메뉴 건너뛰기




Volumn 54, Issue SUPPL. 2, 2005, Pages

Interleukin-6 and diabetes: The good, the bad, or the indifferent?

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ALPHA; INTERLEUKIN RECEPTOR; UNCLASSIFIED DRUG;

EID: 33644755633     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/diabetes.54.suppl_2.S114     Document Type: Review
Times cited : (446)

References (75)
  • 2
    • 21344460247 scopus 로고    scopus 로고
    • An immune origin of type 2 diabetes
    • Kolb H, Mandrup-Poulsen T: An immune origin of type 2 diabetes. Diabetologia 48:1038-1050, 2005
    • (2005) Diabetologia , vol.48 , pp. 1038-1050
    • Kolb, H.1    Mandrup-Poulsen, T.2
  • 3
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes
    • Pickup JC: Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27:813-823, 2004
    • (2004) Diabetes Care , vol.27 , pp. 813-823
    • Pickup, J.C.1
  • 4
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death: The signal-transduction of immune-mediated beta-cell apoptosis
    • Eizirik DL, Mandrup-Poulsen T: A choice of death: the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44:2115-2133, 2001
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 5
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson MA, Eisenbarth GS: Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358:221-229, 2001
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 6
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM: Role of insulin resistance in human disease. Diabetes 37:1595-1607, 1988
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 7
    • 1542297244 scopus 로고    scopus 로고
    • IL-6 signal transduction and its physiological roles: The signal orchestration model
    • Kamimura D, Ishihara K, Hirano T: IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149:1-38, 2003
    • (2003) Rev Physiol Biochem Pharmacol , vol.149 , pp. 1-38
    • Kamimura, D.1    Ishihara, K.2    Hirano, T.3
  • 9
    • 0040780540 scopus 로고    scopus 로고
    • Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation
    • Terry CF, Loukaci V, Green FR: Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 275:18138-18144, 2000
    • (2000) J Biol Chem , vol.275 , pp. 18138-18144
    • Terry, C.F.1    Loukaci, V.2    Green, F.R.3
  • 10
    • 0032189103 scopus 로고    scopus 로고
    • The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
    • Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102:1369-1376, 1998
    • (1998) J Clin Invest , vol.102 , pp. 1369-1376
    • Fishman, D.1    Faulds, G.2    Jeffery, R.3    Mohamed-Ali, V.4    Yudkin, J.S.5    Humphries, S.6    Woo, P.7
  • 11
    • 14044259453 scopus 로고    scopus 로고
    • Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity
    • Wang H, Zhang Z, Chu W, Cooper JJ, Elbein SC: Molecular screening and association analyses of the interleukin 6 receptor gene variants with type 2 diabetes, diabetic nephropathy, and insulin sensitivity. J Clin Endocrinol Metab 90:1123-1129, 2005
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1123-1129
    • Wang, H.1    Zhang, Z.2    Chu, W.3    Cooper, J.J.4    Elbein, S.C.5
  • 13
    • 0035164602 scopus 로고    scopus 로고
    • The soluble interleukin 6 receptor: Mechanisms of production and implications in disease
    • Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM: The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 15:43-58, 2001
    • (2001) FASEB J , vol.15 , pp. 43-58
    • Jones, S.A.1    Horiuchi, S.2    Topley, N.3    Yamamoto, N.4    Fuller, G.M.5
  • 14
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex
    • Boulanger MJ, Chow DC, Brevnova EE, Garcia KC: Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex. Science 300:2101-2104, 2003
    • (2003) Science , vol.300 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 15
    • 0033780153 scopus 로고    scopus 로고
    • A polymorphism in the promoter region of the gene for interleukin-6 is associated with susceptibility to type 1 diabetes mellitus
    • Jahromi MM, Millward BA, Demaine AG: A polymorphism in the promoter region of the gene for interleukin-6 is associated with susceptibility to type 1 diabetes mellitus. J Interferon Cytokine Res 20:885-888, 2000
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 885-888
    • Jahromi, M.M.1    Millward, B.A.2    Demaine, A.G.3
  • 16
    • 3242795010 scopus 로고    scopus 로고
    • Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes
    • Eerligh P, Koeleman BPC, Dudbridge F, Bruining GJ, Roep BO, Giphart MJ: Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes. Genes Immun 5:36-40, 2004
    • (2004) Genes Immun , vol.5 , pp. 36-40
    • Eerligh, P.1    Bpc, K.2    Dudbridge, F.3    Bruining, G.J.4    Roep, B.O.5    Giphart, M.J.6
  • 20
    • 7044231463 scopus 로고    scopus 로고
    • Genetic predisposition of the interleukin-6 response to inflammation: Implications for a variety of major diseases?
