An essential role for gp130 in neointima formation following arterial injury

Circulation Research

Volumn 100, Issue 6, 2007, Pages 807-816

  Wang, Dong ^a   Liu, Zhimin ^a   Li, Quanyi ^a   Karpurapu, Manjula ^a   Kundumani Sridharan, Venkatesh ^a   Cao, Huiqing ^a   Dronadula, Nagadhara ^a   Rizvi, Farhan ^a   Bajpai, Arun K ^a   Zhang, Chunxiang ^a   Müller Newen, Gerhard ^b   Harris, Kevin W ^c   Rao, Gadiparthi N ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c University of Alabama at Birmingham   (United States)

Author keywords

Cyclin D1; Cytokines; Migration; Smooth muscle cells; Transcription factors

Indexed keywords

ADENOVIRUS VECTOR; CYCLIN D1; GLYCOPROTEIN GP 130; INTERLEUKIN 6; MESSENGER RNA; SMALL INTERFERING RNA; STAT3 PROTEIN;

ANGIOGENESIS; ANGIOPLASTY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTICLE; BLOOD VESSEL WALL; CAROTID ARTERY; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; INTIMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; CAROTID ARTERY INJURIES; CELL MOVEMENT; CELLS, CULTURED; CYCLIN D1; CYTOKINE RECEPTOR GP130; DISEASE MODELS, ANIMAL; GENE TRANSFER TECHNIQUES; INTERLEUKIN-6; MUSCLE, SMOOTH, VASCULAR; RATS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS; TUNICA INTIMA;

EID: 34147190251     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000261350.61711.9e     Document Type: Article

References (41)

