Interleukin-6 activates phosphoinositol-3′ kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways

Oncogene

Volumn 23, Issue 19, 2004, Pages 3368-3375

  Hsu, Jung Hsin ^a   Shi, Yijiang ^a   Frost, Patrick ^a   Yan, Huajun ^a   Hoang, Bao ^a   Sharma, Sanjai ^a   Gera, Joseph ^a   Lichtenstein, Alan ^a,b  

^a UCLA MEDICAL CENTER   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

AKT; Interleukin 6; Multiple myeloma; Phosphatidylinositol 3 kinase

Indexed keywords

INTERLEUKIN 6; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P21; PROTEIN P85; RAS PROTEIN; STAT3 PROTEIN;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MULTIPLE MYELOMA; MYELOMA CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL LINE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-6; MULTIPLE MYELOMA; ONCOGENE PROTEIN P21(RAS); PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 2442715069     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207459     Document Type: Article

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