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Volumn 4, Issue 4, 1998, Pages 408-414

Evidence for the involvement of endothelial cell integrin αVβ3 in the disruption of the tumor vasculature induced by TNF and IFN-γ

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; COLLAGEN; FIBRINOGEN; FIBRONECTIN; GAMMA INTERFERON; INTEGRIN; LYSOPHOSPHATIDIC ACID; MANGANESE CHLORIDE; MELPHALAN; MONOCLONAL ANTIBODY; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR; VITRONECTIN;

EID: 0040887215     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0498-408     Document Type: Article
Times cited : (436)

References (50)
  • 1
    • 0016723594 scopus 로고
    • An endotoxin-induced serum factor that causes necrosis of tumors
    • Carswell, E.A. et al. An endotoxin-induced serum factor that causes necrosis of tumors Proc. Natl. Acad. Sci. USA 72, 3666-3670 (1975).
    • (1975) Proc. Natl. Acad. Sci. USA , vol.72 , pp. 3666-3670
    • Carswell, E.A.1
  • 2
    • 0026531756 scopus 로고
    • High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma
    • Liénard, D., Ewalenko, P., Delmotte, J.J., Renard, N. & Lejeune, F.J. High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J. Clin. Oncol. 10, 52-60(1992).
    • (1992) J. Clin. Oncol. , vol.10 , pp. 52-60
    • Liénard, D.1    Ewalenko, P.2    Delmotte, J.J.3    Renard, N.4    Lejeune, F.J.5
  • 3
    • 0029034065 scopus 로고
    • High dose recombinant tumour necrosis factor (rTNF alpha) administered by isolation perfusion for advanced tumours of the limbs: A model for biochemotherapy of cancer, fur
    • Lejeune, F.J. High dose recombinant tumour necrosis factor (rTNF alpha) administered by isolation perfusion for advanced tumours of the limbs: a model for biochemotherapy of cancer, fur. J. Cancer 6, 1009-1016 (1995).
    • (1995) J. Cancer , vol.6 , pp. 1009-1016
    • Lejeune, F.J.1
  • 4
    • 0028329569 scopus 로고
    • Isolated perfusion of the limb with high-dose tumor necrosis factor-alpha (TNF-alpha), interferon gamma (IFN-γ) and melphalan for melanoma stage III. Results of a multi-centre pilot study
    • Liénard, D. et al. Isolated perfusion of the limb with high-dose tumor necrosis factor-alpha (TNF-alpha), interferon gamma (IFN-γ) and melphalan for melanoma stage III. Results of a multi-centre pilot study. Melanoma Res. 4, Suppl. 1, 21-26 (1994).
    • (1994) Melanoma Res. , vol.4 , Issue.1 SUPPL. , pp. 21-26
    • Liénard, D.1
  • 5
    • 0029144112 scopus 로고
    • Von Willenbrand Factor release and platelet aggregation in human melanoma after perfusion with TNFα
    • Renard, N. et al. von Willenbrand Factor release and platelet aggregation in human melanoma after perfusion with TNFα. J. Pathol. 176, 279-287 (1995).
    • (1995) J. Pathol. , vol.176 , pp. 279-287
    • Renard, N.1
  • 6
    • 0028232019 scopus 로고
    • Early endothelium activation and polymorphonuclear cell invasion preceed specific necrosis of human melanoma and sarcoma treated by intravascular high dose of Tumor Necrosis Factor alpha
    • Renard, N. et al. Early endothelium activation and polymorphonuclear cell invasion preceed specific necrosis of human melanoma and sarcoma treated by intravascular high dose of Tumor Necrosis Factor alpha. Int. J. Cancer 57, 656-663 (1994).
    • (1994) Int. J. Cancer , vol.57 , pp. 656-663
    • Renard, N.1
  • 7
    • 0028143758 scopus 로고
    • Confocal microscopic analysis of integrin expression on the microvasculature and its sprouts in the neonatal foreskin
    • Enenstein, J. & Kramer, R.H. Confocal microscopic analysis of integrin expression on the microvasculature and its sprouts in the neonatal foreskin. J. Invest. Dermatol. 103, 381-386 (1994).
    • (1994) J. Invest. Dermatol. , vol.103 , pp. 381-386
    • Enenstein, J.1    Kramer, R.H.2
  • 8
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • Brooks, P.C., Clark, R.A. & Cheresh, D.A. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264, 569-571 (1994).
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 9
    • 0030993245 scopus 로고    scopus 로고
    • Immunohistochemical analysis of integrin alpha v beta 3 expression on tumor-associated vessels of human carcinomas
    • Max, R. et al. Immunohistochemical analysis of integrin alpha v beta 3 expression on tumor-associated vessels of human carcinomas. Int. J. Cancer 71, 320-324 (1997).
