Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis

Journal of Immunology

Volumn 162, Issue 9, 1999, Pages 5205-5211

  Algeciras Schimnich, Alicia ^a   Griffith, Thomas S ^c   Lynch, David H ^c   Paya, Carlos V ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; INTERLEUKIN 2 RECEPTOR ANTIBODY; RAPAMYCIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; NORMAL HUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; STEADY STATE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECEPTOR GENE;

AMINO ACID SEQUENCE; ANTIGENS, CD95; APOPTOSIS; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL CYCLE; CELLS, CULTURED; CYCLOSPORINE; DOWN-REGULATION; HUMANS; IMMUNE SERA; IMMUNITY, NATURAL; INTERLEUKIN-2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SIROLIMUS; T-LYMPHOCYTES;

EID: 0033136321     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Ju, S.-T., D. J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D. H. Sherr, B. Z. Stanger, and A. Marshak-Rothestein. 1995. Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444.
2. Van Parijs, L., A. Ibraghimov, and A. K. Abbas. 1996. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance. Immunity 4:321.
3. Singer, G. G., and A. K. Abbas. 1994. The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365.
4. Mogil, R. J., L. Radvanyi, R. Gonzalez-Quintial, R. Miller, G. Mills, A. N. Theofilopoulos, and D. R. Green. 1995. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int. Immunol. 7:1451.
5. Nagata, S., and P. Golstein. 1995. The Fas death factor. Science 267:1449.
6. Dhein, J., H. Walczak, C. Baumler, K. M. Debatin, and P. H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature 373:438.
7. Alderson, M. R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F. Ramsdell, and D. H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71.
8. Ju, S. T., D. J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D. H. Sherr, and B. Z. Stanger. 1995. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444.
9. Rieux-Laucat, F., F. Le Deist, C. Hivroz, I. A. G. Roberts, K. M. Debatin, A. Fischer, and J. P. de Villartay. 1995. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268:1347.
10. Reap, E. A., D. Leslie, M. Abrahams, R. A. Eisenberg, and P. L. Cohen. 1995. Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice. J. Immunol. 154:936.
11. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
12. Ramsdell, R., M. S. Seaman, R. E. Miller, T. W. Tough, M. R. Alderson, and D. H. Lynch. 1994. gld/gld mice are unable to express a functional ligand for Fas. Eur. J. Immunol. 24:928.
13. Fisher, G. H., F. J. Rosenberg, S. E. Straus, J. K. Dale, L. A. Middelton, A. Y. Lin, W. Strober, M. J. Lenardo, and J. M. Puck. 1995. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81:935.
14. Boise, L. H., and C. B. Thompson. 1996. Hierarchical control of lymphocyte survival. Science 274:67.
15. Lenardo, M. J. 1991. Interleukin-2 programs mouse ab T lymphocytes for apoptosis. Nature 353:858.
16. Van Parijs, L., A. Biuckians, A. Ibragimov, F. W. Alt, D. M. Willerford, and A. K. Abbas. 1997. Functional responses and apoptosis of CD25 (IL-2Rα)-deficient T cells expressing a transgenic antigen receptor. J. Immunol. 158:3738.
17. Kneitz, B., T. Herrmann, S. Yonehara, and A. Schimpl. 1995. Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur. J. Immunol. 25:2572.
18. Willerford, D. M., J. Chen, J. A. Ferry, L. Davidson, A. Ma, and F. W. Alt. 1995. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521.
19. Chinnaiyan, A. M., K. O'Rourke, M. Tewari, and V. M. Dixit. 1995. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81:505.
20. Chinnaiyan, A. M., C. G. Tepper, M. F. Seldin, K. O'Rourke, F. C. Kischkel, S. Hellbardt, P. H. Krammer, M. E. Peter, and V. M. Dixit. 1996. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem. 271:4961.
21. Boldin, M. P., T. M. Goncharov, Y. V. Goltsev, and D. Wallach. 1996. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85:803.
22. Muzio, M., A. M. Chinnaiyan, F. C. Kischkel, K. O'Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J. D. Bretz, M. Zhang, R. Gentz, et al. 1996. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85:817.
