Tumor-cell resistance to death receptor-induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax

Nature Medicine

Volumn 8, Issue 3, 2002, Pages 274-281

  LeBlanc, Heidi ^a   Lawrence, David ^a   Varfolomeev, Eugene ^a   Totpal, Klara ^a   Morlan, John ^b   Schow, Peter ^c   Fong, Sharon ^a   Schwall, Ralph ^a   Sinicropi, Dominick ^b   Ashkenazi, Avi ^a  

^a Molecular Oncology   (United States)

^b Departments of Analytical Assay Technology   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; FEMALE; FRAMESHIFT MUTATION; GENE DELETION; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MISMATCH REPAIR; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CAMPTOTHECIN; CARRIER PROTEINS; CASPASE 8; CASPASE 9; CASPASES; COLONIC NEOPLASMS; ENZYME ACTIVATION; ETOPOSIDE; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FEMALE; FLOW CYTOMETRY; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICE, NUDE; MITOCHONDRIA; MUTATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0036131142     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0302-274     Document Type: Article

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