Parkin binds to α/β tubulin and increases their ubiquitination and degradation

Journal of Neuroscience

Volumn 23, Issue 8, 2003, Pages 3316-3324

  Ren, Yong ^a   Zhao, Jinghui ^a   Feng, Jian ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Dopamine; Microtubule; Misfolding; Parkin; Parkinson's disease; Tubulin; Ubiquitination

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA TUBULIN; BETA TUBULIN; CHAPERONIN; COLCHICINE; MUTANT PROTEIN; PARKIN; ROTENONE; TOXIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; DEPOLYMERIZATION; GLIA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MICROTUBULE; MITOCHONDRIAL RESPIRATION; NERVE CELL CULTURE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; RESPIRATORY CHAIN;

EID: 0037738525     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-08-03316.2003     Document Type: Article

References (35)

1. Baas PW (1997) Microtubules and axonal growth. Curr Opin Cell Biol 9:29-36.
2. Baas PW (2002) Microtubule transport in the axon. Int Rev Cytol 212:41-62.
3. Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3:1301-1306.
4. Brinkley BR, Barham SS, Barranco SC, Fuller GM (1974) Rotenone inhibition of spindle microtubule assembly in mammalian cells. Exp Cell Res 85:41-46.
5. Burke D, Gasdaska P, Hartwell L (1989) Dominant effects of tubulin overexpression in Saccharomyces cerevisiae. Mol Cell Biol 9:1049-1059.
6. Cappelletti G, Maggioni MG, Maci R (1999) Influence of MPP+ on the state of tubulin polymerisation in NGF-differentiated PC12 cells. J Neurosci Res 56:28-35.
7. Cappelletti G, Pedrotti B, Maggioni MG, Maci R (2001) Microtubule assembly is directly affected by MPP(+) in vitro. Cell Biol Int 25:981-984.
8. Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med 7:1144-1150.
9. Cleveland DW (1989) Autoregulated control of tubulin synthesis in animal cells. Curr Opin Cell Biol 1:10-14.
10. Fallon L, Moreau F, Croft BG, Labib N, Gu WJ, Fon EA (2002) Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem 277:486-491.
11. Feng J, Lin Y (2001) Parkin interacts with MAP1A and promotes its ubiquitination. Soc Neurosci Abstr 27:195.10.
12. Fenteany G, Schreiber SL (1998) Lactacystin, proteasome function, and cell fate. J Biol Chem 273:8545-8548.
13. Galloway PG, Mulvihill P, Perry G (1992) Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am J Pathol 140:809-822.
14. Giasson BI, Lee VM (2001) Parkin and the molecular pathways of Parkinson's disease. Neuron 31:885-888.
15. Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425-479.
16. Higgins DS, Greenamyre JT (1996) [H-3]dihydrorotenone binding to NADH: ubiquinone reductase (complex I) of the electron transport chain: an autoradiographic study. J Neurosci 16:3807-3816.
17. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R (2001) An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105:891-902.
18. Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605-608.
19. Langston JW, Ballard P, Tetrud JW, Irwin I (1983) Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979-980.
20. Lewis SA, Tian GL, Cowan NJ (1997) The alpha- and beta-tubulin folding pathways, Trends Cell Biol 7:479-484.
21. Lowe J, Blanchard A, Morrell K, Lennox G, Reynolds L, Billett M, Landon M, Mayer RJ (1988) Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodies in muscle, and mallory bodies in alcoholic liver disease. J Pathol 155:9-15.
22. Lucking CB, Durr A, Bonifati V, Vaughan J, De Michele G, Gasser T, Harhangi BS, Meco G, Denefle P, Wood NW, Agid Y, Brice A (2000) Association between early-onset Parkinson's disease and mutations in the parkin gene. N Engl J Med 342:1560-1567.
23. Manders EMM, Verbeek FJ, Aten JA (1993) Measurement of co-localization of objects in dual-color confocal images. J Microsc 169:375-382.
24. Marshall LE, Himes RH (1978) Rotenone inhibition of tubulin self-assembly. Biochim Biophys Acta 543:590-594.
25. Mayer RJ, Lowe J, Lennox G, Landon M, MacLennan K, Doherty FJ (1989) Intermediate filament-ubiquitin diseases: implications for cell sanitization. Biochem Soc Symp 55:193-201.
26. Mizuno Y, Suzuki K, Sone N, Saitoh T (1987) Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium ion (MPP+) in isolated-mitochondria from mouse brains. Neurosci Lett 81:204-208.
27. Pachter JS, Yen TJ, Cleveland DW (1987) Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell 51:283-292.
28. Przedborski S, Jackson-Lewis V (1998) Mechanisms of MPTP toxicity. Mov Disord 13:35-38.
29. Scott WK, Nance MA, Watts RL, Hubble JP, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH, Goetz CG, Small GW, Masterman D, Mastaglia F, Laing NG, Stajich JM, Slotterbeck B, et al. (2001) Complete genomic screen in Parkinson disease: evidence for multiple genes. JAMA 286:2239-2244.
30. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25:302-305.
31. Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ (2001) Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease. Science 293:263-269.
32. Vallee RB (1986) Purification of brain microtubules and microtubule-associated protein 1 using taxol. In: Methods in enzymology (Vallee RB, ed), pp 104-115. San Diego: Academic.
33. Wang DM, Moriggl R, Stravopodis D, Carpino N, Marine JC, Teglund S, Feng J, Ihle JN (2000) A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5. EMBO J 19:392-399.
34. Weinstein B, Solomon F (1990) Phenotypic consequences of tubulin overproduction in Saccharornyces cerevisiae: differences between α-tubulin and β-tubulin. Mol Cell Biol 10:5295-5304.
35. Zhang Y, Gao J, Chung KK, Huang H, Dawson VL, Dawson TM (2000) Parkin functions as an E2-dependent ubiquitin-protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCreI-1. Proc Natl Acad Sci USA 97:13354-13359.