Adipocytokines in atherothrombosis: Focus on platelets and vascular smooth muscle cells

Mediators of Inflammation

Volumn 2010, Issue , 2010, Pages

  Anfossi, Giovanni ^a   Russo, Isabella ^a   Doronzo, Gabriella ^a   Pomero, Alice ^a   Trovati, Mariella ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ENDOTHELIN; ENDOTHELIN 1; GHRELIN; INTERLEUKIN 6; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PADGEM PROTEIN; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CHRONIC INFLAMMATION; CYTOKINE RELEASE; ENDOTHELIAL DYSFUNCTION; HUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVIEW; SMOOTH MUSCLE FIBER; THROMBOCYTE FUNCTION; THROMBOCYTE VOLUME; VASCULAR SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; BLOOD; INFLAMMATION; INSULIN RESISTANCE; METABOLISM; OBESITY; PHYSIOLOGY; THROMBOCYTE; THROMBOSIS;

ADIPOKINES; ANIMALS; ATHEROSCLEROSIS; BLOOD PLATELETS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; INTERLEUKIN-6; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OBESITY; THROMBOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955402723     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2010/174341     Document Type: Review

References (343)

1. Yusuf S., Hawken S., unpuu S., Bautista L., Franzosi M. G., Commerford P., Lang C. C., Rumboldt Z., Onen C. L., Lisheng L., Tanomsup S., Wangai P. Jr., Razak F., Sharma A. M., Anand S. S., Obesity and the risk of myocardial infarction in 27 000 participants from 52 countries: a case-control study The Lancet 2005 366 9497 1640 1649
2. Lebovitz H. E., Banerji M. A., Point: visceral adiposity is causally related to insulin resistance Diabetes Care 2005 28 9 2322 2325
3. Klein S., Allison D. B., Heymsfield S. B., Kelley D. E., Leibel R. L., Nonas C., Kahn R., Waist circumference and cardiometabolic risk: a consensus statement from Shaping America's Health: association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association Diabetes Care 2007 30 6 1647 1652
4. Alberti K. G. M. M., Eckel R. H., Grundy S. M., Zimmet P. Z., Cleeman J. I., Donato K. A., Fruchart J.-C., James W. P. T., Loria C. M., Smith S. C., Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 2009 120 16 1640 1645
5. Reaven G., Abbasi F., McLaughlin T., Obesity, insulin resistance, and cardiovascular disease Recent Progress in Hormone Research 2004 59 207 223
6. Van Gaal L. F., Mertens I. L., De Block C. E., Mechanisms linking obesity with cardiovascular disease Nature 2006 444 7121 875 880
7. Kakafika A. I., Liberopoulos E. N., Karagiannis A., Athyros V. G., Mikhailidis D. P., Dyslipidaemia, hypercoagulability and the metabolic syndrome Current Vascular Pharmacology 2006 4 3 175 183
8. Wellen K. E., Hotamisligil G. S., Obesity-induced inflammatory changes in adipose tissue Journal of Clinical Investigation 2003 112 12 1785 1788
9. Fain J. N., Madan A. K., Hiler M. L., Cheema P., Bahouth S. W., Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans Endocrinology 2004 145 5 2273 2282
10. Waki H., Tontonoz P., Endocrine functions of adipose tissue Annual Review of Pathology 2007 2 31 56
11. Matsuzawa Y., Therapy insight: adipocytokines in metabolic syndrome and related cardiovascular disease Nature Clinical Practice Cardiovascular Medicine 2006 3 1 35 42
12. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W. Jr., Obesity is associated with macrophage accumulation in adipose tissue Journal of Clinical Investigation 2003 112 12 1796 1808
13. Hotamisligil G. S., Inflammation and metabolic disorders Nature 2006 444 7121 860 867
14. Harman-Boehm I., Blher M., Redel H., Sion-Vardy N., Ovadia S., Avinoach E., Shai I., Klting N., Stumvoll M., Bashan N., Rudich A., Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity Journal of Clinical Endocrinology and Metabolism 2007 92 6 2240 2247
15. Rajala M. W., Scherer P. E., Minireview: the adipocyteat the crossroads of energy homeostasis, inflammation, and atherosclerosis Endocrinology 2003 144 9 3765 3773
16. Suganami T., Nishida J., Ogawa Y., A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 10 2062 2068
17. Umemura S., Nyui N., Tamura K., Hibi K., Yamaguchi S., Nakamaru M., Ishigami T., Yabana M., Kihara M., Inoue S., Ish M. II, Plasma angiotensinogen concentrations in obese patients American Journal of Hypertension 1997 10 6 629 633
18. Francischetti E. A., Genelhu V. A., Obesity-hypertension: an ongoing pandemic International Journal of Clinical Practice 2007 61 2 269 280
19. Calabro P., Yeh E. T. H., Intra-abdominal adiposity, inflammation, and cardiovascular risk: new insight into global cardiometabolic risk Current Hypertension Reports 2008 10 1 32 38
20. Alessi M.-C., Juhan-Vague I., Metabolic syndrome, haemostasis and thrombosis Thrombosis and Haemostasis 2008 99 6 995 1000
21. Anfossi G., Russo I., Trovati M., Platelet dysfunction in central obesity Nutrition, Metabolism and Cardiovascular Diseases 2009 19 6 440 449
22. Anfossi G., Russo I., Doronzo G., Trovati M., Contribution of insulin resistance to vascular dysfunction Archives of Physiology and Biochemistry 2009 115 4 199 217
23. George J. N., Platelets The Lancet 2000 355 9214 1531 1539
24. Junt T., Schulze H., Chen Z., Massberg S., Goerge T., Krueger A., Wagner D. D., Graf T., Italiano J. E. Jr., Shivdasani R. A., Von Andrian U. H., Dynamic visualization of thrombopoiesis within bone marrow Science 2007 317 5845 1767 1770
25. Bluteau D., Lordier L., Di Stefano A., Chang Y., Raslova H., Debili N., Vainchenker W., Regulation of megakaryocyte maturation and platelet formation Journal of Thrombosis and Haemostasis 2009 7 1 227 234
26. Gawaz M., Langer H., May A. E., Platelets in inflammation and atherogenesis Journal of Clinical Investigation 2005 115 12 3378 3384
27. Lindemann S., Krmer B., Seizer P., Gawaz M., Platelets, inflammation and atherosclerosis Journal of Thrombosis and Haemostasis 2007 5 1 203 211
28. Ruggeri Z. M., Mendolicchio G. L., Adhesion mechanisms in platelet function Circulation Research 2007 100 12 1673 1685
29. Varga-Szabo D., Pleines I., Nieswandt B., Cell adhesion mechanisms in platelets Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 3 403 413
30. Rivera J., Lozano M. L., Navarro-Nez L., Vicente Garca V., Platelet receptors and signaling in the dynamics of thrombus formation Haematologica 2009 94 5 700 711
31. Crawley J. T. B., Zanardelli S., Chion C. K. N. K., Lane D. A., The central role of thrombin in hemostasis Journal of Thrombosis and Haemostasis 2007 5 1 95 101
32. Offermanns S., Activation of platelet function through G protein-coupled receptors Circulation Research 2006 99 12 1293 1304
33. Gachet C., P2 receptors, platelet function and pharmacological implications Thrombosis and Haemostasis 2008 99 3 466 472
34. Nakahata N., Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology Pharmacology Therapeutics 2008 118 1 18 35
35. Sachais B. S., Higazi A. A.-R., Cines D. B., Poncz M., Kowalska M. A., Interactions of platelet factor 4 with the vessel wall Seminars in Thrombosis and Hemostasis 2004 30 3 351 358
36. Blair P., Flaumenhaft R., Platelet -granules: basic biology and clinical correlates Blood Reviews 2009 23 4 177 189
37. Dav G., Patrono C., Mechanisms of disease: platelet activation and atherothrombosis The New England Journal of Medicine 2007 357 24 2482 2494 (Pubitemid 350272787)
38. Ross R., Atherosclerosisan inflammatory disease The New England Journal of Medicine 1999 340 2 115 126
39. Langer H. F., Gawaz M., Platelet-vessel wall interactions in atherosclerotic disease Thrombosis and Haemostasis 2008 99 3 480 486
40. Krtz F., Sohn H.-Y., Pohl U., Reactive oxygen species: players in the platelet game Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 11 1988 1996
41. Gleissner C. A., von Hundelshausen P., Ley K., Platelet chemokines in vascular disease Arteriosclerosis, Thrombosis, and Vascular Biology 2008 28 11 1920 1927
42. Ruggeri Z. M., Platelets in atherothrombosis Nature Medicine 2002 8 11 1227 1234
43. Huo Y., Ley K. F., Role of platelets in the development of atherosclerosis Trends in Cardiovascular Medicine 2004 14 1 18 22
44. Nassar T., Sachais B. S., Akkawi S., Kowalska M. A., Bdeir K., Leitersdorf E., Hiss E., Ziporen L., Aviram M., Cines D., Poncz M., Higazi A. A.-R., Platelet factor 4 enhances the binding of oxidized low-density lipoprotein to vascular wall cells Journal of Biological Chemistry 2003 278 8 6187 6193
45. van Kooten G., Banchereau J., CD40-CD40 ligand Journal of Leukocyte Biology 2000 67 1 2 17
