The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program

Cancer Research

Volumn 65, Issue 14, 2005, Pages 6237-6244

  De Craene, Bram ^a   Gilbert, Barbara ^a   Stove, Christophe ^a   Bruyneel, Erik ^b   Van Roy, Frans ^a   Berx, Geert ^a,c  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

^c Unit of Molecular and Cellular Oncology ^*  (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR SNAIL; UVOMORULIN;

ARTICLE; BINDING SITE; CANCER CELL; CELL DIFFERENTIATION; CELL INVASION; COMPLEX FORMATION; DNA MICROARRAY; EPITHELIUM CELL; GASTRULATION; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE REPRESSION; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERMEDIATE FILAMENT; MESENCHYME CELL; PRIORITY JOURNAL; PROMOTER REGION; TUMOR CELL;

ACTINS; CELL AGGREGATION; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; COLORECTAL NEOPLASMS; CYTOSKELETON; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 22244432840     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3545     Document Type: Article

References (24)

1. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-54.
2. Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002;3:155-66.
3. De Craene B, van Roy F, Berx G. Unraveling signalling cascades for the Snail family of transcription factors. Cell Signal 2005;17:535-47.
4. Cano A, Perez-Moreno MA, Rodrigo I, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2:76-83.
5. Batlle E, Sancho E, Franci C, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000;2:84-9.
6. Berx G, Van Roy F. Epithelial cell plasticity by dynamic transcriptional regulation of E-cadherin. In: Savagner P, editor. Rise and fall of epithelial phenotype. New York/ Dordrecht (the Netherlands): Kluwer Academic Plenum; 2004. p. 01-13.
7. Ikenouchi J, Matsuda M, Furuse M, Tsukita S. Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 2003;116:1959-67.
8. Guaita S, Puig I, Franci C, et al. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 2002;277:39209-16.
9. Comijn J, Berx G, Vermassen P, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 2001;7:1267-78.
10. Dabrowski M, Aerts S, Van Hummelen P, et al. Gene profiling of hippocampal neuronal culture. J Neurochem 2003;85:1279-88.
11. Vanpoucke G, Goossens S, De Craene B, Gilbert B, van Roy F, Berx G. GATA-4 and MEF2C transcription factors control the tissue-specific expression of the αT-catenin gene CTNNA3. Nucleic Acids Res 2004;32:4155-65.
12. van de Wetering M, Sancho E, Verweij C, et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50.
13. Ohkubo T, Ozawa M. The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation. J Cell Sci 2004;117:1675-85.
14. Michl P, Barth C, Buchholz M, et al. Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res 2003;63:6265-71.
15. Gotzmann J, Huber H, Thallinger C, et al. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness. J Cell Sci 2002;115:1189-202.
16. Valdes F, Alvarez AM, Locascio A, et al. The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor β in fetal rat hepatocytes. Mol Cancer Res 2002;1:68-78.
17. Chen X, Bonne S, Hatzfeld M, van Roy F, Green KJ. Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and β-catenin signaling. J Biol Chem 2002;277:10512-22.
18. Hesse M, Franz T, Tamai Y, Taketo MM, Magin TM. Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality. EMBO J 2000;19:5060-70.
19. Chen X, Whitney EM, Gao SY, Yang VW. Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol 2003;326:665-77.
20. Segre JA, Bauer C, Fuchs E. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet 1999;22:356-60.
21. Murthy A, Gonzalez-Agosti C, Cordero E, et al. NHE-BF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem 1998;273:1273-6.
22. Lu C, Huang X, Ma HF, et al. Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein. Neuroscience 2003;120:121-31.
23. Maul RS, Song Y, Amann KJ, Gerbin SC, Pollard TD, Chang DD. EPLIN regulates actin dynamics by cross-linking and stabilizing filaments. J Cell Biol 2003;160:399-407.
24. Wang X, Kumar R, Navarre J, Casanova JE, Goldenring JR. Regulation of vesicle trafficking in Madin-Darby canine kidney cells by Rab11a and Rab25. J Biol Chem 2000;275:29138-46.