Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 37402-37408

  Hasty, Alyssa H ^a   Shimano, Hitoshi ^b   Osuga, Jun Ichi ^a   Namatame, Ichiji ^a   Takahashi, Akimitsu ^b   Yahagi, Naoya ^a   Perrey, Stéphane ^a   Iizuka, Yoko ^a   Tamura, Yoshiaki ^a   Amemiya Kudo, Michiyo ^a   Yoshikawa, Tomohiro ^a   Okazaki, Hiroaki ^a   Ohashi, Ken ^a   Harada, Kenji ^a   Matsuzaka, Takashi ^b   Sone, Hirohito ^b   Gotoda, Takanari ^a   Nagai, Ryozo ^a   Ishibashi, Shun ^a   Yamada, Nobuhiro ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DISEASES; ENZYMES; INSULIN;

INSULIN RESISTANCES;

BIOCHEMISTRY;

APOLIPOPROTEIN B; CHOLESTEROL; LEPTIN RECEPTOR; LIVER ENZYME; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; TRIACYLGLYCEROL; LEPTIN; LIPOPROTEIN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; FEMALE; GENOTYPE; HORMONAL THERAPY; HORMONE DEFICIENCY; HYPERCHOLESTEROLEMIA; HYPERLIPOPROTEINEMIA; HYPERTRIGLYCERIDEMIA; LIPID ANALYSIS; LIPOGENESIS; LIVER METABOLISM; MALE; METABOLIC DISORDER; MOUSE; MOUSE MUTANT; NONHUMAN; OBESITY; PRIORITY JOURNAL; ANIMAL; ARTERIOSCLEROSIS; BLOOD; C57BL MOUSE; DIET; DISEASE MODEL; METABOLISM;

ANIMALIA; MURINAE;

ANIMALS; ARTERIOSCLEROSIS; DIET; DISEASE MODELS, ANIMAL; HYPERCHOLESTEROLEMIA; HYPERTRIGLYCERIDEMIA; LEPTIN; LIPOPROTEINS; MICE; MICE, INBRED C57BL; RECEPTORS, LDL;

EID: 0035813206     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010176200     Document Type: Article

References (21)

1. Coleman, D. L. (1978) Diabetologia 14, 141-148
2. Zhang, Y., Proenca, R., Maffel, M., Barone, M., Leopold, L., and Friedman, J. M. (1994) Nature 372, 425-432
3. Nishina, P. M., Lowe, S., Wang, J., and Paigen, B. (1994) Metabolism 43, 549-553
4. Li, X., Grundy, S. M., and Patel, S. B. (1997) J. Lipid Res. 38, 1277-1288
5. Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., and Breslow, J. L. (1992) Cell 71, 343-353
6. Zhang, S. H., Reddick, R. L., Piedrahita, J. A., and Maeda, N. (1992) Science 258, 468-471
7. Ishibashi, S., Goldstein, J. L., Brown, M. S., Herz, J., and Burns, D. K. (1994) J. Clin. Invest. 93, 1885-1893
8. Rohlmann, A., Gotthardt, M., Hammer, R. E., and Herz, J. (1998) J. Clin. Invest. 101, 689-695
9. Horton, J. D., Shimano, H., Hamilton, R. L., Brown, M. S., and Goldstein, J. L. (1999) J. Clin. Invest. 103, 1067-1076
10. Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., and Herz, J. (1993) J. Clin. Invest. 92, 883-893
11. Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M., and Goldstein, J. L. (1996) J. Clin. Invest. 7, 1575-1584
12. Shimano, H., Yahagi, N., Amemiya-Kudo, M., Hasty, A., Osuga, J., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., Harada, K., Gotoda, T., Ishibashi, S., and Yamada, N. (1999) J. Biol. Chem. 274, 35832-35839
13. Yagyu, H., Ishibashi, S., Chen, Z., Osuga, J., Okazaki, M., Perrey, S., Kitamine, T., Shimada, M., Ohashi, K., Harada, K., Shionoiri, F., Yahagi, N., Gotoda, T., Yazaki, Y., and Yamada, N. (1999) J. Lipid Res. 40, 1677-1685
14. Paigen, B., Morrow, A., Holmes, P. A., Mitchell, D., and Williams, R. A. (1987) Atherosclerosis 68, 231-240
15. Silver, D. L., Jiang, X.-C., and Tall, A. R. (1999) J. Biol. Chem. 274, 4140-4146
16. Shimomura, I., Bashmakov, Y., and Horton, J. (1999) J. Biol. Chem. 274, 30028-30032
17. Horton, J. D., Bashmakov, Y., Shimomura, I., and Shimano, H. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 5987-5992
18. Yahagi, N., Shimano, H., Hasty, A., Amemiya-Kudo, M., Okazaki, H., Tamura, Y., Iizuka, Y., Shionoiri, F., Ohashi, K., Osuga, J., Harada, K., Gotoda, T., Nagai, R., Ishibashi, S., and Yamada, N. (1999) J. Biol. Chem. 274, 35840-35844
19. Osono, Y., Woollett, L. A., Herz, J., and Dietschy, J. M. (1995) J. Clin. Invest. 95, 1124-1132
20. Silver, D. L., Wang, N., and Tall, A. R. (2000) J. Clin. Invest. 105, 151-159
21. Muir, J. R. (1967) Clin. Chim. Acta 17, 312-314