46. Phipps R. P., Koumas L., Leung E., Reddy S. Y., Blieden T., Kaufman J., The CD40-CD40 ligand system: a potential therapeutic target in atherosclerosis Current Opinion in Investigational Drugs 2001 2 6 773 777
47. Santilli F., Basili S., Ferroni P., Dav G., CD40/CD40L system and vascular disease Internal and Emergency Medicine 2007 2 4 256 268
48. Antoniades C., Bakogiannis C., Tousoulis D., Antonopoulos A. S., Stefanadis C., The CD40/CD40 ligand system: linking inflammation with atherothrombosis Journal of the American College of Cardiology 2009 54 8 669 677
49. Prasad K. S. S., Andre P., He M., Bao M., Manganello J., Phillips D. R., Soluble CD40 ligand induces 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling Proceedings of the National Academy of Sciences of the United States of America 2003 100 21 12367 12371
50. Poggi M., Jager J., Paulmyer-Lacroix O., Peiretti F., Gremeaux T., Verdier M., Grino M., Stepanian A., Msika S., Burcelin R., De Prost D., Tanti J. F., Alessi M. C., The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes Diabetologia 2009 52 6 1152 1163
51. Henn V., Slupsky J. R., Grfe M., Anagnostopoulos I., Frster R., Mller-Berghaus G., Kroczek R. A., CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells Nature 1998 391 6667 591 594 (Pubitemid 28157601)
52. Desideri G., Ferri C., Effects of obesity and weight loss on soluble CD40L levels Journal of the American Medical Association 2003 289 14 1781 1782
53. Gokulakrishnan K., Deepa R., Mohan V., Gross M. D., Soluble P-selectin and CD40L levels in subjects with prediabetes, diabetes mellitus, and metabolic syndromethe Chennai Urban Rural Epidemiology Study Metabolism 2006 55 2 237 242
54. Angelico F., Alessandri C., Ferro D., Pignatelli P., Del Ben M., Fiorello S., Cangemi R., Loffredo L., Violi F., Enhanced soluble CD40L in patients with the metabolic syndrome: relationship with in vivo thrombin generation Diabetologia 2006 49 6 1169 1174
55. Natal C., Restituto P., Iigo C., Colina I., Dez J., Varo N., The proinflammatory mediator CD40 ligand is increased in the metabolic syndrome and modulated by adiponectin Journal of Clinical Endocrinology and Metabolism 2008 93 6 2319 2327
56. von Hundelshausen P., Weber K. S. C., Huo Y., Proudfoot A. E. I., Nelson P. J., Ley K., Weber C., RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium Circulation 2001 103 13 1772 1777 (Pubitemid 32291415)
57. Simak J., Gelderman M. P., Cell membrane microparticles in blood and blood products: potentially pathogenic agents and diagnostic markers Transfusion Medicine Reviews 2006 20 1 1 26
58. Tan K. T., Lip G. Y. H., The potential role of platelet microparticles in atherosclerosis Thrombosis and Haemostasis 2005 94 3 488 492
59. Polasek J., Procoagulant potential of platelet granules Platelets 2004 15 7 403 407
60. Merten M., Pakala R., Thiagarajan P., Benedict C. R., Platelet microparticles promote platelet interaction with subendothelial matrix in a glycoprotein IIb/IIIa-dependent mechanism Circulation 1999 99 19 2577 2582
61. Lindemann S., Tolley N. D., Dixon D. A., McIntyre T. M., Prescott S. M., Zimmerman G. A., Weyrich A. S., Activated platelets mediate inflammatory signaling by regulated interleukin 1 synthesis Journal of Cell Biology 2001 154 3 485 490
62. Massberg S., Vogt F., Dickfeld T., Brand K., Page S., Gawaz M., Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells Thrombosis Research 2003 110 4 187 194
63. Mause S. F., von Hundelshausen P., Zernecke A., Koenen R. R., Weber C., Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 7 1512 1518
64. Vinik A. I., Erbas T., Sun Park T., Nolan R., Pittenger G. L., Platelet dysfunction in type 2 diabetes Diabetes Care 2001 24 8 1476 1485
65. Bath P. M. W., Butterworth R. J., Platelet size: measurement, physiology and vascular disease Blood Coagulation Fibrinolysis 1996 7 2 157 161
66. Vizioli L., Muscari S., Muscari A., The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases International Journal of Clinical Practice 2009 63 10 1509 1515
67. Coban E., Ozdogan M., Yazicioglu G., Akcit F., The mean platelet volume in patients with obesity International Journal of Clinical Practice 2005 59 8 981 982
68. Coban E., Yilmaz A., Sari R., The effect of weight loss on the mean platelet volume in obese patients Platelets 2007 18 3 212 216
69. Muscari A., De Pascalis S., Cenni A., Ludovico C., Castaldini N., Antonelli S., Bianchi G., Magalotti D., Zoli M., Determinants of mean platelet volume (MPV) in an elderly population: relevance of body fat, blood glucose and ischaemic electrocardiographic changes Thrombosis and Haemostasis 2008 99 6 1079 1084
70. Thompson C. B., Jakubowski J. A., Quinn P. G., Deykin D., Valeri C. R., Platelet size and age determine platelet function independently Blood 1984 63 6 1372 1375
71. Martin J. F., Shaw T., Heggie J., Penington D. G., Measurement of the density of human platelets and its relationship to volume British Journal of Haematology 1983 54 3 337 352
72. Brown A. S., Hong Y., de Belder A., Beacon H., Beeso J., Sherwood R., Edmonds M., Martin J. F., Erusalimsky J. D., Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology 1997 17 4 802 807
73. Kimura H., Ishibashi T., Shikama Y., Interleukin-1 (IL-1 ) induces thrombocytosis in mice: possible implication of IL-6 Blood 1990 76 12 2493 2500
74. Battinelli E., Willoughby S. R., Foxall T., Valeri C. R., Loscalzo J., Induction of platelet formation from megakaryocytoid cells by nitric oxide Proceedings of the National Academy of Sciences of the United States of America 2001 98 25 14458 14463
75. Lefer A. M., Ma X.-L., Cytokines and growth factors in endothelial dysfunction Critical Care Medicine 1993 21 2 S9 S14
76. Dav G., Guagnano M. T., Ciabattoni G., Basili S., Falco A., Marinopiccoli M., Nutini M., Sensi S., Patrono C., Platelet activation in obese women: role of inflammation and oxidant stress Journal of the American Medical Association 2002 288 16 2008 2014
77. Trovati M., Anfossi G., Cavalot F., Massucco P., Mularoni E., Emanuelli G., Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo Diabetes 1988 37 6 780 786
78. Trovati M., Anfossi G., Influence of insulin and of insulin resistance on platelet and vascular smooth muscle cell function Journal of Diabetes and Its Complications 2002 16 1 35 40
79. Russo I., Massucco P., Mattiello L., Cavalot F., Anfossi G., Trovati M., Comparison between the effects of the rapid recombinant insulin analog aspart and those of human regular insulin on platelet cyclic nucleotides and aggregation Thrombosis Research 2002 107 1-2 31 37
80. Hiramatsu K., Nozaki H., Arimori S., Reduction of platelet aggregation induced by euglycaemic insulin clamp Diabetologia 1987 30 5 310 313
81. Westerbacka J., Yki-Jrvinen H., Turpeinen A., Rissanen A., Vehkavaara S., Syrjl M., Lassila R., Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesity Arteriosclerosis, Thrombosis, and Vascular Biology 2002 22 1 167 172
82. Trovati M., Anfossi G., Massucco P., Mattiello L., Costamagna C., Piretto V., Mularoni E., Cavalot F., Bosia A., Ghigo D., Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine-3',5'-cyclic monophosphate and adenosine-3',5'-cyclic monophosphate Diabetes 1997 46 5 742 749
83. Trovati M., Mularoni E. M., Burzacca S., Ponziani M. C., Massucco P., Mattiello L., Piretto V., Cavalot F., Anfossi G., Impaired insulin-induced platelet antiaggregating effect in obesity and in obese NIDDM patients Diabetes 1995 44 11 1318 1322
84. Trovati M., Anfossi G., Insulin, insulin resistance and platelet function: similarities with insulin effects on cultured vascular smooth muscle cells Diabetologia 1998 41 6 609 622
85. Ferreira I. A., Mocking A. I. M., Feijge M. A. H., Gorter G., Van Haeften T. W., Heemskerk J. W. M., Akkerman J.-W. N., Platelet inhibition by insulin is absent in type 2 diabetes mellitus Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 2 417 422
86. Anfossi G., Russo I., Massucco P., Mattiello L., Doronzo G., De Salve A., Trovati M., Impaired synthesis and action of antiaggregating cyclic nucleotides in platelets from obese subjects: possible role in platelet hyperactivation in obesity European Journal of Clinical Investigation 2004 34 7 482 489
87. Russo I., Del Mese P., Doronzo G., De Salve A., Secchi M., Trovati M., Anfossi G., Platelet resistance to the antiaggregatory cyclic nucleotides in central obesity involves reduced phosphorylation of vasodilator-stimulated phosphoprotein Clinical Chemistry 2007 53 6 1053 1060
88. Vincent H. K., Innes K. E., Vincent K. R., Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity Diabetes, Obesity and Metabolism 2007 9 6 813 839
89. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., Nakayama O., Makishima M., Matsuda M., Shimomura I., Increased oxidative stress in obesity and its impact on metabolic syndrome Journal of Clinical Investigation 2004 114 12 1752 1761
90. Suematsu M., Katsuki A., Sumida Y., Gabazza E. C., Murashima S., Matsumoto K., Kitagawa N., Akatsuka H., Hori Y., Nakatani K., Togashi K., Yano Y., Adachi Y., Decreased circulating levels of active ghrelin are associated with increased oxidative stress in obese subjects European Journal of Endocrinology 2005 153 3 403 407
91. Goldstein B. J., Scalia R. G., Ma X. L., Protective vascular and myocardial effects of adiponectin Nature Clinical Practice Cardiovascular Medicine 2009 6 1 27 35
92. Pignatelli P., Pulcinelli F. M., Lenti L., Gazzaniga P. P., Violi F., Hydrogen peroxide is involved in collagen-induced platelet activation Blood 1998 91 2 484 490
93. Pulcinelli F. M., Pignatelli P., Violi F., Gazzaniga P. P., Platelets and oxygen radicals: mechanisms of functional modulation Haematologica 2001 86 11, supplement 2 31 34
94. Begonja A. J., Gambaryan S., Geiger J. R., Aktas B., Pozgajova M., Nieswandt B., Walter U., Platelet NAD(P)H-oxidase-generated ROS production regulates IIb 3-integrin activation independent of the NO/cGMP pathway Blood 2005 106 8 2757 2760
95. Morrow J. D., Hill K. E., Burk R. F., Nammour T. M., Badr K. F., Roberts L. J. II, A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism Proceedings of the National Academy of Sciences of the United States of America 1990 87 23 9383 9387
96. Milne G. L., Yin H., Morrow J. D., Human biochemistry of the isoprostane pathway Journal of Biological Chemistry 2008 283 23 15533 15537
97. Patrono C., FitzGerald G. A., Isoprostanes: potential markers of oxidant stress in atherothrombotic disease Arteriosclerosis, Thrombosis, and Vascular Biology 1997 17 11 2309 2315
98. Roberts L. J. II, Morrow J. D., Measurement of F2 -isoprostanes as an index of oxidative stress in vivo Free Radical Biology Medicine 2000 28 4 505 513
99. Montuschi P., Barnes P. J., Roberts L. J. II, Isoprostanes: markers and mediators of oxidative stress FASEB Journal 2004 18 15 1791 1800
100. Cipollone F., Ciabattoni G., Patrignani P., Pasquale M., Di Gregorio D., Bucciarelli T., Dav G., Cuccurullo F., Patrono C., Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina Circulation 2000 102 9 1007 1013
101. Pratic D., Smyth E. M., Violi F., FitzGerald G. A., Local amplification of platelet function by 8-epi prostaglandin F2 is not mediated by thromboxane receptor isoforms Journal of Biological Chemistry 1996 271 25 14916 14924
102. Khasawneh F. T., Huang J.-S., Mir F., Srinivasan S., Tiruppathi C., Le Breton G. C., Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF2 with the thromboxane A2 receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets Biochemical Pharmacology 2008 75 12 2301 2315
103. Audoly L. P., Rocca B., Fabre J.-E., Koller B. H., Thomas D., Loeb A. L., Coffman T. M., FitzGerald G. A., Cardiovascular responses to the isoprostanes iPF2()-III and iPE2-III are mediated via the thromboxane A2 receptor in vivo Circulation 2000 101 24 2833 2840
104. Dav G., Gresele P., Violi F., Basili S., Catalano M., Giammarresi C., Volpato R., Nenci G. G., Ciabattoni G., Patrono C., Diabetes mellitus, hypercholesterolemia, and hypertension but not vascular disease per se are associated with persistent platelet activation in vivo: evidence derived from the study of peripheral arterial disease Circulation 1997 96 1 69 75
105. Keaney J. F. Jr., Larson M. G., Vasan R. S., Wilson P. W. F., Lipinska I., Corey D., Massaro J. M., Sutherland P., Vita J. A., Benjamin E. J., Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham study Arteriosclerosis, Thrombosis, and Vascular Biology 2003 23 3 434 439
106. Park K., Gross M., Lee D.-H., Holvoet P., Himes J. H., Shikany J. M., Jacobs D. R. Jr., Oxidative stress and insulin resistance: the coronary artery risk development in young adults study Diabetes Care 2009 32 7 1302 1307
107. Tsai I.-J., Croft K. D., Mori T. A., Falck J. R., Beilin L. J., Puddey I. B., Barden A. E., 20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction Free Radical Biology Medicine 2009 46 2 263 270
108. Owens G. K., Kumar M. S., Wamhoff B. R., Molecular regulation of vascular smooth muscle cell differentiation in development and disease Physiological Reviews 2004 84 3 767 801
109. Yoshida T., Owens G. K., Molecular determinants of vascular smooth muscle cell diversity Circulation Research 2005 96 3 280 291
110. Moncada S., Higgs E. A., Nitric oxide and the vascular endothelium Handbook of Experimental Pharmacology 2006 176, part 1 213 254
111. Tsai E. J., Kass D. A., Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics Pharmacology Therapeutics 2009 122 3 216 238
112. Lee J. H., Ragolia L., AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cells American Journal of Physiology 2006 291 6 C1355 C1365
113. Berk B. C., Vascular smooth muscle growth: autocrine growth mechanisms Physiological Reviews 2001 81 3 999 1030
114. Azar Z. M., Mehdi M. Z., Srivastava A. K., Insulin-like growth factor type-1 receptor transactivation in vasoactive peptide and oxidant-induced signaling pathways in vascular smooth muscle cells Canadian Journal of Physiology and Pharmacology 2007 85 1 105 111
115. Muniyappa R., Montagnani M., Koh K. K., Quon M. J., Cardiovascular actions of insulin Endocrine Reviews 2007 28 5 463 491
116. Hsueh W. A., Law R. E., Insulin signaling in the arterial wall American Journal of Cardiology 1999 84 1A 21J 24J
117. Wang C. C., Gurevich I., Draznin B., Insulin affects vascular smooth muscle cell phenotype and migration via distinct signaling pathways Diabetes 2003 52 10 2562 2569
118. Peuler J. D., Phare S. M., Iannucci A. R., Hodorek M. J., Differential inhibitory effects of antidiabetic drugs on arterial smooth muscle cell proliferation American Journal of Hypertension 1996 9 2 188 192
119. Xi X.-P., Graf K., Goetze S., Hsueh W. A., Law R. E., Inhibition of MAP kinase blocks insulin-mediated DNA synthesis and transcriptional activation of c-fos by Elk-1 in vascular smooth muscle cells FEBS Letters 1997 417 3 283 286
120. Cruzado M., Risler N., Castro C., Ortiz A., Rttler M. E., Proliferative effect of insulin on cultured smooth muscle cells from rat mesenteric resistance vessels American Journal of Hypertension 1998 11 1 54 58
121. Doronzo G., Russo I., Mattiello L., Anfossi G., Bosia A., Trovati M., Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance European Journal of Clinical Investigation 2004 34 10 664 673
122. Doronzo G., Russo I., Mattiello L., Riganti C., Anfossi G., Trovati M., Insulin activates hypoxia-inducible factor-1 in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signalling Diabetologia 2006 49 5 1049 1063
123. Muniyappa R., Quon M. J., Insulin action and insulin resistance in vascular endothelium Current Opinion in Clinical Nutrition and Metabolic Care 2007 10 4 523 530
124. Pugh C. W., Ratcliffe P. J., Regulation of angiogenesis by hypoxia: role of the HIF system Nature Medicine 2003 9 6 677 684
125. Ferrara N., Davis-Smyth T., The biology of vascular endothelial growth factor Endocrine Reviews 1997 18 1 4 25
126. Raines E. W., Ross R., Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis British Heart Journal 1993 69 1 S30 S37
127. Ross R., Cell biology of atherosclerosis Annual Review of Physiology 1995 57 791 804
128. Newby A. C., Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and non-matrix substrates Cardiovascular Research 2006 69 3 614 624
129. Newby A. C., Metalloproteinases and vulnerable atherosclerotic plaques Trends in Cardiovascular Medicine 2007 17 8 253 258
130. Johnson J. L., Matrix metalloproteinases: influence on smooth muscle cells and atherosclerotic plaque stability Expert Review of Cardiovascular Therapy 2007 5 2 265 282
131. Vink A., Schoneveld A. H., Lamers D., Houben A. J. S., van der Groep P., van Diest P. J., Pasterkamp G., HIF-1alpha expression is associated with an atheromatous inflammatory plaque phenotype and upregulated in activated macrophages Atherosclerosis 2007 195 2 e69 e75
132. Sluimer J. C., Gasc J.-M., van Wanroij J. L., Kisters N., Groeneweg M., Sollewijn Gelpke M. D., Cleutjens J. P., van den Akker L. H., Corvol P., Wouters B. G., Daemen M. J., Bijnens A.-P. J., Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis Journal of the American College of Cardiology 2008 51 13 1258 1265
