An IκB-α mutant inhibits cytokine gene expression and proliferation in human vascular smooth muscle cells

Journal of Surgical Research

Volumn 102, Issue 2, 2002, Pages 198-206

  Wang, Zhongbiao ^a   Castresana, Manuel R ^a   Detmer, Kristina ^a   Newman, Walter H ^a  

^a MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cell growth; Cytokine gene expression; Nuclear factor B; Vascular smooth muscle cells; Viral mediated gene transfer

Indexed keywords

ADENOVIRUS VECTOR; CYTOKINE; I KAPPA B ALPHA; I KAPPA B ALPHA M; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MUTANT PROTEIN; SYNAPTOTAGMIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; I KAPPA B; LIPOPOLYSACCHARIDE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DENSITY; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; GENE TRANSFER; HUMAN; HUMAN CELL; INTERNAL MAMMARY ARTERY; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSACTIVATION; VIRUS INFECTION; ADENOVIRUS; CELL COUNT; CELL DIVISION; CELL SURVIVAL; CYTOLOGY; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; IMMUNOLOGY; MAMMARY ARTERY; METABOLISM; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE;

ADENOVIRIDAE; APOPTOSIS; CELL COUNT; CELL DIVISION; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; GENETIC VECTORS; HUMANS; I-KAPPA B PROTEINS; INTERLEUKIN-6; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MAMMARY ARTERIES; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036024969     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2001.6320     Document Type: Article

References (44)

1. A cascade model for restenosis: A special case of atherosclerosis progression
2. Atherosclerosis - An inflammatory disease
3. Detection and localization of tumor necrosis factor in human atheroma
4. Tumor necrosis factor gene expression in human vascular intimal smooth muscle cells detected by in situ hybridization
5. Tumor necrosis factor-alpha in human arterial wall with atherosclerosis
6. Proliferating arterial smooth muscle cells after balloon injury express TNF-α but not interleukin-1 or basic fibroblast growth factor
7. Smooth muscle cells of the coronary arterial tunica media express tumor necrosis factor-α and proliferate during acute rejection of rabbit cardiac allografts
8. Function and activation of NF-kB in the immune system
9. Role of nuclear factor-kB in atherogenesis
10. The NF-kB and IkB proteins: New discoveries and insights
11. Nuclear factor-κB regulates induction of apoptosis and inhibitor of apoptosis protein-1 expression in vascular smooth muscle cells
12. Delineation of an antiapoptotic action of glucocorticoids in hepatoma cells: The role of nuclear factor-κB
13. 1
14. The role of nuclear factor-kB in cytokine gene regulation
15. The NF-κB and IκB system in injured arteries
16. Activation of the NF-κB and IκB system in smooth muscle cells after rat arterial injury: Induction of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1
17. The nuclear factor-kB signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis
18. Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion
19. Phosphorylation of human IκB-α in serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
20. Human blood vessels release tumor necrosis factor alpha from a smooth muscle cell source
21. Inhibition of release of tumor necrosis factor-α from human vascular tissue and smooth muscle cells by glucocorticoids
22. Molecular cloning of the complimentary DNA for human tumor necrosis factor
23. Genomic structure of the murine IL-6 gene: High degree conservation of the regulatory sequences between mouse and human
24. Coding region of interleukin-8 gene of lung giant cell carcinoma LU65C cells that produce LUCT/interleukin-8: Homogenity in interleukin-8 genes
25. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice
26. Methods for construction of adenovirus vectors
27. Enhancement of liposome-mediated gene-transfer into vascular tissue by replication deficient adenovirus
28. Accurate transcription initiated by RNA polymerase II in a soluble extract from isolated mammalian nuclei
29. Single-step method of RNA isolation by acid guanidinium isothiocynate-phenol-chloroform extraction
30. Overexpression of inducible nitric oxide synthase by neointimal smooth muscle cells
31. A rapid and simple method for the isolation of apoptotic DNA fragments
32. Differential staining of apoptotic nuclei in living cells: Application to macronuclear elimination in Tetrahymena
33. Disruption of Hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-κB activation
34. Inflammation, obesity, stress and coronary heart disease: Is interleukin-6 the link?
35. Interleukin-8 mediates downregulation of tissue inhibitor of metalloproteinase-1 expression in cholesterol-loaded human macrophages: Relevance to stability of atherosclerotic plaque
36. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm
37. Distinct functional properties of I kappa B alpha and I kappa B beta
38. Antisense oligonucleotides to the p65 subunit of NF-kB inhibit vascular smooth muscle cell adherence and proliferation and prevent neointima fromation in rat carotid arteries
39. Liposomal delivery of purified inhibitory-κBα inhibits tumor necrosis factor-α-induced human vascular smooth muscle proliferation
40. The NF-κB inhibitory peptide, IκBα, prevents human vascular smooth muscle proliferation
41. Overexpression of truncated IκBα induces TNF-α-dependent apoptosis in human vascular smooth muscle cells
42. Inhibition of the transcription factor nuclear factor-κB by adenoviral-mediated expression of IκBαM results in tumor cell death
43. Cytoskeletal control of gene expression: Depolymerization of microtubules activates NF-κB