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Volumn 102, Issue 1, 2003, Pages 303-310

The proteasome inhibitor PS-341 sensitizes neoplastic cells to TRAIL-mediated apoptosis by reducing levels of c-FLIP

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

EID: 0038240386     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-09-2975     Document Type: Article
Times cited : (210)

References (48)
  • 1
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • Adams J, Palombella VJ, Sausville EA, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999;59:2615-2622.
    • (1999) Cancer Res , vol.59 , pp. 2615-2622
    • Adams, J.1    Palombella, V.J.2    Sausville, E.A.3
  • 2
    • 0033817518 scopus 로고    scopus 로고
    • Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341
    • Frankel A, Man S, Elliott P, Adams J, Kerbel RS. Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin Cancer Res. 2000;6:3719-3728.
    • (2000) Clin Cancer Res , vol.6 , pp. 3719-3728
    • Frankel, A.1    Man, S.2    Elliott, P.3    Adams, J.4    Kerbel, R.S.5
  • 3
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo JB, Chen Z, Dong G, et al. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res. 2001;7:1419-1428.
    • (2001) Clin Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3
  • 4
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res. 2001;61:3071-3076.
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 5
    • 0036023407 scopus 로고    scopus 로고
    • A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
    • Aghajanian C, Soignet S, Dizon DS, et al. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res. 2002;8:2505-2511.
    • (2002) Clin Cancer Res , vol.8 , pp. 2505-2511
    • Aghajanian, C.1    Soignet, S.2    Dizon, D.S.3
  • 6
    • 0003305854 scopus 로고    scopus 로고
    • Dose dependent inhibition of 20S proteasome results in a serum IL-6 and PSA decline in patients with androgen-independent prostate cancer treated with the proteasome inhibitor PS-341
    • Logothetis CJ, Yang H, Daliani D, et al. Dose dependent inhibition of 20S proteasome results in a serum IL-6 and PSA decline in patients with androgen-independent prostate cancer treated with the proteasome inhibitor PS-341 [abstract]. ASCO. 2001;20:186a.
    • (2001) ASCO , vol.20
    • Logothetis, C.J.1    Yang, H.2    Daliani, D.3
  • 7
    • 0000814476 scopus 로고    scopus 로고
    • A phase I trial of the proteasome inhibitor PS-341 in patients with advanced cancer
    • Erlichman C, Adjei AA, Thomas JP, et al. A phase I trial of the proteasome inhibitor PS-341 in patients with advanced cancer [abstract]. ASCO. 2001;20:85a.
    • (2001) ASCO , vol.20
    • Erlichman, C.1    Adjei, A.A.2    Thomas, J.P.3
  • 8
    • 0035215395 scopus 로고    scopus 로고
    • Proteasome inhibition in cancer: Development of PS-341
    • Adams J. Proteasome inhibition in cancer: development of PS-341. Semin Oncol. 2001;28:613-619.
    • (2001) Semin Oncol , vol.28 , pp. 613-619
    • Adams, J.1
  • 9
    • 0032929520 scopus 로고    scopus 로고
    • Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
    • Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999;5:157-163.
    • (1999) Nat Med , vol.5 , pp. 157-163
    • Walczak, H.1    Miller, R.E.2    Ariail, K.3
  • 10
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB
    • Baldwin AS. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest. 2001;107:241-246.
    • (2001) J Clin Invest , vol.107 , pp. 241-246
    • Baldwin, A.S.1
  • 11
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang CY, Mayo MW, Korneluk RG, Goeddel DV, Baldwin AS Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 1998;281:1680-1683.
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin A.S., Jr.5
  • 12
    • 0032516651 scopus 로고    scopus 로고
    • IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival
    • Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF. IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival. Science. 1998;281:998-1001.
    • (1998) Science , vol.281 , pp. 998-1001
    • Wu, M.X.1    Ao, Z.2    Prasad, K.V.3    Wu, R.4    Schlossman, S.F.5
  • 13
    • 0033621956 scopus 로고    scopus 로고
    • The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L)
    • Chen C, Edelstein LC, Gelinas C. The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol Cell Biol. 2000;20:2687-2695.
    • (2000) Mol Cell Biol , vol.20 , pp. 2687-2695
    • Chen, C.1    Edelstein, L.C.2    Gelinas, C.3
  • 14
    • 0033558215 scopus 로고    scopus 로고
    • The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
    • Zong WX, Edelstein LC, Chen C, Bash J, Gelinas C. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev. 1999;13:382-387.