133. Osada-Oka M., Ikeda T., Imaoka S., Akiba S., Sato T., VEGF-enhanced proliferation under hypoxia by an autocrine mechanism in human vascular smooth muscle cells Journal of Atherosclerosis and Thrombosis 2008 15 1 26 33
134. Holm P. W., Slart R. H. J. A., Zeebregts C. J., Hillebrands J. L., Tio R. A., Atherosclerotic plaque development and instability: a dual role for VEGF Annals of Medicine 2009 41 4 257 264
135. Stiles C. D., Capone G. T., Scher C. D., Dual control of cell growth by somatomedins and platelet-derived growth factor Proceedings of the National Academy of Sciences of the United States of America 1979 76 3 1279 1283
136. Raines E. W., PDGF and cardiovascular disease Cytokine and Growth Factor Reviews 2004 15 4 237 254
137. Yanagi H., Sasaguri Y., Sugama K., Morimatsu M., Nagase H., Production of tissue collagenase (matrix metalloproteinase 1) by human aortic smooth muscle cells in response to platelet-derived growth factor Atherosclerosis 1991 91 3 207 216
138. Galis Z. S., Muszynski M., Sukhova G. K., Simon-Morrissey E., Unemori E. N., Lark M. W., Amento E., Libby P., Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion Circulation Research 1994 75 1 181 189
139. Sasaguri T., Arima N., Tanimoto A., Shimajiri S., Hamada T., Sasaguri Y., A role for interleukin 4 in production of matrix metalloproteinase 1 by human aortic smooth muscle cells Atherosclerosis 1998 138 2 247 253
140. Doronzo G., Russo I., Mattiello L., Trovati M., Anfossi G., C-reactive protein increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells Journal of Laboratory and Clinical Medicine 2005 146 5 287 298 (Pubitemid 41464406)
141. Raffetto J. D., Khalil R. A., Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease Biochemical Pharmacology 2008 75 2 346 359
142. Chai H., Aghaie K., Zhou W., Soluble CD40 ligand induces human coronary artery smooth muscle cells proliferation and migration Surgery 2009 146 1 5 11
143. Davies M. J., Richardson P. D., Woolf N., Katz D. R., Mann J., Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content British Heart Journal 1993 69 5 377 381
144. Weissberg P. L., Clesham G. J., Bennett M. R., Is vascular smooth muscle cell proliferation beneficial? The Lancet 1996 347 8997 305 307
145. Littlewood T. D., Bennett M. R., Apoptotic cell death in atherosclerosis Current Opinion in Lipidology 2003 14 5 469 475
146. Clarke M. C. H., Figg N., Maguire J. J., Davenport A. P., Goddard M., Littlewood T. D., Bennett M. R., Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis Nature Medicine 2006 12 9 1075 1080
147. Lutgens E., de Muinck E. D., Kitslaar P. J. E. H. M., Tordoir J. H. M., Wellens H. J. J., Daemen M. J. A. P., Biphasic pattern of cell turnover characterizes the progression from fatty streaks to ruptured human atherosclerotic plaques Cardiovascular Research 1999 41 2 473 479
148. Schaub F. J., Liles W. C., Ferri N., Sayson K., Seifert R. A., Bowen-Pope D. F., Fas and Fas-associated death domain protein regulate monocyte chemoattractant protein-1 expression by human smooth muscle cells through caspase- and calpain-dependent release of interleukin-1 Circulation Research 2003 93 6 515 522
149. Schaub F. J., Han D. K. M., Liles W. C., Adams L. D., Coats S. A., Ramachandran R. K., Seifert R. A., Schwartz S. M., Bowen-Pope D. F., Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells Nature Medicine 2000 6 7 790 796
150. Flynn P. D., Byrne C. D., Baglin T. P., Weissberg P. L., Bennett M. R., Thrombin generation by apoptotic vascular smooth muscle cells Blood 1997 89 12 4378 4384
151. Proudfoot D., Skepper J. N., Hegyi L., Bennett M. R., Shanahan C. M., Weissberg P. L., Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies Circulation Research 2000 87 11 1055 1062
152. Mallat Z., Hugel B., Ohan J., Lesche G., Freyssinet J.-M., Tedgui A., Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity Circulation 1999 99 3 348 353
153. Mallat Z., Benamer H., Hugel B., Benessiano J., Steg P. G., Freyssinet J.-M., Tedgui A., Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes Circulation 2000 101 8 841 843
154. Schecter A. D., Spirn B., Rossikhina M., Giesen P. L. A., Bogdanov V., Fallon J. T., Fisher E. A., Schnapp L. M., Nemerson Y., Taubman M. B., Release of active tissue factor by human arterial smooth muscle cells Circulation Research 2000 87 2 126 132
155. Gizard F., Amant C., Barbier O., Bellosta S., Robillard R., Percevault F., Sevestre H., Krimpenfort P., Corsini A., Rochette J., Glineur C., Fruchart J.-C., Torpier G., Staels B., PPARa inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a Journal of Clinical Investigation 2005 115 11 3228 3238
156. Gizard F., Nomiyama T., Zhao Y., Findeisen H. M., Heywood E. B., Jones K. L., Staels B., Bruemmer D., The PPAR /p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation Circulation Research 2008 103 10 1155 1163
157. Gizard F., Bruemmer D., Transcriptional control of vascular smooth muscle cell proliferation by peroxisome proliferator-activated receptor- : therapeutic implications for cardiovascular diseases PPAR Research 2008 2008 11
158. Erds B., Miller A. W., Busija D. W., Impaired endothelium-mediated relaxation in isolated cerebral arteries from insulin-resistant rats American
159. Frisbee J. C., Stepp D. W., Impaired NO-dependent dilation of skeletal muscle arterioles in hypertensive diabetic obese Zucker rats American Journal of Physiology 2001 281 3 H1304 H1311
160. Erds B., Snipes J. A., Miller A. W., Busija D. W., Cerebrovascular dysfunction in Zucker obese rats is mediated by oxidative stress and protein kinase C Diabetes 2004 53 5 1352 1359
161. Cooper S. A., Whaley-Connell A., Habibi J., Wei Y., Lastra G., Manrique C., Stas S., Sowers J. R., Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance American Journal of Physiology 2007 293 4 H2009 H2023
162. Rask-Madsen C., King G. L., Mechanisms of disease: endothelial dysfunction in insulin resistance and diabetes Nature Clinical Practice Endocrinology Metabolism 2007 3 1 46 56
163. Beckman J. S., Koppenol W. H., Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly American Journal of Physiology 1996 271 5, part 1 C1424 C1437
164. Bagi Z., Mechanisms of coronary microvascular adaptation to obesity American Journal of Physiology 2009 297 3 R556 R567
165. Baron A. D., Insulin resistance and vascular function Journal of Diabetes and its Complications 2002 16 1 92 102
166. Dandona P., Aljada A., Chaudhuri A., Mohanty P., Garg R., Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation Circulation 2005 111 11 1448 1454
167. Marasciulo F. L., Montagnani M., Potenza M. A., Endothelin-1: the Yin and Yang on vascular function Current Medicinal Chemistry 2006 13 14 1655 1665
168. Russo I., Del Mese P., Doronzo G., Mattiello L., Viretto M., Bosia A., Anfossi G., Trovati M., Resistance to the nitric oxide/cyclic guanosine 5′ -monophosphate/protein kinase G pathway in vascular smooth muscle cells from the obese zucker rat, a classical animal model of insulin resistance: role of oxidative stress Endocrinology 2008 149 4 1480 1489
169. Laight D. W., Kengatharan K. M., Gopaul N. K., Änggård E. E., Carrier M. J., Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo British Journal of Pharmacology 1998 125 4 895 901
170. Suzuki L. A., Poot M., Gerrity R. G., Bornfeldt K. E., Diabetes accelerates smooth muscle accumulation in lesions of atherosclerosis: lack of direct growth-promoting effects of high glucose levels Diabetes 2001 50 4 851 860
171. Trivedi P. S., Barouch L. A., Cardiomyocyte apoptosis in animal models of obesity Current Hypertension Reports 2008 10 6 454 460
172. Absher P. M., Schneider D. J., Baldor L. C., Russell J. C., Sobel B. E., The retardation of vasculopathy induced by attenuation of insulin resistance in the corpulent JCR:LA-cp rat is reflected by decreased vascular smooth muscle cell proliferation in vivo Atherosclerosis 1999 143 2 245 251
173. Desouza C. V., Gerety M., Hamel F. G., Neointimal hyperplasia and vascular endothelial growth factor expression are increased in normoglycemic, insulin resistant, obese fatty rats Atherosclerosis 2006 184 2 283 289
174. Kim J., Bachmann R. A., Chen J., Interleukin-6 and insulin resistance Vitamins and Hormones 2009 80 613 633
175. Komowski R., Mintz G. S., Kent K. M., Pichard A. D., Satler L. F., Bucher T. A., Hong M. K., Popma J. J., Leon M. B., Increased restenosis in diabetes mellitus after coronary interventions is due to exaggerated intimal hyperplasia: a serial intravascular ultrasound study Circulation 1997 95 6 1366 1369