    • (1997) Int. J. Cancer , vol.71 , pp. 320-324
    • Max, R.1
  • 10
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks, P.C. et al. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164 (1994).
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1
  • 11
    • 0028972105 scopus 로고
    • Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin
    • Brooks, P.C. et al. Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest. 96, 1815-1822 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 1815-1822
    • Brooks, P.C.1
  • 12
    • 0030038229 scopus 로고    scopus 로고
    • Suppression of p53 activity and p21 WAF1/CIP1 expression by vascular cell integrin alpha v beta 3 during angiogenesis
    • Stromblad, S., Becker, J.C., Yebra, M., Brooks, P.C. & Cheresh, D.A. Suppression of p53 activity and p21 WAF1/CIP1 expression by vascular cell integrin alpha v beta 3 during angiogenesis. J. Clin. Invest. 98, 426-433 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 426-433
    • Stromblad, S.1    Becker, J.C.2    Yebra, M.3    Brooks, P.C.4    Cheresh, D.A.5
  • 13
    • 0025807704 scopus 로고
    • Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor (integrin beta 3) in human endothehal cells
    • Defilippi, P. et al. Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor (integrin beta 3) in human endothehal cells. J. Biol. Chem. 266, 7638-7645 (1991).
    • (1991) J. Biol. Chem. , vol.266 , pp. 7638-7645
    • Defilippi, P.1
  • 15
    • 0028987936 scopus 로고
    • Integrins and signal transduction pathways: The road taken
    • Clark, E.A. & Brugge, J.S. Integrins and signal transduction pathways: the road taken. Science 268, 233-239 (1995).
    • (1995) Science , vol.268 , pp. 233-239
    • Clark, E.A.1    Brugge, J.S.2
  • 16
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes, C.D. & Hall, A. Rho, rac, and cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62 (1995).
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 17
    • 0027979834 scopus 로고
    • A mechanism for divalent cation regulation of beta 3-integrins
    • Smith, J.W., Piotrowicz, R.S. & Mathis, D. A mechanism for divalent cation regulation of beta 3-integrins. J. Biol. Chem. 269, 960-967 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 960-967
    • Smith, J.W.1    Piotrowicz, R.S.2    Mathis, D.3
  • 18
    • 0029039630 scopus 로고
    • Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit
    • Honda, S. et al. Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit. J. Biol. Chem. 270, 11947-11954 (1995).
    • (1995) J. Biol. Chem. , vol.270 , pp. 11947-11954
    • Honda, S.1
  • 19
    • 0029670835 scopus 로고    scopus 로고
    • Activation of the integrin alpha V beta 3 involves a discrete cation-binding site that regulates conformation
    • Pelletier, A.J., Kunicki, T. & quaranta, V. Activation of the integrin alpha V beta 3 involves a discrete cation-binding site that regulates conformation. J. Biol. Chem. 271, 1364-1370 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 1364-1370
    • Pelletier, A.J.1    Kunicki, T.2    Quaranta, V.3
  • 20
    • 0027451706 scopus 로고
    • The extracellular matrix as a cell survival factor
    • Meredith, J., Jr., Fazeli, B. & Schwartz, M.A. The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961 (1993).
    • (1993) Mol. Biol. Cell , vol.4 , pp. 953-961
    • Meredith Jr., J.1    Fazeli, B.2    Schwartz, M.A.3
  • 21
    • 0028072225 scopus 로고
    • Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
    • Re, F. et al. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J. Cell Biol. 127, 537-546 (1994).
    • (1994) J. Cell Biol. , vol.127 , pp. 537-546
    • Re, F.1
  • 22
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S.M. & Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626 (1994).
    • (1994) J. Cell Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 23
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1, 27-30 (1995).
    • (1995) Nature Med. , vol.1 , pp. 27-30
    • Folkman, J.1
  • 24
    • 0028041223 scopus 로고
    • Rationale for using TNF alpha and chemotherapy in regional therapy of melanoma
    • Lejeune, F. et al. Rationale for using TNF alpha and chemotherapy in regional therapy of melanoma. J. Cell. Biochem. 56, 52-61 (1994).
    • (1994) J. Cell. Biochem. , vol.56 , pp. 52-61
    • Lejeune, F.1
  • 25
    • 15844420283 scopus 로고    scopus 로고
    • Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
    • Brooks P.C. et al. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 85, 683-693 (1996).
