Endotoxin-mediated delayed islet graft function is associated with increased intra-islet cytokine production and islet cell apoptosis

Transplantation

Volumn 71, Issue 1, 2001, Pages 125-132

  Berney, Thierry ^a   Molano, R Damaris ^a   Cattan, Pierre ^a   Pileggi, Antonello ^a   Vizzardelli, Caterina ^a   Oliver, Robert ^a   Ricordi, Camillo ^a   Inverardi, Luca ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL TISSUE; APOPTOSIS; ARTICLE; GRAFT REJECTION; GRAFT SURVIVAL; MALE; MOUSE; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL;

EID: 0035862989     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200101150-00020     Document Type: Article

References (38)

1. Results, research priorities, and reasons for optimism: Islet transplantation for patients with type I diabetes
2. Human islet cell transplantation: New perspectives for an old challenge
3. Destruction of islet isograft by severe non-specific inflammation
4. Local immunomodulation to promote co-stimulatory blockade
5. Differential roles of Mac-1+ cells, and CD4+ and CD8+ T lymphocytes in primary nonfunction and classic rejection of islet allografts
6. Human pancreatic islet beta-cell destruction by cytokines involves oxygen free radicals and aldehyde production
7. Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans
8. Hepatic nitric oxide generation as a putative mechanism for failure of intrahepatic cell grafts
9. Effect of 15-deoxyspergualin on immediate function and long-term survival of transplanted islets in murine recipients of a marginal islet mass
10. Prolongation of canine islet allograft survival by 15-deoxyspergualin
11. Transplantation of allogeneic islets of Langerhans in the rat liver: Effects of macrophage depletion on graft survival and microenvironment activation
12. Human tumor necrosis factor potentiates human interleukin-1-mediated rat pancreatic β-cell cytotoxicity
13. Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets
14. IL-1 produced and released endogenously within human islets inhibits β cell function
15. Endotoxin contamination may be responsible for the unexplained failure of human pancreatic islet transplantation
16. Endotoxin impairs the engraftment of rat islets transplanted beneath the kidney capsule of C57BL/6-mice
17. Assessment of intracellular insulin content during all steps of human islet isolation procedure
18. Endotoxin-mediated activation of cytokine production in human PB-MCs by collagenase and Ficoll
19. Endotoxin activity of collagenase in human islet transplantation
20. Structural and functional changes resulting from islet isolation lead to islet cell death
21. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
22. Improved human islet isolation using a new enzyme blend, liberase
23. Quantification of low copy transcripts by continuous SYBR Green I monitoring during amplification
24. Improved pig islet yield and post-culture recovery using Liberase PI purified enzyme blend
25. Evaluation of a purified enzyme blend for the recovery and function of canine pancreatic islets
26. Significant progress in porcine islet mass isolation utilizing liberase HI for enzymatic low-temperature pancreas digestion
27. Expression of CD14 in human β cells and human insular cell lines
28. Evidence for IL-6 production by and effects on the pancreatic beta-cell
29. Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells
30. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells
31. Human endothelial cells produce IL-6: Lack of responses to exogenous IL-6
32. Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro
33. Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice
34. Apoptosis occurs in freshly isolated human islets under standard culture conditions
35. Apoptosis in the pancreatic islet cells of the neonatal rat is associated with a reduced expression of insulin-like growth factor II that may act as a survival factor
36. Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation
37. DNA fragmentation is an early event in cytokine-induced islet beta-cell destruction
38. LPS-induced TNF-alpha release from and apoptosis in rat cardiomyocytes: Obligatory role for CD14 in mediating the LPS response