176. Dzau V. J., Braun-Dullaeus R. C., Sedding D. G., Vascular proliferation and atherosclerosis: new perspectives and therapeutic strategies Nature Medicine 2002 8 11 1249 1256
177. Protack C. D., Bakken A. M., Xu J., Saad W. A., Lumsden A. B., Davies M. G., Metabolic syndrome: a predictor of adverse outcomes after carotid revascularization Journal of Vascular Surgery 2009 49 5 1172 1180
178. Takagi T., Akasaka T., Yamamuro A., Honda Y., Hozumi T., Morioka S., Yoshida K., Impact of insulin resistance on neointimal tissue proliferation after coronary stent implantationIntravascular ultrasound studies Journal of Diabetes and its Complications 2002 16 1 50 55
179. Piatti P., Di Mario C., Monti L. D., Fragasso G., Sgura F., Caumo A., Setola E., Lucotti P., Galluccio E., Ronchi C., Origgi A., Zavaroni I., Margonato A., Colombo A., Association of insulin resistance, hyperleptinemia and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting Circulation 2003 108 17 2074 2081
180. Shah A., Mehta N., Reilly M. P., Adipose inflammation, insulin resistance, and cardiovascular disease Journal of Parenteral and Enteral Nutrition 2008 32 6 638 644
181. Fantuzzi G., Faggioni R., Leptin in the regulation of immunity, inflammation, and hematopoiesis Journal of Leukocyte Biology 2000 68 4 437 446
182. Abeywardena M. Y., Leifert W. R., Warnes K. E., Varghese J. N., Head R. J., Cardiovascular biology of interleukin-6 Current Pharmaceutical Design 2009 15 15 1809 1821
183. Schuett H., Luchtefeld M., Grothusen C., Grote K., Schieffer B., How much is too much? Interleukin-6 and its signalling in atherosclerosis Thrombosis and Haemostasis 2009 102 2 215 222
184. Yudkin J. S., Kumari M., Humphries S. E., Mohamed-Ali V., Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000 148 2 209 214
185. Wang Z., Castresana M. R., Newman W. H., Reactive oxygen and NF- B in VEGF-induced migration of human vascular smooth muscle cells Biochemical and Biophysical Research Communications 2001 285 3 669 674
186. Hartge M. M., Unger T., Kintscher U., The endothelium and vascular inflammation in diabetes Diabetes and Vascular Disease Research 2007 4 2 84 88
187. Lamb R. E., Goldstein B. J., Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function International Journal of Clinical Practice 2008 62 7 1087 1095
188. Bruno E., Hoffman R., Effect of interleukin 6 on in vitro human megakaryocytopoiesis: its interaction with other cytokines Experimental Hematology 1989 17 10 1038 1043
189. Baatout S., Interleukin-6 and megakaryocytopoiesis: an update Annals of Hematology 1996 73 4 157 162
190. Williams J. L., Pipia G. G., Datta N. S., Long M. W., Thrombopoietin requires additional megakaryocyte-active cytokines for optimal ex vivo expansion of megakaryocyte precursor cells Blood 1998 91 11 4118 4126
191. Lazzari L., Henschler R., Lecchi L., Rebulla P., Mertelsmann R., Sirchia G., Interleukin-6 and interleukin-11 act synergistically with thrombopoietin and stem cell factor to modulate ex vivo expansion of human CD41+ and CD61+ megakaryocytic cells Haematologica 2000 85 1 25 30
192. Kurzrock R., Thrombopoietic factors in chronic bone marrow failure states: the platelet problem revisited Clinical Cancer Research 2005 11 4 1361 1367
193. Samocha-Bonet D., Justo D., Rogowski O., Saar N., Abu-Abeid S., Shenkerman G., Shapira I., Berliner S., Tomer A., Platelet counts and platelet activation markers in obese subjects Mediators of Inflammation 2008 2008 6
194. Ly H. Q., Kirtane A. J., Murphy S. A., Buros J., Cannon C. P., Braunwald E., Gibson C. M., Association of platelet counts on presentation of clinical outcomes in ST-elevation myocardial infarction (from the TIMI Trials) American Journal of Cardiology 2006 98 1 1 5
195. Kerr R., Stirling D., Ludlam C. A., Interleukin 6 and haemostasis British Journal of Haematology 2001 115 1 3 12
196. Fan Y., Ye J., Shen F., Zhu Y., Yeghiazarians Y., Zhu W., Chen Y., Lawton M. T., Young W. L., Yang G.-Y., Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro Journal of Cerebral Blood Flow and Metabolism 2008 28 1 90 98
197. Kranzhfer R., Schmidt J., Pfeiffer C. A. H., Hagl S., Libby P., Kbler W., Angiotensin induces inflammatory activation of human vascular smooth muscle cells Arteriosclerosis, Thrombosis, and Vascular Biology 1999 19 7 1623 1629 (Pubitemid 29323820)
198. Wang Z., Castresana M. R., Detmer K., Newman W. H., An I B- mutant inhibits cytokine gene expression and proliferation in human vascular smooth muscle cells Journal of Surgical Research 2002 102 2 198 206
199. Wang Z., Castresana M. R., Newman W. H., NF- B is required for TNF- -directed smooth muscle cell migration FEBS Letters 2001 508 3 360 364
200. Wang D., Liu Z., Li Q., Karpurapu M., Kundumani-Sridharan V., Cao H., Dronadula N., Rizvi F., Bajpai A. K., Zhang C., Mller-Newen G., Harris K. W., Rao G. N., An essential role for gp130 in neointima formation following arterial injury Circulation Research 2007 100 6 807 816
201. Ikeda U., Ikeda M., Oohara T., Oguchi A., Kamitani T., Tsuruya Y., Kano S., Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner American Journal of Physiology 1991 260 5 H1713 H1717
202. Nabata T., Morimoto S., Koh E., Shiraishi T., Ogihara T., Interleukin-6 stimulates c-myc expression and proliferation of cultured vascular smooth muscle cells Biochemistry International 1990 20 3 445 454
203. Hojo Y., Ikeda U., Katsuki T., Mizuno O., Fukazawa H., Kurosaki K., Fujikawa H., Shimada K., Interleukin 6 expression in coronary circulation after coronary angioplasty as a risk factor for restenosis Heart 2000 84 1 83 87
204. Sukhija R., Fahdi I., Garza L., Fink L., Scott M., Aude W., Pacheco R., Bursac Z., Grant A., Mehta J. L., Inflammatory Markers, Angiographic Severity of Coronary Artery Disease, and Patient Outcome American Journal of Cardiology 2007 99 7 879 884
205. Warner S. J. C., Libby P., Human vascular smooth muscle cells. Target for and source of tumor necrosis factor Journal of Immunology 1989 142 1 100 109
206. Barath P., Fishbein M. C., Cao J., Berenson J., Helfant R. H., Forrester J. S., Detection and localization of tumor necrosis factor in human atheroma American Journal of Cardiology 1990 65 5 297 302
207. Galic S., Oakhill J.S., Steinberg G.R., Adipose tissue as an endocrine organ Molecular and Cellular Endocrinology 2010 316 2 129 139
208. Nieto-Vazquez I., Fernndez-Veledo S., Krmer D. K., Vila-Bedmar R., Garcia-Guerra L., Lorenzo M., Insulin resistance associated to obesity: the link TNF-alpha Archives of Physiology and Biochemistry 2008 114 3 183 194
209. Hotamisligil G. S., Arner P., Caro J. F., Atkinson R. L., Spiegelman B. M., Increased adipose tissue expression of tumor necrosis factor- in human obesity and insulin resistance Journal of Clinical Investigation 1995 95 5 2409 2415
210. Nilsson J., Jovinge S., Niemann A., Reneland R., Lithell H., Relation between plasma tumor necrosis factor-a and insulin sensitivity in elderly men with non-insulin-dependent diabetes mellitus Arteriosclerosis, Thrombosis, and Vascular Biology 1998 18 8 1199 1202
211. Miyazaki Y., Pipek R., Mandarino L. J., DeFronzo R. A., Tumor necrosis factor a and insulin resistance in obese type 2 diabetic patients International Journal of Obesity 2003 27 1 88 94
212. Rask-Madsen C., Domnguez H., Ihlemann N., Hermann T., Kber L., Torp-Pedersen C., Tumor necrosis factor- inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans Circulation 2003 108 15 1815 1821
213. Youd J. M., Rattigan S., Clark M. G., Acute impairment of insulin-mediated capillary recruitment and glucose uptake rat skeletal muscle vivo by TNF- Diabetes 2000 49 11 1904 1909
214. Aljada A., Ghanim H., Assian E., Dandona P., Tumor necrosis factor- inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells Metabolism 2002 51 4 487 491
215. Eringa E. C., Stehouwer C. D. A., Walburg K., Clark A. D., Van Nieuw Amerongen G. P., Westerhof N., Sipkema P., Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-a dependence on c-Jun N-terminal kinase Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 2 274 280
216. Martens F. M. A. C., Rabelink T. J., Op 't Roodt J., De Koning E. J. P., Visseren F. L. J., TNF- induces endothelial dysfunction in diabetic adults, an effect reversible by the PPAR- agonist pioglitazone European Heart Journal 2006 27 13 1605 1609
217. Landry D. B., Couper L. L., Bryant S. R., Lindner V., Activation of the NF- B and I B system in smooth muscle cells after rat arterial injury: induction of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 American Journal of Pathology 1997 151 4 1085 1095