    • Bennermo M, Held C, Stemme S, Ericsson CG, Silveira A, Green F, Tornvall P: Genetic predisposition of the interleukin-6 response to inflammation: implications for a variety of major diseases? Clin Chem 50:2136-2140, 2004
    • (2004) Clin Chem , vol.50 , pp. 2136-2140
    • Bennermo, M.1    Held, C.2    Stemme, S.3    Ericsson, C.G.4    Silveira, A.5    Green, F.6    Tornvall, P.7
  • 21
    • 0030922247 scopus 로고    scopus 로고
    • Repression of interleukin-6 gene expression by 17 beta-estradiol: Inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor
    • Ray P, Ghosh SK, Zhang DH, Ray A: Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. FEBS Lett 409:79-85, 1997
    • (1997) FEBS Lett , vol.409 , pp. 79-85
    • Ray, P.1    Ghosh, S.K.2    Zhang, D.H.3    Ray, A.4
  • 23
    • 2542458388 scopus 로고    scopus 로고
    • A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus
    • Stephens JW, Hurel SJ, Cooper JA, Acharya J, Miller GJ, Humphries SE: A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus. Mol Genet Metab 82:180-186, 2004
    • (2004) Mol Genet Metab , vol.82 , pp. 180-186
    • Stephens, J.W.1    Hurel, S.J.2    Cooper, J.A.3    Acharya, J.4    Miller, G.J.5    Humphries, S.E.6
  • 27
    • 0142185104 scopus 로고    scopus 로고
    • Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians
    • Wolford JK, Colligan PB, Gruber JD, Bogardus C: Variants in the interleukin 6 receptor gene are associated with obesity in Pima Indians. Mol Genet Metab 80:338-343, 2003
    • (2003) Mol Genet Metab , vol.80 , pp. 338-343
    • Wolford, J.K.1    Colligan, P.B.2    Gruber, J.D.3    Bogardus, C.4
  • 29
    • 0037312898 scopus 로고    scopus 로고
    • The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity
    • Kubaszek A, Pihlajamaki J, Punnonen K, Karhapaa P, Vauhkonen I, Laakso M: The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. Diabetes 52:558-561, 2003
    • (2003) Diabetes , vol.52 , pp. 558-561
    • Kubaszek, A.1    Pihlajamaki, J.2    Punnonen, K.3    Karhapaa, P.4    Vauhkonen, I.5    Laakso, M.6
  • 31
    • 0025251790 scopus 로고
    • Inhibition of insulin secretion from rat islets of Langerhans by interleukin-6: An effect distinct from that of interleukin-1
    • Southern C, Schulster D, Green IC: Inhibition of insulin secretion from rat islets of Langerhans by interleukin-6: an effect distinct from that of interleukin-1. Biochem J 272:243-245, 1990
    • (1990) Biochem J , vol.272 , pp. 243-245
    • Southern, C.1    Schulster, D.2    Green, I.C.3
  • 32
    • 0025159212 scopus 로고
    • Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro
    • Sandler S, Bendtzen K, Eizirik DL, Welsh M: Interleukin-6 affects insulin secretion and glucose metabolism of rat pancreatic islets in vitro. Endocrinology 126:1288-1294, 1990
    • (1990) Endocrinology , vol.126 , pp. 1288-1294
    • Sandler, S.1    Bendtzen, K.2    Eizirik, D.L.3    Welsh, M.4
  • 34
    • 0031710647 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor potentiates the β-cell inhibitory effect of IL-1 in rat pancreatic islets: Association with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase
    • Wadt KA, Larsen CM, Andersen HU, Nielsen K, Karlsen AE, Mandrup-Poulsen T: Ciliary neurotrophic factor potentiates the β-cell inhibitory effect of IL-1 in rat pancreatic islets: association with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Diabetes 47:1602-1608, 1998
    • (1998) Diabetes , vol.47 , pp. 1602-1608
    • Wadt, K.A.1    Larsen, C.M.2    Andersen, H.U.3    Nielsen, K.4    Karlsen, A.E.5    Mandrup-Poulsen, T.6
  • 35
    • 0042839568 scopus 로고    scopus 로고
