Nitric oxide synthase: Models and mechanisms

Current Opinion in Chemical Biology

Volumn 4, Issue 6, 2000, Pages 687-695

  Groves, John T ^a   Wang, Charles C Y ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TRYPTOPHAN 2,3 DIOXYGENASE;

BIOSYNTHESIS; DIABETES MELLITUS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYMOLOGY; GRAFT REJECTION; HEART MUSCLE ISCHEMIA; OXIDATION REDUCTION POTENTIAL; REPERFUSION INJURY; REVIEW; SEPTIC SHOCK; X RAY CRYSTALLOGRAPHY;

EID: 0033637918     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1367-5931(00)00146-0     Document Type: Review

References (72)

1. Discovery of some of the biological effects of nitric oxide and its role in cell signaling
2. Endothelium-derived relaxing factor: Discovery, early studies, and identification as nitric oxide
3. NO in vascular biology
4. Formation and reactions of the heme-dioxygen intermediate in the first and second steps of nitric oxide synthesis as studied by stopped-flow spectroscopy under single-turnover conditions
5. Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric-oxide synthase from murine macrophages
6. N(ω)-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine
7. On the mechanism of the nitric-oxide synthase-catalyzed conversion of N-omega-hydroxy-L-arginine to citrulline and nitric-oxide
8. Macrophage nitric oxide synthase: Tetrahydrobiopterin decreases the NADPH stoichiometry
9. Nitric oxides synthase activity in mitochondria
10. Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria - Evidence for intramitochondrial peroxynitrite formation
11. Mammalian nitric oxide synthase
12. Reactivity of the flavin semiquinone of nitric oxide synthase in the oxygenation of arginine to N-G-hydroxyarginine, the first step of nitric oxide synthesis
13. Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginlne, the first oxygenation step in the enzymic synthesis of nitric oxide
14. Tetrahydrobiopterin, cytokines, and nitric oxide synthesis
15. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
16. Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen
17. Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase
18. Nitric oxide synthase structure and electron transfer
19. Theoretical studies on N-G-hydroxy-L-arginine and derived radicals: Implications for the mechanism of nitric oxide synthase
20. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate
21. Heme-mediated oxygen activation in biology: Cytochrome c oxidase and nitric oxide synthase
22. Crystal structure of constitutive endothelial nitric oxide synthase: A paradigm for pterin function involving a novel metal center
23. Structures of the N-omega-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins
24. Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase implications for dimer stability and comparison with endothelial nitric-oxide synthase
25. ENDOR spectroscopic evidence for the position and structure of N-G-hydroxy-L-arginine bound to holo-neuronal nitric oxide synthase
26. ENDOR studies of L-arginine and N-G-hydroxy-L-arginine bound to all three holo-nitric oxide synthase isozymes
27. No NO from NOS
28. Formation of free nitric-oxide from L-arginine by nitric-oxide synthase - Direct enhancement of generation by superoxide-dismutase
29. Direct measurement of NO generation from nNOS
30. Mechanism of superoxide generation by neuronal nitric-oxide synthase
31. Allosteric regulation of neuronal nitric oxide synthase by tetrahydrobiopterin and suppression of auto-damaging superoxide
32. Constitutive and inducible nitric-oxide synthases incorporate molecular-oxygen into both nitric-oxide and citrulline
33. L-citrulline production from L-arginine by macrophage NOS
34. Catalysis by nitric oxide synthase
35. Pterin-dependent amino acid hydroxylase
36. Activation of neuronal nitric-oxide synthase by the 5-methyl analog of tetrahydrobiopterin. Functional evidence against reductive oxygen activation by the pterin cofactor
37. Mutation of the five conserved histidines in the endothelial nitric-oxide synthase hemoprotein domain. No evidence for a non-heme metal requirement for catalysis
38. Oxidation of NG-hydroxy-L-arginine by nitric-oxide synthase: Evidence for the involvement of the heme in catalysis
39. Analysis of neuronal NO synthase under single-turnover conditions: Conversion of N-omega-hydroxyarginine to nitric oxide and citrulline
40. Nitric oxide modulates the catalytic activity of myeloperoxidase
41. Unusual oxidative chemistry of N-omega-hydroxyarginine and N-hydroxyguanidine catalyzed at an engineered cavity in a heme peroxidase
42. NO formation from oxidation of N-aryl N'-hydroxyguanidine
43. Multiple catalytic functions of train nitric-oxide synthase biochemical-characterization, cofactor-requirement, and the role of N(G.W)-hydroxy-L-arginine as an intermediate
44. Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin
45. Nitric-oxide synthase structure and mechanism
46. Multiple activated oxygen species in P450 catalysis - Contributions to specificity in drug metabolism
47. Models of nitric oxide synthase: Iron(III) porphyrin-catalyzed oxidation of fluorenone oxime to nitric oxide and fluorenone
48. Formation of N-delta-cyanoornithine from N-G-hydroxy-L-arginine and hydrogen peroxide by neuronal nitric oxide synthase: Implications for mechanism
49. Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase
50. The ferrous dioxygen complex of the oxygenase domain of neuronal nitric-oxide synthase
51. Models for nitric oxide synthase
52. Reactive iron porphyrin derivatives related to the catalytic cycles of cytochrome-P-450 and peroxidase - Studies of the mechanism of oxygen activation
53. Direct observation of the push effect on the O-O bond-cleavage of acylperoxoiron(III) porphyrin complexes
54. Comparative effects of substrates and pterin cofactor on the heme midpoint potential in inducible and neuronal nitric oxide synthases
55. Equilibrium acidities and homolytic bond-dissociation energies of the H-O bonds in oximes and amidoximes
56. Solvent effects on homolytic bond dissociation energies of hydroxylic acids
57. CO(SALEN) catalyzed oxidation of oximes with tert-butyl hydroperoxide
58. Isotope effects and alternative substrate reactivities for tryptophan 2,3-dioxygenase
59. A chemical model of tryptophan 2,3-dioxygenase: Reactivity and formation of a reactive intermediate in the dioxygenation processes
60. Important role of Fe(III)TPP-oxygen-skatole ternary complex in tryptophan dioxygenase model reaction system
61. Burgi-Dunitz trajectory in enzyme chemistry
62. Geometrical reaction coordinates. II Nucleophilic addition to the carbonyl group
63. Mechanism of inactivation of neuronal nitric oxide synthase by N-omega-allyl-L-arginine
64. On the transition-states of electrophilic radical additions to alkenes
65. Redox chemistry of water-soluble iron, manganese, and chromium metalloporphyrins and acid-base behavior of their lyate axial ligands in aqueous-solution - Influence of electronic effects
66. Determination of pterins in biological samples by liquid chromatography/electrochemistry with a dual-electrode detector
67. Direct electron injection from electrodes to cytochrome P450(cam) in biomembranes-like films
68. Comparative effects of substrates and pterin cofactor on the heme midpoint potential in inducible and neuronal nitric oxide synthases
69. L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric-oxide synthase