    • (1996) Cell , vol.85 , pp. 683-693
    • Brooks, P.C.1
  • 27
    • 0029954523 scopus 로고    scopus 로고
    • Biology of chemokine and classical chemoattractant receptors: Differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells
    • Campbell, J.J., Qin, S., Bacon, K.B., Mackay, C.R. & Butcher, E.C. Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells. J. Cell Biol. 134, 255-266 (1996).
    • (1996) J. Cell Biol. , vol.134 , pp. 255-266
    • Campbell, J.J.1    Qin, S.2    Bacon, K.B.3    Mackay, C.R.4    Butcher, E.C.5
  • 28
    • 0028221289 scopus 로고
    • Negative feedback regulation of human platelets via autocrine activation of the platelet derived growth factor alpha receptor
    • Vassboth, F.S., Havnen, O.K., Heldin, C.H. & Holmsen, H. Negative feedback regulation of human platelets via autocrine activation of the platelet derived growth factor alpha receptor. J. Biol. Chem. 269, 13874-13879 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 13874-13879
    • Vassboth, F.S.1    Havnen, O.K.2    Heldin, C.H.3    Holmsen, H.4
  • 29
    • 0024485922 scopus 로고
    • Integrin phosphorylation is modulated during the differentiation of F-9 teratocarcinoma stem cells
    • Dahl, S.C. & Grabel, L.B. Integrin phosphorylation is modulated during the differentiation of F-9 teratocarcinoma stem cells. J. Cell Biol. 108, 183-190 (1989).
    • (1989) J. Cell Biol. , vol.108 , pp. 183-190
    • Dahl, S.C.1    Grabel, L.B.2
  • 30
    • 0025183918 scopus 로고
    • Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface
    • Adams, J.C. & Watt, F.M. Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface. Cell 63, 425-435 (1990).
    • (1990) Cell , vol.63 , pp. 425-435
    • Adams, J.C.1    Watt, F.M.2
  • 31
    • 0026084784 scopus 로고
    • Cell-surface regulation of beta 1-integrin activity on developing retinal neurons
    • Neugebauer, K.M. & Reichardt, L.F. Cell-surface regulation of beta 1-integrin activity on developing retinal neurons. Nature 350, 68-71 (1991).
    • (1991) Nature , vol.350 , pp. 68-71
    • Neugebauer, K.M.1    Reichardt, L.F.2
  • 32
    • 0028990008 scopus 로고
    • Regulation of integrin alpha 5 beta 1 affinity during myogenic differentiation
    • Boettiger, D. et al. Regulation of integrin alpha 5 beta 1 affinity during myogenic differentiation. Dev. Biol. 169, 261-272 (1995).
    • (1995) Dev. Biol. , vol.169 , pp. 261-272
    • Boettiger, D.1
  • 33
    • 0030909050 scopus 로고    scopus 로고
    • Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
    • Hughes, P.E. et al. Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 88, 521-530 (1997).
    • (1997) Cell , vol.88 , pp. 521-530
    • Hughes, P.E.1
  • 34
    • 0027471215 scopus 로고
    • Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho
    • Tominaga, T. et al. Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho. J. Cell Biol. 120, 1529-1537 (1993).
    • (1993) J. Cell Biol. , vol.120 , pp. 1529-1537
    • Tominaga, T.1
  • 35
    • 0027426128 scopus 로고
    • Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells
    • Saklatvala, J., Rawlinson, L.M., Marshall, C.J. & Kracht, M. Interleukin 1 and tumour necrosis factor activate the mitogen-activated protein (MAP) kinase kinase in cultured cells. Febs Letters 334, 189-192 (1993).
    • (1993) Febs Letters , vol.334 , pp. 189-192
    • Saklatvala, J.1    Rawlinson, L.M.2    Marshall, C.J.3    Kracht, M.4
  • 36
    • 0028945215 scopus 로고
    • Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase
    • Belka, C. et al. Tumor necrosis factor (TNF)-alpha activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase. Embo J. 14, 1156-1165 (1995).
    • (1995) Embo J. , vol.14 , pp. 1156-1165
    • Belka, C.1
  • 37
    • 0029954969 scopus 로고    scopus 로고
    • The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21 ras-dependent manner
    • Xia, K. et al. The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21 ras-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 93, 11681-11686 (1996).
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 11681-11686
    • Xia, K.1
  • 38
    • 0025037064 scopus 로고
    • IFN-γ enhances endothelial activation induced by tumor necrosis factor but not IL-1
    • Doukas, J. & Pober, J.S. IFN-γ enhances endothelial activation induced by tumor necrosis factor but not IL-1. J. Immunol. 145, 1727-1733 (1990).
