Insulin action and insulin resistance in vascular endothelium

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 10, Issue 4, 2007, Pages 523-530

  Muniyappa, Ranganath ^a   Quon, Michael J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Endothelial dysfunction; Insulin resistance; Metabolic syndrome; Nitric oxide

Indexed keywords

ANGIOTENSIN II ANTAGONIST; CARDIOVASCULAR AGENT; CELL ADHESION MOLECULE; ENALAPRIL; ENDOTHELIN 1; EPIGALLOCATECHIN; GLUCOSAMINE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; INSULIN SENSITIZING AGENT; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RAMIPRIL; ROSIGLITAZONE; SILDENAFIL; SIMVASTATIN; TRIMETAZIDINE;

BLOOD FLOW; CAPILLARY FLOW; CARDIOVASCULAR DISEASE; COMBINATION CHEMOTHERAPY; DIET; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; EXERCISE; HUMAN; HYPERTENSION; INFLAMMATION; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; METABOLIC REGULATION; METABOLISM; NONHUMAN; REVIEW; SIGNAL DETECTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TARGET ORGAN; VASODILATATION;

CARDIOVASCULAR PHYSIOLOGY; CARDIOVASCULAR SYSTEM; ENDOTHELIUM, VASCULAR; HUMANS; INSULIN; INSULIN RESISTANCE; NITRIC OXIDE; SIGNAL TRANSDUCTION;

EID: 34250676461     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32819f8ecd     Document Type: Review

References (51)