    • Role of cytokines in the pathogenesis of autoimmune diabetes mellitus
    • Rabinovitch A, Suarez-Pinzon WL: Role of cytokines in the pathogenesis of autoimmune diabetes mellitus. Rev Endocr Metab Disord 4:291-299, 2003
    • (2003) Rev Endocr Metab Disord , vol.4 , pp. 291-299
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 36
    • 17944385649 scopus 로고    scopus 로고
    • Activation of Reg gene, a gene for insulin-producing beta-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation
    • Akiyama T, Takasawa S, Nata K, Kobayashi S, Abe M, Shervani NJ, Ikeda T, Nakagawa K, Unno M, Matsuno S, Okamoto H: Activation of Reg gene, a gene for insulin-producing beta-cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Proc Natl Acad Sci U S A 98:48-53, 2001
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 48-53
    • Akiyama, T.1    Takasawa, S.2    Nata, K.3    Kobayashi, S.4    Abe, M.5    Shervani, N.J.6    Ikeda, T.7    Nakagawa, K.8    Unno, M.9    Matsuno, S.10    Okamoto, H.11
  • 38
    • 0036067631 scopus 로고    scopus 로고
    • A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice
    • Gurr W, Yavari R, Wen L, Shaw M, Mora C, Christa L, Sherwin RS: A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice. Diabetes 51:339-346, 2002
    • (2002) Diabetes , vol.51 , pp. 339-346
    • Gurr, W.1    Yavari, R.2    Wen, L.3    Shaw, M.4    Mora, C.5    Christa, L.6    Sherwin, R.S.7
  • 39
    • 0027218427 scopus 로고
    • Insulin-dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a TH2 and not a TH1 mediated event
    • Anderson JT, Cornelius JG, Jarpe AJ, Winter WE, Peck AB: Insulin-dependent diabetes in the NOD mouse model. II. Beta cell destruction in autoimmune diabetes is a TH2 and not a TH1 mediated event. Autoimmunity 15:113-122, 1993
    • (1993) Autoimmunity , vol.15 , pp. 113-122
    • Anderson, J.T.1    Cornelius, J.G.2    Jarpe, A.J.3    Winter, W.E.4    Peck, A.B.5
  • 40
    • 0028568369 scopus 로고
    • Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice
    • DiCosmo BF, Picarella D, Flavell RA: Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice. Int Immunol 6:1829-1837, 1994
    • (1994) Int Immunol , vol.6 , pp. 1829-1837
    • DiCosmo, B.F.1    Picarella, D.2    Flavell, R.A.3
  • 41
    • 0028321588 scopus 로고
    • Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice
    • Campbell IL, Hobbs MV, Dockter J, Oldstone MB, Allison J: Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice. Am J Pathol 145:157-166, 1994
    • (1994) Am J Pathol , vol.145 , pp. 157-166
    • Campbell, I.L.1    Hobbs, M.V.2    Dockter, J.3    Oldstone, M.B.4    Allison, J.5
  • 43
    • 0028971717 scopus 로고
    • Demonstration of a TH1 cytokine profile in the late phase of NOD insulitis
    • Pilstrom B, Bjork L, Bohme J: Demonstration of a TH1 cytokine profile in the late phase of NOD insulitis. Cytokine 7:806-814, 1995
    • (1995) Cytokine , vol.7 , pp. 806-814
    • Pilstrom, B.1    Bjork, L.2    Bohme, J.3
  • 44
    • 0345700727 scopus 로고    scopus 로고
    • Inflammatory cytokines and the risk to develop type 2 diabetes: Results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    • Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF: Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52:812-817, 2003
    • (2003) Diabetes , vol.52 , pp. 812-817
    • Spranger, J.1    Kroke, A.2    Mohlig, M.3    Hoffmann, K.4    Bergmann, M.M.5    Ristow, M.6    Boeing, H.7    Pfeiffer, A.F.8
  • 45
    • 1442301080 scopus 로고    scopus 로고
    • Inflammatory markers and risk of developing type 2 diabetes in women
