Mutation of the DR5/TRAIL receptor 2 gene is infrequent in hepatocellular carcinoma

Cancer Letters

Volumn 181, Issue 2, 2002, Pages 205-208

  Jeng, Yung Ming ^a   Hsu, Hey Chi ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Hepatocellular carcinoma; Mutation; Tumor necrosis factor related apoptosis inducing ligand receptor 2

Indexed keywords

TUMOR NECROSIS FACTOR;

ARTICLE; BREAST CANCER; CARCINOGENESIS; CHROMOSOME 8P; CHROMOSOME MAP; CONTROLLED STUDY; GENE MUTATION; HEAD AND NECK CANCER; HETEROZYGOSITY; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LUNG CANCER; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; RNA SPLICING;

CARCINOMA, HEPATOCELLULAR; GENES, TUMOR SUPPRESSOR; HUMANS; LIVER NEOPLASMS; MUTATION; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR;

EID: 0037178558     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(02)00051-4     Document Type: Article

References (18)

1. Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma
2. Allelic losses at chromosome 8p21-23 are early and frequent events in the pathogenesis of lung cancer
3. Localization of chromosome 8p regions involved in early tumorigenesis of oral and laryngeal squamous carcinoma
4. Homozygous deletions at 8p22 and 8p21 in prostate pancer implicate these regions as the sites for candidate tumor suppressor genes
5. Loss of heterozygosity from the short arm of chromosome 8 is associated with invasive behavior in breast cancer
6. Apoptosis by death factor
7. TRAIL: A molecule with multiple receptors and control mechanisms
8. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL
9. The receptor for the cytotoxic ligand TRAIL
10. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB
11. Rare loss-of-function mutation of a death receptor gene in head and neck cancer
12. Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers
13. Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers
14. Somatic mutations of TRAIL-receptor 1 and TRAIL-receptor 2 genes in non-Hodgkin's lymphoma
15. Genomic organization and mutation analyzes of the DR5/TRAIL receptor 2 gene in colorectal carcinomas
16. TRAIL receptor-2 signals apoptosis through FADD and caspase-8
17. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
18. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma