Investigation of oxidant stress and vasodepression to glyceryl trinitrate in the obese Zucker rat in vivo

British Journal of Pharmacology

Volumn 125, Issue 4, 1998, Pages 895-901

  Laight, David W ^a   Kengatharan, K M ^a   Gopaul, Nitin K ^a   Änggård, Erik E ^a   Carrier, Martin J ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

Nitrate tolerance; Nitric oxide; Oxidant stress; Zucker rat

Indexed keywords

ACETYLCHOLINE; ALPHA TOCOPHEROL; ANTIOXIDANT; GLYCERYL TRINITRATE; PROBUCOL; PROSTAGLANDIN F2 ALPHA; SCAVENGER; SUPEROXIDE; TIRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DRUG TOLERANCE; INTRAVENOUS DRUG ADMINISTRATION; LIPID PEROXIDATION; MALE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRESSOR RESPONSE; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; RAT;

ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; BODY WEIGHT; DIETARY SUPPLEMENTS; DRUG TOLERANCE; LIPID PEROXIDATION; MALE; NITROGLYCERIN; OBESITY; OXIDATIVE STRESS; PROSTAGLANDINS F; RATS; RATS, ZUCKER; VASOCONSTRICTOR AGENTS; VITAMIN E;

EID: 0031728129     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702132     Document Type: Article

References (51)