    • (1990) J. Immunol. , vol.145 , pp. 1727-1733
    • Doukas, J.1    Pober, J.S.2
  • 39
    • 0028814601 scopus 로고
    • Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-γ plus TNF-α and inhibition by IL-4 and IL-13
    • Marfaing-Koka, A. et al. Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-γ plus TNF-α and inhibition by IL-4 and IL-13. J. Immunol. 154, 1870-1878 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 1870-1878
    • Marfaing-Koka, A.1
  • 40
    • 0026775859 scopus 로고
    • Interferon-gamma induces cell surface expression for both types of tumor necrosis factor receptors
    • Pandita, R., Pocsik, E. & Aggarwal, B.B. Interferon-gamma induces cell surface expression for both types of tumor necrosis factor receptors. Febs Letters 312, 87-90 (1992).
    • (1992) Febs Letters , vol.312 , pp. 87-90
    • Pandita, R.1    Pocsik, E.2    Aggarwal, B.B.3
  • 41
    • 0029034506 scopus 로고
    • The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-alpha
    • Ohmori, Y. & Hamilton, T.A. The interferon-stimulated response element and a kappa B site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-alpha. J. Immunol. 154, 5235-5244 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 5235-5244
    • Ohmori, Y.1    Hamilton, T.A.2
  • 42
    • 0027957398 scopus 로고
    • HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons
    • Johnson, D.R. & Pober, J.S. HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons. Molec. Cel. Biol. 14, 1322-1332 (1994).
    • (1994) Molec. Cel. Biol. , vol.14 , pp. 1322-1332
    • Johnson, D.R.1    Pober, J.S.2
  • 43
    • 0345284286 scopus 로고    scopus 로고
    • Treatment of in-transit melanoma metastases with Tumor Necrosis Factor (TNF) and chemotherapy administered in isolated limb perfusion (ILP)
    • Lejeune, F.J., Lienard, D., Schraffordt Koops, H., Kroon, B. & Eggermont, A.M.M. Treatment of in-transit melanoma metastases with Tumor Necrosis Factor (TNF) and chemotherapy administered in isolated limb perfusion (ILP). Melanoma Res. 7, S48 (1997).
    • (1997) Melanoma Res. , vol.7
    • Lejeune, F.J.1    Lienard, D.2    Schraffordt Koops, H.3    Kroon, B.4    Eggermont, A.M.M.5
  • 44
    • 0028500836 scopus 로고
    • Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN-γ receptors
    • Digne, A.S., Richards, E., Old, L.J. & Schreiber, R.D. Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFN-γ receptors. Immunity 1, 447-456 (1994).
    • (1994) Immunity , vol.1 , pp. 447-456
    • Digne, A.S.1    Richards, E.2    Old, L.J.3    Schreiber, R.D.4
  • 45
    • 0029001244 scopus 로고
    • Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
    • Sato, T.N. et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376, 70-74 (1995).
    • (1995) Nature , vol.376 , pp. 70-74
    • Sato, T.N.1
  • 46
    • 0030480322 scopus 로고    scopus 로고
    • Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    • Suri, C. et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171-1180 (1996).
    • (1996) Cell , vol.87 , pp. 1171-1180
    • Suri, C.1
  • 47
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    • Maisonpierre, P.C. et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55-60 (1997).
    • (1997) Science , vol.277 , pp. 55-60
    • Maisonpierre, P.C.1
  • 48
    • 0025996029 scopus 로고
    • Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion
    • Spertini, O. et al. Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J. Immunol. 147, 2565-2573 (1991).
    • (1991) J. Immunol. , vol.147 , pp. 2565-2573
    • Spertini, O.1
  • 49
    • 0026950540 scopus 로고
    • High serum levels of TNF-alpha after its administration for isolation perfusion of the limb
    • Gérain, J., Lienard, D., Ewalenko, P. & Lejeune, F.J. High serum levels of TNF-alpha after its administration for isolation perfusion of the limb. Cytokine 4, 585-591 (1992).
    • (1992) Cytokine , vol.4 , pp. 585-591
    • Gérain, J.1    Lienard, D.2    Ewalenko, P.3    Lejeune, F.J.4
  • 50
    • 0028029566 scopus 로고
    • Growth inhibition of human colorectal-carcinoma cells by interleukin-4 and expression of functional interleukin-4 receptors
    • Lahm, H. et al. Growth inhibition of human colorectal-carcinoma cells by interleukin-4 and expression of functional interleukin-4 receptors. Int. J. Cancer 59, 440-447 (1994).
    • (1994) Int. J. Cancer , vol.59 , pp. 440-447
    • Lahm, H.1


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