TRIB3 is implicated in glucotoxicity- and oestrogen receptor-stress-induced β-cell apoptosis

Journal of Endocrinology

Volumn 199, Issue 3, 2008, Pages 407-416

  Qian, Bo ^a,b   Wang, Haiyan ^c   Men, Xiuli ^b   Zhang, Wenjian ^b   Cai, Hanqing ^b   Xu, Shiqing ^b   Xu, Yaping ^b   Ye, Liya ^b   Wollheim, Claes B ^c   Lou, Jinning ^b  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; ESTROGEN RECEPTOR; GLUCOSE; INSULIN; NERVE PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; THAPSIGARGIN; TRIBBLE 3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL GROWTH; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENE SILENCING; GOTO KAKIZAKI RAT; IN VITRO STUDY; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL LINE; CELL PROLIFERATION; DNA FRAGMENTATION; FLOW CYTOMETRY; GENE EXPRESSION; GLUCOSE; IN SITU NICK-END LABELING; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDATIVE STRESS; PROTEIN KINASES; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; THAPSIGARGIN; XANTHINE OXIDASE;

EID: 57449102900     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-08-0331     Document Type: Article

References (30)

1. Boudeau J, Miranda-Saavedra D, Barton GJ & Alessi DR 2006 Emerging roles of pseudokinases. Trends in Cell Biology 16 443-445.
2. Carracedo A, Gironella M, Lorente M, Garcia S, Guzmán M, Velasco G & Iovanna JL 2006 Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes. Cancer Research 66 6748-6755.
3. Cavaghan MK, Ehrmann DA & Polonsky KS 2000 Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. Journal of Clinical Investigation 106 329-333.
4. Dickson LM & Rhodes CJ 2004 Pancreatic β-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt? American Journal of Physiology Endocrinology and Metabolism 287 E192-E198.
5. Du K, Herzig S, Kulkarni RN & Montminy M 2003 TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300 1574-1577.
6. Eizirik DL, Cardozo AK & Cnop M 2008 The role of endoplasmic reticulum stress in diabetes mellitus. Endocrine Reviews 29 42-61.
7. Elghazi L, Rachdi L, Weiss AJ, Cras-Méneuur C & Bernal-Mizrachi E 2007 Regulation of beta-cell mass and function by Akt/ protein kinase B signaling pathway. Diabetes, Obesity and Metabolism 9 147-157.
8. Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano K, Bonini P, Bertuzzi F et al. 2001 High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program. Diabetes 50 1290-1301.
9. Gossen M, Freundlieb S, Bender G, Müller G, Hillen W & Bujard H 1995 Transcriptional activation by tetracyclines in mammalian cells. Science 268 1766-1769.
10. Grill V & Björklund A 2001 Overstimulation and beca-cell function. Diabetes 50 S122-S124.
11. Harding HF, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H, Sabatini DD & Ron D 2001 Diabetes mellitus and exocrine pancreatic dysfunction in perk -/- truce reveals a role for translational control in secretory cell survival. Molecular Cell 7 1153-1163.
12. He L, Simmen FA, Mehendale HM, Ronis MJ & Badger TM 2006 Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/ protein kinase B activation. Journal of Biological Chemistry 281 11126-11134.
13. Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF et al. 2006 Skeletal muscle- selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Molecular and Cellular Biology 26 8217-8227.
14. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olelsky J & Montminy M 2004 PGC-1 promotes insulin resistance in liver through PPAR- α-dependent induction of TRB-3. Nature Medicine 10 530-534.
15. Koyama M, Wida R, Sakuraba H, Mizukami H & Yagihashi S 1998 Accelerated loss ofislet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus. American Journal of Pathology 153 537-545.
16. Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV & Biden TJ 2007 Endoplasmic reticulum stress contributes to β-cell apoptosis in type 2 diabetes. Diabetologia 50 752-763.
17. Lee YH & White MF 2004 Insulin receptor substrate proteins and diabetes. Archives of Pharmacological Research 207 361-370.
18. Maedler K, Spinas GA, Lehmann R, Sergeev F, Weber M, Fontana A, Kaiser N & Donath MY 2001 Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 50 1683-1690.
19. Maedler K, Oberholzer J, Bucher P, Spinas GA & Donath MY 2003 Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 52 726-733.
20. Marchetti P, Bugliani M, Lupi R,, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL & Coop M 2007 The endoplasmic reticulum in pancreatic beta-cells of type 2 diabetes patients. Diabetologia 50 2486-2494.
21. Matsushima R, Harada N, Webster NJ, Tsutsumi YM & Nakaya Y 2006 Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity. Journal of Biological Chemistry 281 29719-29729.
22. Mayumi-Matsuda K, Kojima S, Suzuki H & Sakata T 1999 Ideritification of a novel kinase-like gene induced during neuronal cell death. Biochemical and Biophysical Research Communications 258 260-264.
23. Muoio DM & Newgard CB 2008 Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes. Nature Reviews. Molecular Cell Biology 9 193-205.
24. Ohoka N, Yoshii S, Hattori T, Onozaki K & Hayashi H 2005 TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO Journal 24 1243-1255.
25. Robertson RP 2006 Oxidative stress and impaired secretion in type 2 diabets. Current Opinion in Pharmacology 6 1-5.
26. Shapiro AM, Hao E, Rajotte RV & Kneteman NM 1996 High yield of rodent islets with intraductal collagenase and stationary digestion: a comparison with standard technique. Cell Transplantation 5 631-638.
27. Shih CM, Ko WC & Wu JS 2004 Mediating of caspase-independent apoptosis by cadmium, through the mitochondria-ROS pathway in MRC-5 fibroblasts. Journal of Cellular Biochemistry 91 384-397.
28. Wang H & Iynedjian PB 1997 Modulation of glucose responsiveness of insuhnoma beta-cells by graded overexpression of glucokinase. PNAS 94 43722-4377.
29. Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M & Wollheim CB 2002 Foxa2 (HNF3β) controls multiple genes implicated in metabolism-secretion coupling of glucose induced insulin release. Journal of Biological Chemistry 277 17564-17570.
30. Wang H, Kouri G & Wollheim CB 2005 ER stress and SREBP-1 activation are implicated in β-cell glucolipotoxicity. Journal of Cell Science 118 3905-3915.