    • Hu FB, Meigs JB, Li TY, Rifai N, Manson JE: Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes 53:693-700, 2004
    • (2004) Diabetes , vol.53 , pp. 693-700
    • Hu, F.B.1    Meigs, J.B.2    Li, T.Y.3    Rifai, N.4    Manson, J.E.5
  • 46
    • 0035908632 scopus 로고    scopus 로고
    • C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
    • Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM: C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334, 2001
    • (2001) JAMA , vol.286 , pp. 327-334
    • Pradhan, A.D.1    Manson, J.E.2    Rifai, N.3    Buring, J.E.4    Ridker, P.M.5
  • 47
    • 0024406719 scopus 로고
    • Evidence for IL-6 production by and effects on the pancreatic beta-cell
    • Campbell IL, Cutri A, Wilson A, Harrison LC: Evidence for IL-6 production by and effects on the pancreatic beta-cell. J Immunol 143:1188-1191, 1989
    • (1989) J Immunol , vol.143 , pp. 1188-1191
    • Campbell, I.L.1    Cutri, A.2    Wilson, A.3    Harrison, L.C.4
  • 48
    • 3042739678 scopus 로고    scopus 로고
    • Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: Absence of development of age-related obesity
    • Di Gregorio GB, Hensley L, Lu T, Ranganathan G, Kern PA: Lipid and carbohydrate metabolism in mice with a targeted mutation in the IL-6 gene: absence of development of age-related obesity. Am J Physiol Endocrinol Metab 287:E182-E187, 2004
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Di Gregorio, G.B.1    Hensley, L.2    Lu, T.3    Ranganathan, G.4    Kern, P.A.5
  • 53
    • 4143148710 scopus 로고    scopus 로고
    • Interleukin-6 and insulin sensitivity: Friend or foe?
    • Carey AL, Febbraio MA: Interleukin-6 and insulin sensitivity: friend or foe? Diabetologia 47:1135-1142, 2004
    • (2004) Diabetologia , vol.47 , pp. 1135-1142
    • Carey, A.L.1    Febbraio, M.A.2
  • 55
    • 0031762908 scopus 로고    scopus 로고
    • Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: Depot difference and regulation by glucocorticoid
    • Fried SK, Bunkin DA, Greenberg AS: Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850, 1998
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 847-850
    • Fried, S.K.1    Bunkin, D.A.2    Greenberg, A.S.3
  • 56
    • 0037397789 scopus 로고    scopus 로고
    • Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes
    • Pedersen M, Bruunsgaard H, Weis N, Hendel HW, Andreassen BU, Eldrup E, Dela F, Pedersen BK: Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mech Ageing Dev 124:495-502, 2003
    • (2003) Mech Ageing Dev , vol.124 , pp. 495-502
    • Pedersen, M.1    Bruunsgaard, H.2    Weis, N.3    Hendel, H.W.4    Andreassen, B.U.5    Eldrup, E.6    Dela, F.7    Pedersen, B.K.8
  • 60
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V, Nagaev I, Smith U: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278:45777-45784, 2003
    • (2003) J Biol Chem , vol.278 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 61
    • 0242299763 scopus 로고    scopus 로고
    • Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: Prevention by rosiglitazone
    • Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M: Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun 311:372-379, 2003
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 372-379
    • Lagathu, C.1    Bastard, J.P.2    Auclair, M.3    Maachi, M.4    Capeau, J.5    Caron, M.6
  • 62
    • 4544256147 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling
    • Shi H, Tzameli I, Bjorbaek C, Flier JS: Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling. J Biol Chem 279:34733-34740, 2004
    • (2004) J Biol Chem , vol.279 , pp. 34733-34740
    • Shi, H.1    Tzameli, I.2    Bjorbaek, C.3    Flier, J.S.4
