunity , vol.30 , pp. 180-192
    • Strasser, A.1    Jost, P.J.2    Nagata, S.3
  • 157
    • 55549107524 scopus 로고    scopus 로고
    • CD95 stimulation results in the formation of a novel death effector domain protein-containing complex
    • Lavrik, I. N.; Mock, T.; Golks, A.; Hoffmann, J. C.; Baumann, S.; Krammer, P. H. CD95 stimulation results in the formation of a novel death effector domain protein-containing complex. J. Biol. Chem., 2008, 283, 26401-26408.
    • (2008) J. Biol. Chem , vol.283 , pp. 26401-26408
    • Lavrik, I.N.1    Mock, T.2    Golks, A.3    Hoffmann, J.C.4    Baumann, S.5    Krammer, P.H.6
  • 158
    • 3342935962 scopus 로고    scopus 로고
    • The Fas signalling pathway and its role in the pathogenesis of cancer
    • Houston, A.; O'Connell, J. The Fas signalling pathway and its role in the pathogenesis of cancer. Curr. Opin. Pharmacol., 2004, 4, 321-326.
    • (2004) Curr. Opin. Pharmacol , vol.4 , pp. 321-326
    • Houston, A.1    O'Connell, J.2
  • 159
    • 0141853168 scopus 로고    scopus 로고
    • Live and let die: Regulatory mechanisms in Fas-mediated apoptosis
    • Curtin, J. F.; Cotter, T. G. Live and let die: regulatory mechanisms in Fas-mediated apoptosis. Cell Signal, 2003, 15, 983-992.
    • (2003) Cell Signal , vol.15 , pp. 983-992
    • Curtin, J.F.1    Cotter, T.G.2
  • 161
    • 0042466637 scopus 로고    scopus 로고
    • Interdimer processing mechanism of procaspase-8 activation
    • Chang, D. W.; Xing, Z.; Capacio, V. L.; Peter, M. E.; Yang, X. Interdimer processing mechanism of procaspase-8 activation. EMBO J., 2003, 22, 4132-4142.
    • (2003) EMBO J , vol.22 , pp. 4132-4142
    • Chang, D.W.1    Xing, Z.2    Capacio, V.L.3    Peter, M.E.4    Yang, X.5
  • 164
    • 0242351062 scopus 로고    scopus 로고
    • The Bcl-2- regulated apoptotic pathway
    • Willis, S.; Day, C. L.; Hinds, M. G.; Huang, D. C. The Bcl-2- regulated apoptotic pathway. J Cell Sci., 2003, 116, 4053-4056.
    • (2003) J Cell Sci , vol.116 , pp. 4053-4056
    • Willis, S.1    Day, C.L.2    Hinds, M.G.3    Huang, D.C.4
  • 168
    • 0030808385 scopus 로고    scopus 로고
    • Thymineless death in colon carcinoma cells is mediated via fas signaling
    • Houghton, J. A.; Harwood, F. G.; Tillman, D. M. Thymineless death in colon carcinoma cells is mediated via fas signaling. Proc. Natl. Acad. Sci. U.S.A., 1997, 94, 8144-8149.
    • (1997) Proc. Natl. Acad. Sci. U.S.A , vol.94 , pp. 8144-8149
    • Houghton, J.A.1    Harwood, F.G.2    Tillman, D.M.3
  • 169
    • 0032014073 scopus 로고    scopus 로고
    • DNA. damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
    • Kasibhatla, S.; Brunner, T.; Genestier, L.; Echeverri, F.; Mahboubi, A.; Green, D. R. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1. Mol. Cell, 1998, 1, 543-551.
    • (1998) Mol. Cell , vol.1 , pp. 543-551
    • Kasibhatla, S.1    Brunner, T.2    Genestier, L.3    Echeverri, F.4    Mahboubi, A.5    Green, D.R.6
  • 171
    • 0033599527 scopus 로고    scopus 로고
    • STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs
    • Micheau, O.; Hammann, A.; Solary, E.; Dimanche-Boitrel, M. T. STAT-1-independent upregulation of FADD and procaspase-3 and -8 in cancer cells treated with cytotoxic drugs. Biochem. Biophys. Res. Commun., 1999, 256, 603-607.
    • (1999) Biochem. Biophys. Res. Commun , vol.256 , pp. 603-607
    • Micheau, O.1    Hammann, A.2    Solary, E.3    Dimanche-Boitrel, M.T.4
  • 172
    • 0035279153 scopus 로고    scopus 로고
    • Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis
    • Fulda, S.; Meyer, E.; Friesen, C.; Susin, S. A.; Kroemer, G.; Debatin, K. M. Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene, 2001, 20, 1063-1075.
