Clinical use of TNF revisited: Improving penetration of anti-cancer agents by increasing vascular permeability

Journal of Clinical Investigation

Volumn 110, Issue 4, 2002, Pages 433-435

  Lejeune, Ferdy J ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CADHERIN; DOXORUBICIN; MATRIX METALLOPROTEINASE; MELPHALAN; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR; VASCULOTROPIN;

BLOOD VESSEL PERMEABILITY; CANCER; CANCER CHEMOTHERAPY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; HUMAN; MELANOMA; NONHUMAN; NOTE; PRIORITY JOURNAL; SOFT TISSUE SARCOMA; TUMOR GROWTH;

EID: 0036678175     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0216493     Document Type: Note

References (22)

1. Seed and soil revisited: Contribution of the organ microenvironment to cancer metastasis
2. Understanding barriers to drug delivery: High resolution in vivo imaging is key
3. Vascular permeability factor (VPF, VEGF) in tumor biology
4. Effect of local anti-VEGF antibody treatment on tumor microvessel permeability
5. Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts
6. Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor
7. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
8. Increased brain tumor microvessel permeability after intracarotid bradykinin infusion is mediated by nitric oxide
9. Enhanced vascular permeability in solid tumor involving peroxynitrite and matrix metalloproteinases
10. Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability
11. Intracarotid low dose bradykinin infusion selectively increases tumor permeability through activation of bradykinin B2 receptors in malignant gliomas
12. Clinical applications of TNF-alpha in cancer
13. A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability
14. High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma
15. Tumor-necrosis factor can enhance radio-antibody uptake in human colon carcinoma xenografts by increasing vascular permeability
16. In vivo effects of tumor necrosis factor-alpha on capillary permeability and vascular tone in a skeletal muscle
17. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma
18. Tumour necrosis factor alpha increases melphalan concentration in tumour tissue after isolated limb perfusion
19. TNF-alpha augments intratumoural concentrations of doxorubicin in TNF-alpha-based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects
20. Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats
21. Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
22. Isolated limb perfusion with high-dose tumor necrosis factoralpha in combination with interferon-gamma and melphalan for nonresectable extremity soft tissue sarcomas: A multicenter trial