  • 64
    • 0037101934 scopus 로고    scopus 로고
    • Metabolic effects of interleukin-6 in human splanchnic and adipose tissue
    • Lyngso D, Simonsen L, Bulow J: Metabolic effects of interleukin-6 in human splanchnic and adipose tissue. J Physiol 543:379-386, 2002
    • (2002) J Physiol , vol.543 , pp. 379-386
    • Lyngso, D.1    Simonsen, L.2    Bulow, J.3
  • 65
    • 4344698092 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients
    • Rieusset J, Bouzakri K, Chevillotte E, Ricard N, Jacquet D, Bastard JP, Laville M, Vidal H: Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients. Diabetes 53:2232-2241, 2004
    • (2004) Diabetes , vol.53 , pp. 2232-2241
    • Rieusset, J.1    Bouzakri, K.2    Chevillotte, E.3    Ricard, N.4    Jacquet, D.5    Bastard, J.P.6    Laville, M.7    Vidal, H.8
  • 67
    • 3142710172 scopus 로고    scopus 로고
    • Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with type 2 diabetes: Evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
    • Carey AL, Bruce CR, Sacchetti M, Anderson MJ, Olsen DB, Saltin B, Hawley JA, Febbraio MA: Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness. Diabetologia 47:1029-1037, 2004
    • (2004) Diabetologia , vol.47 , pp. 1029-1037
    • Carey, A.L.1    Bruce, C.R.2    Sacchetti, M.3    Anderson, M.J.4    Olsen, D.B.5    Saltin, B.6    Hawley, J.A.7    Febbraio, M.A.8
  • 69
    • 3042721664 scopus 로고    scopus 로고
    • Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
    • Febbraio MA, Hiscock N, Sacchetti M, Fischer CP, Pedersen BK: Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 53:1643-1648, 2004
    • (2004) Diabetes , vol.53 , pp. 1643-1648
    • Febbraio, M.A.1    Hiscock, N.2    Sacchetti, M.3    Fischer, C.P.4    Pedersen, B.K.5
  • 71
    • 0242268894 scopus 로고    scopus 로고
    • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    • Klover PJ, Zimmers TA, Koniaris LG, Mooney RA: Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52:2784-2789, 2003
    • (2003) Diabetes , vol.52 , pp. 2784-2789
    • Klover, P.J.1    Zimmers, T.A.2    Koniaris, L.G.3    Mooney, R.A.4
  • 72
    • 0031596597 scopus 로고    scopus 로고
    • Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes
    • Kanemaki T, Kitade H, Kaibori M, Sakitani K, Hiramatsu Y, Kamiyama Y, Ito S, Okumura T: Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes. Hepatology 27:1296-1303, 1998
    • (1998) Hepatology , vol.27 , pp. 1296-1303
    • Kanemaki, T.1    Kitade, H.2    Kaibori, M.3    Sakitani, K.4    Hiramatsu, Y.5    Kamiyama, Y.6    Ito, S.7    Okumura, T.8
  • 73
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Mooney RA: Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51:3391-3399, 2002
    • (2002) Diabetes , vol.51 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 74
    • 0037853260 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Zimmers TA, Koniaris LG, Furlanetto RW, Mooney RA: Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 278:13740-13746, 2003
    • (2003) J Biol Chem , vol.278 , pp. 13740-13746
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Zimmers, T.A.4    Koniaris, L.G.5    Furlanetto, R.W.6    Mooney, R.A.7
  • 75
    • 0142087565 scopus 로고    scopus 로고
    • The therapeutic potential of interleukin-6 in treating obesity
    • Wallenius K, Jansson JO, Wallenius V: The therapeutic potential of interleukin-6 in treating obesity. Expert Opin Biol Ther 3:1061-1070, 2003
    • (2003) Expert Opin Biol Ther , vol.3 , pp. 1061-1070
    • Wallenius, K.1    Jansson, J.O.2    Wallenius, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.