    • (2001) Oncogene , vol.20 , pp. 1063-1075
    • Fulda, S.1    Meyer, E.2    Friesen, C.3    Susin, S.A.4    Kroemer, G.5    Debatin, K.M.6
  • 173
    • 0036153928 scopus 로고    scopus 로고
    • Fas receptor-mediated apoptosis: A clinical application
    • Timmer, T.; de Vries, E. G.; de Jong, S. Fas receptor-mediated apoptosis: a clinical application? J. Pathol., 2002, 196, 125-134.
    • (2002) J. Pathol , vol.196 , pp. 125-134
    • Timmer, T.1    de Vries, E.G.2    de Jong, S.3
  • 174
    • 58149456883 scopus 로고    scopus 로고
    • Death receptors as targets for anti-cancer therapy
    • Papenfuss, K.; Cordier, S. M.; Walczak, H. Death receptors as targets for anti-cancer therapy. J. Cell Mol. Med., 2008, 12, 2566-2585.
    • (2008) J. Cell Mol. Med , vol.12 , pp. 2566-2585
    • Papenfuss, K.1    Cordier, S.M.2    Walczak, H.3
  • 175
    • 0031472398 scopus 로고    scopus 로고
    • Gene transfer of Fas ligand induces tumor regression in vivo
    • Arai, H.; Gordon, D.; Nabel, E. G.; Nabel, G. J. Gene transfer of Fas ligand induces tumor regression in vivo. Proc. Natl. Acad. Sci. U.S.A., 1997, 94, 13862-13867.
    • (1997) Proc. Natl. Acad. Sci. U.S.A , vol.94 , pp. 13862-13867
    • Arai, H.1    Gordon, D.2    Nabel, E.G.3    Nabel, G.J.4
  • 176
    • 0035318305 scopus 로고    scopus 로고
    • Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity
    • Aoki, K.; Kurooka, M.; Chen, J. J.; Petryniak, J.; Nabel, E. G.; Nabel, G. J. Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity. Nat. Immunol., 2001, 2, 333-337.
    • (2001) Nat. Immunol , vol.2 , pp. 333-337
    • Aoki, K.1    Kurooka, M.2    Chen, J.J.3    Petryniak, J.4    Nabel, E.G.5    Nabel, G.J.6
  • 177
    • 0041856115 scopus 로고    scopus 로고
    • Generation of a FasL-basedproapoptotic fusion protein devoid of systemic toxicity due to cell surface antigen-restricted Activation
    • Samel, D.; Muller, D.; Gerspach, J.; Assohou-Luty, C.; Sass, G.; Tiegs, G.; Pfizenmaier, K.; Wajant, H. Generation of a FasL-basedproapoptotic fusion protein devoid of systemic toxicity due to cell surface antigen-restricted Activation. J. Biol. Chem., 2003, 278, 32077-32082.
    • (2003) J. Biol. Chem , vol.278 , pp. 32077-32082
    • Samel, D.1    Muller, D.2    Gerspach, J.3    Assohou-Luty, C.4    Sass, G.5    Tiegs, G.6    Pfizenmaier, K.7    Wajant, H.8
  • 178
    • 0031044915 scopus 로고    scopus 로고
    • In vivo analysis of Fas antigen-mediated apoptosis: Effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver
    • Nishimura, Y.; Hirabayashi, Y.; Matsuzaki, Y.; Musette, P.; Ishii, A.; Nakauchi, H.; Inoue, T.; Yonehara, S. In vivo analysis of Fas antigen-mediated apoptosis: effects of agonistic anti-mouse Fas mAb on thymus, spleen and liver. Int. Immunol., 1997, 9, 307-316.
    • (1997) Int. Immunol , vol.9 , pp. 307-316
    • Nishimura, Y.1    Hirabayashi, Y.2    Matsuzaki, Y.3    Musette, P.4    Ishii, A.5    Nakauchi, H.6    Inoue, T.7    Yonehara, S.8
  • 180
    • 0031438150 scopus 로고    scopus 로고
    • Amelioration of systemic autoimmune disease by the stimulation of apoptosis- promoting receptor Fas with anti-Fas mAb
    • Nishimura-Morita, Y.; Nose, M.; Inoue, T.; Yonehara, S. Amelioration of systemic autoimmune disease by the stimulation of apoptosis- promoting receptor Fas with anti-Fas mAb. Int. Immunol., 1997, 9, 1793-1799.
    • (1997) Int. Immunol , vol.9 , pp. 1793-1799
    • Nishimura-Morita, Y.1    Nose, M.2    Inoue, T.3    Yonehara, S.4
  • 182
    • 70449707487 scopus 로고    scopus 로고
    • Improving TNF as a cancer therapeutic: Tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects
    • Gerspach, J.; Pfizenmaier, K.; Wajant, H. Improving TNF as a cancer therapeutic: tailor-made TNF fusion proteins with conserved antitumor activity and reduced systemic side effects. Biofactors, 2009, 35, 364-372.
    • (2009) Biofactors , vol.35 , pp. 364-372
    • Gerspach, J.1    Pfizenmaier, K.2    Wajant, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.