1. Hojo Y, Ikeda U, Katsuki T, Mizuno O, Fukazawa H, Kurosaki K, Fujikawa H, Shimada K. Interleukin 6 expression in coronary circulation after coronary angioplasty as a risk factor for restenosis. Heart. 2000;84:83-87.
2. Liu Z, Dronadula N, Rao GN. A novel role for nuclear factor of activated T cells in receptor tyrosine kinase and G protein-coupled receptor agonist-induced vascular smooth muscle cell motility. J Biol Chem. 2004;279:41218-41226.
3. Kranzhofer R, Schmidt J, Pfeiffer CA, Hagl S, Libby P, Kubler W. Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1999;19:1623-1629.
4. Ikeda U, Ikeda M, Oohara T, Oguchi A, Kamitani T, Tsuruya Y, Kano S. Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner. Am J Physiol. 1991;260:H1713-H1717.
5. Wang Z, Newman WH. Smooth muscle cell migration stimulated by interleukin 6 is associated with cytoskeletal reorganization. J Surg Res. 2003;111:261-266.
6. Pflanz S, Kurth I, Grotzinger J, Heinrich PC, Muller-Newen G. Two different epitopes of the signal transducer gp130 sequentially cooperate on IL-6-induced receptor activation. J Immunol. 2000;165:7042-7049.
7. Taga T, Kishimoto T. Gp130 and the interleukin-6 family of cytokines. Annu Rev Immunol. 1997;15:797-819.
8. Lutticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur AG, Wilks AF, Yasukawa K Taga T. Association of transcription factor APRF and protein kinase JAK1 with the interleukin-6 signal transducer gp130. Science. 1994;263:89-92.
9. Narazaki M, Witthuhn BA, Yoshida K, Silvennoinen O, Yasukawa K, Ihle JN, Kishimoto T, Taga T. Activation of JAK2 Kinase mediated by the interleukin-6 signal transducer gp130. Proc Natl Acad Sci U S A. 1994;91:2285-2289.
10. Stahl N, Farrugella TJ, Boulton TG, Zhong Z, Darnell JE Jr, Yancopoulos GD. Choice of STATs and other substrates specified by modular tyrosine based motifs in cytokine receptors. Science. 1995;267:1349-1353.
11. Jenkins BJ, Roberts AW, Najdovska M, Grail D, Ernst M. The threshold of gp130-dependent STAT-3 signaling is critical for normal regulation of hematopoiesis. Blood. 2005;105:3512-3520.
12. McLoughlin RM, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, Ernst M, Topley N, Jones SA. IL-6 trans-signaling via STAT-3 directs T cell infiltration in acute inflammation. Proc Natl Acad Sci U S A. 2005;102:9589-9594.
13. Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu HJ, Ernst M. Hyperactivation of STAT-3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling. Nat Med. 2005;11:845-852.
14. Selander KS, Li L, Watson L, Merrell M, Dahmen H, Heinrich PC, Muller-Newen G, Harris KW. Inhibition of gp130 signaling in breast cancer blocks constitutive activation of STAT-3 and inhibits in vivo malignancy. Cancer Res. 2004;64:6924-6933.
15. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell JE Jr. STAT-3 as an oncogene. Cell. 1999;98:295-303.
16. Flowers LO, Subramaniam PS, Johnson HM. A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT-3 in prostate cancer cells. Oncogene. 2005;24:2114-2120.
17. Hodge DR, Xiao W, Peng B, Cherry JC, Munroe DJ, Farrar WL. Enforced expression of superoxide dismutase 2/ manganese superoxide dismutase disrupts autocrine interleukin-6 stimulation in human multiple myeloma cells and enhances dexamethasone-induced apoptosis. Cancer Res. 2005;65:6255-6263.
18. Niwa Y, Kanda H, Shikauchi Y, Saiura A, Matsubara K, Kitagawa T, Yamamoto J, Kubo T, Yoshikawa H. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene. 2005;24:6406-6417.
19. Nilsson MB, Langley RR, Fidler IJ. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res. 2005;65:10794-10800.
20. 2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells. J Biol Chem. 2003;278:9986-9992.
21. 2 axis in platelet-derived growth factor BB-induced vascular smooth muscle cell motility. J Biol Chem. 2004;279:46122-46128.
22. 2 expression is required for thrombin-induced vascular smooth muscle cell motility. J Biol Chem. 2005;280:3112-3120.
23. Liu Z, Zhang C, Dronadula N, Li Q, Rao GN. Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model. J Biol Chem. 2005;280:14700-14708.
24. Cao H, Dronadula N, Rizvi F, Li Q, Srivastava K, Gerthoffer WT, Rao GN. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Circ Res. 2006;98:913-922.
25. Berkner KL. Development of adenovirus vectors for the expression of heterologous genes. Biotecniques. 1988;6:616-629.
26. Dronadula N, Rizvi F, Blaskova E, Li Q, Rao GN. Involvement of cAMP-response element binding protein-1 in arachidonic acid-induced vascular smooth muscle cell motility. J Lipid Res. 2006;47:767-777.
27. Kitazawa S, Kitazawa R, Maeda S. Transcriptional regulation of rat cyclin D1 gene by CpG methylation status in promoter region. J Biol Chem. 1999;274:28787-28793.
28. Jackson CL, Raines EW, Ross R, Reidy MA. Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury. Arterioscler Thromb. 1993;13:1218-1226.
29. Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res. 1994;75:539-545.
30. Matsumura I, Kitamura T, Wakao H, Tanaka H, Hashimoto K, Albanese C, Downward J, Pestell RG, Kanakura Y. Transcriptional regulation of the cyclin D1 promoter by STAT-5: its involvement in cytokine-dependent growth of hematopoietic cells. EMBO J. 1999;18:1367-1377.
31. Neumeister P, Pixley FJ, Xiong Y, Xie H, Wu K, Ashton A, Cammer M, Chan A, Symons M, Stanley ER, Pestell RG. Cyclin D1 governs adhesion and motility of macrophages. Mol Biol Cell. 2003;14:2005-2015.
32. Li Z, Wang C, Jiao X, Lu Y, Fu M, Quong AA, Dye C, Yang J, Dai M, Ju X, Zhang X, Li A, Burbelo P, Stanley ER, Pestell RG. Cyclin D1 regulates cellular migration through the inhibition of thrombospondin 1 and ROCK signaling. Mol Cell Biol. 2006;26:4240-4256.
33. Vlasic N, Ramos L, Mittelman A, Stemerman MB. Inhibition of smooth muscle cell proliferation and DNA synthesis by vasoprin - a biologic response modifier. Atherosclerosis. 1993;104:79-85.
34. Clowes AW, Reidy MA, Clowes MM. Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium. Lab Invest. 1983;49:327-333.
35. Rittersma SZ, Meuwissen M, van der Loos CM, Koch KT, de Winter RJ, Piek JJ, van der Wal AC. Eosinophilic infiltration in restenotic tissue following coronary stent implantation. Atherosclerosis. 2006;184:157-162.
36. Piek JJ, van der Wal AC, Meuwissen M, Koch KT, Chamuleau SA, Teeling P, van der Loos CM, Becker AE. Plaque inflammation in restenotic coronary lesions of patients with stable or unstable angina. J Am Coll Cardiol. 2000;35:963-967.
37. Fredji S, Bescond J, Louault C, Delwail A, Lecron JC, Poyreau D. Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation. J Cell Physiol. 2005;204:428-436.
38. Ruef J, Meshel AS, Hu Z, Horaist C, Ballinger CA, Thompson LJ, Subbarao VD, Dumont JA, Patterson C. Flavopiridol inhibits smooth muscle cell proliferation in vitro and neointimal formation in vivo after carotid injury in the rat. Circulation. 1999;100:659-665.
39. Fu M, Wang C, Rao M, Wu X, Bouras T, Zhang X, Li Z, Jiao X, Yang J, Li A, Perkins ND, Thimmapaya B, Kung AL, Munoz A, Giordano A, Lisanti MP, Pestell RG. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J Biol Chem. 2005;280:29728-29742.
40. Watanabe S, Mu W, Kahn A, Jing N, Li JH, Lan HY, Nakagawa T, Ohasshi R, Johnson RJ. Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells. Am J Nephrol. 2004;24:387-392.
41. Spinetti G, Wang M, Monticone R, Zhang J, Zhao D, Lakatta EG. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol. 2004;24:1397-1402.