218. Skoog T., Dichtl W., Boquist S., Skoglund-Andersson C., Karpe F., Tang R., Bond M. G., De Faire U., Nilsson J., Eriksson P., Hamsten A., Plasma tumour necrosis factor- and early carotid atherosclerosis in healthy middle-aged men European Heart Journal 2002 23 5 376 383
219. Ridker P. M., Rifai N., Pfeffer M., Sacks F., Lepage S., Braunwald E., Elevation of tumor necrosis factor- and increased risk of recurrent coronary events after myocardial infarction Circulation 2000 101 18 2149 2153
220. Bar J., Zosmer A., Hod M., Elder M. G., Sullivan M. H. F., The regulation of platelet aggregation in vitro by interleukin-1 and tumor necrosis factor- : changes in pregnancy and in pre-eclampsia Thrombosis and Haemostasis 1997 78 4 1255 1261
221. De Biase L., Pignatelli P., Lenti L., Tocci G., Piccioni F., Riondino S., Pulcinelli F. M., Rubattu S., Volpe M., Violi F., Enhanced TNFa and oxidative stress in patients with heart failure: effect of TNFa on platelet O2 production Thrombosis and Haemostasis 2003 90 2 317 325
222. Pignatelli P., De Biase L., Lenti L., Tocci G., Brunelli A., Cangemi R., Riondino S., Grego S., Volpe M., Violi F., Tumor necrosis factor- as trigger of platelet activation in patients with heart failure Blood 2005 106 6 1992 1994
223. Bodary P. F., Links between adipose tissue and thrombosis in the mouse Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 11 2284 2291
224. Ng S. B., Tan Y. H., Guy G. R., Differential induction of the interleukin-6 gene by tumor necrosis factor and interleukin-1 Journal of Biological Chemistry 1994 269 29 19021 19027
225. Considine R. V., Sinha M. K., Heiman M. L., Kriauciunas A., Stephens T. W., Nyce M. R., Ohannesian J. P., Marco C. C., Mckee L. J., Bauer T. L., Caro J. F., Serum immunoreactive-leptin concentrations in normal-weight and obese humans The New England Journal of Medicine 1996 334 5 292 295
226. Campfield L. A., Smith F. J., Guisez Y., Devos R., Burn P., Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks Science 1995 269 5223 546 549
227. Heymsfield S. B., Greenberg A. S., Fujioka K., Dixon R. M., Kushner R., Hunt T., Lubina J. A., Patane J., Self B., Hunt P., McCamish M., Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial Journal of the American Medical Association 1999 282 16 1568 1575
228. Betowski J., Wjcicka G., Jamroz A., Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia Atherosclerosis 2003 170 1 21 29
229. Bodary P. F., Gu S., Shen Y., Hasty A. H., Buckler J. M., Eitzman D. T., Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 8 e119 e122
230. Hasty A. H., Shimano H., Osuga J.-I., Namatame I., Takahashi A., Yahagi N., Perrey S., Iizuka Y., Tamura Y., Amemiya-Kudo M., Yoshikawa T., Okazaki H., Ohashi K., Harada K., Matsuzaka T., Sone H., Gotoda T., Nagai R., Ishibashi S., Yamada N., Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor Journal of Biological Chemistry 2001 276 40 37402 37408
231. Martin S. S., Qasim A., Reilly M. P., Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease Journal of the American College of Cardiology 2008 52 15 1201 1210
232. Wallace A. M., McMahon A. D., Packard C. J., Kelly A., Shepherd J., Gaw A., Sattar N., Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS) Circulation 2001 104 25 3052 3056
233. Gmez-Ambrosi J., Salvador J., Silva C., Pastor C., Rotellar F., Gil M. J., Cienfuegos J. A., Frhbeck G., Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin Thrombosis and Haemostasis 2006 95 6 991 996
234. Lieb W., Sullivan L. M., Harris T. B., Roubenoff R., Benjamin E., Levy D., Fox C. S., Wang T. J., Wilson P. W., Kannel W. B., Vasan R. S., Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals Diabetes Care 2009 32 4 612 616
235. Frhbeck G., Nutrition society medal lecture: a heliocentric view of leptin Proceedings of the Nutrition Society 2001 60 3 301 318
236. Sderberg S., Stegmayr B., Ahlbeck-Glader C., Slunga-Birgander L., Ahrn B., Olsson T., High leptin levels are associated with stroke Cerebrovascular Diseases 2003 15 1-2 63 69
237. Wolk R., Berger P., Lennon R. J., Brilakis E. S., Johnson B. D., Somers V. K., Plasma leptin and prognosis in patients with established coronary atherosclerosis Journal of the American College of Cardiology 2004 44 9 1819 1824
238. Reilly M. P., Iqbal N., Schutta M., Wolfe M. L., Scally M., Localio A. R., Rader D. J., Kimmel S. E., Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes Journal of Clinical Endocrinology and Metabolism 2004 89 8 3872 3878
239. Qasim A., Mehta N. N., Tadesse M. G., Wolfe M. L., Rhodes T., Girman C., Reilly M. P., Adipokines, insulin resistance, and coronary artery calcification Journal of the American College of Cardiology 2008 52 3 231 236
240. Piatti P. M., Monti L. D., Insulin resistance, hyperleptinemia and endothelial dysfunction in coronary restenosis Current Opinion in Pharmacology 2005 5 2 160 164
241. Nakata M., Yada T., Soejima N., Maruyama I., Leptin promotes aggregation of human platelets via the long form of its receptor Diabetes 1999 48 2 426 429
242. Konstantinides S., Schfer K., Koschnick S., Loskutoff D. J., Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity Journal of Clinical Investigation 2001 108 10 1533 1540
243. Corsonello A., Perticone F., Malara A., De Domenico D., Loddo S., Buemi M., Ientile R., Corica F., Leptin-dependent platelet aggregation in healthy, overweight and obese subjects International Journal of Obesity 2003 27 5 566 573
244. Elbatarny H. S., Maurice D. H., Leptin-mediated activation of human platelets: involvement of a leptin receptor and phosphodiesterase 3A-containing cellular signaling complex American Journal of Physiology 2005 289 4 E695 E702
245. Konstantinides S., Schfer K., Loskutoff D. J., The prothrombotic effects of leptin: possible implications for the risk of cardiovascular disease in obesity Annals of the New York Academy of Sciences 2001 947 134 142
246. Corica F., Corsonello A., Lucchetti M., Malara A., Domenico D. D., Cannav L., Foti S., Valenti A., Ientile R., Saitta A., Relationship between metabolic syndrome and platelet responsiveness to leptin in overweight and obese patients International Journal of Obesity 2007 31 5 842 849
247. Dellas C., Schfer K., Rohm I., Lankeit M., Ellrott T., Faustin V., Riggert J., Hasenfuss G., Konstantinides S., Absence of leptin resistance in platelets from morbidly obese individuals may contribute to the increased thrombosis risk in obesity Thrombosis and Haemostasis 2008 100 6 1123 1129
248. Canavan B., Salem R. O., Schurgin S., Koutkia P., Lipinska I., Laposata M., Grinspoon S., Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation Journal of Clinical Endocrinology and Metabolism 2005 90 10 5779 5785
249. Corsonello A., Corica F., Leptin, obesity and platelet responsiveness: another piece in the puzzle Thrombosis and Haemostasis 2008 100 6 960 961
250. Rahmouni K., Morgan D. A., Morgan G. M., Mark A. L., Haynes W. G., Role of selective leptin resistance in diet-induced obesity hypertension Diabetes 2005 54 7 2012 2018
251. Kougias P., Chai H., Lin P. H., Yao Q., Lumsden A. B., Chen C., Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease Journal of Surgical Research 2005 126 1 121 129
252. Darvall K. A. L., Sam R. C., Silverman S. H., Bradbury A. W., Adam D. J., Obesity and Thrombosis European Journal of Vascular and Endovascular Surgery 2007 33 2 223 233
253. Beltowski J., Leptin and atherosclerosis Atherosclerosis 2006 189 1 47 60
254. Nakagawa K., Higashi Y., Sasaki S., Oshima T., Matsuura H., Chayama K., Leptin causes vasodilation in humans Hypertension Research 2002 25 2 161 165
255. Matsuda K., Teragawa H., Fukuda Y., Nakagawa K., Higashi Y., Chayama K., Leptin causes nitric-oxide independent coronary artery vasolidation in humans Hypertension Research 2003 26 2 147 152
256. Frhbeck G., Pivotal role of nitric oxide in the control of blood pressure after leptin administration Diabetes 1999 48 4 903 908
257. Lembo G., Vecchione C., Fratta L., Marino G., Trimarco V., D'Amati G., Trimarco B., Leptin induces direct vasodilation through distinct endothelial mechanisms Diabetes 2000 49 2 293 297
258. Vecchione C., Aretini A., Maffei A., Marino G., Selvetella G., Poulet R., Trimarco V., Frati G., Lembo G., Cooperation between insulin and leptin in the modulation of vascular tone Hypertension 2003 42 2 166 170
259. Oda A., Taniguchi T., Yokoyama M., Leptin stimulates rat aortic smooth muscle cell proliferation and migration Kobe Journal of Medical Sciences 2001 47 3 141 150