1. AHLNER, J., ANDERSSON, R.G.G., TORFGARD, K. & AXELSON, K.L. (1941). Organic nitrate esters: clinical use and mechanisms of action. Pharmacol. Rev., 43, 351-423.
2. AMBROZY, S.L., SHEHIN, S.E., CHIOU, C.-Y., SOWERS, J.R. & ZEMEL, M. B. (1991). Effects of dietary calcium on blood pressure, vascular reactivity and vascular smooth muscle calcium efflux rate in Zucker rats. Am. J. Hypertens., 4, 592-596.
3. AUGUET, M., DELAFLOTTE, P. & BRAQUET, P. (1989). Increased influence of endothelium in obese Zucker rat aorta. J. Pharm. Pharmacol., 41, 861-864.
4. BASSENGE, E. & FINK, B. (1995). Suppression of nitrate induced tolerance by vitamin C and other antioxidants. In Biology of Nitric Oxide Part 5. ed. Moncada, S., Stamler, J., Gross, S. & Higgs, E.A. p. 198. London: Portland Press.
5. BAYNES, J.W. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes, 40, 405-412.
6. BENNETT, B.M., MCDONALD, B.J.. NIGAM, R. & SIMON, W.C. (1994). Biotransformation of organic nitrates and vascular smooth muscle function. Trends Pharmacol. Sci., 15, 245-249.
7. BRAY, G.A. (1977). The Zucker-fatty rat: a review. Fed. Proc. 36, 148-153.
8. CHONG, S.J. & FUNG, H.-L. (1990). Biochemical and pharmacological interactions between nitroglycerin and thiols. Biochem. Pharmacol., 42, 1433-1439.
9. DARLEY-USMAR, V., WISEMAN, H. & HALLIWEEL, B. (1995). Nitric oxide and oxygen free radicals: a question of balance. FEBS LETT., 369, 131-135.
10. ELKAYAM, U. (1991). Tolerance to organic nitrates: evidence, mechanisms, clinical relevance, and strategies for prevention. Ann. Int. Med., 114, 667-677.
11. FEENER, E.P. & KING, G.L. (1997). Vascular dysfunction in diabetes mellitus. Lancet, 30,(suppl. 1), 9-13.
12. FINK, B., DIKALOV, S., SKATCHKOV, M. & BASSENGE, E. (1997). Nitroglycerin and oxidative stress: new ESR spin trap for superoxide radical detection in vivo. Circ., 96, 240.
13. GIUGLIANO, D., ACAMPORA, R. & D'ONOFRIO, E. (1994). Medical hypothesis: cardiovascular complications of diabetes mellitus-from glucose to insulin and back. Diabete Metabolisme, 20, 445-453.
14. GIUGLIANO, D., CERIELLO, A. & PAOLISSO, G. (1995a). Oxidative stress and diabetic vascular complications. Diabetes Care, 19, 257-267.
15. GIUGLIANO, D., MARFELLA, R., VERRAZZO, G., ACAMPORA, R., DONZELLA, C., QUATRARO, A., COPPOLA, L. & D'ONOFRIO, F. (1995b). Abnormal rheologic effects of glyceryl trinitrate in patients with non-insulin dependent diabetes mellitus and reversal by antioxidants. Ann. Intern. Med., 123, 338-343.
16. 2x levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Lett., 368, 225-229.
17. GROWCOTT, J.W., COX, B., TORR, V., HATTON, R. & ROLLINGSWORTH, M. (1995). Hyperreactivity of aortae from the obese Zucker rat: impairment of smooth muscle function? Br. J. Pharmacol., 114, P189.
18. GRYGLEWSKI, R.J., PALMER, R.M. & MONCADA, S. (1986). superoxide anion is involved in the breakdown of endothelium-derived relaxing factor. Nature, 320, 454-458.
19. HALLIWELL, B. (1991). Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am. J. Med., 91(suppl. 3C), 14-21.
20. HALLIWELL, B. (1993). The role of oxygen radicals in human disease, with particular reference to the vascular system. Haemostasis, 23(suppl. 1), 118-126.
21. KATUSIC, Z.S. (1996). Superoxide anion and endothelial regulation of arterial tone. Free Rad. Biol. Med., 20, 443-448.
22. KAWAMURA, M., HEINECKE, J.W. & CHAIT, A. (1994). Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway. J. Clin. Invest., 94, 771-778.
23. KEEN, C.L., OLIN, K.L., OSTER, M.H., THURMOND, D.C., GERMAN, B.J., STERN, J.S. & PHINNEY, S.D. (1992). The obese Zucker rat and its lean control are characterized by marked differences in the antioxidant defence system. Faseb J., 5, A1677.
24. KRISHNA MOHAN, I. & DAS, U.N. (1997). Oxidant stress, antioxidants and nitric oxide in non-insulin dependent diabetes mellitus. Med. Sci. Res., 25, 55-57.
25. LAIGHT, D.W., ANDREWS, T.J., HAJ-YEHIA, A.I., CARRIER, M.J. & ÄNGGÅRD, E.E. (1997a). Microassay of superoxide anion scavenging activity in vitro. Environ. Toxicol. Pharmacol., 3, 65-68.
26. LAIGHT, D.W., CARRIER, M.J. & ÄNGGÅRD, E.E. (1997b). Investigation of role for oxidant stress in vascular tolerance development to glyceryl trinitrate in vitro. Br. J. Pharmacol., 120, 1477-1482.