    • (1999) Genes Dev , vol.13 , pp. 382-387
    • Zong, W.X.1    Edelstein, L.C.2    Chen, C.3    Bash, J.4    Gelinas, C.5
  • 15
    • 0034744033 scopus 로고    scopus 로고
    • NF-kappaB inducers upregulate cFLIP, a cyclo-heximide-sensitive inhibitor of death receptor signaling
    • Kreuz S, Siegmund D, Scheurich P, Wajant H. NF-kappaB inducers upregulate cFLIP, a cyclo-heximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol. 2001;21:3964-3973.
    • (2001) Mol Cell Biol , vol.21 , pp. 3964-3973
    • Kreuz, S.1    Siegmund, D.2    Scheurich, P.3    Wajant, H.4
  • 16
    • 0035340285 scopus 로고    scopus 로고
    • The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells
    • Franco AV, Zhang XD, Van Berkel E, et al. The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells. J Immunol. 2001;166:5337-5345.
    • (2001) J Immunol , vol.166 , pp. 5337-5345
    • Franco, A.V.1    Zhang, X.D.2    Van Berkel, E.3
  • 17
    • 0034353454 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines
    • Keane MM, Rubinstein Y, Cuello M, et al. Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines. Breast Cancer Res Treat. 2000;64:211-219.
    • (2000) Breast Cancer Res Treat , vol.64 , pp. 211-219
    • Keane, M.M.1    Rubinstein, Y.2    Cuello, M.3
  • 18
    • 0031810458 scopus 로고    scopus 로고
    • Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells
    • Jeremias I, Kupatt C, Baumann B, et al. Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells. Blood. 1998;91:4624-4631.
    • (1998) Blood , vol.91 , pp. 4624-4631
    • Jeremias, I.1    Kupatt, C.2    Baumann, B.3
  • 19
    • 0034477093 scopus 로고    scopus 로고
    • NF-kappa B does not modulate sensitivity of renal carcinoma cells to TNF alpha-related apoptosis-inducing ligand (TRAIL)
    • Pawlowski JE, Nesterov A, Scheinman RI, Johnson TR, Kraft AS. NF-kappa B does not modulate sensitivity of renal carcinoma cells to TNF alpha-related apoptosis-inducing ligand (TRAIL). Anticancer Res. 2000;20:4243-4255.
    • (2000) Anticancer Res , vol.20 , pp. 4243-4255
    • Pawlowski, J.E.1    Nesterov, A.2    Scheinman, R.I.3    Johnson, T.R.4    Kraft, A.S.5
  • 20
    • 0032697485 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways
    • Hu WH, Johnson H, Shu HB. Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J Biol Chem. 1999;274:30603-30610.
    • (1999) J Biol Chem , vol.274 , pp. 30603-30610
    • Hu, W.H.1    Johnson, H.2    Shu, H.B.3
  • 21
    • 0023740799 scopus 로고
    • Interpretation of clinical trials in diffuse large-cell lymphoma
    • Armitage JO, Cheson BD. Interpretation of clinical trials in diffuse large-cell lymphoma. J Clin Oncol. 1988;6:1335-1347.
    • (1988) J Clin Oncol , vol.6 , pp. 1335-1347
    • Armitage, J.O.1    Cheson, B.D.2
  • 22
    • 0025152039 scopus 로고
    • Treatment of testicular cancer: A new and improved model
    • Einhorn LH. Treatment of testicular cancer: a new and improved model. J Clin Oncol. 1990;8:1777-1781.
    • (1990) J Clin Oncol , vol.8 , pp. 1777-1781
    • Einhorn, L.H.1
  • 23
    • 0027940491 scopus 로고
    • Leukemia relapse after allogeneic bone marrow transplantation: A review
    • Giralt SA, Champlin RE. Leukemia relapse after allogeneic bone marrow transplantation: a review. Blood. 1994;84:3603-3612.
    • (1994) Blood , vol.84 , pp. 3603-3612
    • Giralt, S.A.1    Champlin, R.E.2
  • 24
    • 0034886002 scopus 로고    scopus 로고
    • High-dose chemotherapy and hematopoietic stem cell transplantation for breast cancer: Past or future?
    • Baynes RD, Dansey RD, Klein JL, et al. High-dose chemotherapy and hematopoietic stem cell transplantation for breast cancer: past or future? Semin Oncol. 2001;28:377-388.