23. Chinnaiyan, A. M., and V. M. Dixit. 1997. Portrait of an executioner: the molecular mechanism of Fas/APO-1-induced apoptosis. Semin. Immunol. 9:69.
24. Hu, S., C. Vincenz, M. Buller, and V. M. Dixit. 1997. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis. J. Biol. Chem. 272:9621.
25. Thome, M., P. Schneider, K. Hofmann, H. Fickenscher, E. Meinl, F. Neipel, C. Mattmann, K. Burns, J.-L. Bodmer, M. Schröter, et al. 1997. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386:517.
26. Irmler, M., M. Thome, M. Hahne, P. Schneider, K. Hofmann, V. Steiner, J.-L. Bodmer, M. Schröter, K. Burns, C. Mattmann, et al. 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388:190.
27. Srinivasula, S. M., M. Ahmad, S. Ottilie, F. Bullrich, S. Banks, Y. Wang, T. Fernandes-Alnemri, C. M. Croce, G. Litwack, K. J. Tomaselli, et al. 1997. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. 272:18542.
28. Hu, S., C. Vincenz, J. Ni, R. Gentz, and V. M. Dixit. 1997. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis. J. Biol. Chem. 272:17255.
29. Goltsev, Y. V., A. V. Kovalenko, E. Arnold, E. E. Varfolomeev, V. M. Brodianskii, and D. Wallach. 1997. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. 272:19641.
30. Refaelli, J., L. Van Parijs, C. A. London, J. Tschoop, and A. K. Abbas. 1998. Biochemical mechanisms of IL-2 regulated Fas-mediated T cell apoptosis. Immunity 8:615.
31. Griffith, T. S., W. A. Chin, G. C. Jackson, D. H. Lynch, and M. Z. Kubin. 1998. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells. J. Immunol. 161:2833.
32. Ezhevsky, S. A., H. Nagahara, A. M. Vocero-Akbani, D. R. Gius, M. C. Wei, and S. F. Dowdy. 1997. Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. USA 94:10699.
33. Lissy, N. A., L. F. Van Dyk, M. Becker-Hapak, A. Vocero-Akbani, J. H. Mendler, and S. F. Dowdy. 1998. TCR antigen-induced cell death occurs from a late G1 phase cell cycle check point. Immunity 8:57.
34. Green, D. R., and D.W. Scott. 1994. Activation-induced apoptosis in lymphocytes. Curr. Opin. Immunol. 6:476.
35. Krammer, P. H., I. Behrmann, P. Daniel, J. Dhein, and K.-M. Debatin. 1994. Regulation of apoptosis in the immune system. Curr. Biol. 6:279.
36. Suzuki, H., T. M. Kundig, C. Furlonger, A. Wakeham, E. Timms, T. Matsuyama, R. Schmits, J. J. Simard, P. S. Ohashi, and H. Griesser. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268: 1472.
37. Schreiber, S. L., and G. R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol. Today 13:136.
38. Dumont, F. J., M. J. Staruch, S. L. Koprak, M. R. Melino, and N. H. Sigal. 1990. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J. Immunol. 144:251.
39. 1/S-phase growth arrest in T lymphocytes. J. Biol. Chem. 268:3734.
40. Abraham, R. T., and G. J. Wiederrecht. 1996. Immunopharmacology of rapamycin. Anna. Rev. Immunol. 14:483 (Abstr.).
41. Johnson, R. T., C. S. Downes, and R. E. Meyn. 1993. The synchronization of mammalian cells. In The Cell Cycle: A Practical Approach. P. Fantes and R. Brooks, eds. IRL Press at Oxford University Press, Oxford and New York, pp. 1-23.
42. Lalande, M. 1990. A reversible arrest point in the late G1 phase of the mammalian cell cycle. Exp. Cell Res. 186:332.
43. Dianzani, U., M. Bragardo, D. DiFranco, C. Alliandi, P. Scagni, D. Buonfiglio, V. Redoglia, S. Bonissoni, A. Correra, I. Dianzani, et al. 1997. Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatrie patients with autoimmunity/lymphoproliferation. Blood 89:2871.
44. Sneller, M. C., J. Wang, J. K. Dale, W. Strober, L. A. Middelton, Y. Choi, T. A. Fleisher, M. S. Lim, E. S. Jaffe, J. M. Puck, et al. 1997. Clinical, immunologic, and genetic features of an autoimmune lymphoproliferation syndrome associated with abnormal lymphocyte apoptosis. Blood 89:1341.
45. Peter, M. E., F. C. Kischkel, C. G. Scheuerpflug, J. P. Medema, K.-M. Debatin, and P. H. Krammer. 1997. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex. Eur. J. Immunol. 27:1207.
46. Boehme, S. A., and M. J. Leonardo. 1993. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur. J. Immunol. 23:1552.
47. Pagano, M., S. W. Tam, A. M. Theodoras, P. Beer-Romero, G. Del Sal, V. Chau, P. R. Yew, G. F. Draetta, and M. Rolfe. 1995. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682.