27. LEFFLER, C.W., MIRRO, R., THOMPSON, M., SHIBATA, M., ARMSTEAD, W.M., POURCYROUS, M. & THELIN, O. (1991). Activated oxygen species do not mediate hypercapnia-induced cerebral vasodilation in new-born pigs. Am. J. Physiol., 261, H335-H342.
28. MAXWELL., S.R.J. (1995). Prospects for the use of antioxidant therapies. Drugs. 49, 345-361.
29. MCVEIGH, G.E. BRENNAN, G.M., HAYES, R. & JOHNSTON, D. (1994). Primary nitrate tolerance in diabetes mellitus. Diabetologia. 37, 115-117.
30. MCVEIGH, G.E., BRENNAN, G.M., JOHNSTON, G.D., MCDERMOTT, B.J., MCGRATH, L.T., HENRY, W.R., ANDREWS, J.W. & HAYES, J.R. (1992). Impaired endothelium-dependent and independent vasodilation in patients with Type 2 diabetes mellitus. Diabetologia, 35, 771-776.
31. MILLER, R.W. & RAPP, U. (1973). The oxidation of catechols by reduced flavins and dehydrogenases. J. Biol. Chem., 248, 6084-6090.
32. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
33. MORROW, J.D. & ROBERTS II. L.J. (1996). The Isoprostanes. Current knowledge and directions for future research, Biochem. Pharmacol., 51, 1-9.
34. MÜNZEL, T., KURZ, S., HEITZER, T. & HARRISON, D.G. (1996). New insights into mechanisms underlying nitrate tolerance. Am. J. Cardiol., 77, 24C-30C.
35. MÜNZEL, T., SAYEGH, S., FREEMAN, B.A., TARPEY, M.M. & HARRISON, D.G. (1995). Evidence for enhanced vascular superoxide union production in nitrate tolerance. J. Clin. Invest., 95, 187-194.
36. NEWMAN, C.M., WARREN, J.B. & TAYLOR, G.W. (1990). Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N-acetyl-L-but not N-acetyl-D-cysteine. Br. J. Pharmacol., 99, 825-829.
37. NOUROOZ-ZADEH, J., & TAJADDINI-SARMADI, J., MCCARTHY, S., BETTERIDGE, D.J. & WOLFF, S.P. (1995). Elevated levels of authentic plasma hydroperoxides in NIDDM Diabetes. 44, 1054-1058.
38. PALMER, R.M.J., FERRIGE, A.G. & MONCADA, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 327, 524-526.
39. PAMIDIMUKKALA, J. & JANDHYALA, B. (1996). Evaluation of haemodynamics, vascular reactivity and baroreceptor compensation in the insulin resistant Zucker obese rats. Clin. Exp. Hypertens., 18, 1089-1104.
40. PAOLISSO, G., D'AMORE, A., VOLPE, C., BALBI, V., SACCOMANNO, F., GALZERANO, D., GIUGLIANO, D., VARRICCHIO, M. & D'ONOFRIO, F. (1994). Evidence for a relationship between oxidative stress and insulin action in non-insulin-dependent (Type II) diabetic patients. Metab. 43, 1426-1429.
41. SEXL, V., MANCUSI, G., RABERGER, G. & SCHÜTZ, W. (1995). Age-related changes in vascular reactivity in genetically diabetic rats. Pharmacol., 50, 238-246.
42. STERN, J., JOHNSON, P.R., GREENWOOD, M.R., HIRSCH, J. & ZUCKER, L.M. (1972). Insulin resistance and pancreatic insulin release in the genetically obese Zucker rat. Proc. Soc. Exp. Biol. Med., 139, 66-69.
43. TESFAMARIAM, B. (1993). Free radicals in diabetic endothelial cell dysfunction. Free Rad. Biol. Med., 16, 383-391.
44. THADANI, U., & DE VANE, P.J. (1992). Efficacy of isosorbide mononitrate in angina pectoris. Am. J. Cardiol., 70, 676-716.
45. TING, H.H. TIMIMI, E.K., BOLES, K.S., CREAGER, S.J., GANZ, P. & CREAGER, M.A. (1996). Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest., 97, 22-28.
46. TURNER, N.C. & WHITE, P. (1996). Effects of streptozotocin-induced diabetes on vascular reactivity in genetically hyperinsulinaemic obese Zucker rats. J. Cardiovasc. Pharmacol., 27, 884-890.
47. UTEPBERGENOV, D.I., FINK, B., SKATCHKOV, M.P. & KHRAMTSOV, J.N. (1996). Ascorbate-induced thiol mediated prevention of tolerance to organic nitrates. FASEB. J., 10, 3281.
48. VORMANN, J., BLUMENTHAL, A., MERKER, H.J. & GÜNTHER, T. (1997). Reduced glucosuria by oral magnesium supplementation and decreased lipid peroxidation by increased vitamin E supply in obese Zucker rats. Magnesium-Bulletin, 19, 81-91.
49. WATANABE, H., KAKIHANA, M., OHTSUKA, S. & SUGISHITA, Y. (1997). Randomised, double-blind, placebo-controlled study of supplemental vitamin E on attenuation of the development of nitrate tolerance. Circ., 96, 2545-2550.
50. WOLFF, S.P. (1993). Diabetes mellitus and free radicals. Br. Med. Bull., 49, 642-652.
51. ZUCKER, L.M. & ANTONIADES, H.N. (1972). Insulin and obesity in the Zucker genetically obese 'fatty' rat. Endocrinol., 90, 1320-1330.