    • (2001) Semin Oncol , vol.28 , pp. 377-388
    • Baynes, R.D.1    Dansey, R.D.2    Klein, J.L.3
  • 25
    • 0034643512 scopus 로고    scopus 로고
    • Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer: Philadelphia Bone Marrow Transplant Group
    • Stadtmauer EA, O'Neill A, Goldstein LJ, et al. Conventional-dose chemotherapy compared with high-dose chemotherapy plus autologous hematopoietic stem-cell transplantation for metastatic breast cancer: Philadelphia Bone Marrow Transplant Group. N Engl J Med. 2000;342:1069-1076.
    • (2000) N Engl J Med , vol.342 , pp. 1069-1076
    • Stadtmauer, E.A.1    O'Neill, A.2    Goldstein, L.J.3
  • 26
    • 0003633755 scopus 로고
    • Washington, DC: National Academy Press; NIH publication no. 86-23
    • National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Academy Press; 1985. NIH publication no. 86-23.
    • (1985) Guide for the Care and Use of Laboratory Animals
  • 27
    • 0033849643 scopus 로고    scopus 로고
    • T cell lysis of murine renal cancer: Multiple signaling pathways for cell death via Fas
    • Sayers TJ, Brooks AD, Seki N, et al. T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas. J Leukoc Biol. 2000;68:81-86.
    • (2000) J Leukoc Biol , vol.68 , pp. 81-86
    • Sayers, T.J.1    Brooks, A.D.2    Seki, N.3
  • 28
    • 0035423575 scopus 로고    scopus 로고
    • Three-color flow cytometric assay for the study of the mechanisms of cell-mediated cytotoxicity
    • Derby E, Reddy V, Kopp W, et al. Three-color flow cytometric assay for the study of the mechanisms of cell-mediated cytotoxicity. Immunol Lett. 2001;78:35-39.
    • (2001) Immunol Lett , vol.78 , pp. 35-39
    • Derby, E.1    Reddy, V.2    Kopp, W.3
  • 29
    • 0034037622 scopus 로고    scopus 로고
    • Proteasome inhibition measurements: Clinical application
    • Lightcap ES, McCormack TA, Pien CS, et al. Proteasome inhibition measurements: clinical application. Clin Chem. 2000;46:673-683.
    • (2000) Clin Chem , vol.46 , pp. 673-683
    • Lightcap, E.S.1    McCormack, T.A.2    Pien, C.S.3
  • 30
    • 0035863798 scopus 로고    scopus 로고
    • The restricted expression of granzyme M in human lymphocytes
    • Sayers TJ, Brooks AD, Ward JM, et al. The restricted expression of granzyme M in human lymphocytes. J Immunol. 2001;166:765-771.
    • (2001) J Immunol , vol.166 , pp. 765-771
    • Sayers, T.J.1    Brooks, A.D.2    Ward, J.M.3
  • 31
    • 0035736099 scopus 로고    scopus 로고
    • The proteasome: A new target for novel drug therapies
    • Elliott PJ, Ross JS. The proteasome: a new target for novel drug therapies. Am J Clin Pathol. 2001;116:637-646.
    • (2001) Am J Clin Pathol , vol.116 , pp. 637-646
    • Elliott, P.J.1    Ross, J.S.2
  • 32
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-kappaB inhibition
    • Cusack JC Jr, Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. 2001;61:3535-3540.
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack J.C., Jr.1    Liu, R.2    Houston, M.3
  • 33
    • 0034875305 scopus 로고    scopus 로고
    • Chemo sensitization of pancreatic cancer by inhibition of the 26S proteasome
    • Bold RJ, Virudachalam S, McConkey DJ. Chemo sensitization of pancreatic cancer by inhibition of the 26S proteasome. J Surg Res. 2001;100:11-17.
    • (2001) J Surg Res , vol.100 , pp. 11-17
    • Bold, R.J.1    Virudachalam, S.2    McConkey, D.J.3
  • 34
    • 0035341494 scopus 로고    scopus 로고
    • Enhancement of radiosensitivity by proteasome inhibition: Implications for a role of NF-kappaB
    • Russo SM, Tepper JE, Baldwin AS Jr, et al. Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Int J Radiat Oncol Biol Phys. 2001;50:183-193.
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 183-193
    • Russo, S.M.1    Tepper, J.E.2    Baldwin A.S., Jr.3
  • 35
    • 0037151079 scopus 로고    scopus 로고
    • An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
    • Kim Y, Suh N, Sporn M, Reed JC. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem. 2002;277:22320-22329.
    • (2002) J Biol Chem , vol.277 , pp. 22320-22329
    • Kim, Y.1    Suh, N.2    Sporn, M.3    Reed, J.C.4
  • 36
    • 17944373682 scopus 로고    scopus 로고
    • Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells
    • Fukazawa T, Fujiwara T, Uno F, et al. Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Oncogene. 2001;20:5225-5231.