260. Li L., Mamputu J.-C., Wiernsperger N., Renier G., Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin Diabetes 2005 54 7 2227 2234
261. Parhami F., Tintut Y., Ballard A., Fogelman A. M., Demer L. L., Leptin enhances the calcification of vascular cells artery wall as a target of leptin Circulation Research 2001 88 9 954 960
262. Cleland S. J., Sattar N., Petrie J. R., Forouhi N. G., Elliott H. L., Connell J. M. C., Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease Clinical Science 2000 98 5 531 535
263. Scherer P. E., Williams S., Fogliano M., Baldini G., Lodish H. F., A novel serum protein similar to C1q, produced exclusively in adipocytes Journal of Biological Chemistry 1995 270 45 26746 26749
264. Han S. H., Quon M. J., Kim J.-A., Koh K. K., Adiponectin and cardiovascular disease: response to therapeutic interventions Journal of the American College of Cardiology 2007 49 5 531 538
265. Pieiro R., Iglesias M. J., Gallego R., Raghay K., Eiras S., Rubio J., Diguez C., Gualillo O., Gonzlez-Juanatey J. R., Lago F., Adiponectin is synthesized and secreted by human and murine cardiomyocytes FEBS Letters 2005 579 23 5163 5169
266. Havel P. J., Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin Current Opinion in Lipidology 2002 13 1 51 59
267. Meier U., Gressner A. M., Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin Clinical Chemistry 2004 50 9 1511 1525
268. Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M. J., Adiponectin stimulates production of nitric oxide in vascular endothelial cells Journal of Biological Chemistry 2003 278 45 45021 45026
269. Soodini G. R., Hamdy O., Adiponectin and leptin in relation to insulin sensitivity Metabolic Syndrome and Related Disorders 2004 2 2 114 123
270. Dyck D. J., Adipokines as regulators of muscle metabolism and insulin sensitivity Applied Physiology, Nutrition, and Metabolism 2009 34 3 396 402
271. Ouchi N., Kihara S., Arita Y., Okamoto Y., Maeda K., Kuriyama H., Hotta K., Nishida M., Takahashi M., Muraguchi M., Ohmoto Y., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y., Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF- B signaling through a cAMP-dependent pathway Circulation 2000 102 11 1296 1301
272. Ouchi N., Walsh K., Adiponectin as an anti-inflammatory factor Clinica Chimica Acta 2007 380 1-2 24 30
273. Kobashi C., Urakaze M., Kishida M., Kibayashi E., Kobayashi H., Kihara S., Funahashi T., Takata M., Temaru R., Sato A., Yamazaki K., Nakamura N., Kobayashi M., Adiponectin inhibits endothelial synthesis of interleukin-8 Circulation Research 2005 97 12 1245 1252
274. Pischon T., Girman C. J., Hotamisligil G. S., Rifai N., Hu F. B., Rimm E. B., Plasma adiponectin levels and risk of myocardial infarction in men Journal of the American Medical Association 2004 291 14 1730 1737
275. Kato H., Kashiwagi H., Shiraga M., Tadokoro S., Kamae T., Ujiie H., Honda S., Miyata S., Ijiri Y., Yamamoto J., Maeda N., Funahashi T., Kurata Y., Shimomura I., Tomiyama Y., Kanakura Y., Adiponectin acts as an endogenous antithrombotic factor Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 1 224 230
276. Elbatarny H. S., Netherton S. J., Ovens J. D., Ferguson A. V., Maurice D. H., Adiponectin, ghrelin, and leptin differentially influence human platelet and human vascular endothelial cell functions: implication in obesity-associated cardiovascular diseases European Journal of Pharmacology 2007 558 13 7 13
277. Bhagat K., Vallance P., Inflammatory cytokines impair endothelium-dependent dilatation in human veins in vivo Circulation 1997 96 9 3042 3047
278. Lau D. C. W., Dhillon B., Yan H., Szmitko P. E., Verma S., Adipokines: molecular links between obesity and atheroslcerosis American Journal of Physiology 2005 288 5 H2031 H2041
279. Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., Kumada M., Hotta K., Nishida M., Takahashi M., Nakamura T., Shimomura I., Muraguchi M., Ohmoto Y., Funahashi T., Matsuzawa Y., Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell Circulation 2002 105 24 2893 2898
280. Wang Y., Lam K. S. L., Xu J. Y., Lu G., Xu L. Y., Cooper G. J. S., Xu A., Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner Journal of Biological Chemistry 2005 280 18 18341 18347
281. Okamoto Y., Arita Y., Nishida M., Muraguchi M., Ouchi N., Takahashi M., Igura T., Inui Y., Kihara S., Nakamura T., Yamashita S., Miyagawa J., Funahashi T., Matsuzawa Y., An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls Hormone and Metabolic Research 2000 32 2 47 50
282. Kumada M., Kihara S., Ouchi N., Kobayashi H., Okamoto Y., Ohashi K., Maeda K., Nagaretani H., Kishida K., Maeda N., Nagasawa A., Funahashi T., Matsuzawa Y., Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages Circulation 2004 109 17 2046 2049
283. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K., Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 1999 402 6762 656 660
284. Broglio F., Prodam F., Riganti F., Muccioli G., Ghigo E., Ghrelin: from somatotrope secretion to new perspectives in the regulation of peripheral metabolic functions Frontiers of Hormone Research 2006 35 102 114
285. Tschp M., Weyer C., Tataranni P. A., Devanarayan V., Ravussin E., Heiman M. L., Circulating ghrelin levels are decreased in human obesity Diabetes 2001 50 4 707 709
286. Sharma V., McNeill J. H., The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology Current Vascular Pharmacology 2005 3 2 169 180
287. Tesauro M., Schinzari F., Rovella V., Di Daniele N., Lauro D., Mores N., Veneziani A., Cardillo C., Ghrelin restores the endothelin 1/nitric oxide balance in patients with obesity-related metabolic syndrome Hypertension 2009 54 5 995 1000
288. Rossi F., Castelli A., Bianco M. J., Bertone C., Brama M., Santiemma V., Ghrelin inhibits contraction and proliferation of human aortic smooth muscle cells by cAMP/PKA pathway activation Atherosclerosis 2009 203 1 97 104
289. Li G.-Z., Jiang W., Zhao J., Pan C.-S., Cao J., Tang C.-S., Chang L., Ghrelin blunted vascular calcification in vivo and in vitro in rats Regulatory Peptides 2005 129 13 167 176
290. Tatemoto K., Hosoya M., Habata Y., Fujii R., Kakegawa T., Zou M.-X., Kawamata Y., Fukusumi S., Hinuma S., Kitada C., Kurokawa T., Onda H., Fujino M., Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor Biochemical and Biophysical Research Communications 1998 251 2 471 476
291. Carpn C., Dray C., Attan C., Valet P., Portillo M. P., Churruca I., Milagro F. I., Castan-Laurell I., Expanding role for the apelin/APJ system in physiopathology Journal of Physiology and Biochemistry 2007 63 4 359 374
292. Boucher J., Masri B., Daviaud D., Gesta S., Guign C., Mazzucotelli A., Castan-Laurell I., Tack I., Knibiehler B., Carpn C., Audigier Y., Saulnier-Blache J.-S., Valet P., Apelin, a newly identified adipokine up-regulated by insulin and obesity Endocrinology 2005 146 4 1764 1771
293. Wei L., Hou X., Tatemoto K., Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes Regulatory Peptides 2005 132 13 27 32
294. Japp A. G., Cruden N. L., Amer D. A. B., Li V. K. Y., Goudie E. B., Johnston N. R., Sharma S., Neilson I., Webb D. J., Megson I. L., Flapan A. D., Newby D. E., Vascular effects of apelin in vivo in man Journal of the American College of Cardiology 2008 52 11 908 913
295. Chandrasekaran B., Dar O., McDonagh T., The role of apelin in cardiovascular function and heart failure European Journal of Heart Failure 2008 10 8 725 732
296. Chen M. M., Ashley E. A., Deng D. X. F., Tsalenko A., Deng A., Tabibiazar R., Ben-Dor A., Fenster B., Yang E., King J. Y., Fowler M., Robbins R., Johnson F. L., Bruhn L., McDonagh T., Dargie H., Yakhini Z., Tsao P. S., Quertermous T., Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction Circulation 2003 108 12 1432 1439
297. Leeper N. J., Tedesco M. M., Kojima Y., Schultz G. M., Kundu R. K., Ashley E. A., Tsao P. S., Dalman R. L., Quertermous T., Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation American Journal of Physiology 2009 296 5 H1329 H1335
298. Betowski J., Apelin and visfatin: unique beneficial adipokines upregulated in obesity? Medical Science Monitor 2006 12 6 RA112 RA119
299. Hashimoto T., Kihara M., Imai N., Yoshida S.-I., Shimoyamada H., Yasuzaki H., Ishida J., Toya Y., Kiuchi Y., Hirawa N., Tamura K., Yazawa T., Kitamura H., Fukamizu A., Umemura S., Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis American Journal of Pathology 2007 171 5 1705 1712
300. Masri B., Morin N., Cornu M., Knibiehler B., Audigier Y., Apelin (6577) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells FASEB Journal 2004 18 15 1909 1911