1. Vincent MA, Montagnani M, Quon MJ. Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium. Curr Diab Rep 2003; 3:279-288.
2. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006; 113:1888-1904. This editorial reviews the mechanisms that couple vascular and metabolic physiology, the role of inflammation in insulin resistance and endothelial dysfunction, and the role of insulin resistance in coupling vascular and metabolic pathophysiology.
3. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 2006; 7:85-96.
4. Takahashi S, Mendelsohn ME. Synergistic activation of endothelial nitric-oxide synthase (eNOS) by HSP90 and Akt: calcium-independent eNOS activation involves formation of an HSP90-Akt-CaM-bound eNOS complex. J Biol Chem 2003; 278:30821-30827.
5. Montagnani M, Golovchenko I, Kim I, et al. Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem 2002; 277:1794-1799.
6. Andreozzi F, Laratta E, Procopio C, et al. Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol 2007; 27:2372-2383. This study elucidates the effect of interleukin-6 on insulin signaling involved in the production of nitric oxide in human endothelial cells.
7. Potenza MA, Marasciulo FL, Chieppa DM, et al. Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production. Am J Physiol Heart Circ Physiol 2005; 289:H813-H822.
8. Potenza MA, Marasciulo FL, Tarquinio M, et al. Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance. Diabetes 2006; 55:3594-3603.
9. Formoso G, Chen H, Kim JA, et al. Dehydroepiandrosterone mimics acute actions of insulin to stimulate production of both nitric oxide and endothelin 1 via distinct phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-dependent pathways in vascular endothelium. Mol Endocrinol 2006; 20:1153-1163.
10. Mukai Y, Wang CY, Rikitake Y, Liao JK. Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type-1 expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol 2006; 292:H1937-H1942.
11. Lteif A, Vaishnava P, Baron AD, Mather KJ. Endothelin limits insulin action in obese/insulin-resistant humans. Diabetes 2007; 56:728-734. This study demonstrates that increased endogenous endothelin action contributes to insulin resistance in skeletal muscle of obese individuals.
12. Kashyap SR, Roman LJ, Lamont J, et al. Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects. J Clin Endocrinol Metab 2005; 90:1100-1105.
13. Ross RM, Kolka CM, Rattigan S, Clark MG. Acute blockade by endothelin-1 of haemodynamic insulin action in rats. Diabetologia 2007; 50:443-451.
14. Bradley EA, Clark MG, Rattigan S. Acute effects of wortmannin on insulin's hemodynamic and metabolic actions in vivo. Am J Physiol Endocrinol Metab 2007; 292:E779-E787.
15. Eringa EC, Stehouwer CD, van Nieuw Amerongen GP, et al. Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium. Am J Physiol Heart Circ Physiol 2004; 287:H2043-H2048.
16. Cardillo C, Nambi SS, Kilcoyne CM, et al. Insulin stimulates both endothelin and nitric oxide activity in the human forearm. Circulation 1999; 100:820-825.
17. Kim F, Tysseling KA, Rice J, et al. Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta. Arterioscler Thromb Vasc Biol 2005; 25:989-994.
18. Wang XL, Zhang L, Youker K, et al. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase. Diabetes 2006; 55:2301-2310.
19. Du X, Edelstein D, Obici S, et al. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest 2006; 116:1071-1080. In nondiabetic rodent models of insulin resistance, inactivation of eNOS was prevented by inhibition of fatty acid oxidation and by reduction of superoxide levels. This study provides a novel mechanism for FFA-induced reduction in NOS activity.
20. Clerk LH, Rattigan S, Clark MG. Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. Diabetes 2002; 51:1138-1145.
21. Piatti PM, Monti LD, Conti M, et al. Hypertriglyceridemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans. Diabetes 1996; 45:316-321.
22. Monti LD, Setola E, Fragasso G, et al. Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy. Am J Physiol Endocrinol Metab 2006; 290:E54-E59. In this study, inhibition of fatty acid oxidation with trimetazidine simultaneously increases insulin-stimulated nitric oxide formation and reduces endothelin-1 release in patients with type 2 diabetes.
23. Du XL, Edelstein D, Dimmeler S, et al. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 2001; 108:1341-1348.
24. Wallis MG, Smith ME, Kolka CM, et al. Acute glucosamine-induced insulin resistance in muscle in vivo is associated with impaired capillary recruitment. Diabetologia 2005; 48:2131-2139.
25. Xu B, Chibber R, Ruggiero D, et al. Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products. Faseb J 2003; 17:1289-1291.
26. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 2006; 114:597-605.
27. Desideri G, Gaspardone A, Gentile M, et al. Endothelial activation in patients with cardiac syndrome X. Circulation 2000; 102:2359-2364.
28. Cardillo C, Campia U, Bryant MB, Panza JA. Increased activity of endogenous endothelin in patients with type II diabetes mellitus. Circulation 2002; 106:1783-1787.
29. Scognamiglio R, Negut C, De Kreutzenberg SV, et al. Postprandial myocardial perfusion in healthy subjects and in type 2 diabetic patients. Circulation 2005; 112:179-184.
30. Vincent MA, Clerk LH, Lindner JR, et al. Mixed meal and light exercise each recruit muscle capillaries in healthy humans. Am J Physiol Endocrinol Metab 2006; 290:E1191-E1197. This study demonstrates that mixed meals or light exercise recruits skeletal muscle capillary recruitment.
31. Anderson HD, Rahmutula D, Gardner DG. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem 2004; 279:963-969.
32. Eringa EC, Stehouwer CD, Walburg K, et al. Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinase. Arterioscler Thromb Vasc Biol 2006; 26:274-280. This study demonstrates that TNF-α inhibits vasodilator (nitric oxide mediated) but not vasoconstrictor (endothelin 1-mediated) effects of insulin in skeletal muscle resistance arteries.
33. Zhang L, Wheatley CM, Richards SM, et al. TNF-alpha acutely inhibits vascular effects of physiological but not high insulin or contraction. Am J Physiol Endocrinol Metab 2003; 285:E654-E660.
34. Sury MD, Frese-Schaper M, Muhlemann MK, et al. Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase. Free Radic Biol Med 2006; 41:1372-1383.
35. Xu JW, Morita I, Ikeda K, et al. C-reactive protein suppresses insulin signaling in endothelial cells: role of spleen tyrosine kinase. Mol Endocrinol 2007; 21:564-573. This study elucidates the molecular mechanisms through which C-reactive protein simultaneously increases insulin-induced endothelin-1 secretion and decreases nitric oxide production in the endothelium.
36. Rask-Madsen C, Dominguez H, Ihlemann N, et al. Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 2003; 108:1815-1821.
37. Civitarese AE, Carling S, Heilbronn LK, et al. Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans. PLoS Med 2007; 4:e76. This study suggests that short-term caloric restriction (with or without physical exercise) simultaneously improves insulin sensitivity, raises circulating adiponectin levels, and increases skeletal muscle eNOS expression in humans.
38. Hamdy O, Ledbury S, Mullooly C, et al. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 2003; 26:2119-2125.
39. Hambrecht R, Adams V, Erbs S, et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003; 107:3152-3158.
40. Maeda S, Jesmin S, Iemitsu M, et al. Weight loss reduces plasma endothelin-1 concentration in obese men. Exp Biol Med (Maywood) 2006; 231:1044-1047.
41. Piatti PM, Monti LD, Valsecchi G, et al. Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care 2001; 24:875-880.
42. Lucotti P, Setola E, Monti LD, et al. Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab 2006; 291:E906-E912.
43. Iso H, Date C, Wakai K, et al. The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med 2006; 144:554-562.
44. Potenza MA, Marasciulo FL, Tarquinio M, et al. Epigallocatechin gallate, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial ischemia/reperfusion injury in spontaneously hypertensive rats (SHR). Am J Physiol Endocrinol Metab 2007 [Epub ahead of print]. This study demonstrates that EGCG administration to insulin-resistant rats simultaneously improves endothelial dysfunction and insulin resistance by targeting the imbalance in PI3K/Akt and MAPK pathways.
45. Wang TD, Chen WJ, Cheng WC, et al. Relation of improvement in endothelium-dependent flow-mediated vasodilation after rosiglitazone to changes in asymmetric dimethylarginine, endothelin-1, and C-reactive protein in nondiabetic patients with the metabolic syndrome. Am J Cardiol 2006; 98:1057-1062.
46. Koh KK, Quon MJ, Han SH, et al. Vascular and metabolic effects of combined therapy with ramipril and simvastatin in patients with type 2 diabetes. Hypertension 2005; 45:1088-1093.
47. Yamamoto E, Yamashita T, Tanaka T, et al. Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects. Arterioscler Thromb Vasc Biol 2007; 27:556-563.
48. Economides PA, Caselli A, Tiani E, et al. The effects of atorvastatin on endothelial function in diabetic patients and subjects at risk for type 2 diabetes. J Clin Endocrinol Metab 2004; 89:740-747.
49. Davis BJ, Xie Z, Viollet B, Zou MH. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes 2006; 55:496-505. This study demonstrates that AMP-activated kinase dependent, heat shock protein 90 mediated eNOS activation may mediate the beneficial effects of metformin on the endothelium.
50. Orio F Jr, Palomba S, Cascella T, et al. Improvement in endothelial structure and function after metformin treatment in young normal-weight women with polycystic ovary syndrome: results of a 6-month study. J Clin Endocrinol Metab 2005; 90:6072-6076.
51. Ayala JE, Bracy DP, Julien BM, et al. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 2007; 56:1025-1033.