    • (2001) Oncogene , vol.20 , pp. 5225-5231
    • Fukazawa, T.1    Fujiwara, T.2    Uno, F.3
  • 37
    • 0033136321 scopus 로고    scopus 로고
    • Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis
    • Algeciras-Schimnich A, Griffith TS, Lynch DH, Paya CV. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. J Immunol. 1999;162:5205-5211.
    • (1999) J Immunol , vol.162 , pp. 5205-5211
    • Algeciras-Schimnich, A.1    Griffith, T.S.2    Lynch, D.H.3    Paya, C.V.4
  • 38
    • 0033662341 scopus 로고    scopus 로고
    • Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
    • Yeh WC, Itie A, Elia AJ, et al. Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity. 2000;12:633-642.
    • (2000) Immunity , vol.12 , pp. 633-642
    • Yeh, W.C.1    Itie, A.2    Elia, A.J.3
  • 39
    • 0037006003 scopus 로고    scopus 로고
    • The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis
    • Bin L, Li X, Xu LG, Shu HB. The short splice form of Casper/c-FLIP is a major cellular inhibitor of TRAIL-induced apoptosis. FEBS Lett. 2002;510:37-40.
    • (2002) FEBS Lett , vol.510 , pp. 37-40
    • Bin, L.1    Li, X.2    Xu, L.G.3    Shu, H.B.4
  • 40
    • 0034659824 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis
    • Zamai L, Secchiero P, Pierpaoli S, et al. TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis. Blood. 2000;95:3716-3724.
    • (2000) Blood , vol.95 , pp. 3716-3724
    • Zamai, L.1    Secchiero, P.2    Pierpaoli, S.3
  • 41
    • 0032717188 scopus 로고    scopus 로고
    • TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells
    • Gazitt Y. TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells. Leukemia. 1999;13:1817-1824.
    • (1999) Leukemia , vol.13 , pp. 1817-1824
    • Gazitt, Y.1
  • 42
    • 0035211881 scopus 로고    scopus 로고
    • Novel therapies targeting the myeloma cell and its bone marrow microenvironment
    • Hideshima T, Chauhan D, Podar K, et al. Novel therapies targeting the myeloma cell and its bone marrow microenvironment. Semin Oncol. 2001;28:607-612.
    • (2001) Semin Oncol , vol.28 , pp. 607-612
    • Hideshima, T.1    Chauhan, D.2    Podar, K.3
  • 43
    • 0035437171 scopus 로고    scopus 로고
    • TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
    • Mitsiades CS, Treon SP, Mitsiades N, et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood. 2001;98:795-804.
    • (2001) Blood , vol.98 , pp. 795-804
    • Mitsiades, C.S.1    Treon, S.P.2    Mitsiades, N.3
  • 44
    • 0035313175 scopus 로고    scopus 로고
    • TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells
    • Nieda M, Nicol A, Koezuka Y, et al. TRAIL expression by activated human CD4(+)V alpha 24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. Blood. 2001;97:2067-2074.
    • (2001) Blood , vol.97 , pp. 2067-2074
    • Nieda, M.1    Nicol, A.2    Koezuka, Y.3
  • 45
    • 0032169208 scopus 로고    scopus 로고
    • TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells
    • Thomas WD, Hersey P. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells. J Immunol. 1998;161:2195-2200.
    • (1998) J Immunol , vol.161 , pp. 2195-2200
    • Thomas, W.D.1    Hersey, P.2
  • 46
    • 0032713075 scopus 로고    scopus 로고
    • Safety and antitumor activity of recombinant soluble Apo2 ligand
    • Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest. 1999;104:155-162.
    • (1999) J Clin Invest , vol.104 , pp. 155-162
    • Ashkenazi, A.1    Pai, R.C.2    Fong, S.3
  • 47
    • 0034022160 scopus 로고    scopus 로고
    • Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
    • Jo M, Kim TH, Seol DW, et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med. 2000;6:564-567.
    • (2000) Nat Med , vol.6 , pp. 564-567
    • Jo, M.1    Kim, T.H.2    Seol, D.W.3
  • 48
    • 0034596514 scopus 로고    scopus 로고
    • Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL)
    • Nitsch R, Bechmann I, Deisz RA, et al. Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL). Lancet. 2000;356:827-828.
    • (2000) Lancet , vol.356 , pp. 827-828
    • Nitsch, R.1    Bechmann, I.2    Deisz, R.A.3


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