301. Kleinz M. J., Skepper J. N., Davenport A. P., Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells Regulatory Peptides 2005 126 3 233 240
302. Hashimoto T., Kihara M., Ishida J., Imai N., Yoshida S.-I., Toya Y., Fukamizu A., Kitamura H., Umemura S., Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26 6 1267 1272
303. Li F., Li L., Qin X., Pan W., Feng F., Chen F., Zhu B., Liao D., Tanowitz H., Albanese C., Chen L., Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1 Frontiers in Bioscience 2008 13 10 3786 3792
304. Samal B., Sun Y., Stearns G., Xie C., Suggs S., McNiece I., Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor Molecular and Cellular Biology 1994 14 2 1431 1437
305. Moschen A. R., Kaser A., Enrich B., Mosheimer B., Theurl M., Niederegger H., Tilg H., Visfatin, an adipocytokine with proinflammatory and immunomodulating properties Journal of Immunology 2007 178 3 1748 1758
306. Rasouli N., Kern P. A., Adipocytokines and the metabolic complications of obesity Journal of Clinical Endocrinology and Metabolism 2008 93 11 s64 s73
307. Garten A., Petzold S., Krner A., Imai S.-I., Kiess W., Nampt: linking NAD biology, metabolism and cancer Trends in Endocrinology and Metabolism 2009 20 3 130 138
308. Fukuhara A., Matsuda M., Nishizawa M., Segawa K., Tanaka M., Kishimoto K., Matsuki Y., Murakami M., Ichisaka T., Murakami H., Watanabe E., Takagi T., Akiyoshi M., Ohtsubo T., Kihara S., Yamashita S., Makishima M., Funahashi T., Yamanaka S., Hiramatsu R., Matsuzawa Y., Shimomura I., Visfatin: a protein secreted by visceral fat that Mimics the effects of insulin Science 2005 307 5708 426 430 (Pubitemid 40139988)
309. Yamawaki H., Hara N., Okada M., Hara Y., Visfatin causes endothelium-dependent relaxation in isolated blood vessels Biochemical and Biophysical Research Communications 2009 383 4 503 508
310. Wanecq E., Prvot D., Carpn C., Lack of direct insulin-like action of visfatin/Nampt/PBEF1 in human adipocytes Journal of Physiology and Biochemistry 2009 65 4 351 359
311. Hausenloy D. J., Drug discovery possibilities from visfatin cardioprotection? Current Opinion in Pharmacology 2009 9 2 202 207
312. van der Veer E., Nong Z., O'Neil C., Urquhart B., Freeman D., Pickering J. G., Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation Circulation Research 2005 97 1 25 34
313. Wang P., Xu T.-Y., Guan Y.-F., Su D.-F., Fan G.-R., Miao C.-Y., Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide Cardiovascular Research 2009 81 2 370 380
314. Steppan C. M., Brown E. J., Wright C. M., Bhat S., Banerjee R. R., Dai C. Y., Enders G. H., Silberg D. G., Wen X., Wu G. D., Lazar M. A., A family of tissue-specific resistin-like molecules Proceedings of the National Academy of Sciences of the United States of America 2001 98 2 502 506
315. McTernan C. L., McTernan P. G., Harte A. L., Levick P. L., Barnett A. H., Kumar S., Resistin, central obesity, and type 2 diabetes The Lancet 2002 359 9300 46 47
316. Janke J., Engeli S., Gorzelniak K., Luft F. C., Sharma A. M., Resistin gene expression in human adipocytes is not related to insulin resistance Obesity Research 2002 10 1 1 5
317. Filkov M., Haluzk M., Gay S., enolt L., The role of resistin as a regulator of inflammation: implications for various human pathologies Clinical Immunology 2009 133 2 157 170
318. Bokarewa M., Nagaev I., Dahlberg L., Smith U., Tarkowski A., Resistin, an adipokine with potent proinflammatory properties Journal of Immunology 2005 174 9 5789 5795
319. Verma S., Li S.-H., Wang C.-H., Fedak P. W. M., Li R.-K., Weisel R. D., Mickle D. A. G., Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction Circulation 2003 108 6 736 740
320. Kawanami D., Maemura K., Takeda N., Harada T., Nojiri T., Imai Y., Manabe I., Utsunomiya K., Nagai R., Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions Biochemical and Biophysical Research Communications 2004 314 2 415 419
321. Gmez-Ambrosi J., Frhbeck G., Evidence for the involvement of resistin in inflammation and cardiovascular disease Current Diabetes Reviews 2005 1 3 227 234
322. Jung H. S., Park K.-H., Cho Y. M., Chung S. S., Cho H. J., Cho S. Y., Kim S. J., Kim S. Y., Lee H. K., Park K. S., Resistin is secreted from macrophages in atheromas and promotes atherosclerosis Cardiovascular Research 2006 69 1 76 85
323. Calabro P., Samudio I., Willerson J. T., Yeh E. T. H., Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways Circulation 2004 110 21 3335 3340
324. Ferri C., Bellini C., Desideri G., Baldoncini R., Properzi G., Santucci A., De Mattia G., Circulating endothelin-1 levels in obese patients with the metabolic syndrome Experimental and Clinical Endocrinology and Diabetes 1997 105 2 38 40
325. Irving R. J., Noon J. P., Watt G. C. M., Webb D. J., Walker B. R., Activation of the endothelin system in insulin resistance QJM 2001 94 6 321 326
326. Maeda S., Jesmin S., Iemitsu M., Otsuki T., Matsuo T., Ohkawara K., Nakata Y., Tanaka K., Goto K., Miyauchi T., Weight loss reduces plasma endothelin-1 concentration in obese men Experimental Biology and Medicine 2006 231 6 1044 1047
327. Masaki T., The discovery of endothelins Cardiovascular Research 1998 39 3 530 533
328. Jagroop I. A., Daskalopoulou S. S., Mikhailidis D. P., Endothelin-1 and human platelets Current Vascular Pharmacology 2005 3 4 393 399
329. Knfler R., Urano T., Malyszko J., Takada Y., Takada A., In vitro effect of endothelin-1 on collagen, and ADP-induced aggregation in human whole blood and platelet rich plasma Thrombosis Research 1995 77 1 69 78
330. Scott-Burden T., Resink T. J., Hahn A. W.A., Vanhoutte P. M., Induction of endothelin secretion by angiotensin II: effects on growth and synthetic activity of vascular smooth muscle cells Journal of Cardiovascular Pharmacology 1991 17 supplement 7 S96 S100
331. Anfossi G., Cavalot F., Massucco P., Mattiello L., Mularoni E., Hahn A., Trovati M., Insulin influences immunoreactive endothelin release by human vascular smooth muscle cells Metabolism 1993 42 9 1081 1083
332. Haug C., Voisard R., Lenich A., Baur R., Hher M., Osterhues H., Hannekum A., Vogel U., Mattfeldt T., Hombach V., Grnert A., Increased endothelin release by cultured human smooth muscle cells from atherosclerotic coronary arteries Cardiovascular Research 1996 31 5 807 813 (Pubitemid 26175147)
333. Ivey M. E., Osman N., Little P. J., Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis Atherosclerosis 2008 199 2 237 247
334. Komuro I., Kurihara H., Sugiyama T., Takaku F., Yazaki Y., Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells FEBS Letters 1988 238 2 249 252
335. Kohno M., Yokokawa K., Yasunari K., Kano H., Minami M., Yoshikawa J., Effect of the endothelin family of peptides on human coronary artery smooth-muscle cell migration Journal of Cardiovascular Pharmacology 1998 31 supplement 1 S84 S89
336. Ishida N., Tsujioka K., Tomoi M., Saida K., Mitsui Y., Differential activities of two distinct endothelin family peptides on ileum and coronary artery FEBS Letters 1989 247 2 337 340
337. Harris A. K., Hutchinson J. R., Sachidanandam K., Johnson M. H., Dorrance A. M., Stepp D. W., Fagan S. C., Ergul A., Type 2 diabetes causes remodeling of cerebrovasculature via differential regulation of matrix metalloproteinases and collagen synthesis: role of endothelin-1 Diabetes 2005 54 9 2638 2644
338. Naito S., Shimizu S., Maeda S., Wang J., Paul R., Fagin J. A., Ets-1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells American Journal of Physiology 1998 274 2 C472 C480
339. Rodriguez-Vita J., Ruiz-Ortega M., Ruprez M., Esteban V., Sanchez-Lpez E., Plaza J. J., Egido J., Endothelin-1, via ETA receptor and independently of transforming growth factor-, increases the connective tissue growth factor in vascular smooth muscle cells Circulation Research 2005 97 2 125 134
340. Karalis K. P., Giannogonas P., Kodela E., Koutmani Y., Zoumakis M., Teli T., Mechanisms of obesity and related pathology: linking immune responses to metabolic stress FEBS Journal 2009 276 20 5747 5754
341. Bourlier V., Bouloumie A., Role of macrophage tissue infiltration in obesity and insulin resistance Diabetes and Metabolism 2009 35 4 251 260
342. Ingelsson E., Larson M. G., Yin X., Wang T. J., Meigs J. B., Lipinska I., Benjamin E. J., Keaney J. F. Jr., Vasan R. S., Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample Journal of Clinical Endocrinology and Metabolism 2008 93 8 3149 3157
343. hman M. K., Wright A. P., Wickenheiser K. J., Luo W., Eitzman D. T., Visceral adipose tissue and atherosclerosis Current Vascular Pharmacology 2009 7 2 169 179